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Book ; Online: Current Topics in Caesarean Section

Tsikouras, Panagiotis / Nikolettos, Nikolaos / Rath, Werner / Friedrich Von Tempelhoff, Georg

2021

Keywords	Gynaecology & obstetrics ; cesarean section, preterm birth, inflammation, breastfeeding, immunology, body mass index
Language	English
Size	1 electronic resource (258 pages)
Publisher	IntechOpen
Document type	Book ; Online
Note	English
HBZ-ID	HT030647351
ISBN	9781839691805 ; 1839691808
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Book ; Online: Ectopic Pregnancy and Prenatal Diagnosis

Wu, Wei / Tang, Qiuqin / Tsikouras, Panagiotis / Rath, Werner / Von Tempelhoff, Georg-Friedrich / Nikolettos, Nikolaos

2022

Keywords	Gynaecology & obstetrics ; Clinical & internal medicine
Language	English
Size	1 electronic resource (190 pages)
Publisher	IntechOpen
Document type	Book ; Online
Note	English
HBZ-ID	HT030378729
ISBN	9781803558424 ; 1803558423
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: The Role of Urothelial Cancer-Associated 1 in Gynecological Cancers.

Nousiopoulou, Eleni / Vrettou, Kleio / Damaskos, Christos / Garmpis, Nikolaos / Garmpi, Anna / Tsikouras, Panagiotis / Nikolettos, Nikolaos / Nikolettos, Konstantinos / Psilopatis, Iason

Current issues in molecular biology

2024 Volume 46, Issue 3, Page(s) 2772–2797

Abstract: Gynecological cancers (GC) represent some of the most frequently diagnosed malignancies in women worldwide. Long-non-coding RNAs (lncRNAs) are regulatory RNAs increasingly being recognized for their role in tumor progression and metastasis in various ... ...

Abstract	Gynecological cancers (GC) represent some of the most frequently diagnosed malignancies in women worldwide. Long-non-coding RNAs (lncRNAs) are regulatory RNAs increasingly being recognized for their role in tumor progression and metastasis in various cancers. Urothelial cancer-associated 1 (UCA1) is a lncRNA, first found deregulated in bladder cancer, and many studies have exposed its oncogenic effects in more tumors since. However, the role of UCA1 in gynecological malignancies is still unclear. This review aims to analyze and define the role of UCA1 in GC, in order to identify its potential use as a diagnostic, prognostic, or therapeutic biomarker of GC. By employing the search terms "UCA1", "breast cancer", "endometrial cancer", "ovarian cancer", "cervical cancer", "vaginal cancer", and "vulvar cancer" in the PubMed database for the literature review, we identified a total of sixty-three relevant research articles published between 2014 and 2024. Although there were some opposing results, UCA1 was predominantly found to be upregulated in most of the breast, endometrial, ovarian, cervical, and vulvar cancer cells, tissue samples, and mouse xenograft models. UCA1 overexpression mainly accounts for enhanced tumor proliferation and increased drug resistance, while also being associated with some clinicopathological features, such as a high histological grade or poor prognosis. Nonetheless, no reviews were identified about the involvement of UCA1 in vaginal carcinogenesis. Therefore, further clinical trials are required to explore the role of UCA1 in these malignancies and, additionally, examine its possible application as a target for upcoming treatments, or as a novel biomarker for GC diagnosis and prognosis.
Language	English
Publishing date	2024-03-21
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2000024-8
ISSN	1467-3045 ; 1467-3037
ISSN (online)	1467-3045
ISSN	1467-3037
DOI	10.3390/cimb46030174
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: ARID1 and BRG1 Expression in Endometrial Cancer.

Kontomanolis, Emmanuel N / Symeonidis, Panagiotis / Nikolettos, Konstantinos / Perros, Paraskevas / Rody, Achim / Tsikouras, Panagiotis / Nikolettos, Nikolaos / Giatromanolaki, Alexandra

In vivo (Athens, Greece)

2024 Volume 38, Issue 3, Page(s) 1260–1265

Abstract: Background/aim: Endometrial cancer (EC) is the predominant malignancy among gynecologic cancers and ranks fourth among all types of cancer. Recently, researchers have focused on the development of new prognostic biomarkers. Subunits of the SWI/SNF ... ...

Abstract	Background/aim: Endometrial cancer (EC) is the predominant malignancy among gynecologic cancers and ranks fourth among all types of cancer. Recently, researchers have focused on the development of new prognostic biomarkers. Subunits of the SWI/SNF protein complex, like the ARID1 and BRG1, have been associated with the development of endometrial cancer. The present study aimed to evaluate the expression patterns of ARID1A and BRG1 in a collection of endometrioid adenocarcinomas of the uterus using immunohistochemistry. Patients and methods: The study comprised a total of thirty-three individuals diagnosed with stage I endometrioid endometrial cancer, treated with radical hysterectomy. The histological material was then examined to assess the cytoplasmic and nuclear expression of the proteins. Results: ARID1A exhibited expression in both the cytoplasm and nucleus of cancer cells, whereas BRG1 was mainly expressed in the nuclei. In addition, ARID1A exhibited a notable decrease in expression in grade 3 histology, with no significant correlation with the depth of myometrial invasion. The reduced expression was highly related to tumor expansion into the endocervix. The findings demonstrated a total absence of ARID1A expression in 27% of endometrioid carcinomas, with a significant reduction in expression in an additional 51% of cancer cells. These findings align with the most recent published data. In contrast, in the current study, BRG1 was rarely down-regulated and was extensively expressed in the majority of endometrioid carcinomas, preventing the possibility of statistical analysis. Conclusion: In summary, ARID1A expression loss can be used as a biomarker to guide post-operative therapy; however, further investigation is needed, especially for early-stage endometrial cancer.
MeSH term(s)	Humans ; Female ; Endometrial Neoplasms/pathology ; Endometrial Neoplasms/metabolism ; Endometrial Neoplasms/genetics ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Nuclear Proteins/genetics ; Nuclear Proteins/metabolism ; DNA Helicases/genetics ; DNA Helicases/metabolism ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; Middle Aged ; Aged ; Biomarkers, Tumor/metabolism ; Immunohistochemistry ; Neoplasm Staging ; Prognosis ; Gene Expression Regulation, Neoplastic ; Carcinoma, Endometrioid/pathology ; Carcinoma, Endometrioid/metabolism ; Carcinoma, Endometrioid/genetics ; Adult ; Neoplasm Grading
Chemical Substances	ARID1A protein, human ; SMARCA4 protein, human (EC 3.6.1.-) ; Transcription Factors ; Nuclear Proteins ; DNA Helicases (EC 3.6.4.-) ; DNA-Binding Proteins ; Biomarkers, Tumor
Language	English
Publishing date	2024-04-28
Publishing country	Greece
Document type	Journal Article
ZDB-ID	807031-3
ISSN	1791-7549 ; 0258-851X
ISSN (online)	1791-7549
ISSN	0258-851X
DOI	10.21873/invivo.13563
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 2288: Show issues

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Article ; Online: Embryonic Cell-free DNA in Spent Culture Medium: A Non-invasive Tool for Aneuploidy Screening of the Corresponding Embryos.

Sialakouma, Afrodite / Karakasiliotis, Ioannis / Ntala, Vaia / Nikolettos, Nikolaos / Asimakopoulos, Byron

In vivo (Athens, Greece)

2021 Volume 35, Issue 6, Page(s) 3449–3457

Abstract: Background/aim: Preimplantation genetic testing (PGT) for chromosomal screening, based on embryo biopsy, has significant limitations. Cell-free DNA (cf-DNA) has been detected in spent culture medium (SCM), opening new horizons for the development of non- ...

Abstract	Background/aim: Preimplantation genetic testing (PGT) for chromosomal screening, based on embryo biopsy, has significant limitations. Cell-free DNA (cf-DNA) has been detected in spent culture medium (SCM), opening new horizons for the development of non-invasive PGT (ni-PGT). In this study, we evaluated the diagnostic performance of ni-PGT for aneuploidy (niPGT-A), comparing the results of trophectoderm biopsies (TE) and respective SCM from individually cultured embryos via Next Generation Sequencing (NGS). Materials and methods: Forty fresh embryos were analyzed. TE and SCM from blastocysts were collected and analyzed. Results: We detected cfDNA in 100% of samples tested. The overall concordance rate between the ni-PGT-A and PGT-A was 27/33 (81.8%). The full concordance rate was 21/33 (63.6%). The aneuploidy agreement was 91.66%, and the euploidy agreement was 76.19%. Conclusion: We found a good accordance between TE and SCM analysis, suggesting that niPGT-A could be a reliable alternative for chromosomal abnormalities assessment of in vitro cultured embryos.
MeSH term(s)	Aneuploidy ; Blastocyst ; Cell-Free Nucleic Acids/genetics ; Female ; Genetic Testing ; Humans ; Pregnancy ; Preimplantation Diagnosis
Chemical Substances	Cell-Free Nucleic Acids
Language	English
Publishing date	2021-11-12
Publishing country	Greece
Document type	Journal Article
ZDB-ID	807031-3
ISSN	1791-7549 ; 0258-851X
ISSN (online)	1791-7549
ISSN	0258-851X
DOI	10.21873/invivo.12645
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 2288: Show issues

Location:
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Article: A Retrospective Study of Various Iron Preparations Oral Administration in Pregnant Women with Iron Deficiency Anemia.

Constantinos, Bouschanetzis / Bothou, Anastasia / Oikonomou, Efthimis / Kiriakou, Demetris / Papanikolopoulou, Stavroula / Michalopoulos, Spyridon / Nikolettos, Konstantinos / Trypsiannis, Grigorios / Nikolettos, Nikolaos / Tsikouras, Panagiotis

Materia socio-medica

2023 Volume 35, Issue 2, Page(s) 157–164

Abstract: During pregnancy anemia is a common medical condition, with iron deficiency and megaloblastic anemia being the most common. The symptoms range from very mild to severe and if left without proper medical treatment, there can be serious consequences for ... ...

Abstract	During pregnancy anemia is a common medical condition, with iron deficiency and megaloblastic anemia being the most common. The symptoms range from very mild to severe and if left without proper medical treatment, there can be serious consequences for both mother and fetus. The most frequent pregnancy problem is anemia. The term "Iron Deficiency Anemia" refers to erythropoiesis under conditions of absolute iron deficiency. This presupposes the depletion of iron stores in the body. Iron deficiency anemia or Sideropenic anemia is the most common form of anemia worldwide. Special attention must be given to nutrition during pregnancy. In the current retrospective study, it was evaluated the contribution of various iron preparations substitution during the pregnancy and puerperium.
Language	English
Publishing date	2023-09-13
Publishing country	Bosnia and Herzegovina
Document type	Journal Article
ISSN	1512-7680
ISSN	1512-7680
DOI	10.5455/msm.2023.35.157-164
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Retrospective Study of the Correlation Between Twin Pregnancies and Perinatal Outcome in Association to the Impact of Preterm Birth.

Michalopoulos, Spyridon / Tsikouras, Panagiotis / Varlami, Vassiliki / Lambrinos, Dimitrios / Bothou, Anastasia / Nikolettos, Konstantinos / Papanikolopoulou, Stavroula / Marinos, Georgios / Iatrakis, Georgios / Nikolettos, Nikolaos

Materia socio-medica

2023 Volume 35, Issue 3, Page(s) 215–221

Abstract: Background: Twin pregnancies make up 2% to 4% of all births. Incidence of spontaneous twin pregnancies varies around the world, with percentages ranging from 8/1000 to >17/1000 births. The variation in twin pregnancy rates is thought to be due to ... ...

Abstract	Background: Twin pregnancies make up 2% to 4% of all births. Incidence of spontaneous twin pregnancies varies around the world, with percentages ranging from 8/1000 to >17/1000 births. The variation in twin pregnancy rates is thought to be due to dizygotic pregnancies, since monozygotic pregnancies have a consistent incidence of 3.5/1000 to 4/1000 births. The incidence of twin pregnancies after the widespread use of assisted reproduction has increased significantly. Objective: The purpose of the present study is to investigate factors , who contribute to improve the perinatal outcome in twin pregnancies. Support will be provided by the results of twin pregnancies by the Department of Obstetrics and Gynaecology of Demokrition University of Thrace (Alexandroupolis, Greece) in the last fifteen years. Methods: From the above Department, data were collected on the number of twin pregnancies, maternal age, gestational age, mode of delivery (spontaneous delivery or caesarean section), birth weight and rate of twin pregnancies with assisted reproduction. Results: The results showed the increasing trend of twin pregnancies and births. A total of 304 twin pregnancies were identified (rate 2.75%). The rate of assisted reproduction was 34.83% in our sample, while the rate of cesarean deliveries was 95.5%, showing a large increase in recent years. In ten cases, normal delivery was successfully performed. The gestational age in twin pregnancies that ended with normal delivery was 37.37 + 3 weeks and the fetuses were both cephalic presentations. The main reason for admission of newborns to the NICU Department was prematurity. Conclusion: The constantly improving education of perinatalists and understanding of the pathophysiology may lead to individualization of their treatment, and improvement of their prognosis based on recent scientific data from other international centers.
Language	English
Publishing date	2023-09-19
Publishing country	Bosnia and Herzegovina
Document type	Journal Article
ISSN	1512-7680
ISSN	1512-7680
DOI	10.5455/msm.2023.35.215-221
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: The Impact of Endometriosis on Pregnancy.

Tsikouras, Panagiotis / Oikonomou, Efthimios / Bothou, Anastasia / Chaitidou, Penelopi / Kyriakou, Dimitrios / Nikolettos, Konstantinos / Andreou, Sotirios / Gaitatzi, Foteini / Nalbanti, Theopi / Peitsidis, Panagiotis / Michalopoulos, Spyridon / Zervoudis, Stefanos / Iatrakis, George / Nikolettos, Nikolaos

Journal of personalized medicine

2024 Volume 14, Issue 1

Abstract: Despite the increased frequency of endometriosis, it remains one of the most enigmatic disorders regarding its effects on pregnancy. Endometriosis adversely affects both natural and assisted conception. Impaired folliculogenesis, which causes follicular ... ...

Abstract	Despite the increased frequency of endometriosis, it remains one of the most enigmatic disorders regarding its effects on pregnancy. Endometriosis adversely affects both natural and assisted conception. Impaired folliculogenesis, which causes follicular dysfunction and low egg quality, as well as luteal phase problems, reduced fertilization, and abnormal embryogenesis, are some of the mechanisms advocated to explain reproductive dysfunction. There is a rising need for a comprehensive study of the potential negative consequences of this condition on pregnancy outcomes, including the postpartum period, as more women with a medical history of endometriosis become pregnant. Obstetrical complications (small for gestational age [SGA], cesarean section [CS], miscarriage, hemorrhage, low placental adhesion, and preterm delivery) are statistically elevated in women with endometriosis. Furthermore, ruptured ovarian endometrioma, appendicitis, intestinal perforation, and hemoperitoneum have been described in pregnancy. Obstetricians are largely unfamiliar with these complications, as they have not been thoroughly investigated. The development and pathogenesis of endometriosis is an important field of study and has not yet been fully elucidated. Finding these mechanisms is crucial for the development of new and more effective strategies to treat this condition. Endometriosis can have an impact on obstetric and neonatal outcomes of pregnancy, in addition to its potential effects on conception. To date, no additional monitoring is recommended for pregnancies with a history of endometriosis. However, more studies are urgently needed to assess the need for the tailored pregnancy monitoring of women with endometriosis.
Language	English
Publishing date	2024-01-22
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662248-8
ISSN	2075-4426
ISSN	2075-4426
DOI	10.3390/jpm14010126
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Labor management and neonatal outcomes in cardiotocography categories II and III (Review).

Tsikouras, Panagiotis / Oikonomou, Efthimios / Bothou, Anastasia / Kyriakou, Dimimitrios / Nalbanti, Theopi / Andreou, Sotirios / Daniilidis, Angelos / Peitsidis, Panagiotis / Nikolettos, Konstantinos / Iatrakis, Georgios / Nikolettos, Nikolaos

Medicine international

2024 Volume 4, Issue 3, Page(s) 27

Abstract: The safe care of both mothers and fetuses during labor is a primary goal of all health professionals. The assessment of fetal oxygenation and well-being is a key aspect of perinatal care provided. Fetal heart rate (FHR) auscultation became part of daily ... ...

Abstract	The safe care of both mothers and fetuses during labor is a primary goal of all health professionals. The assessment of fetal oxygenation and well-being is a key aspect of perinatal care provided. Fetal heart rate (FHR) auscultation became part of daily obstetric practice in a number of countries during the 20th century and remains a key method of fetal monitoring, particularly in low-risk pregnancies. Cardiotocography (CTG) is the continuous monitoring and recording of the FHR and uterine myometrial activity, making it possible to assess the fetal condition. It therefore plays a critical role in the detection of fetal hypoxia during labor, a condition directly related to short- and long-term complications in the newborn. Herein, particular reference is made to the management of CTG category II and III standards, as well as to the handling of childbirth. In addition, specific FHR patterns are associated with immediate neonatal outcomes based on updated studies conducted worldwide. Finally, the prognostic significance of CTG and its potential as a prospective avenue for further investigation are also highlighted herein. Given that the misinterpretation of CTG findings is the most common cause of medical-legal responsibility, this knowledge field requires more emphasis and attention. The aim of the present review was to further deepen the knowledge on issues that mainly concern the safety and monitoring of pregnant women and fetuses during childbirth.
Language	English
Publishing date	2024-04-01
Publishing country	England
Document type	Journal Article ; Review
ISSN	2754-1304
ISSN (online)	2754-1304
DOI	10.3892/mi.2024.151
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Association of Anti-Ro/SSA and Anti-La/SSB Autoantibodies With Pregnancy Outcome in the General Population.

Dragoutsos, Georgios / Tsiggalou, Christina / Oikonomou, Efthymios / Bothou, Anastasia / Trypsiannis, Grigorios / Nikolettos, Konstantinos / Damaskos, Christos / Garmpis, Nikolaos / Kyriakou, Dimitrios / Nalbanti, Theopi / Iatrakis, Georgios / Nikolettos, Nikolaos / Tsikouras, Panagiotis

Materia socio-medica

2024 Volume 36, Issue 1, Page(s) 47–53

Abstract: Background: Autoimmune diseases encompass a diverse array of disorders that disturb the optimal functioning of the immune system, which is to eliminate the 'foreign or/and dangerous' to mistakenly target the body's own tissues.: Objective: The aim of ...

Abstract	Background: Autoimmune diseases encompass a diverse array of disorders that disturb the optimal functioning of the immune system, which is to eliminate the 'foreign or/and dangerous' to mistakenly target the body's own tissues. Objective: The aim of this research is to evaluate the most effective approach to managing autoimmune diseases within the framework of pregnancy. Methods: The exact causes and etiologies of these diseases are multifactorial and mostly still unclear. Ro/SSA autoantibodies and La/SSB, could be found in Sjögren's disease (SJ), systemic lupus (SLE) and other autoimmune disorders. Smoking, stress, UV exposure, vitamin D deficiency, and other genetic and environmental factors have been identified as risk factors for rheumatic diseases. Results: Over the years, an ever-increasing incidence of these diseases has been observed in the general population, with the female sex being at increased risk for their occurrence. This fact raises the question of what should be the management of these pathological entities during pregnancy. Taking into account the very significant impact on the quality of paitients'daily life and the seemingly augmented prevalence of autoimmune diseases, as well as their preference in the female population, the reasonable question arises as to what should be the optimal management of these diseases in the context of pregnancy. Conclusion: Given the limited data of the global medical community regarding the etiological factors and mechanisms that trigger the onset of rheumatic diseases, the management of pregnant women is a complex conundrum that health professionals are challenged to face and solve.
Language	English
Publishing date	2024-04-08
Publishing country	Bosnia and Herzegovina
Document type	Journal Article
ISSN	1512-7680
ISSN	1512-7680
DOI	10.5455/msm.2024.36.47-53
Database	MEDical Literature Analysis and Retrieval System OnLINE

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