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  1. Article: Comparative Analysis of Physicochemical Properties and Microbial Composition in High-Temperature

    Deng, Ling / Mao, Xiang / Liu, Dan / Ning, Xin-Qiang / Shen, Yi / Chen, Bo / Nie, Hong-Fang / Huang, Dan / Luo, Hui-Bo

    Frontiers in microbiology

    2020  Volume 11, Page(s) 588117

    Abstract: ... High- ... ...

    Abstract High-temperature
    Language English
    Publishing date 2020-11-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2020.588117
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Anti-IFN-γ autoantibodies underlie disseminated Talaromyces marneffei infections.

    Guo, Jing / Ning, Xin-Qiang / Ding, Jing-Ya / Zheng, Yan-Qing / Shi, Na-Na / Wu, Feng-Yao / Lin, You-Kun / Shih, Han-Po / Ting, He-Ting / Liang, Gang / Lu, Xiang-Chan / Kong, Jin-Ling / Wang, Ke / Lu, Yi-Bo / Fu, Yu-Jiao / Hu, Rong / Li, Tian-Min / Pan, Kai-Su / Li, Xiu-Ying /
    Huang, Chun-Yang / Lo, Yu-Fang / Chang, Ian Yi-Feng / Yeh, Chun-Fu / Tu, Kun-Hua / Tsai, Yu-Huan / Ku, Cheng-Lung / Cao, Cun-Wei

    The Journal of experimental medicine

    2020  Volume 217, Issue 12

    Abstract: Talaromyces marneffei causes life-threatening opportunistic infections, mainly in Southeast Asia and South China. T. marneffei mainly infects patients with human immunodeficiency virus (HIV) but also infects individuals without known immunosuppression. ... ...

    Abstract Talaromyces marneffei causes life-threatening opportunistic infections, mainly in Southeast Asia and South China. T. marneffei mainly infects patients with human immunodeficiency virus (HIV) but also infects individuals without known immunosuppression. Here we investigated the involvement of anti-IFN-γ autoantibodies in severe T. marneffei infections in HIV-negative patients. We enrolled 58 HIV-negative adults with severe T. marneffei infections who were otherwise healthy. We found a high prevalence of neutralizing anti-IFN-γ autoantibodies (94.8%) in this cohort. The presence of anti-IFN-γ autoantibodies was strongly associated with HLA-DRB1*16:02 and -DQB1*05:02 alleles in these patients. We demonstrated that adult-onset acquired immunodeficiency due to autoantibodies against IFN-γ is the major cause of severe T. marneffei infections in HIV-negative patients in regions where this fungus is endemic. The high prevalence of anti-IFN-γ autoantibody-associated HLA class II DRB1*16:02 and DQB1*05:02 alleles may account for severe T. marneffei infections in Southeast Asia. Our findings clarify the pathogenesis of T. marneffei infection and pave the way for developing novel treatments.
    MeSH term(s) Adult ; Aged ; Alleles ; Autoantibodies/blood ; Autoantibodies/immunology ; Case-Control Studies ; Female ; HLA-DRB1 Chains/immunology ; Humans ; Interferon-gamma/immunology ; Male ; Middle Aged ; Mycoses/blood ; Mycoses/immunology ; Mycoses/microbiology ; Talaromyces/physiology ; Young Adult
    Chemical Substances Autoantibodies ; HLA-DRB1 Chains ; Interferon-gamma (82115-62-6)
    Language English
    Publishing date 2020-09-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 218343-2
    ISSN 1540-9538 ; 0022-1007
    ISSN (online) 1540-9538
    ISSN 0022-1007
    DOI 10.1084/jem.20190502
    Database MEDical Literature Analysis and Retrieval System OnLINE

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