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  1. AU="Nikola Stikov"
  2. AU=Galindo-Villegas Jorge
  3. AU="Gerolymatos, Andreas"
  4. AU="Odeny, D A"
  5. AU="Naserghandi, Alvand"
  6. AU="Nelson, Eric Andrew"
  7. AU=Verkman Alan S.
  8. AU=Garg Parvesh M
  9. AU="Luigi Aprea"
  10. AU="Cortes, Jorge Alberto"
  11. AU="Malehi, Amal Saki"
  12. AU=Rieber Nikolaus
  13. AU="Jennifer R Habel"
  14. AU="Sun, Yan Ni"
  15. AU="Nath, Sujith S"
  16. AU=Gao Xuesong
  17. AU="Tankelevich, Michael"
  18. AU=Jean Guillaume
  19. AU=Xiong J
  20. AU="Rollins, Alicia"
  21. AU="Shufang Sun"
  22. AU="Daisuke Kasai"
  23. AU="Bernadette L. Jenner"
  24. AU=Zhang Jing
  25. AU="Stoica, Maria"
  26. AU="Romina Valentini"
  27. AU="Bagó, György Attila"
  28. AU="Bahrar, Harsh"
  29. AU="Judd, Dallin"

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  1. Artikel ; Online: On the open-source landscape of PLOS Computational Biology.

    Mathieu Boudreau / Jean-Baptiste Poline / Pierre Bellec / Nikola Stikov

    PLoS Computational Biology, Vol 17, Iss 2, p e

    2021  Band 1008725

    Schlagwörter Biology (General) ; QH301-705.5
    Sprache Englisch
    Erscheinungsdatum 2021-02-01T00:00:00Z
    Verlag Public Library of Science (PLoS)
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: Beyond advertising

    Elizabeth DuPre / Chris Holdgraf / Agah Karakuzu / Loïc Tetrel / Pierre Bellec / Nikola Stikov / Jean-Baptiste Poline

    PLoS Computational Biology, Vol 18, Iss 1, p e

    New infrastructures for publishing integrated research objects.

    2022  Band 1009651

    Schlagwörter Biology (General) ; QH301-705.5
    Sprache Englisch
    Erscheinungsdatum 2022-01-01T00:00:00Z
    Verlag Public Library of Science (PLoS)
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: An interactive meta-analysis of MRI biomarkers of myelin

    Matteo Mancini / Agah Karakuzu / Julien Cohen-Adad / Mara Cercignani / Thomas E Nichols / Nikola Stikov

    eLife, Vol

    2020  Band 9

    Abstract: Several MRI measures have been proposed as in vivo biomarkers of myelin, each with applications ranging from plasticity to pathology. Despite the availability of these myelin-sensitive modalities, specificity and sensitivity have been a matter of ... ...

    Abstract Several MRI measures have been proposed as in vivo biomarkers of myelin, each with applications ranging from plasticity to pathology. Despite the availability of these myelin-sensitive modalities, specificity and sensitivity have been a matter of discussion. Debate about which MRI measure is the most suitable for quantifying myelin is still ongoing. In this study, we performed a systematic review of published quantitative validation studies to clarify how different these measures are when compared to the underlying histology. We analyzed the results from 43 studies applying meta-analysis tools, controlling for study sample size and using interactive visualization (https://neurolibre.github.io/myelin-meta-analysis). We report the overall estimates and the prediction intervals for the coefficient of determination and find that MT and relaxometry-based measures exhibit the highest correlations with myelin content. We also show which measures are, and which measures are not statistically different regarding their relationship with histology.
    Schlagwörter myelin ; MRI ; histology ; meta-analysis ; central nervous system ; brain ; Medicine ; R ; Science ; Q ; Biology (General) ; QH301-705.5
    Thema/Rubrik (Code) 310
    Sprache Englisch
    Erscheinungsdatum 2020-10-01T00:00:00Z
    Verlag eLife Sciences Publications Ltd
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel ; Online: qMRI-BIDS

    Agah Karakuzu / Stefan Appelhoff / Tibor Auer / Mathieu Boudreau / Franklin Feingold / Ali R. Khan / Alberto Lazari / Chris Markiewicz / Martijn Mulder / Christophe Phillips / Taylor Salo / Nikola Stikov / Kirstie Whitaker / Gilles de Hollander

    Scientific Data, Vol 9, Iss 1, Pp 1-

    An extension to the brain imaging data structure for quantitative magnetic resonance imaging data

    2022  Band 9

    Abstract: Abstract The Brain Imaging Data Structure (BIDS) established community consensus on the organization of data and metadata for several neuroimaging modalities. Traditionally, BIDS had a strong focus on functional magnetic resonance imaging (MRI) datasets ... ...

    Abstract Abstract The Brain Imaging Data Structure (BIDS) established community consensus on the organization of data and metadata for several neuroimaging modalities. Traditionally, BIDS had a strong focus on functional magnetic resonance imaging (MRI) datasets and lacked guidance on how to store multimodal structural MRI datasets. Here, we present and describe the BIDS Extension Proposal 001 (BEP001), which adds a range of quantitative MRI (qMRI) applications to the BIDS. In general, the aim of qMRI is to characterize brain microstructure by quantifying the physical MR parameters of the tissue via computational, biophysical models. By proposing this new standard, we envision standardization of qMRI through multicenter dissemination of interoperable datasets. This way, BIDS can act as a catalyst of convergence between qMRI methods development and application-driven neuroimaging studies that can help develop quantitative biomarkers for neural tissue characterization. In conclusion, this BIDS extension offers a common ground for developers to exchange novel imaging data and tools, reducing the entrance barrier for qMRI in the field of neuroimaging.
    Schlagwörter Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2022-08-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel ; Online: Design and construction of an optimized transmit/receive hybrid birdcage resonator to improve full body images of medium-sized animals in 7T scanner.

    Nibardo Lopez Rios / Philippe Pouliot / Konstantinos Papoutsis / Alexandru Foias / Nikola Stikov / Frédéric Lesage / Mathieu Dehaes / Julien Cohen-Adad

    PLoS ONE, Vol 13, Iss 2, p e

    2018  Band 0192035

    Abstract: The purpose of this work was to develop an optimized transmit/receive birdcage coil to extend the possibilities of a 7T preclinical MRI system to conduct improved full body imaging in medium-sized animals, such as large New Zealand rabbits. The coil was ... ...

    Abstract The purpose of this work was to develop an optimized transmit/receive birdcage coil to extend the possibilities of a 7T preclinical MRI system to conduct improved full body imaging in medium-sized animals, such as large New Zealand rabbits. The coil was designed by combining calculation and electromagnetic simulation tools. The construction was based on precise mechanical design and careful building practice. A 16-leg, 20 cm long, 16 cm inner diameter, shielded quadrature hybrid structure was selected. Coil parameters were assessed on the bench and images were acquired on phantoms and rabbits. The results were compared to simulations and data obtained with an available commercial coil. An inexpensive assembly with an increase of 2 cm in useful inner diameter and 50 Ω matching with larger animals was achieved. A reduction in radiofrequency (RF) power demand of 31.8%, an improvement in image uniformity of 18.5 percentage points and an increase in signal-to-noise ratio of up to 42.2% were revealed by phantom image acquisitions, which was confirmed by in vivo studies. In conclusion, the proposed coil extended the possibilities of a preclinical 7T system as it improved image studies in relatively large animals by reducing the RF power demand, and increasing image uniformity and signal-to-noise ratio. Shorter scans and time under anesthesia or reduced RF exposure, resulting in better images and lower animal health risk during in vivo experiments, were achieved.
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 600
    Sprache Englisch
    Erscheinungsdatum 2018-01-01T00:00:00Z
    Verlag Public Library of Science (PLoS)
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  6. Artikel ; Online: Arterial stiffness cut-off value and white matter integrity in the elderly

    Atef Badji / Adrián Noriega de la Colina / Agah Karakuzu / Tanguy Duval / Laurence Desjardins-Crépeau / Matthieu Parizet / Sven Joubert / Louis Bherer / Maxime Lamarre-Cliche / Nikola Stikov / Julien Cohen-Adad / Hélène Girouard

    NeuroImage: Clinical, Vol 26, Iss , Pp - (2020)

    2020  

    Abstract: Objective: Central artery stiffness is a confirmed predictor of cardiovascular health status that has been consistently associated with cognitive dysfunction and dementia. The European Society of Hypertension has established a threshold of arterial ... ...

    Abstract Objective: Central artery stiffness is a confirmed predictor of cardiovascular health status that has been consistently associated with cognitive dysfunction and dementia. The European Society of Hypertension has established a threshold of arterial stiffness above which a cardiovascular event is likely to occur. However, the threshold at which arterial stiffness alters brain integrity has never been established. Methods: The aim of this study is to determine the arterial stiffness cut-off value at which there is an impact on the white matter microstructure. This study has been conducted with 53 cognitively elderly without dementia. The integrity of the white matter was assessed using diffusion tensor metrics. Central artery stiffness was evaluated by measuring the carotid-femoral pulse wave velocity (cfPWV). The statistical analyses included 4 regions previously denoted vulnerable to increased central arterial stiffness (the corpus callosum, the internal capsule, the corona radiata and the superior longitudinal fasciculus). Results: The results of this study call into question the threshold value of 10 m/s cfPWV established by the European Society of Hypertension to classify patients in neuro-cardiovascular risk groups. Our results suggest that the cfPWV threshold value would be approximately 8.5 m/s when the microstructure of the white matter is taken as a basis for comparison. Conclusions: Adjustment of the cfPWV value may be necessary for a more accurate distinction between lower and higher risk group of patients for white matter microstructural injury related to arterial stiffness. Targeting the highest risk group for prevention methods may, in turn, help preserve brain health and cognitive functions.
    Schlagwörter Arterial stiffness ; Hypertension ; Aging ; White matter ; Cognition ; Diffusion ; Computer applications to medicine. Medical informatics ; R858-859.7 ; Neurology. Diseases of the nervous system ; RC346-429
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2020-01-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  7. Artikel ; Online: Correction

    Simon Lévy / Marie-Claude Guertin / Ali Khatibi / Aviv Mezer / Kristina Martinu / Jen-I Chen / Nikola Stikov / Pierre Rainville / Julien Cohen-Adad

    PLoS ONE, Vol 13, Iss 6, p e

    Test-retest reliability of myelin imaging in the human spinal cord: Measurement errors versus region- and aging-induced variations.

    2018  Band 0199796

    Abstract: This corrects the article DOI:10.1371/journal.pone.0189944.]. ...

    Abstract [This corrects the article DOI:10.1371/journal.pone.0189944.].
    Schlagwörter Medicine ; R ; Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2018-01-01T00:00:00Z
    Verlag Public Library of Science (PLoS)
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  8. Artikel ; Online: Test-retest reliability of myelin imaging in the human spinal cord

    Simon Lévy / Marie-Claude Guertin / Ali Khatibi / Aviv Mezer / Kristina Martinu / Jen-I Chen / Nikola Stikov / Pierre Rainville / Julien Cohen-Adad

    PLoS ONE, Vol 13, Iss 1, p e

    Measurement errors versus region- and aging-induced variations.

    2018  Band 0189944

    Abstract: To implement a statistical framework for assessing the precision of several quantitative MRI metrics sensitive to myelin in the human spinal cord: T1, Magnetization Transfer Ratio (MTR), saturation imposed by an off-resonance pulse (MTsat) and ... ...

    Abstract To implement a statistical framework for assessing the precision of several quantitative MRI metrics sensitive to myelin in the human spinal cord: T1, Magnetization Transfer Ratio (MTR), saturation imposed by an off-resonance pulse (MTsat) and Macromolecular Tissue Volume (MTV).Thirty-three healthy subjects within two age groups (young, elderly) were scanned at 3T. Among them, 16 underwent the protocol twice to assess repeatability. Statistical reliability indexes such as the Minimal Detectable Change (MDC) were compared across metrics quantified within different cervical levels and white matter (WM) sub-regions. The differences between pathways and age groups were quantified and interpreted in context of the test-retest repeatability of the measurements.The MDC was respectively 105.7ms, 2.77%, 0.37% and 4.08% for T1, MTR, MTsat and MTV when quantified over all WM, while the standard-deviation across subjects was 70.5ms, 1.34%, 0.20% and 2.44%. Even though particular WM regions did exhibit significant differences, these differences were on the same order as test-retest errors. No significant difference was found between age groups for all metrics.While T1-based metrics (T1 and MTV) exhibited better reliability than MT-based measurements (MTR and MTsat), the observed differences between subjects or WM regions were comparable to (and often smaller than) the MDC. This makes it difficult to determine if observed changes are due to variations in myelin content, or simply due to measurement error. Measurement error remains a challenge in spinal cord myelin imaging, but this study provides statistical guidelines to standardize the field and make it possible to conduct large-scale multi-center studies.
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 150
    Sprache Englisch
    Erscheinungsdatum 2018-01-01T00:00:00Z
    Verlag Public Library of Science (PLoS)
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  9. Artikel ; Online: Quantitative analysis of the myelin g-ratio from electron microscopy images of the macaque corpus callosum

    Nikola Stikov / Jennifer S.W. Campbell / Thomas Stroh / Mariette Lavelée / Stephen Frey / Jennifer Novek / Stephen Nuara / Ming-Kai Ho / Barry J. Bedell / Robert F. Dougherty / Ilana R. Leppert / Mathieu Boudreau / Sridar Narayanan / Tanguy Duval / Julien Cohen-Adad / Paul-Alexandre Picard / Alicja Gasecka / Daniel Côté / G. Bruce Pike

    Data in Brief, Vol 4, Iss C, Pp 368-

    2015  Band 373

    Abstract: We provide a detailed morphometric analysis of eight transmission electron micrographs (TEMs) obtained from the corpus callosum of one cynomolgus macaque. The raw TEM images are included in the article, along with the distributions of the axon caliber ... ...

    Abstract We provide a detailed morphometric analysis of eight transmission electron micrographs (TEMs) obtained from the corpus callosum of one cynomolgus macaque. The raw TEM images are included in the article, along with the distributions of the axon caliber and the myelin g-ratio in each image. The distributions are analyzed to determine the relationship between axon caliber and g-ratio, and compared against the aggregate metrics (myelin volume fraction, fiber volume fraction, and the aggregate g-ratio), as defined in the accompanying research article entitled ‘In vivo histology of the myelin g-ratio with magnetic resonance imaging’ (Stikov et al., NeuroImage, 2015).
    Schlagwörter Computer applications to medicine. Medical informatics ; R858-859.7 ; Science (General) ; Q1-390
    Sprache Englisch
    Erscheinungsdatum 2015-09-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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