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  1. Article ; Online: Oral Health in Patients with Inflammatory Bowel Diseases Qualified for Biologic Treatment.

    Nijakowski, Kacper

    International journal of environmental research and public health

    2022  Volume 19, Issue 23

    Abstract: Oral health is closely linked to general health status in the form of a bidirectional relationship [ ... ]. ...

    Abstract Oral health is closely linked to general health status in the form of a bidirectional relationship [...].
    MeSH term(s) Humans ; Oral Health ; Inflammatory Bowel Diseases/drug therapy ; Patients
    Language English
    Publishing date 2022-11-24
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph192315584
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Salivary Biomarkers for Alzheimer's Disease: A Systematic Review with Meta-Analysis.

    Nijakowski, Kacper / Owecki, Wojciech / Jankowski, Jakub / Surdacka, Anna

    International journal of molecular sciences

    2024  Volume 25, Issue 2

    Abstract: Alzheimer's Disease (AD) is the most common neurodegenerative disease which manifests with progressive cognitive impairment, leading to dementia. Considering the noninvasive collection of saliva, we designed the systematic review to answer the question " ... ...

    Abstract Alzheimer's Disease (AD) is the most common neurodegenerative disease which manifests with progressive cognitive impairment, leading to dementia. Considering the noninvasive collection of saliva, we designed the systematic review to answer the question "Are salivary biomarkers reliable for the diagnosis of Alzheimer's Disease?" Following the inclusion and exclusion criteria, 30 studies were included in this systematic review (according to the PRISMA statement guidelines). Potential biomarkers include mainly proteins, metabolites and even miRNAs. Based on meta-analysis, in AD patients, salivary levels of beta-amyloid42 and p-tau levels were significantly increased, and t-tau and lactoferrin were decreased at borderline statistical significance. However, according to pooled AUC, lactoferrin and beta-amyloid42 showed a significant predictive value for salivary-based AD diagnosis. In conclusion, potential markers such as beta-amyloid42, tau and lactoferrin can be detected in the saliva of AD patients, which could reliably support the early diagnosis of this neurodegenerative disease.
    MeSH term(s) Humans ; Alzheimer Disease/diagnosis ; Neurodegenerative Diseases ; Lactoferrin ; MicroRNAs ; Biomarkers
    Chemical Substances Lactoferrin (EC 3.4.21.-) ; MicroRNAs ; Biomarkers
    Language English
    Publishing date 2024-01-18
    Publishing country Switzerland
    Document type Meta-Analysis ; Systematic Review ; Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25021168
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Salivary Biomarkers for Parkinson's Disease: A Systematic Review with Meta-Analysis.

    Nijakowski, Kacper / Owecki, Wojciech / Jankowski, Jakub / Surdacka, Anna

    Cells

    2024  Volume 13, Issue 4

    Abstract: Parkinson's Disease (PD) is a common neurodegenerative disease which manifests with motor features, such as bradykinesia, resting tremor, rigidity, and postural instability. Using the non-invasive technique of saliva collection, we designed a systematic ... ...

    Abstract Parkinson's Disease (PD) is a common neurodegenerative disease which manifests with motor features, such as bradykinesia, resting tremor, rigidity, and postural instability. Using the non-invasive technique of saliva collection, we designed a systematic review to answer the question "Are salivary biomarkers reliable for the diagnosis of Parkinson's Disease?". Following inclusion and exclusion criteria, 30 studies were included in this systematic review (according to the PRISMA statement guidelines). Mostly proteins were reported as potential biomarkers in saliva. Based on meta-analysis, in PD patients, salivary levels of total alpha-synuclein were significantly decreased, and those of oligomeric alpha-synuclein were significantly increased. Also, according to pooled AUC, heme oxygenase-1 demonstrated significant predictive value for saliva-based PD diagnosis. In conclusion, some potential biomarkers, especially alpha-synuclein, can be altered in the saliva of PD patients, which could be reliably useful for early diagnosis of this neurodegenerative disease differentiating other synucleopathies.
    MeSH term(s) Humans ; Parkinson Disease/diagnosis ; Parkinson Disease/metabolism ; alpha-Synuclein/metabolism ; Neurodegenerative Diseases/metabolism ; Saliva/metabolism ; Biomarkers/metabolism
    Chemical Substances alpha-Synuclein ; Biomarkers
    Language English
    Publishing date 2024-02-14
    Publishing country Switzerland
    Document type Meta-Analysis ; Systematic Review ; Journal Article ; Review
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells13040340
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Eating Disorders and Dental Erosion: A Systematic Review.

    Nijakowski, Kacper / Jankowski, Jakub / Gruszczyński, Dawid / Surdacka, Anna

    Journal of clinical medicine

    2023  Volume 12, Issue 19

    Abstract: Both eating disorders and dental erosion are increasingly affecting adolescents and young adults. Thus, our systematic review was designed to answer the question: "Is there a relationship between dental erosion and eating disorders?" Following the ... ...

    Abstract Both eating disorders and dental erosion are increasingly affecting adolescents and young adults. Thus, our systematic review was designed to answer the question: "Is there a relationship between dental erosion and eating disorders?" Following the inclusion and exclusion criteria, 31 studies were included in this systematic review (according to the PRISMA statement guidelines). Based on the meta-analysis, 54.4% of patients with bulimia nervosa and 26.7% with anorexia nervosa experienced tooth erosion. For the whole group of 1699 patients with eating disorders, erosive lesions were observed in 42.1% of patients. Bulimics were more than 10 times more likely to experience dental erosion compared to healthy individuals (OR = 10.383 [95%CI: 4.882-22.086]). Similarly, more than 16 times increased odds of tooth erosion were found in patients with self-induced vomiting (OR = 16.176 [95%CI: 1.438-181.918]). In conclusion, eating disorders are associated with an increased risk of developing erosive lesions, especially in patients with bulimia nervosa.
    Language English
    Publishing date 2023-09-24
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12196161
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Kleefstra Syndrome-Dental Manifestations and Needs: A Case Report with a Literature Review.

    Karlak, Victoria / Jankowski, Jakub / Kolasińska, Julia / Nijakowski, Kacper

    Case reports in dentistry

    2023  Volume 2023, Page(s) 2478465

    Abstract: Kleefstra syndrome (KS) is a rare genetic disorder (prevalence < 1/1 000 000) characterised by autistic spectrum disorder (ASD), childhood hypotonia, and seizures. A typical facial appearance includes microcephaly, arched eyebrows, synophrism, ... ...

    Abstract Kleefstra syndrome (KS) is a rare genetic disorder (prevalence < 1/1 000 000) characterised by autistic spectrum disorder (ASD), childhood hypotonia, and seizures. A typical facial appearance includes microcephaly, arched eyebrows, synophrism, hypertelorism, a short nose, midface hypoplasia, prognathism, and tongue protrusion. This case report presents a 19-year-old female with KS from a dentist's perspective. The patient demonstrates limited mouth opening with a slight deviation of the mandible on the left side. The mandibular prognathism and anterior open bite are visible. A generalised inflammatory gingival enlargement is most likely a response to local irritants like plaque and calculus but is enhanced by the patient's mouth breathing habit. Also, the tongue is unusually large-macroglossia. Dental anomalies were diagnosed by digital panoramic radiograph, including dilaceration of the maxillary left second premolar and taurodontism. The patient was qualified to be treated under general anaesthesia with multiple extractions, restorations, hygienisation procedures, and tooth remineralisation. This individual should also be considered for orthodontic treatment and an eventual tongue reduction procedure. In the case of KS, multidisciplinary cooperation as well as frequent dental check-ups with fluoride prophylaxis are recommended. Unfortunately, dental treatment is still not an integral part of taking care of disabled children and youth with rare diseases.
    Language English
    Publishing date 2023-09-22
    Publishing country Egypt
    Document type Case Reports
    ZDB-ID 2627632-X
    ISSN 2090-6455 ; 2090-6447
    ISSN (online) 2090-6455
    ISSN 2090-6447
    DOI 10.1155/2023/2478465
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Salivary Alterations of Myeloperoxidase in Patients with Systemic Diseases: A Systematic Review.

    Nijakowski, Kacper / Jankowski, Jakub / Gruszczyński, Dawid / Surdacka, Anna

    International journal of molecular sciences

    2023  Volume 24, Issue 15

    Abstract: Salivary myeloperoxidase (MPO) is a key mediator of the oral immune system, acting as an enzyme that utilises ... ...

    Abstract Salivary myeloperoxidase (MPO) is a key mediator of the oral immune system, acting as an enzyme that utilises H
    MeSH term(s) Humans ; Enzyme-Linked Immunosorbent Assay ; Hydrogen Peroxide ; Peroxidase/analysis ; Saliva/chemistry
    Chemical Substances Hydrogen Peroxide (BBX060AN9V) ; Peroxidase (EC 1.11.1.7) ; MPO protein, human (EC 1.11.1.7)
    Language English
    Publishing date 2023-07-28
    Publishing country Switzerland
    Document type Systematic Review ; Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241512078
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Seasonal Influence on Salivary Myeloperoxidase Diurnal Variations in Young Healthy Subjects: A Preliminary Study.

    Nijakowski, Kacper / Rutkowski, Rafał / Gruszczyński, Dawid / Witowski, Janusz / Surdacka, Anna / Kanikowska, Dominika

    Frontiers in bioscience (Landmark edition)

    2024  Volume 29, Issue 1, Page(s) 10

    Abstract: Background: The interaction between oxidative status markers and biological rhythms is considered particularly important in the pathogenesis of many diseases and more effective therapies. We aimed to determine if the salivary secretion of ... ...

    Abstract Background: The interaction between oxidative status markers and biological rhythms is considered particularly important in the pathogenesis of many diseases and more effective therapies. We aimed to determine if the salivary secretion of myeloperoxidase exhibits diurnal variations, and if the potential daily variability differs seasonally.
    Methods: The study was performed in Poznan, Poland (52,25°N, 16,58°E) in 10 healthy male volunteers (age median 23.5 years). Whole mixed unstimulated saliva was collected in summer (August) and winter (December) during 36 h at 2-h intervals starting at 6 a.m. on Saturday and ending at 6 p.m. on Sunday, in the domestic setting. The samples were analysed for myeloperoxidase (MPO) and cortisol by immunoassays. The presence of the circadian rhythm of cortisol secretion in saliva confirmed the rhythmicity of the volunteers.
    Results: For salivary MPO, significantly higher concentrations compared to midnight and noon were observed for 4 a.m. in both summer and winter. Using the cosinor analysis, the variations in salivary MPO levels showed a moderate fit for the 12-h period rhythm (acrophases: in summer 05:37/17:37, in winter 06:16/18:16), without significant differences in the rhythm parameters in summer and winter. However, higher self-reported Global Seasonal Score (which may predispose to seasonal affective disorder) was associated with significantly stronger relative amplitude (RS = 0.811) in winter season only.
    Conclusions: In conclusion, our findings suggest the possible ultradian rhythm for MPO in saliva, with two peaks during the day, regardless of the season.
    MeSH term(s) Humans ; Male ; Young Adult ; Circadian Rhythm ; Healthy Volunteers ; Hydrocortisone/analysis ; Peroxidase ; Seasons ; Ultradian Rhythm
    Chemical Substances Hydrocortisone (WI4X0X7BPJ) ; Peroxidase (EC 1.11.1.7)
    Language English
    Publishing date 2024-01-29
    Publishing country Singapore
    Document type Journal Article
    ZDB-ID 2704569-9
    ISSN 2768-6698 ; 2768-6698
    ISSN (online) 2768-6698
    ISSN 2768-6698
    DOI 10.31083/j.fbl2901010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: The Role of Cellular Metabolism in Maintaining the Function of the Dentine-Pulp Complex: A Narrative Review.

    Nijakowski, Kacper / Ortarzewska, Martyna / Jankowski, Jakub / Lehmann, Anna / Surdacka, Anna

    Metabolites

    2023  Volume 13, Issue 4

    Abstract: The cellular metabolic processes ensure the physiological integrity of the dentine-pulp complex. Odontoblasts and odontoblast-like cells are responsible for the defence mechanisms in the form of tertiary dentine formation. In turn, the main defence ... ...

    Abstract The cellular metabolic processes ensure the physiological integrity of the dentine-pulp complex. Odontoblasts and odontoblast-like cells are responsible for the defence mechanisms in the form of tertiary dentine formation. In turn, the main defence reaction of the pulp is the development of inflammation, during which the metabolic and signalling pathways of the cells are significantly altered. The selected dental procedures, such as orthodontic treatment, resin infiltration, resin restorations or dental bleaching, can impact the cellular metabolism in the dental pulp. Among systemic metabolic diseases, diabetes mellitus causes the most consequences for the cellular metabolism of the dentine-pulp complex. Similarly, ageing processes present a proven effect on the metabolic functioning of the odontoblasts and the pulp cells. In the literature, several potential metabolic mediators demonstrating anti-inflammatory properties on inflamed dental pulp are mentioned. Moreover, the pulp stem cells exhibit the regenerative potential essential for maintaining the function of the dentine-pulp complex.
    Language English
    Publishing date 2023-04-05
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662251-8
    ISSN 2218-1989
    ISSN 2218-1989
    DOI 10.3390/metabo13040520
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Salivary Melatonin Changes in Oncological Patients: A Systematic Review.

    Nijakowski, Kacper / Surdacki, Michał / Sobieszczańska, Małgorzata

    Metabolites

    2022  Volume 12, Issue 5

    Abstract: Melatonin is known as a regulator of circadian sleep and waking rhythm. This hormone secreted by the pineal gland also has protective, oncostatic, and antioxidant properties. This systematic review was designed to answer the question "Is there a ... ...

    Abstract Melatonin is known as a regulator of circadian sleep and waking rhythm. This hormone secreted by the pineal gland also has protective, oncostatic, and antioxidant properties. This systematic review was designed to answer the question "Is there a relationship between salivary melatonin changes and oncological diseases?". Following the inclusion and exclusion criteria, ten studies were included, according to PRISMA statement guidelines. In all included studies, the diagnostic material was unstimulated whole saliva, in which the melatonin changes were determined by different laboratory methods. Most studies concerned changes in melatonin levels in patients with brain tumours due to a direct effect on the circadian rhythm centres. Other studies focused on disorders of melatonin secretion and its inclusion as a diagnostic marker in patients with prostate cancer and oral squamous cell carcinoma. The association between melatonin changes and sleep quality and chronotype in patients with newly diagnosed lung cancer and lymphoma survivors was also investigated. In conclusion, our systematic review may suggest trends for melatonin secretion alterations in oncological patients. However, due to the significant heterogeneity of the included reports, it is not possible to clearly determine a link between changes in salivary melatonin levels and the oncological diagnosis.
    Language English
    Publishing date 2022-05-13
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662251-8
    ISSN 2218-1989
    ISSN 2218-1989
    DOI 10.3390/metabo12050439
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Salivary Metabolomics for Oral Squamous Cell Carcinoma Diagnosis: A Systematic Review.

    Nijakowski, Kacper / Gruszczyński, Dawid / Kopała, Dariusz / Surdacka, Anna

    Metabolites

    2022  Volume 12, Issue 4

    Abstract: Oral squamous cell carcinoma (OSCC) is the most common type of oral cancer in which the consumption of tobacco and alcohol is considered to be the main aetiological factor. Salivary metabolome profiling could identify novel biochemical pathways involved ... ...

    Abstract Oral squamous cell carcinoma (OSCC) is the most common type of oral cancer in which the consumption of tobacco and alcohol is considered to be the main aetiological factor. Salivary metabolome profiling could identify novel biochemical pathways involved in the pathogenesis of various diseases. This systematic review was designed to answer the question "Are salivary metabolites reliable for the diagnosis of oral squamous cell carcinoma?". Following the inclusion and exclusion criteria, nineteen studies were included (according to PRISMA statement guidelines). In all included studies, the diagnostic material was unstimulated whole saliva, whose metabolome changes were determined by different spectroscopic methods. At the metabolic level, OSCC patients differed significantly not only from healthy subjects but also from patients with oral leukoplakia, lichen planus or other oral potentially malignant disorders. Among the detected salivary metabolites, there were the indicators of the impaired metabolic pathways, such as choline metabolism, amino acid pathways, polyamine metabolism, urea cycle, creatine metabolism, glycolysis or glycerolipid metabolism. In conclusion, saliva contains many potential metabolites, which can be used reliably to early diagnose and monitor staging in patients with OSCC. However, further investigations are necessary to confirm these findings and to identify new salivary metabolic biomarkers.
    Language English
    Publishing date 2022-03-26
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662251-8
    ISSN 2218-1989
    ISSN 2218-1989
    DOI 10.3390/metabo12040294
    Database MEDical Literature Analysis and Retrieval System OnLINE

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