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Book ; Thesis: Ergebnisse herzchirurgischer Eingriffe bei Patienten mit Nieren- und Lebertransplantation

Nikolić, Marina

2018

Author's details	vorgelegt von Marina Nikolić
Language	German
Size	104 Blätter, Diagramme, 30 cm
Publishing place	Heidelberg
Publishing country	Germany
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Dissertation, Ruprecht-Karls-Universität Heidelberg, 2018
HBZ-ID	HT019789269
Database	Catalogue ZB MED Medicine, Health

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2018 E 1070	order for loan	Magazin

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Article ; Online: Issues concerning the language standardisation

Nikolić Marina M.

Zbornik Radova Filozofskog Fakulteta u Prištini, Vol 50, Iss 4, Pp 103-

Theoretical view

2020 Volume 116

Abstract: Monitoring and evaluating changes in standard languages, especially in Serbian, in the twenty-first century are the focus of this work. In order to determine the situation in the current norm, it is necessary to consider the Serbian language within the ... ...

Abstract	Monitoring and evaluating changes in standard languages, especially in Serbian, in the twenty-first century are the focus of this work. In order to determine the situation in the current norm, it is necessary to consider the Serbian language within the context of contemporary European languages. Challenges arising in the process of standardisation of the Serbian language (such as the language democratisation stemming from the democratisation of society, modernisation, rapid establishment of a gender-sensitive language and insisting on its use, social network terms, etc.), but likewise the needs that such a language should cover, are common with those in other European languages. The principal aim is to shed light on changes in the traditional Serbian language generating a parallel norm, which we refer to as ʻneo-standard', and whose formation is predominantly influenced by the media. The second objective is to exactly and thoroughly determine the reasons for the emergence of neo-standard, which, as previous research have shown, are common in all European languages.
Keywords	standard language ; neo-standard ; media ; serbian language ; History of scholarship and learning. The humanities ; AZ20-999
Subject code	410
Language	English
Publishing date	2020-01-01T00:00:00Z
Publisher	Faculty of Philosophy, Kosovska Mitrovica
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Subarachnoid and intracerebral hemorrhage in cocaine abusers

Aleksić Ivan / Džambas Jelena / Marinković Nadica / Šegrt Zoran / Nikolić Marina

Vojnosanitetski Pregled, Vol 78, Iss 11, Pp 1166-

2021 Volume 1172

Abstract: Background/Aim. Cocaine is an alkaloid extracted from the leaves of the plants Erythroxylum coca and Erythroxylum novogranatense. It can be taken orally, intranasally, intravenously, by inhalation, or intragenitally. Cocaine abuse can cause subarachnoid ... ...

Abstract	Background/Aim. Cocaine is an alkaloid extracted from the leaves of the plants Erythroxylum coca and Erythroxylum novogranatense. It can be taken orally, intranasally, intravenously, by inhalation, or intragenitally. Cocaine abuse can cause subarachnoid and intracerebral hemorrhage. The aim of this study was to determine cocaine and benzoylecgonine (BZ) concentrations in various body fluids and organs, the frequency of subarachnoid and intracerebral hemorrhage, and the relationship of concentration of cocaine and BZ in different body fluids with subarachnoid and intracerebral hemorrhage. Methods. The study analyzed a total of 26 autopsies reports from 2005 to 2018 with detected cocaine and/or BZ in the bodies during a forensic autopsy at the Institute of Pathology and Forensic Medicine, Military Medical Academy in Belgrade, Serbia. Brain tissue was taken for histopathological analysis and blood from the femoral vein, while urine, gastric content, brain, kidney, and liver with gallbladder samples were taken for toxicological analyses. Results. There were 26 autopsied patients aged 23 to 56 years (mean age 33.77±8.52); 20 (75.92%) were men and 6 (23.08%) were women. Cocaine was found in the blood of 12 (46.15%), in the urine of 15 (57.69%), and in the brain of 8 (30.77%) autopsied patients. BZ was found in the blood of 20 (76.92%), in the urine of 21 (80.77%), and in the brain of 10 (38.46%) autopsied patients. Subarachnoid hemorrhage was found in 10 (38.46%), intracerebral hemorrhage in 18 (69.23%), and both subarachnoid and intracerebral hemorrhage in 6 (23.07%) autopsied patients. Intracerebral (focal and perivascular) hemorrhage was more frequent. There were statistically significantly higher concentrations of both cocaine and BZ in most of the body fluids and organs of examinees with intracranial hemorrhage compared to examinees without hemorrhage. Conclusion. Subarachnoid and intracerebral hemorrhage were frequent findings in autopsied cocaine abusers. The correlation between subarachnoid and intracerebral hemorrhage and cocaine concentrations in blood was moderate. There were strong correlation between subarachnoid and intracerebral hemorrhage and BZ concentrations in almost all the samples.
Keywords	brain ; cocaine ; autopsy ; blood ; cerebral hemorrhage ; cocaine-related disorders ; subarachnoid hemorrhage ; Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Military Health Department, Ministry of Defance, Serbia
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: New words in Serbian public discourse as a consequence of the COVID-19 pandemic

Nikolić Marina M. / Slijepčević-Bjelivuk Svetlana M. / Novokmet Slobodan B.

Zbornik Radova Filozofskog Fakulteta u Prištini, Vol 51, Iss 1, Pp 365-

2021 Volume 390

Abstract: The aim of this work is to present the lexical changes in the Serbian language caused by the COVID-19 pandemic. The paper analyses new words that appeared in the Serbian language which very quickly expanded the domain of their use from specific medical ... ...

Abstract	The aim of this work is to present the lexical changes in the Serbian language caused by the COVID-19 pandemic. The paper analyses new words that appeared in the Serbian language which very quickly expanded the domain of their use from specific medical terminology and became part of everyday spoken Serbian language, including new words motivated by them. Types of neologisms emergence are presented (borrowing from the English language, changing or developing new meanings of the existing words, exploiting the derivative potential of the Serbian language, etc.), as well as their stylistic, orthographic, and pragmatic features. After a detailed analysis, we included a dictionary of neologisms followed by the indispensable comments.
Keywords	new words ; neologisms ; occasionalisms ; compounds ; semi-compounds ; derivatives ; orthography ; derivation ; serbian language ; History of scholarship and learning. The humanities ; AZ20-999
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Faculty of Philosophy, Kosovska Mitrovica
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Cooling down with Entresto. Can sacubitril/valsartan combination enhance browning more than coldness?

Nikolic, Marina / Novakovic, Jovana / Ramenskaya, Galina / Kokorekin, Vladimir / Jeremic, Nevena / Jakovljevic, Vladimir

Diabetology & metabolic syndrome

2022 Volume 14, Issue 1, Page(s) 175

Abstract: Background: It is a growing importance to induce a new treatment approach to encourage weight loss but also to improve maintenance of lost weight. It has been shown that promotion of brown adipose tissue (BAT) function or acquisition of BAT ... ...

Abstract	Background: It is a growing importance to induce a new treatment approach to encourage weight loss but also to improve maintenance of lost weight. It has been shown that promotion of brown adipose tissue (BAT) function or acquisition of BAT characteristics in white adipose tissue (terms referred as "browning") can be protective against obesity. Main text: Amongst numerous established environmental influences on BAT activity, cold exposure is the best interested technique due to its not only effects on of BAT depots in proliferation process but also de novo differentiation of precursor cells via β-adrenergic receptor activation. A novel combination drug, sacubitril/valsartan, has been shown to be more efficient in reducing cardiovascular events and heart failure readmission compared to conventional therapy. Also, this combination of drugs increases the postprandial lipid oxidation contributing to energy expenditure, promotes lipolysis in adipocytes and reduces body weight. To date, there is no research examining potential of combined sacubitril/valsartan use to promote browning or mechanisms in the basis of this thermogenic process. Conclusion: Due to the pronounced effects of cold and sacubitril/valsartan treatment on function and metabolism of BAT, the primary goal of further research should focused on investigation of the synergistic effects of the sacubitril/valsartan treatment at low temperature environmental conditions.
Language	English
Publishing date	2022-11-23
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2518786-7
ISSN	1758-5996
ISSN	1758-5996
DOI	10.1186/s13098-022-00944-4
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Implementation of Harmonized Food Consumption Data Collection in the Balkan Region According to the EFSA EU Menu Methodology Standards.

Gurinović, Mirjana / Nikolić, Marina / Zeković, Milica / Milešević, Jelena / Kadvan, Agnes / Ranić, Marija / Glibetić, Maria

Frontiers in nutrition

2022 Volume 8, Page(s) 809328

Abstract: Initiatives in the Capacity Development in Nutrition Research in the Balkan region in the last decade have been toward the creation of contemporary, harmonized Research Infrastructure (RI) compliant with European standards. This study describes the ... ...

Abstract	Initiatives in the Capacity Development in Nutrition Research in the Balkan region in the last decade have been toward the creation of contemporary, harmonized Research Infrastructure (RI) compliant with European standards. This study describes the process of creation and implementation of the European Food Safety Authority (EFSA) EU Menu methodology in the Balkan region during the EFSA support projects for food consumption data collection in four countries (Serbia, Montenegro, Bosnia and Herzegovina, and North Macedonia). This process entailed the application and improvement of an innovative tool, the DIET ASSESS and PLAN (DAP), a platform for standardized food consumption data collection and dietary intake assessment. DAP comprises computerized food consumption, anthropometric measurements, and physical activity questionnaires, validated food picture book, and FoodEx2 exposure hierarchy with sets of facet descriptors of the interest. It hosts the Balkan food platform with a Serbian food composition database (FCDB) and Regional FCDB, compliant with European Food Information Resource (EuroFIR™) standards. The implementation of the DAP platform in national dietary surveys conducted with the support of the EFSA EU Menu project in Balkan countries enabled harmonized food consumption data compilation and reporting. Application of the methodology entailed the development of study protocol and extensive education and training of study personnel. The entire data collection process was managed by internal and external survey coordinators. A pilot study was conducted to test the entire data collection and control process and was afterward used to make necessary improvements and adjustments to meet EU Menu requirements. Data collected are internationally comparable with food consumption data in other European countries within the framework of the EU Menu program. The existence of such data in the Balkan region will catalyze research activities in emerging topics, such as identification of dietary patterns, the establishment of national nutrient reference values and food-based dietary guidelines (not only in Serbia, but in the whole Balkan region), dietary exposure assessments, the endorsement and evaluation of new food legislations, the environmental and other effects of diet on the food system. The developed and implemented methodology underpins evidence-based policy-making processes lacking in the field of public health nutrition in the region.
Language	English
Publishing date	2022-01-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2776676-7
ISSN	2296-861X
ISSN	2296-861X
DOI	10.3389/fnut.2021.809328
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Article: Lady's Bedstraw as a Powerful Antioxidant for Attenuation of Doxorubicin-Induced Cardiotoxicity.

Bradic, Jovana / Andjic, Marijana / Novakovic, Jovana / Kocovic, Aleksandar / Tomovic, Marina / Petrovic, Anica / Nikolic, Marina / Mitrovic, Slobodanka / Jakovljevic, Vladimir / Pecarski, Danijela

Antioxidants (Basel, Switzerland)

2023 Volume 12, Issue 6

Abstract: This study aimed to examine the effects of a 14-day treatment with lady's bedstraw methanol extract on doxorubicin-induced cardiotoxicity through functional, biochemical and histological examinations. We used 24 ... ...

Abstract	This study aimed to examine the effects of a 14-day treatment with lady's bedstraw methanol extract on doxorubicin-induced cardiotoxicity through functional, biochemical and histological examinations. We used 24 male
Language	English
Publishing date	2023-06-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox12061277
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Lady’s Bedstraw as a Powerful Antioxidant for Attenuation of Doxorubicin-Induced Cardiotoxicity

Bradic, Jovana / Andjic, Marijana / Novakovic, Jovana / Kocovic, Aleksandar / Tomovic, Marina / Petrovic, Anica / Nikolić, Marina / Mitrovic, Slobodanka / Jakovljevic, Vladimir / Pecarski, Danijela

Antioxidants. 2023 June 15, v. 12, no. 6

2023

Abstract: This study aimed to examine the effects of a 14-day treatment with lady’s bedstraw methanol extract on doxorubicin-induced cardiotoxicity through functional, biochemical and histological examinations. We used 24 male Wistar albino rats divided into the ... ...

Abstract	This study aimed to examine the effects of a 14-day treatment with lady’s bedstraw methanol extract on doxorubicin-induced cardiotoxicity through functional, biochemical and histological examinations. We used 24 male Wistar albino rats divided into the following groups: control (CTRL), doxorubicin (DOX), and DOX + GVE (Galium verum extract). GVE was administered orally at a dose of 50 mg/kg per day for 14 days, while a single dose of doxorubicin was injected into the DOX groups. After accomplishing treatment with GVE, cardiac function was assessed, which determined the redox state. During the autoregulation protocol on the Langendorff apparatus, ex vivo cardiodynamic parameters were measured. Our results demonstrated that the consumption of GVE effectively suppressed the disturbed response of the heart to changes in perfusion pressures caused by administration of DOX. Intake of GVE was associated with a reduction in most of the measured prooxidants in comparison to the DOX group. Moreover, this extract was capable of increasing the activity of the antioxidant defense system. Morphometric analyses showed that rat hearts treated with DOX showed more pronounced degenerative changes and necrosis compared to the CTRL group. However, GVE pretreatment seems to be able to prevent the pathological injuries caused by DOX injection via decrease in oxidative stress and apoptosis.
Keywords	Galium verum ; albino ; antioxidant activity ; antioxidants ; apoptosis ; autoregulation ; cardiac output ; cardiotoxicity ; doxorubicin ; heart ; histology ; males ; methanol ; morphometry ; necrosis ; oxidative stress ; rats
Language	English
Dates of publication	2023-0615
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article ; Online
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox12061277
Database	NAL-Catalogue (AGRICOLA)

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Article: Effect of GLP-1 Receptor Agonist on Ischemia Reperfusion Injury in Rats with Metabolic Syndrome.

Ravic, Marko / Srejovic, Ivan / Novakovic, Jovana / Andjic, Marijana / Sretenovic, Jasmina / Muric, Maja / Nikolic, Marina / Bolevich, Sergey / Alekseevich Kasabov, Kirill / Petrovich Fisenko, Vladimir / Stojanovic, Aleksandra / Jakovljevic, Vladimir

Pharmaceuticals (Basel, Switzerland)

2024 Volume 17, Issue 4

Abstract: Metabolic syndrome (MetS) represents an important factor that increases the risk of myocardial infarction, and more severe complications. Glucagon Like Peptide-1 Receptor Agonists (GLP-1RAs) exhibit cardioprotective potential, but their efficacy in MetS- ... ...

Abstract	Metabolic syndrome (MetS) represents an important factor that increases the risk of myocardial infarction, and more severe complications. Glucagon Like Peptide-1 Receptor Agonists (GLP-1RAs) exhibit cardioprotective potential, but their efficacy in MetS-related myocardial dysfunction has not been fully explored. Therefore, we aimed to assess the effects of exenatide and dulaglutide on heart function and redox balance in MetS-induced rats. Twenty-four Wistar albino rats with induced MetS were divided into three groups: MetS, exenatide-treated (5 µg/kg), dulaglutide-treated (0.6 mg/kg). After 6 weeks of treatment, in vivo heart function was assessed via echocardiography, while ex vivo function was evaluated using a Langendorff apparatus to simulate ischemia-reperfusion injury. Heart tissue samples were analyzed histologically, and oxidative stress biomarkers were measured spectrophotometrically from the coronary venous effluent. Both exenatide and dulaglutide significantly improved the ejection fraction by 3% and 7%, respectively, compared to the MetS group. Histological analyses corroborated these findings, revealing a reduction in the cross-sectional area of cardiomyocytes by 11% in the exenatide and 18% in the dulaglutide group, indicating reduced myocardial damage in GLP-1RA-treated rats. Our findings suggest strong cardioprotective potential of GLP-1RAs in MetS, with dulaglutide showing a slight advantage. Thus, both exenatide and dulaglutide are potentially promising targets for cardioprotection and reducing mortality in MetS patients.
Language	English
Publishing date	2024-04-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2193542-7
ISSN	1424-8247
ISSN	1424-8247
DOI	10.3390/ph17040525
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Sacubitril/valsartan promotes white adipose tissue browning in rats with metabolic syndrome through activation of mTORC1.

Nikolic, Marina / Jeremic, Nevena / Lazarevic, Nevena / Stojanovic, Aleksandra / Milojevic Samanovic, Andjela / Novakovic, Jovana / Zivkovic, Vladimir / Nikolic, Milos / Nedeljkovic, Nikola / Mitrovic, Slobodanka / Jakovljevic, Vladimir

BioFactors (Oxford, England)

2024

Abstract: In addition to their usual use in the treatment of cardiovascular disease, weak evidence is available for the potential of combined use of neprilysin inhibitor (sacubitril) and AT1 receptor antagonist (valsartan) to promote browning of white adipose ... ...

Abstract	In addition to their usual use in the treatment of cardiovascular disease, weak evidence is available for the potential of combined use of neprilysin inhibitor (sacubitril) and AT1 receptor antagonist (valsartan) to promote browning of white adipose tissue (WAT) in rats with metabolic syndrome (MetS). This study involved 32 male Wistar albino rats divided into four groups: CTRL-healthy control rats; ENT-healthy rats treated with sacubitril/valsartan; MS-rats with MetS; MS + ENT-rats with MetS treated with sacubitril/valsartan. After finishing the experimental protocol, different WAT depots were isolated for further analysis of molecular pathways. Molecular docking and molecular dynamics studies were used for in silico assessment of the binding affinity of sacubitril and valsartan towards subunits of mechanistic target of rapamycin complex 1 (mTORC1). Sacubitril/valsartan treatment markedly diminished morphological changes in adipose tissue, resulting in smaller lipid size and multilocular lipid droplet structure in WAT. We showed significantly higher protein expression of uncoupling protein-1 (UCP-1) and mTORC1 in WAT of MS + ENT rats, correlating with increased relative gene expression of browning-related markers in tissue of rats treated with sacubitril/valsartan compared with MS group of rats. In silico analysis showed that sacubitrilat and valsartan exhibited the highest binding affinity against mTOR and mLST8, forming stable complexes with these mTORC1 subunits. The observed results confirmed strong potential of combined sacubitril/valsartan treatment to increase browning markers expression in different WAT depots in MetS condition and to form permanent complexes with mTOR and mLST8 subunits over the time.
Language	English
Publishing date	2024-01-29
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	59230-4
ISSN	1872-8081 ; 0951-6433
ISSN (online)	1872-8081
ISSN	0951-6433
DOI	10.1002/biof.2040
Database	MEDical Literature Analysis and Retrieval System OnLINE

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