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  1. Article: Reconstruction of Large Full-Thickness Abdominal Wall Defects Using a Free Functional Latissimus Dorsi Muscle.

    Ninkovic, Marijana / Ninkovic, Marina / Öfner, Dietmar / Ninkovic, Milomir

    Frontiers in surgery

    2022  Volume 9, Page(s) 853639

    Abstract: Introduction: The large full-thickness abdominal wall defect has to be treated by considering anatomical and functional requirements. The abdominal wall must regain total physiological function, which means that the full thickness abdominal wall defect ... ...

    Abstract Introduction: The large full-thickness abdominal wall defect has to be treated by considering anatomical and functional requirements. The abdominal wall must regain total physiological function, which means that the full thickness abdominal wall defect must be reconstructed anatomically, not only according to the anatomical requirements but also maintaining the functional dynamic voluntary movement. Defects in the abdominal wall alter respiratory mechanics and can impair the diaphragm function. Additionally, muscles of the anterolateral abdominal wall increase the stability of the lumbar region of the vertebral column by tensing the thoracolumbar fascia and by increasing intraabdominal pressure.
    Materials and methods: The timing and method of reconstruction must be chosen depending upon the etiology of the defect. Severe traumatic injuries, abdominal wall infections, necrotizing soft tissue loss, or sepsis needs to undergo staged reconstruction following adequate debridement to control the infectious process, establish the zone of injury, and for proper treatment of intraabdominal pathology, thereby achieving temporary primary closure using split-thickness skin grafting to the viscera. At the time of definitive reconstruction, deep skin graft dermabrasion give us a facial-like layer with adequate strength to stabilize the static abdominal wall. This dermal layer is supported by free functional (innervated) latissimus dorsi muscle (fLDM), giving full anatomical coverage and functional stability. After oncologic resections full-thickness abdominal wall reconstruction was performed immediately with a combination of fLDM flaps and meshes.
    Results: A total of 14 patients underwent abdominal wall reconstruction using the fLDM flap. Staged reconstruction was applied in 8 cases. In the remaining six cases, two had no mesh support, three had synthetic mesh, and one had a fascial graft, which were covered with fLDM flap. There were no free flaps failure. One flap revision due to venous anastomosis thrombosis was performed. Donor site seromas occurred in 5 cases and were treated with punction and direct doxycycline injection. Electromyographic testing postoperatively confirmed reinnervation of transplanted LDM.
    Conclusion: Using fLDM as a definitive solution, we are not only able to repair soft tissue defects, but also reconstruct voluntary contractility and dynamic natural functional abdominal wall. Transplanted LDM offers enough contractile capacity and strength to replace the function of the missing abdominal wall muscles.
    Language English
    Publishing date 2022-03-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2773823-1
    ISSN 2296-875X
    ISSN 2296-875X
    DOI 10.3389/fsurg.2022.853639
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Emergency resection is an independent risk factor for decreased long-term overall survival in colorectal cancer: a matched-pair analysis.

    Esswein, Katharina / Ninkovic, Marijana / Gasser, Elisabeth / Barenberg, Lars / Perathoner, Alexander / Kafka-Ritsch, Reinhold

    World journal of surgical oncology

    2023  Volume 21, Issue 1, Page(s) 310

    Abstract: Background: Colorectal cancer is one of the most common malignant neoplasms worldwide. Up to 30% of the patients present in an emergency setting despite an established screening program. Emergency colorectal resection is associated with increased ... ...

    Abstract Background: Colorectal cancer is one of the most common malignant neoplasms worldwide. Up to 30% of the patients present in an emergency setting despite an established screening program. Emergency colorectal resection is associated with increased mortality and morbidity as well as worse oncological outcome. This study aims to analyze the impact on tumor recurrence and survival in patients with an emergency colorectal resection, independent of sex, age, and tumor stage.
    Methods: Patients, who underwent an oncological resection for colorectal cancer at the Medical University of Innsbruck, Department of Visceral, Transplant and Thoracic Surgery, between January 2003 and December 2018 were analyzed retrospectively and screened for emergency resections. Matched pairs were formed to analyze the impact of emergency operations on long-term outcomes, considering tumor stage, sex, and age, comparing it with elective patients.
    Results: In total, 4.5% out of 1297 patients underwent surgery in an emergency setting. These patients had higher UICC (Union internationale contre le cancer) stages than elective patients. After matching the patients for age, sex, and tumor stage, emergency patients still had higher mortality. The incidence of recurrence was higher (47.5% vs. 25.4%, p = 0.003) and the 5-year overall survival decreased (35.6% vs. 64.4%, p < 0.001) compared to the matched patients with elective resection. Correcting for 90-day mortality still a reduction in the 5-year overall survival was demonstrated (44% vs. 70%, p = 0,001). The left-sided colon tumors were more common in the emergency group (45.8% vs. 25.4%, p = 0.006) and the rectal tumors in the elective one (21.2% vs. 3.4%, p = 0.002).
    Conclusion: Patients undergoing emergency resection for colorectal cancer have a decreased tumor-specific and overall survival compared to patients after elective resection, independent of age, sex, and tumor stage, even after correcting for 90-day mortality. These findings confirm the importance of colorectal cancer awareness and screening to reduce emergency resections.
    MeSH term(s) Humans ; Colorectal Neoplasms/pathology ; Retrospective Studies ; Matched-Pair Analysis ; Elective Surgical Procedures ; Neoplasm Recurrence, Local/epidemiology ; Neoplasm Recurrence, Local/surgery ; Risk Factors ; Treatment Outcome
    Language English
    Publishing date 2023-09-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 2118383-1
    ISSN 1477-7819 ; 1477-7819
    ISSN (online) 1477-7819
    ISSN 1477-7819
    DOI 10.1186/s12957-023-03182-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Patientin mit Fieber und rechtsseitigen Leistenschmerzen.

    Moric, Trpimir / Romic, Ivan / Silovski, Hrvoje / Ninkovic, Marijana

    Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen

    2021  Volume 93, Issue 3, Page(s) 301–304

    Title translation Female patient with fever and right-sided inguinal pain.
    MeSH term(s) Female ; Hernia, Inguinal/surgery ; Herniorrhaphy ; Humans ; Pain
    Language German
    Publishing date 2021-08-27
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1521-0
    ISSN 1433-0385 ; 0009-4722
    ISSN (online) 1433-0385
    ISSN 0009-4722
    DOI 10.1007/s00104-021-01493-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Long-term outcome after chronic anastomotic leakage following surgery for low rectal cancer.

    Ponholzer, Florian / Klingler, Clemens Paul / Gasser, Elisabeth / Gehwolf, Philipp / Ninkovic, Marijana / Bellotti, Ruben / Kafka-Ritsch, Reinhold / Öfner, Dietmar

    International journal of colorectal disease

    2022  Volume 37, Issue 8, Page(s) 1807–1816

    Abstract: Purpose: This study analyzed the prevalence and factors influencing the history of chronic anastomotic leakage following low anterior resection for rectal cancer. Furthermore, the treatment of a persisting presacral sinus and the impact of stoma ... ...

    Abstract Purpose: This study analyzed the prevalence and factors influencing the history of chronic anastomotic leakage following low anterior resection for rectal cancer. Furthermore, the treatment of a persisting presacral sinus and the impact of stoma reversal on outcome were evaluated.
    Methods: The institutional database was scanned for all patients with anastomotic leakage, who were primarily treated for low rectal cancer between January 1995 and December 2019. Patients with rectovaginal and rectovesical fistula or an inadequate follow-up were excluded (n = 5). After applying the exclusion criteria, 71 patients remained for analysis.
    Results: A total of 39 patients out of 71 patients with anastomotic leakage (54.9%) developed a persisting presacral sinus. Neoadjuvant radiochemotherapy or chemotherapy showed a significant impact on the formation of a chronic anastomotic leakage (radiochemotherapy: p = 0.034; chemotherapy: p = 0.050), while initial surgical treatment showed no difference for anastomotic healing (p = 0.502), but a significantly better overall survival (p = 0.042). Multiple therapies and surgical revision had a negative impact on patients' rate of natural bowel continuity (p = 0.006/ < 0.001). In addition, the stoma reversal cohort showed improved overall 10-year survival (p = 0.004) and functional results (bowel continuity: p = 0.026; pain: p = 0.031).
    Conclusion: Primary surgical therapy for chronic anastomotic leakage should consist of surgical treatment. Furthermore, the reversal of a protective stoma should be considered a viable option in treating chronic presacral sinus to improve pain symptoms and bowel continuity.
    MeSH term(s) Anastomosis, Surgical/adverse effects ; Anastomosis, Surgical/methods ; Anastomotic Leak/diagnosis ; Humans ; Pain ; Proctectomy ; Rectal Neoplasms/surgery ; Retrospective Studies ; Risk Factors
    Language English
    Publishing date 2022-07-12
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 84975-3
    ISSN 1432-1262 ; 0179-1958
    ISSN (online) 1432-1262
    ISSN 0179-1958
    DOI 10.1007/s00384-022-04213-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Is a less-intensive follow-up for colon cancer in early stages reasonable?

    Esswein, Katharina / Volpi, Marco / Ninkovic, Marijana / Kröpfl, Veronika / Gasser, Elisabeth / Lorenz, Andreas / Stecher, Lea / Kafka-Ritsch, Reinhold / Schneeberger, Stefan / Öfner, Dietmar / Perathoner, Alexander

    International journal of colorectal disease

    2023  Volume 38, Issue 1, Page(s) 60

    Abstract: Purpose: Patients with colon cancer are usually included in an intensive 5-year surveillance protocol after curative resection, independent of the tumor stage, though early stages have a considerably lower risk of recurrence. The aim of this study was ... ...

    Abstract Purpose: Patients with colon cancer are usually included in an intensive 5-year surveillance protocol after curative resection, independent of the tumor stage, though early stages have a considerably lower risk of recurrence. The aim of this study was to analyze the adherence to an intensive follow-up and the risk of recurrence in patients with colon cancer in UICC stages I and II.
    Methods: In this retrospective study, we assessed patients who underwent resection for colon cancer in UICC stages I and II between 2007 and 2016. Data were collected on demographics, tumor stages, therapy, surveillance, recurrent disease, and oncological outcome.
    Results: Of the 232 included patients, 43.5% (n = 101) reached the 5-year follow-up disease-free. Seven (7.5%) patients in stage UICC I and sixteen (11.5%) in UICC II had a recurrence, with the highest risk in patients with pT4 (26.3%). A metachronous colon cancer was detected in four patients (1.7%). The therapy of recurrence was intended to be curative in 57.1% (n = 4) of UICC stage I and in 43.8% (n = 7) of UICC stage II, but only in one of seven patients over 80 years. 44.8% (n = 104) of the patients were lost to follow-up.
    Conclusion: A postoperative surveillance in patients with colon cancer is important and recommended as a recurrent disease can be treated successfully in many patients. However, we suggest that a less intensive surveillance protocol is reasonable for patients with colon cancer in early tumor stages, especially in UICC stage I, as the risk of recurrent disease is low. With elderly and/or frail patients in a reduced general condition, who will not endure further specific therapy in case of a recurrence, the performance of the surveillance should be discussed: we recommend a significant reduction or even renunciation.
    MeSH term(s) Aged ; Humans ; Colonic Neoplasms/therapy ; Retrospective Studies ; Aftercare/methods ; Aged, 80 and over
    Language English
    Publishing date 2023-03-04
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 84975-3
    ISSN 1432-1262 ; 0179-1958
    ISSN (online) 1432-1262
    ISSN 0179-1958
    DOI 10.1007/s00384-023-04350-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Preoperative endoscopic biliary drainage by metal versus plastic stents for resectable perihilar cholangiocarcinoma.

    de Jong, David M / Gilbert, Timothy M / Nooijen, Lynn E / Braunwarth, Eva / Ninkovic, Marijana / Primavesi, Florian / Malik, Hassan Z / Stern, Nick / Sturgess, Richard / Erdmann, Joris I / Voermans, Rogier P / Bruno, Marco J / Koerkamp, Bas Groot / van Driel, Lydi M J W

    Gastrointestinal endoscopy

    2023  Volume 99, Issue 4, Page(s) 566–576.e8

    Abstract: Background and aims: Adequate preoperative biliary drainage (PBD) is recommended in most patients with resectable perihilar cholangiocarcinoma (pCCA). Most expert centers use endoscopic plastic stents rather than self-expandable metal stents (SEMSs). In ...

    Abstract Background and aims: Adequate preoperative biliary drainage (PBD) is recommended in most patients with resectable perihilar cholangiocarcinoma (pCCA). Most expert centers use endoscopic plastic stents rather than self-expandable metal stents (SEMSs). In the palliative setting, however, use of SEMSs has shown longer patency and superior survival. The aim of this retrospective study was to compare stent dysfunction of SEMSs versus plastic stents for PBD in resectable pCCA patients.
    Methods: In this multicenter international retrospective cohort study, patients with potentially resectable pCCAs who underwent initial endoscopic PBD from 2010 to 2020 were included. Stent failure was a composite end point of cholangitis or reintervention due to adverse events or insufficient PBD. Other adverse events, surgical outcomes, and survival were recorded. Propensity score matching (PSM) was performed on several baseline characteristics.
    Results: A total of 474 patients had successful stent placement, of whom 61 received SEMSs and 413 plastic stents. PSM (1:1) resulted in 2 groups of 59 patients each. Stent failure occurred significantly less in the SEMSs group (31% vs 64%; P < .001). Besides less cholangitis after SEMSs placement (15% vs 31%; P = .012), other PBD-related adverse events did not differ. The number of patients undergoing surgical resection was not significantly different (46% vs 49%; P = .71). Complete intraoperative SEMSs removal was successful and without adverse events in all patients.
    Conclusions: Stent failure was lower in patients with SEMSs as PBD compared with plastic stents in patients with resectable pCCA. Removal during surgery was quite feasible. Surgical outcomes were similar.
    MeSH term(s) Humans ; Retrospective Studies ; Klatskin Tumor/surgery ; Klatskin Tumor/etiology ; Stents/adverse effects ; Self Expandable Metallic Stents/adverse effects ; Cholangiocarcinoma/surgery ; Cholangiopancreatography, Endoscopic Retrograde ; Drainage/methods ; Cholangitis/etiology ; Bile Duct Neoplasms/surgery ; Bile Ducts, Intrahepatic ; Cholestasis/etiology ; Treatment Outcome
    Language English
    Publishing date 2023-10-20
    Publishing country United States
    Document type Multicenter Study ; Journal Article
    ZDB-ID 391583-9
    ISSN 1097-6779 ; 0016-5107
    ISSN (online) 1097-6779
    ISSN 0016-5107
    DOI 10.1016/j.gie.2023.10.041
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  7. Article ; Online: Impact of preoperative anemia, iron-deficiency and inflammation on survival after colorectal surgery-A retrospective cohort study.

    Bath, Messina / Viveiros, André / Schaefer, Benedikt / Klein, Sebastian / Pammer, Lorenz M / Wagner, Sonja / Lorenz, Andreas / Rugg, Christopher / Gasser, Elisabeth / Ninkovic, Marijana / Panzer, Marlene / Pertler, Elke / Fries, Dietmar / Tilg, Herbert / Weiss, Guenter / Petzer, Verena / Öfner-Velano, Dietmar / Zoller, Heinz

    PloS one

    2022  Volume 17, Issue 7, Page(s) e0269309

    Abstract: Background: Anemia is present in up to two-thirds of patients undergoing colorectal surgery mainly caused by iron deficiency and inflammation. As anemia is associated with increased risk of perioperative death, diagnosis and treatment of preoperative ... ...

    Abstract Background: Anemia is present in up to two-thirds of patients undergoing colorectal surgery mainly caused by iron deficiency and inflammation. As anemia is associated with increased risk of perioperative death, diagnosis and treatment of preoperative anemia according to etiology have been recommended.
    Objective: The aim of the present study was to assess if the association between anemia and survival in patients undergoing colorectal surgery was determined by the severity of anemia alone or also by anemia etiology.
    Methods: To determine the prevalence of anemia and etiology, preoperative hematological parameters, C-reactive protein, ferritin and transferrin saturation were retrospectively assessed and correlated with outcome in a cohort of patients undergoing colorectal surgery between 2005 and 2019 at the University Hospital of Innsbruck. Anemia was defined as hemoglobin <120 g/L in females and <130 g/L in males. The etiology of anemia was classified on the basis of serum iron parameters, as iron deficiency anemia, anemia of inflammation or other anemia etiologies.
    Results: Preoperative anemia was present in 54% (1316/2458) of all patients. Anemia was associated with iron deficiency in 45% (134/299) and classified as anemia of inflammation in 32% (97/299) of patients with available serum iron parameters. The etiology of anemia was a strong and independent predictor of survival, where iron deficiency and anemia of inflammation were associated with better postoperative survival than other anemia etiologies. One year survival rates were 84.3%, 77.3% and 69.1% for patients with iron deficiency anemia, anemia of inflammation and other anemia types. Inflammation indicated by high C-reactive protein is a strong negative predictor of overall survival.
    Conclusions: Anemia has a high prevalence among patients undergoing colorectal surgery and rational treatment requires early assessment of serum iron parameters and C-reactive protein.
    MeSH term(s) Anemia/complications ; Anemia/epidemiology ; Anemia, Iron-Deficiency/complications ; Anemia, Iron-Deficiency/epidemiology ; C-Reactive Protein/metabolism ; Cohort Studies ; Colorectal Surgery ; Female ; Hemoglobins/metabolism ; Humans ; Inflammation ; Iron ; Iron Deficiencies ; Male ; Retrospective Studies
    Chemical Substances Hemoglobins ; C-Reactive Protein (9007-41-4) ; Iron (E1UOL152H7)
    Language English
    Publishing date 2022-07-27
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0269309
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  8. Article ; Online: An APRI+ALBI Based Multivariable Model as Preoperative Predictor for Posthepatectomy Liver Failure.

    Santol, Jonas / Kim, Sarang / Gregory, Lindsey A / Baumgartner, Ruth / Murtha-Lemekhova, Anastasia / Birgin, Emrullah / Gloor, Severin / Braunwarth, Eva / Ammann, Markus / Starlinger, Johannes / Pereyra, David / Ammon, Daphni / Ninkovic, Marijana / Kern, Anna E / Rumpf, Benedikt / Ortmayr, Gregor / Herrmann, Yannic / Dong, Yawen / Huber, Felix X /
    Weninger, Jeremias / Thiels, Cornelius A / Warner, Susanne G / Smoot, Rory L / Truty, Mark J / Kendrick, Michael L / Nagorney, David N / Cleary, Sean P / Beldi, Guido / Rahbari, Nuh N / Hoffmann, Katrin / Gilg, Stefan / Assinger, Alice / Gruenberger, Thomas / Hackl, Hubert / Starlinger, Patrick

    Annals of surgery

    2023  

    Abstract: Objective and background: Clinically significant posthepatectomy liver failure (PHLF B+C) remains the main cause of mortality after major hepatic resection. This study aimed to establish an APRI+ALBI, aspartate aminotransferase to platelet ratio (APRI) ... ...

    Abstract Objective and background: Clinically significant posthepatectomy liver failure (PHLF B+C) remains the main cause of mortality after major hepatic resection. This study aimed to establish an APRI+ALBI, aspartate aminotransferase to platelet ratio (APRI) combined with albumin-bilirubin grade (ALBI), based multivariable model (MVM) to predict PHLF and compare its performance to indocyanine green clearance (ICG-R15 or ICG-PDR) and albumin-ICG evaluation (ALICE).
    Methods: 12,056 patients from the National Surgical Quality Improvement Program (NSQIP) database were used to generate a MVM to predict PHLF B+C. The model was determined using stepwise backwards elimination. Performance of the model was tested using receiver operating characteristic curve analysis and validated in an international cohort of 2,525 patients. In 620 patients, the APRI+ALBI MVM, trained in the NSQIP cohort, was compared with MVM's based on other liver function tests (ICG clearance, ALICE) by comparing the areas under the curve (AUC).
    Results: A MVM including APRI+ALBI, age, sex, tumor type and extent of resection was found to predict PHLF B+C with an AUC of 0.77, with comparable performance in the validation cohort (AUC 0.74). In direct comparison with other MVM's based on more expensive and time-consuming liver function tests (ICG clearance, ALICE), the APRI+ALBI MVM demonstrated equal predictive potential for PHLF B+C. A smartphone application for calculation of the APRI+ALBI MVM was designed.
    Conclusion: Risk assessment via the APRI+ALBI MVM for PHLF B+C increases preoperative predictive accuracy and represents an universally available and cost-effective risk assessment prior to hepatectomy, facilitated by a freely available smartphone app.
    Language English
    Publishing date 2023-10-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 340-2
    ISSN 1528-1140 ; 0003-4932
    ISSN (online) 1528-1140
    ISSN 0003-4932
    DOI 10.1097/SLA.0000000000006127
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  9. Article ; Online: Low anterior resection syndrome (LARS) in ovarian cancer patients - A multi-centre comparative cohort study.

    Harpain, Felix / Kranawetter, Marlene / Zott, Tobias / Lazaridis, Ioannis I / Guenin, Marc-Olivier / Ninkovic, Marijana / Kronberger, Irmgard E / Tapiolas, Ingrid / Basany, Eloy Espin / Dauser, Bernhard / Herbst, Friedrich / Koh, Cherry / Stift, Anton / Teleky, Bela / Reinthaller, Alexander / Grimm, Christoph / Riss, Stefan

    International journal of surgery (London, England)

    2020  Volume 78, Page(s) 97–102

    Abstract: Background: Low anterior resection syndrome (LARS) is a common functional disorder after low anterior resection impacting the quality of life. Data on LARS derives nearly exclusively from rectal cancer studies. Therefore, the study was designed to ... ...

    Abstract Background: Low anterior resection syndrome (LARS) is a common functional disorder after low anterior resection impacting the quality of life. Data on LARS derives nearly exclusively from rectal cancer studies. Therefore, the study was designed to assess LARS in advanced epithelial ovarian cancer (EOC) patients, who underwent rectal resection and to compare it with a female rectal cancer cohort.
    Material and methods: A cross-sectional multi-centre analysis was performed on female patients suffering from either rectal or EOC who received a low anterior resection as part of their therapy regimen. None of the patients received pre- or postoperative radiotherapy. LARS was defined by using the validated LARS score and its severity was divided into "no", "minor" and "major LARS".
    Results: In total, 125 female patients (44.8% (n = 56) EOC vs. 55.2% (n = 69) rectal cancer patients) met the final inclusion criteria and were retrospectively analyzed. Baseline characteristics were comparable between the groups. Median follow-up was 22 (IQR 12-56) months. In total, 30.4% (n = 38) of the patient group reported bowel dysfunction after surgery. Rates of LARS were not significantly different between EOC and rectal cancer patients (major LARS 16.1% (n = 9) vs. 15.9% (n = 11); minor LARS 17.9% (n = 10) vs. 11.6% (n = 8); p = 0.984). The time interval between surgery and final assessment had no impact on the postoperative bowel function (p = 0.820).
    Conclusion: LARS is a frequent and highly underreported postoperative disorder in EOC patients who require cytoreductive surgery with rectal resection. The functional outcome is comparable to female patients with rectal cancer who underwent low anterior resection without receiving radiotherapy.
    MeSH term(s) Aged ; Carcinoma, Ovarian Epithelial/surgery ; Cross-Sectional Studies ; Cytoreduction Surgical Procedures/adverse effects ; Female ; Humans ; Male ; Middle Aged ; Ovarian Neoplasms/surgery ; Postoperative Complications/epidemiology ; Rectal Neoplasms/surgery ; Rectum/surgery ; Retrospective Studies
    Language English
    Publishing date 2020-04-15
    Publishing country England
    Document type Comparative Study ; Journal Article ; Multicenter Study
    ZDB-ID 2212038-5
    ISSN 1743-9159 ; 1743-9191
    ISSN (online) 1743-9159
    ISSN 1743-9191
    DOI 10.1016/j.ijsu.2020.04.019
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  10. Article ; Online: Routine Use of Bendamustine in Patients with Chronic Lymphocytic Leukemia: An Observational Study.

    Ninkovic, Marijana / Fiegl, Michael / Mian, Michael / Mondello, Patrizia / Kocher, Florian / Waldthaler, Christian / Verdorfer, Irmgard / Steurer, Michael / Gastl, Günther / Pircher, Andreas

    Anticancer research

    2015  Volume 35, Issue 9, Page(s) 5129–5139

    Abstract: Bendamustine is an established treatment option in chronic lymphocytic leukemia (CLL) and frequently used in Austria and Italy. Therefore, we analyzed 100 unselected, consecutive patients with CLL (treatment-naïve and relapsed/refractory) receiving ... ...

    Abstract Bendamustine is an established treatment option in chronic lymphocytic leukemia (CLL) and frequently used in Austria and Italy. Therefore, we analyzed 100 unselected, consecutive patients with CLL (treatment-naïve and relapsed/refractory) receiving bendamustine in a real-life setting. Most patients were treated with bendamustine in combination with rituximab (BR). However, bendamustine monotherapy was additionally evaluated. Patients treated with BR had a significantly higher overall response rate of 76% (complete response=22%) when compared to those treated solely with bendamustine (overall response rate=50%; complete response=13%). Overall survival (OS) and progression -ree survival (PFS) were significantly lower in the bendamustine-treated group (OS=14.3 months; PFS=8.3 months) compared to the BR group (OS=42.7; PFS=22.5 months; both p<0.001). In multivariate analysis, patients with a good cytogenetic risk and those receiving BR had a significantly better OS. Grade 3/4 hematological complications were seen in 32% of the patients. Hence, bendamustine, especially in combination with rituximab, is an effective therapy with manageable toxicity for non-selected patients with CLL including those pre-treated with fludarabine and the elderly.
    MeSH term(s) Antineoplastic Agents/adverse effects ; Antineoplastic Agents/therapeutic use ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Bendamustine Hydrochloride/adverse effects ; Bendamustine Hydrochloride/therapeutic use ; Cohort Studies ; Disease-Free Survival ; Humans ; Leukemia, Lymphocytic, Chronic, B-Cell/drug therapy ; Multivariate Analysis ; Rituximab/adverse effects ; Rituximab/therapeutic use ; Treatment Outcome
    Chemical Substances Antineoplastic Agents ; Rituximab (4F4X42SYQ6) ; Bendamustine Hydrochloride (981Y8SX18M)
    Language English
    Publishing date 2015-09
    Publishing country Greece
    Document type Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 604549-2
    ISSN 1791-7530 ; 0250-7005
    ISSN (online) 1791-7530
    ISSN 0250-7005
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