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  1. Article ; Online: Evaluation of culture conditions for sewage-based surveillance of antibiotic resistance in Klebsiella pneumoniae.

    Bobis Camacho, Julián / Nilsson, Johanna / Larsson, Dan Göran Joakim / Flach, Carl-Fredrik

    Journal of global antimicrobial resistance

    2024  Volume 37, Page(s) 122–128

    Abstract: Background: Recent studies have shown promise in predicting clinical antibiotic resistance rates from sewage data. Few have focused on Klebsiella pneumoniae, despite its virulence and importance as carrier of antibiotic resistance. Several media have ... ...

    Abstract Background: Recent studies have shown promise in predicting clinical antibiotic resistance rates from sewage data. Few have focused on Klebsiella pneumoniae, despite its virulence and importance as carrier of antibiotic resistance. Several media have been suggested for the isolation of K. pneumoniae from complex samples. However, comprehensive evaluations of culture protocols for isolation of K. pneumoniae from sewage are lacking.
    Methods: Here, influent samples from a major Swedish sewage treatment plant were used to evaluate ten culture conditions in parallel: cultivation on Brilliant green containing Inositol-Nitrate-Deoxycholate agar (BIND), Bruce agar, Klebsiella ChromoSelect Selective agar®, MacConkey-Inositol-Carbenicillin, or Simmons Citrate Agar with Inositol (SCAI) incubated at either 37°C or 42°C for 44 h. The culture conditions were compared based on colony counts of presumed K. pneumoniae and identification precision assessed by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.
    Results: The sensitivity was lowest for BIND, whereas it was similar for the other media irrespective of incubation temperature. For four media, a better precision was observed after incubation at 42°C compared to 37°C, to a large extent explained by a lower frequency of captured Klebsiella oxytoca. SCAI incubated at 42°C showed the highest precision (84.4%). By combining this protocol with subsequent antibiotic resistance screening of collected isolates, low resistance rates in sewage K. pneumoniae were revealed, potentially reflecting the local resistance landscape.
    Conclusion: When combined with downstream analyses, SCAI incubated at 42°C could be a valuable culture protocol for sewage-based studies on various aspects of K. pneumoniae epidemiology including antibiotic resistance prevalence.
    Language English
    Publishing date 2024-03-27
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2710046-7
    ISSN 2213-7173 ; 2213-7173
    ISSN (online) 2213-7173
    ISSN 2213-7173
    DOI 10.1016/j.jgar.2024.03.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Incidence and risk factors for medication-related osteonecrosis after tooth extraction in cancer patients-A systematic review.

    Schwech, Nurda / Nilsson, Johanna / Gabre, Pia

    Clinical and experimental dental research

    2022  Volume 9, Issue 1, Page(s) 55–65

    Abstract: Objectives: Antiresorptive medication has been reported to be associated with medication-related osteonecrosis of the jaw (MRONJ). This systematic review aims at investigating the incidence of and risk factors for MRONJ after tooth extractions in cancer ...

    Abstract Objectives: Antiresorptive medication has been reported to be associated with medication-related osteonecrosis of the jaw (MRONJ). This systematic review aims at investigating the incidence of and risk factors for MRONJ after tooth extractions in cancer patients treated with high-dose bisphosphonate and denosumab (BP and DS). MATERIAL AND METHODS: The protocol followed the PRISMA statement list and was registered in PROSPERO. Searches were performed for literature published up to April 2021 in the electronic databases PubMed, Embase, Web of Science, and CINAHL and then supplemented by manual research.
    Results: The search process resulted in 771 identified articles, of which seven studies fitted the population, intervention, comparison, and outcome framework. All were observational studies and four had control groups. A total of 550 patients treated with BP and DS were identified of whom 271 had received tooth extractions after medication onset. Due to significant heterogenicity in the collected data, only a qualitative analysis was performed. The MRONJ incidence after tooth extractions varied between 11% and 50% at the patient level. MRONJ occurred up to 3 years after the tooth extraction. Teeth affected by inflammation before the extraction and additional osteotomy during the surgical procedure were identified as risk factors.
    Conclusions: Reliable methods of diagnosing MRONJ and adequate follow-up periods are important factors in obtaining the actual incidence of MRONJ after tooth extractions in patients treated with high-dose BP and DS.
    MeSH term(s) Humans ; Bisphosphonate-Associated Osteonecrosis of the Jaw/epidemiology ; Bisphosphonate-Associated Osteonecrosis of the Jaw/etiology ; Bisphosphonate-Associated Osteonecrosis of the Jaw/drug therapy ; Incidence ; Diphosphonates/adverse effects ; Tooth Extraction/adverse effects ; Risk Factors ; Neoplasms/drug therapy ; Neoplasms/surgery ; Neoplasms/complications
    Chemical Substances Diphosphonates
    Language English
    Publishing date 2022-12-04
    Publishing country United States
    Document type Systematic Review ; Journal Article ; Review
    ZDB-ID 2829558-4
    ISSN 2057-4347 ; 2057-4347
    ISSN (online) 2057-4347
    ISSN 2057-4347
    DOI 10.1002/cre2.698
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  3. Article: Risk assessment of industrial excess heat collaborations – Empirical data from new and ongoing installations

    Lygnerud, Kristina / Klugman, Sofia / Fransson, Nathalie / Nilsson, Johanna

    Energy. 2022 Sept. 15, v. 255

    2022  

    Abstract: Excess heat could meet approximately 25% of the heat demand in the European building sector. However, the recovery of excess heat is low, which has been attributed to financial, technical and organisational barriers. There is limited information on the ... ...

    Abstract Excess heat could meet approximately 25% of the heat demand in the European building sector. However, the recovery of excess heat is low, which has been attributed to financial, technical and organisational barriers. There is limited information on the perceived risk exposure of excess heat recovery at different points in time, before undertaking the investment or after having undertaken the investment, and at locations with existing district heating networks or not (greenfield). This is unfortunate because experience can enable new collaborations. In this paper, we compare the perceived risk exposure of four greenfield and two ongoing industrial excess heat recovery collaborations. In doing so, we confirm previously identified barriers, such as difficulty to agree on the value of excess heat, the risk of a single heat source and lack of regulation. We also find that, with experience, changes to the excess heat-generating processes are increasingly important, whereas, greenfield sites find the lack of ‘know-how’ to be risky. However, the main conclusion from this paper is that the risks of industrial excess heat recovery collaborations appear to be over-emphasised. In fact, risk exposure of industrial activity can be reduced through industrial waste heat recovery as excess heat is characterized by limited price fluctuations and new environmental requirements from customers and authorities can be met proactively. Combining experience with a standardised excess heat recovery policy should significantly reduce the risk exposure of new collaborations.
    Keywords energy ; green infrastructure ; industrial wastes ; issues and policy ; prices ; risk assessment ; risk perception ; risk reduction ; waste heat recovery
    Language English
    Dates of publication 2022-0915
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 2019804-8
    ISSN 0360-5442 ; 0360-5442
    ISSN (online) 0360-5442
    ISSN 0360-5442
    DOI 10.1016/j.energy.2022.124452
    Database NAL-Catalogue (AGRICOLA)

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  4. Article ; Online: Anxiety and depressive symptoms in women with fear of birth: A longitudinal cohort study.

    Hildingsson, Ingegerd / Nilsson, Johanna / Merio, Elida / Larsson, Birgitta

    European journal of midwifery

    2021  Volume 5, Page(s) 32

    Abstract: Introduction: Anxiety and depression during pregnancy could imply difficulties in the attachment to the unborn baby. The objective of this study was to investigate the prevalence and change in anxiety and depressive symptoms in pregnant women with fear ... ...

    Abstract Introduction: Anxiety and depression during pregnancy could imply difficulties in the attachment to the unborn baby. The objective of this study was to investigate the prevalence and change in anxiety and depressive symptoms in pregnant women with fear of birth. Another aim was to explore associations between symptoms of anxiety and depression on prenatal attachment.
    Methods: This is a longitudinal cohort study of 77 pregnant women with fear of birth in three hospitals in Sweden. Data were collected by three questionnaires in mid and late pregnancy and two months after birth.
    Results: Anxiety symptoms were more often reported than depressive symptoms, significantly decreasing over time in both conditions. Anxiety symptoms were associated with low education level, negative feelings towards the upcoming birth, and levels of fear of birth. Depressive symptoms were associated with levels of fear of birth. One in five women presented with fear of birth, anxiety, and depressive symptoms, suggesting that co-morbidity was quite common in this sample. Depressive symptoms and co-morbidity were negatively associated with prenatal attachment.
    Conclusions: This study shows that symptoms of anxiety and depression in women with fear of birth vary over time and that co-morbidity is quite common. Lack of emotional well-being was related to prenatal attachment. Healthcare professionals must identify and support women with anxiety and depressive symptoms and fear of birth so that difficulties in the relationship between the mother and the newborn baby might be reduced.
    Language English
    Publishing date 2021-08-02
    Publishing country Greece
    Document type Journal Article
    ISSN 2585-2906
    ISSN (online) 2585-2906
    DOI 10.18332/ejm/138941
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  5. Article ; Online: Treatment Effect of Zoledronic Acid in Chronic Non-bacterial Osteomyelitis of the Jaw: A Case Series.

    Jansen, Rasmus Bo / Nilsson, Johanna / Buch-Larsen, Kristian / Kofod, Thomas / Schwarz, Peter

    Calcified tissue international

    2023  Volume 114, Issue 2, Page(s) 129–136

    Abstract: Chronic non-bacterial osteomyelitis (CNO) is an autoinflammatory, osteolytic bone disorder sometimes localized to a unifocal site in the jaw, causing long-term pain and reduced function. The aim of this study was to describe the patients with CNO of the ... ...

    Abstract Chronic non-bacterial osteomyelitis (CNO) is an autoinflammatory, osteolytic bone disorder sometimes localized to a unifocal site in the jaw, causing long-term pain and reduced function. The aim of this study was to describe the patients with CNO of the jaw, focusing on treatment with zoledronic acid for pain relief. An analysis of medical records of 24 patients with CNO of the jaw, including treatment with zoledronic acid and effects on pain relief. Descriptive statistics and nonparametric tests were used to describe the population and compare treatment effects, respectively. The average treatment period was 33.4 months (median 23; Q1 11.5; Q3 42.0) with an average of 4.1 infusions (median 3; Q1 2; Q3 5) of zoledronic acid. The average pain VAS score (visual analogue scale) was significantly reduced from 7.7 (median 8; Q1 6.5; Q3 8.5) to 2.5 points (median 2; Q1 0.5; Q3 4.5) (p < 0.001). At final visit, 46% of patients reported no pain and 38% reported a reduction of pain. At least 67% of patients had at least one episode of pain recurrence, and most patients experienced the first recurrence within a year of initial treatment. Four patients (16%) had no pain relief from the treatment. In this group of patients with CNO of the jaw, there was a positive response to treatment with zoledronic acid on pain relief, averaging 5.2 points on a pain VAS score, with 84% of patients treated experiencing either a partial or a total reduction in pain after about 2.5 years.
    MeSH term(s) Humans ; Zoledronic Acid/therapeutic use ; Osteomyelitis/drug therapy ; Osteomyelitis/epidemiology ; Bone and Bones ; Pain/complications ; Diphosphonates/therapeutic use
    Chemical Substances Zoledronic Acid (6XC1PAD3KF) ; Diphosphonates
    Language English
    Publishing date 2023-11-22
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 304266-2
    ISSN 1432-0827 ; 0944-0747 ; 0008-0594 ; 0171-967X
    ISSN (online) 1432-0827
    ISSN 0944-0747 ; 0008-0594 ; 0171-967X
    DOI 10.1007/s00223-023-01154-4
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  6. Article ; Online: Rumination mediates associations between microaggressions and sleep quality in Black Americans: the toll of racial microstressors.

    Wilson, Elizabeth J / Primgaard, Anahi R / Hambrick, Erin P / Marszalek, Jacob M / Berkley-Patton, Jannette / Nilsson, Johanna E / Bennett, Kymberley K

    Journal of behavioral medicine

    2024  Volume 47, Issue 3, Page(s) 515–530

    Abstract: Disparities in health outcomes between Black and White Americans are well-documented, including sleep quality, and disparities in sleep may lead to disparities in health over the life course. A meta-model indicates that cognitive processes may underly ... ...

    Abstract Disparities in health outcomes between Black and White Americans are well-documented, including sleep quality, and disparities in sleep may lead to disparities in health over the life course. A meta-model indicates that cognitive processes may underly the connection between race and poor sleep quality, and ultimately, health disparities. That is, there are race-specific stressors that disproportionately affect Black Americans, which are associated with poor health through biological, cognitive, and behavioral mechanisms (e.g., sleep). Among these race-specific stressors is discrimination, which has been linked to poor sleep quality, and there is a body of literature connecting perseverative cognition (e.g., rumination and worry or vigilance) to poor sleep. Microaggressions, a more subtle but pervasive form of discrimination, are another race-specific stressor. Although less research has considered the connection of microaggressions to perseverative cognition, there are some studies linking microaggressions to health outcomes and sleep. Therefore, using a cross-sectional survey, we tested the following hypotheses: racism-related vigilance and rumination would mediate the relationship between discrimination and poor sleep as well as between microaggressions and poor sleep among Black Americans (N = 223; mean age = 35.77 years, 53.8% men, 86% employed, 66.8% with college degree or higher education). Results of seven parallel mediation models showed that neither rumination nor racism-related vigilance mediated a relationship between discrimination and poor sleep quality. However, rumination partially mediated relationships between the six microaggression sub-scales and poor sleep quality: there were significant indirect effects for Foreigner/Not Belonging (β = .13, SE = 0.03, 95% CI 0.08, 0.20), Criminality (β = .11, SE = 0.03, 95% CI 0.05, 0.17), Sexualization (β = .10, SE = 0.03, 95% CI 0.05, 0.17), Low-Achieving/Undesirable (β = .10, SE = 0.03, 95% CI 0.05, 0.15), Invisibility (β = .15, SE = 0.04, 95% CI 0.08, 0.23), and Environmental Invalidations (β = .15, SE = 0.04, 95% CI 0.08, 0.23). Overall, these findings indicate support for the meta-model, demonstrating a specific pathway from racial microstressors to poor sleep quality. Furthermore, these results suggest the importance of developing clinical and community approaches to address the impact of microaggressions on Black Americans' sleep quality.
    MeSH term(s) Adult ; Female ; Humans ; Male ; Black or African American ; Cross-Sectional Studies ; Microaggression ; Racism/psychology ; Sleep Initiation and Maintenance Disorders ; Sleep Quality ; Rumination, Cognitive ; Health Status Disparities
    Language English
    Publishing date 2024-01-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 441827-x
    ISSN 1573-3521 ; 0160-7715
    ISSN (online) 1573-3521
    ISSN 0160-7715
    DOI 10.1007/s10865-023-00464-0
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  7. Article ; Online: Evaluation of in-house, haptic assisted surgical planning for virtual reduction of complex mandibular fractures.

    Nilsson, Johanna / Nysjö, Fredrik / Nyström, Ingela / Kämpe, Johan / Thor, Andreas

    International journal of computer assisted radiology and surgery

    2021  Volume 16, Issue 6, Page(s) 1059–1068

    Abstract: Purpose: The management of complex mandible fractures, i.e. severely comminuted or fractures of edentulous/atrophic mandibles, can be challenging. This is due to the three-dimensional loss of bone, which limits the possibility for accurate anatomic ... ...

    Abstract Purpose: The management of complex mandible fractures, i.e. severely comminuted or fractures of edentulous/atrophic mandibles, can be challenging. This is due to the three-dimensional loss of bone, which limits the possibility for accurate anatomic reduction. Virtual surgery planning (VSP) can provide improved accuracy and shorter operating times, but is often not employed for trauma cases because of time constraints and complex user interfaces limited to two-dimensional interaction with three-dimensional data.
    Methods: In this study, we evaluate the accuracy, precision, and time efficiency of the haptic assisted surgery planning system (HASP), an in-house VSP system that supports stereo graphics, six degrees-of-freedom input, and haptics to improve the surgical planning. Three operators performed planning in HASP on computed tomography (CT) and cone beam computed tomography (CBCT) images of a plastic skull model and on twelve retrospective cases with complex mandible fractures.
    Results: The results show an accuracy and reproducibility of less than 2 mm when using HASP for virtual fracture reduction, with an average planning time of 15 min including time for segmentation in the software BoneSplit.
    Conclusion: This study presents an in-house haptic assisted planning tool for cranio-maxillofacial surgery with high usability that can be used for preoperative planning and evaluation of complex mandible fractures.
    Language English
    Publishing date 2021-04-27
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2365628-1
    ISSN 1861-6429 ; 1861-6410
    ISSN (online) 1861-6429
    ISSN 1861-6410
    DOI 10.1007/s11548-021-02353-w
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    Zs.A 6615: Show issues Location:
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  8. Article ; Online: Closed and open state dependent block of potassium channels cause opposing effects on excitability - a computational approach.

    Ågren, Richard / Nilsson, Johanna / Århem, Peter

    Scientific reports

    2019  Volume 9, Issue 1, Page(s) 8175

    Abstract: Block of voltage-gated potassium (Kv) channels has been demonstrated to affect neuronal activity described as increasing excitability. The effect has been associated with a closed-state dependent block. However, the block of Kv channels in e.g. local ... ...

    Abstract Block of voltage-gated potassium (Kv) channels has been demonstrated to affect neuronal activity described as increasing excitability. The effect has been associated with a closed-state dependent block. However, the block of Kv channels in e.g. local anesthetic and antiarrhythmics, is open state-dependent. Since the reduced excitability in this case mainly is due to sodium channel block, the role of the Kv channel block is concealed. The present investigation aims to analyse the specific role of state-dependent Kv channel block for excitability. Using a computational approach, with introduced blocked states in the Kv channel of the Frankenhaeuser-Huxley axon membrane model, we calculated the effects on threshold, firing and presynaptic Ca influx. The Ca influx was obtained from an N-type Cav channel model linked to the Frankenhaeuser-Huxley membrane. The results suggested that a selective block of open Kv channels decreased the rate of repetitive firing and the consequent Ca influx, thus challenging the traditional view. In contrast, presence of a closed-state block, increased the firing rate and the Ca influx. These findings propose that Kv channel block may either increase or decrease cellular excitability, thus highlighting the importance of further investigating the role of state-specific blocking mechanisms.
    MeSH term(s) Action Potentials/physiology ; Animals ; Axons/metabolism ; Biophysical Phenomena ; Calcium/metabolism ; Computational Biology ; Humans ; Ion Channel Gating/drug effects ; Ion Channel Gating/physiology ; Membranes/metabolism ; Mice ; Models, Theoretical ; Neurons/drug effects ; Neurons/physiology ; Potassium/metabolism ; Potassium Channel Blockers/chemistry ; Potassium Channels, Voltage-Gated/antagonists & inhibitors ; Potassium Channels, Voltage-Gated/chemistry ; Potassium Channels, Voltage-Gated/metabolism ; Xenopus laevis/metabolism ; Xenopus laevis/physiology
    Chemical Substances Potassium Channel Blockers ; Potassium Channels, Voltage-Gated ; Potassium (RWP5GA015D) ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2019-06-03
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-019-44564-x
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  9. Article ; Online: Cerebrospinal fluid biomarker panel for synaptic dysfunction in a broad spectrum of neurodegenerative diseases.

    Nilsson, Johanna / Pichet Binette, Alexa / Palmqvist, Sebastian / Brum, Wagner S / Janelidze, Shorena / Ashton, Nicholas J / Spotorno, Nicola / Stomrud, Erik / Gobom, Johan / Zetterberg, Henrik / Brinkmalm, Ann / Blennow, Kaj / Hansson, Oskar

    Brain : a journal of neurology

    2024  

    Abstract: Synaptic dysfunction and degeneration is likely the key pathophysiology for the progression of cognitive decline in various dementia disorders. Synaptic status can be monitored by measurement of synaptic proteins in cerebrospinal fluid (CSF). In the ... ...

    Abstract Synaptic dysfunction and degeneration is likely the key pathophysiology for the progression of cognitive decline in various dementia disorders. Synaptic status can be monitored by measurement of synaptic proteins in cerebrospinal fluid (CSF). In the current study, the aim was to investigate and compare both known and new synaptic proteins as potential biomarkers of synaptic dysfunction, especially in the context of Alzheimer's disease (AD). Seventeen synaptic proteins were quantified in CSF using two different targeted mass spectrometry assays in the prospective Swedish BioFINDER-2 study. The study included 958 individuals, characterized as having mild cognitive impairment (MCI, n = 205), AD dementia (n = 149), and a spectrum of other neurodegenerative diseases (n = 171), as well as cognitively unimpaired (CU, n = 443). Synaptic protein levels were compared between diagnostic groups and their associations with cognitive decline and key neuroimaging measures (Aβ-PET, tau-PET, and cortical thickness) were assessed. Among the 17 synaptic proteins examined, 14 were specifically elevated in the AD continuum. SNAP-25, 14-3-3 zeta/delta, beta-synuclein, and neurogranin exhibited the highest discriminatory accuracy to differentiate AD dementia from controls (AUCs = 0.81-0.93). SNAP-25 and 14-3-3 zeta/delta also had the strongest associations with tau-PET, Aβ-PET, and cortical thickness at baseline, and were associated with longitudinal changes in these imaging biomarkers (β(SE)=-0.056(0.0006) to 0.058(0.005), p < 0.0001). SNAP-25 was the strongest predictor of progression to AD dementia in non-demented individuals (Hazard ratio = 2.11). In contrast, neuronal pentraxins were decreased in all neurodegenerative diseases (except for Parkinson's disease), and NPTX2 showed the strongest associations with subsequent cognitive decline (longitudinal MMSE; β(SE) = 0.57(0.1), p ≤ 0.0001 and mPACC; β(SE) = 0.095(0.024), p ≤ 0.001) across the AD continuum. Interestingly, utilizing a ratio of the proteins that displayed higher levels in AD, such as SNAP-25 or 14-3-3 zeta/delta, over NPTX2 improved the biomarkers' association with cognitive decline and brain atrophy. We found that especially 14-3-3 zeta/delta and SNAP-25 are promising synaptic biomarkers of pathophysiological changes in AD. Neuronal pentraxins were identified as general indicators of neurodegeneration and associated with cognitive decline across various neurodegenerative dementias. The ratios of SNAP-25/NPTX2 and 14-3-3 zeta/delta/NPTX2 were found to best predict cognitive decline and brain atrophy.
    Language English
    Publishing date 2024-02-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 80072-7
    ISSN 1460-2156 ; 0006-8950
    ISSN (online) 1460-2156
    ISSN 0006-8950
    DOI 10.1093/brain/awae032
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  10. Article ; Online: Time matters - Differences between computer-assisted surgery and conventional planning in cranio-maxillofacial surgery: A systematic review and meta-analysis.

    Nilsson, Johanna / Hindocha, Nishma / Thor, Andreas

    Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery

    2019  Volume 48, Issue 2, Page(s) 132–140

    Abstract: The aim of the study was to assess if there is a time difference (operative time, ischemia time, planning time and hospitalization) between computer-assisted surgery (CAS) and conventional planning in cranio-maxillofacial surgery. An electronic search ... ...

    Abstract The aim of the study was to assess if there is a time difference (operative time, ischemia time, planning time and hospitalization) between computer-assisted surgery (CAS) and conventional planning in cranio-maxillofacial surgery. An electronic search was performed in June 2018. Studies comparing time difference between CAS and traditional planning were included. 28 publications were included, with 536 patients in the CAS group and 784 in the control group. 18 studies reported on mandibular/maxillary reconstruction and a meta-analysis was conducted on 15 of these studies. This meta-analysis was undertaken to demonstrate the difference between the groups regarding operative time, ischemia time and hospitalization for mandibular/maxillary reconstruction and showed a decreased operative time for the CAS group with a mean difference of -84.61 min, 95% confidence interval [-106.77, -62,45], p < 0.001. Ischemia time was also decreased, with a mean difference of -36.14 min, 95% confidence interval [-50.57, -21.71], p < 0.001. This systematic review and meta-analysis suggests that CAS is shortening the operative time and ischemia time for mandibular/maxillary reconstruction. It also leads to a reduction in hospitalization. Additionally, CAS seems to shorten the preoperative planning time for orthognathic surgery.
    MeSH term(s) Humans ; Maxilla ; Reconstructive Surgical Procedures ; Surgery, Computer-Assisted
    Language English
    Publishing date 2019-12-20
    Publishing country Scotland
    Document type Journal Article ; Meta-Analysis ; Systematic Review
    ZDB-ID 91267-0
    ISSN 1878-4119 ; 1010-5182 ; 0301-0503
    ISSN (online) 1878-4119
    ISSN 1010-5182 ; 0301-0503
    DOI 10.1016/j.jcms.2019.11.024
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