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  1. Book ; Audio / Video ; Thesis: EGFL7 ligates alpha v beta 3 integrin to enhance blood vessel formation

    Nikolic, Iva

    2011  

    Author's details Iva Nikolic
    Language English
    Size 1 CD-ROM, 12 cm
    Publishing country Germany
    Document type Book ; Audio / Video ; Thesis
    Thesis / German Habilitation thesis Frankfurt (Main), Univ., Diss., 2011
    Accompanying material Beil. ([1] Bl.)
    HBZ-ID HT017034640
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2011 MO 703 order for loan Magazin

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  2. Article ; Online: Advances in cardiac resuscitation in the emergency department.

    Medlej, Kamal / Nikolic, Ivana

    Emergency medicine practice

    2022  Volume 24, Issue 9, Page(s) 1–24

    Abstract: Cardiogenic shock, cardiac arrest, and circulatory failure are life-threatening, and recognizing the underlying etiology and initiating treatment to promote perfusion are key to managing these patients and improving outcomes. This issue reviews the ... ...

    Abstract Cardiogenic shock, cardiac arrest, and circulatory failure are life-threatening, and recognizing the underlying etiology and initiating treatment to promote perfusion are key to managing these patients and improving outcomes. This issue reviews the current evidence on diagnosis and management of cardiogenic shock, including oxygen supplementation, red blood cell transfusion, vasopressors, and inotropes. A summary of the various mechanical circulatory support options, including inclusion/exclusion criteria and admission and inter-facility transfer guidance, is included. Special considerations regarding the resuscitation and management of patients with intracorporeal left ventricular assist devices who are experiencing circulatory failure are outlined, including testing, imaging, and treatment.
    MeSH term(s) Emergency Service, Hospital ; Heart Arrest/diagnosis ; Heart Arrest/etiology ; Heart Arrest/therapy ; Heart-Assist Devices/adverse effects ; Humans ; Resuscitation ; Shock, Cardiogenic/diagnosis ; Shock, Cardiogenic/therapy
    Language English
    Publishing date 2022-09-02
    Publishing country United States
    Document type Journal Article
    ISSN 1559-3908
    ISSN (online) 1559-3908
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  3. Article ; Online: Physicochemical properties and stability of oil-in-water emulsions stabilized by soy protein isolate and xanthan gum.

    Krstonošić, Veljko / Pavlović, Nebojša / Nikolić, Ivana / Milutinov, Jovana / Ćirin, Dejan

    International journal of biological macromolecules

    2024  Volume 260, Issue Pt 2, Page(s) 129610

    Abstract: The aim of this work was to determine rheological and disperse characteristics and stability of oil-in-water emulsions stabilized by soy protein isolate (SPI) and xanthan gum (XG), as natural components. The effects of their combination on emulsion ... ...

    Abstract The aim of this work was to determine rheological and disperse characteristics and stability of oil-in-water emulsions stabilized by soy protein isolate (SPI) and xanthan gum (XG), as natural components. The effects of their combination on emulsion stabilization have not been investigated yet. The existence of interactions between the two macromolecules were indicated by the influence of XG on SPI surface hydrophobicity and surface tension values. Increase in SPI concentration from 1 to 3 % shift of distribution curves towards smaller particle size, while the opposite effects of further increase of SPI was obtained. The emulsions stabilized by SPI showed shear-thinning flow behavior, which changed to thixotropic at 5 % of SPI concentration. The presence of XG in emulsions at low concentrations did not affect the size distribution of the droplets, while at 0.1 % of XG Sauter mean diameter value raised and distribution curves were shifted towards a higher particle size. The presence of XG at higher concentration resulted in thixotropic flow behavior of emulsions. Also, increase in XG concentration led to the increase in consistency index and extent of non-Newtonian behavior of emulsions and enhanced the influence of the elastic modulus and creaming stability of the systems.
    MeSH term(s) Emulsions/chemistry ; Soybean Proteins/chemistry ; Water/chemistry ; Polysaccharides, Bacterial/chemistry
    Chemical Substances Emulsions ; xanthan gum (TTV12P4NEE) ; Soybean Proteins ; Water (059QF0KO0R) ; Polysaccharides, Bacterial
    Language English
    Publishing date 2024-01-19
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2024.129610
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  4. Article ; Online: Assessment of Soy Protein Acid Hydrolysate-Xanthan Gum Mixtures on the Stability, Disperse and Rheological Properties of Oil-in-Water Emulsions.

    Ćirin, Dejan / Pavlović, Nebojša / Nikolić, Ivana / Krstonošić, Veljko

    Polymers

    2023  Volume 15, Issue 9

    Abstract: There is a growing need for natural ingredients that could be utilized for the production of food, pharmaceutical, and cosmetic emulsions. Soy protein acid hydrolysate (SPAH) is a plant-based additive used in the food industry mainly as a flavor enhancer. ...

    Abstract There is a growing need for natural ingredients that could be utilized for the production of food, pharmaceutical, and cosmetic emulsions. Soy protein acid hydrolysate (SPAH) is a plant-based additive used in the food industry mainly as a flavor enhancer. For the purpose of this work, however, it was mixed with a well-known natural polysaccharide, xanthan gum (XG), to produce stable 30% (w/w) sunflower oil-in-water emulsions using a rotor-stator homogenizer. In order to assess the emulsifying properties of the SPAH and its mixtures with XG, the surface tension properties of their water solutions, particle size, creaming stability, and rheological properties of the emulsions were investigated. Since the emulsions prepared using only SPAH, in various concentrations, were not stable, systems containing 5% of SPAH and 0.1, 0.2, 0.3, 0.4, or 0.5% of XG were then studied. The increase in concentration of the macromolecule led to an increase in creaming stability. The emulsions with 5% SPAH and 0.5% XG were stable for at least 14 days. The increase in XG concentration led to a decrease in d
    Language English
    Publishing date 2023-05-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527146-5
    ISSN 2073-4360 ; 2073-4360
    ISSN (online) 2073-4360
    ISSN 2073-4360
    DOI 10.3390/polym15092195
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  5. Article: Transesterification of Sunflower Oil in the Presence of the Cosolvent Assisted by Hydrodynamic Cavitation

    Nikolić, Ivan / Jovanović, Jelena / Koturević, Biljana / Adnadjević, Borivoj

    BioEnergy research. 2022 Sept., v. 15, no. 3

    2022  

    Abstract: Combination of chemical treatment by cosolvent with hydrodynamic cavitation is a novel technique of intensification of alkali-catalyzed transesterification of sunflower oil with methanol. The paper investigated the effect of operating parameters such as ... ...

    Abstract Combination of chemical treatment by cosolvent with hydrodynamic cavitation is a novel technique of intensification of alkali-catalyzed transesterification of sunflower oil with methanol. The paper investigated the effect of operating parameters such as reaction mixture inlet pressure (p₁), methanol to oil molar ratio (M₁), the concentration of catalyst (Cc), methanol to tetrahydrofuran (THF) molar ratio (M₂), temperature (T), and a number of passes through the hydrodynamic cavitation reactor (n) of transesterification of sunflower oil in the presence of the cosolvent assisted by hydrodynamic cavitation (ACTC) on the triglyceride conversion (TC). ACTC was performed by a venturi-type cavitation reactor (VCR) of a given design. The effect of the operational parameters on the TC was investigated by the method of independent variation of the value of one operating parameter. The obtained results indicated that (a) at p₁ ≥ 304.0 kPa TC increased from TC = 0 to TC = 98% following the rise in p₁; (b) maximum TC = 95% was achieved at M₁ = 3; (c) rise in M₁ within range 3 ≤ M₁ ≤ 9 led to a linear increase from TC = 95 to TC = 100%; (d) maximum TC = 95% was achieved at 1.0%wt ≤ Cc ≥ 1.1%wt; (e) maximum TC = 99% was achieved at M₂ = 1.5; (f) TC linearly decreased from TC = 95 to TC = 88% with T rise from T = 20 to T = 55 °C; (g) the rise in n resulted in a linear increase of TC from TC = 94 (n = 1) to TC = 99% (n = 10); and (h) cavitation yield (CY) declines from CY = 0.528 (n = 1) to CY = 0.056 g/J (n = 10).
    Keywords bioenergy ; catalysts ; chemical treatment ; hydrodynamics ; methanol ; research ; sunflower oil ; temperature ; tetrahydrofuran ; transesterification ; triacylglycerols
    Language English
    Dates of publication 2022-09
    Size p. 1568-1578.
    Publishing place Springer US
    Document type Article
    ZDB-ID 2424546-X
    ISSN 1939-1242 ; 1939-1234
    ISSN (online) 1939-1242
    ISSN 1939-1234
    DOI 10.1007/s12155-021-10387-w
    Database NAL-Catalogue (AGRICOLA)

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  6. Article ; Online: CRISPR/Cas9-Targeted Disruption of Two Highly Homologous

    Nikolić, Ivana / Samardžić, Jelena / Stevanović, Strahinja / Miljuš-Đukić, Jovanka / Milisavljević, Mira / Timotijević, Gordana

    International journal of molecular sciences

    2023  Volume 24, Issue 3

    Abstract: Global climate change has a detrimental effect on plant growth and health, causing serious losses in agriculture. Investigation of the molecular mechanisms of plant responses to various environmental pressures and the generation of plants tolerant to ... ...

    Abstract Global climate change has a detrimental effect on plant growth and health, causing serious losses in agriculture. Investigation of the molecular mechanisms of plant responses to various environmental pressures and the generation of plants tolerant to abiotic stress are imperative to modern plant science. In this paper, we focus on the application of the well-established technology CRISPR/Cas9 genome editing to better understand the functioning of the intrinsically disordered protein DSS1 in plant response to oxidative stress. The Arabidopsis genome contains two highly homologous DSS1 genes,
    MeSH term(s) Arabidopsis/metabolism ; Arabidopsis Proteins/genetics ; Arabidopsis Proteins/metabolism ; CRISPR-Cas Systems ; Gene Editing/methods ; Oxidative Stress/genetics ; Plants, Genetically Modified/genetics ; Plants, Genetically Modified/metabolism
    Chemical Substances Arabidopsis Proteins ; Dss1 protein, Arabidopsis
    Language English
    Publishing date 2023-01-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24032442
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  7. Article ; Online: Genome Analysis of Two Pseudomonas syringae pv.

    Ranković, Tamara / Nikolić, Ivan / Berić, Tanja / Popović, Tatjana / Lozo, Jelena / Medić, Olja / Stanković, Slaviša

    Microbiology spectrum

    2023  , Page(s) e0359822

    Abstract: Members of the Pseudomonas syringae species complex are heterogeneous bacteria that are the most abundant bacterial plant pathogens in the plant phyllosphere, with strong abilities to exist on and infect different plant hosts and survive in/outside ... ...

    Abstract Members of the Pseudomonas syringae species complex are heterogeneous bacteria that are the most abundant bacterial plant pathogens in the plant phyllosphere, with strong abilities to exist on and infect different plant hosts and survive in/outside agroecosystems. In this study, the draft genome sequences of two pathogenic P. syringae pv.
    Language English
    Publishing date 2023-03-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2807133-5
    ISSN 2165-0497 ; 2165-0497
    ISSN (online) 2165-0497
    ISSN 2165-0497
    DOI 10.1128/spectrum.03598-22
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  8. Article ; Online: Economic implications of autonomous adaptation of firms and households in a resource-rich coastal city.

    Taberna, Alessandro / Filatova, Tatiana / Hochrainer-Stigler, Stefan / Nikolic, Igor / Noll, Brayton

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 20348

    Abstract: Climate change intensifies the likelihood of extreme flood events worldwide, amplifying the potential for compound flooding. This evolving scenario represents an escalating risk, emphasizing the urgent need for comprehensive climate change adaptation ... ...

    Abstract Climate change intensifies the likelihood of extreme flood events worldwide, amplifying the potential for compound flooding. This evolving scenario represents an escalating risk, emphasizing the urgent need for comprehensive climate change adaptation strategies across society. Vital to effective response are models that evaluate damages, costs, and benefits of adaptation strategies, encompassing non-linearities and feedback between anthropogenic and natural systems. While flood risk modeling has progressed, limitations endure, including inadequate stakeholder representation and indirect risks such as business interruption and diminished tax revenues. To address these gaps, we propose an innovative version of the Climate-economy Regional Agent-Based model that integrates a dynamic, rapidly expanding agglomeration economy populated by interacting households and firms with extreme flood events. Through this approach, feedback loops and cascading effects generated by flood shocks are delineated within a socio-economic system of boundedly-rational agents. By leveraging extensive behavioral data, our model incorporates a risk layering strategy encompassing bottom-up and top-down adaptation, spanning individual risk reduction to insurance. Calibrated to resemble a research-rich coastal megacity in China, our model demonstrates how synergistic adaptation actions at all levels effectively combat the mounting climate threat. Crucially, the integration of localized risk management with top-down approaches offers explicit avenues to address both direct and indirect risks, providing significant insights for constructing climate-resilient societies.
    Language English
    Publishing date 2023-11-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-46318-2
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  9. Article: Repertoire and abundance of secreted virulence factors shape the pathogenic capacity of

    Nikolić, Ivan / Glatter, Timo / Ranković, Tamara / Berić, Tanja / Stanković, Slaviša / Diepold, Andreas

    Frontiers in microbiology

    2023  Volume 14, Page(s) 1205257

    Abstract: Pseudomonas ... ...

    Abstract Pseudomonas syringae
    Language English
    Publishing date 2023-06-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2023.1205257
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  10. Article ; Online: Novel hybrid compounds of sclareol and doxorubicin as potential anticancer nanotherapy for glioblastoma.

    Stepanović, Ana / Terzić Jovanović, Nataša / Korać, Aleksandra / Zlatović, Mario / Nikolić, Igor / Opsenica, Igor / Pešić, Milica

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

    2024  Volume 174, Page(s) 116496

    Abstract: Two novel hybrid compounds, CON1 and CON2, have been developed by combining sclareol (SC) and doxorubicin (DOX) into a single molecular entity. These hybrid compounds have a 1:1 molar ratio of covalently linked SC and DOX. They have demonstrated ... ...

    Abstract Two novel hybrid compounds, CON1 and CON2, have been developed by combining sclareol (SC) and doxorubicin (DOX) into a single molecular entity. These hybrid compounds have a 1:1 molar ratio of covalently linked SC and DOX. They have demonstrated promising anticancer properties, especially in glioblastoma cells, and have also shown potential in treating multidrug-resistant (MDR) cancer cells that express the P-glycoprotein (P-gp) membrane transporter. CON1 and CON2 form nanoparticles, as confirmed by Zetasizer, transmission electron microscopy (TEM), and chemical modeling. TEM also showed that CON1 and CON2 can be found in glioblastoma cells, specifically in the cytoplasm, different organelles, nucleus, and nucleolus. To examine the anticancer properties, the U87 glioblastoma cell line, and its corresponding multidrug-resistant U87-TxR cell line, as well as patient-derived astrocytoma grade 3 cells (ASC), were used, while normal human lung fibroblasts were used to determine the selectivity. CON1 and CON2 exhibited better resistance and selectivity profiles than DOX, showing less cytotoxicity, as evidenced by real-time cell analysis, DNA damage determination, cell death induction, mitochondrial respiration, and mitochondrial membrane depolarization studies. Cell cycle analysis and the β-galactosidase activity assay suggested that glioblastoma cells die by senescence following CON1 treatment. Overall, CON1 and CON2 showed great potential as they have better anticancer features than DOX. They are promising candidates for additional preclinical and clinical studies on glioblastoma.
    MeSH term(s) Humans ; Glioblastoma/drug therapy ; Glioblastoma/pathology ; Doxorubicin/pharmacology ; Cell Line, Tumor ; Antineoplastic Agents/pharmacology ; Drug Resistance, Neoplasm/drug effects ; Diterpenes/pharmacology ; Diterpenes/chemistry ; Nanoparticles/chemistry ; Apoptosis/drug effects ; Brain Neoplasms/drug therapy ; Brain Neoplasms/pathology ; Brain Neoplasms/metabolism ; DNA Damage/drug effects ; Membrane Potential, Mitochondrial/drug effects ; Cell Survival/drug effects ; Drug Resistance, Multiple/drug effects
    Chemical Substances Doxorubicin (80168379AG) ; sclareol (B607NP0Q8Y) ; Antineoplastic Agents ; Diterpenes
    Language English
    Publishing date 2024-03-26
    Publishing country France
    Document type Journal Article
    ZDB-ID 392415-4
    ISSN 1950-6007 ; 0753-3322 ; 0300-0893
    ISSN (online) 1950-6007
    ISSN 0753-3322 ; 0300-0893
    DOI 10.1016/j.biopha.2024.116496
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