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  1. AU="Nisa, Maherun"
  2. AU="Resnick, Adam C"
  3. AU="Thomas, Brodie"
  4. AU="Yaming Wang"
  5. AU="Lee, Chun‐Tsu"
  6. AU="Albert Gargallo‐Garriga"
  7. AU="Serwin, Natalia Maria"
  8. AU="La Rosa, Stefano"
  9. AU="Yin-Yin Xie"
  10. AU=White David P
  11. AU="Maria Teresa Viadero"
  12. AU="Wingeter, Márcia A"
  13. AU="Stein, Joshua D"
  14. AU="De Vecchis, Liana"
  15. AU="Chapman, Janet"
  16. AU="Umlai, Umm-Kulthum Ismail"
  17. AU="Reddi, Jyoti M"
  18. AU=Zeissig Sebastian
  19. AU="Valentini, Mariaconsuelo"

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  1. Artikel ; Online: A conserved role for γ-tubulin as a regulator of E2F transcription factors.

    Raynaud, Cécile / Nisa, Maherun

    Journal of experimental botany

    2020  Band 71, Heft 4, Seite(n) 1199–1202

    Mesh-Begriff(e) Cell Cycle ; Cell Cycle Proteins ; E2F Transcription Factors ; Transcription Factors/genetics ; Tubulin
    Chemische Substanzen Cell Cycle Proteins ; E2F Transcription Factors ; Transcription Factors ; Tubulin
    Sprache Englisch
    Erscheinungsdatum 2020-02-04
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2976-2
    ISSN 1460-2431 ; 0022-0957
    ISSN (online) 1460-2431
    ISSN 0022-0957
    DOI 10.1093/jxb/erz557
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: The Plant DNA Damage Response: Signaling Pathways Leading to Growth Inhibition and Putative Role in Response to Stress Conditions.

    Nisa, Maher-Un / Huang, Ying / Benhamed, Moussa / Raynaud, Cécile

    Frontiers in plant science

    2019  Band 10, Seite(n) 653

    Abstract: Maintenance of genome integrity is a key issue for all living organisms. Cells are constantly exposed to DNA damage due to replication or transcription, cellular metabolic activities leading to the production of Reactive Oxygen Species (ROS) or even ... ...

    Abstract Maintenance of genome integrity is a key issue for all living organisms. Cells are constantly exposed to DNA damage due to replication or transcription, cellular metabolic activities leading to the production of Reactive Oxygen Species (ROS) or even exposure to DNA damaging agents such as UV light. However, genomes remain extremely stable, thanks to the permanent repair of DNA lesions. One key mechanism contributing to genome stability is the DNA Damage Response (DDR) that activates DNA repair pathways, and in the case of proliferating cells, stops cell division until DNA repair is complete. The signaling mechanisms of the DDR are quite well conserved between organisms including in plants where they have been investigated into detail over the past 20 years. In this review we summarize the acquired knowledge and recent advances regarding the DDR control of cell cycle progression. Studying the plant DDR is particularly interesting because of their mode of development and lifestyle. Indeed, plants develop largely post-embryonically, and form new organs through the activity of meristems in which cells retain the ability to proliferate. In addition, they are sessile organisms that are permanently exposed to adverse conditions that could potentially induce DNA damage in all cell types including meristems. In the second part of the review we discuss the recent findings connecting the plant DDR to responses to biotic and abiotic stresses.
    Sprache Englisch
    Erscheinungsdatum 2019-05-17
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2711035-7
    ISSN 1664-462X
    ISSN 1664-462X
    DOI 10.3389/fpls.2019.00653
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: The plant DNA polymerase theta is essential for the repair of replication-associated DNA damage.

    Nisa, Maherun / Bergis, Clara / Pedroza-Garcia, Jose-Antonio / Drouin-Wahbi, Jeannine / Mazubert, Christelle / Bergounioux, Catherine / Benhamed, Moussa / Raynaud, Cécile

    The Plant journal : for cell and molecular biology

    2021  Band 106, Heft 5, Seite(n) 1197–1207

    Abstract: Safeguarding of genome integrity is a key process in all living organisms. Due to their sessile lifestyle, plants are particularly exposed to all kinds of stress conditions that could induce DNA damage. However, very few genes involved in the maintenance ...

    Abstract Safeguarding of genome integrity is a key process in all living organisms. Due to their sessile lifestyle, plants are particularly exposed to all kinds of stress conditions that could induce DNA damage. However, very few genes involved in the maintenance of genome integrity are indispensable to plants' viability. One remarkable exception is the POLQ gene, which encodes DNA polymerase theta (Pol θ), a non-replicative polymerase involved in trans-lesion synthesis during DNA replication and double-strand break (DSB) repair. The Arabidopsis tebichi (teb) mutants, deficient in Pol θ, have been reported to display severe developmental defects, leading to the conclusion that Pol θ is required for normal plant development. However, this essential role of Pol θ in plants is challenged by contradictory reports regarding the phenotypic defects of teb mutants and the recent finding that rice (Oryza sativa) null mutants develop normally. Here we show that the phenotype of teb mutants is highly variable. Taking advantage of hypomorphic mutants for the replicative DNA polymerase epsilon, which display constitutive replicative stress, we show that Pol θ allows maintenance of meristem activity when DNA replication is partially compromised. Furthermore, we found that the phenotype of Pol θ mutants can be aggravated by modifying their growth conditions, suggesting that environmental conditions impact the basal level of replicative stress and providing evidence for a link between plants' responses to adverse conditions and mechanisms involved in the maintenance of genome integrity.
    Mesh-Begriff(e) Arabidopsis/genetics ; Arabidopsis/physiology ; Arabidopsis Proteins/genetics ; Arabidopsis Proteins/metabolism ; DNA Breaks, Double-Stranded ; DNA Damage ; DNA Polymerase II/genetics ; DNA Polymerase II/metabolism ; DNA Repair ; DNA Replication ; DNA, Plant/genetics ; DNA-Directed DNA Polymerase/genetics ; DNA-Directed DNA Polymerase/metabolism ; Genomic Instability ; Genotype ; Meristem/genetics ; Meristem/physiology ; Models, Biological ; Mutation ; Phenotype ; Plant Roots/genetics ; Plant Roots/physiology ; Stress, Physiological ; DNA Polymerase theta
    Chemische Substanzen Arabidopsis Proteins ; DNA, Plant ; POL2a protein, Arabidopsis (EC 2.7.7.-) ; TEBICHI protein, Arabidopsis (EC 2.7.7.-) ; DNA Polymerase II (EC 2.7.7.7) ; DNA-Directed DNA Polymerase (EC 2.7.7.7)
    Sprache Englisch
    Erscheinungsdatum 2021-05-14
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1088037-9
    ISSN 1365-313X ; 0960-7412
    ISSN (online) 1365-313X
    ISSN 0960-7412
    DOI 10.1111/tpj.15295
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel: The plant DNA polymerase theta is essential for the repair of replication‐associated DNA damage

    Nisa, Maherun / Bergis, Clara / Pedroza‐Garcia, Jose‐Antonio / Drouin‐Wahbi, Jeannine / Mazubert, Christelle / Bergounioux, Catherine / Benhamed, Moussa / Raynaud, Cécile

    plant journal. 2021 June, v. 106, no. 5

    2021  

    Abstract: Safeguarding of genome integrity is a key process in all living organisms. Due to their sessile lifestyle, plants are particularly exposed to all kinds of stress conditions that could induce DNA damage. However, very few genes involved in the maintenance ...

    Abstract Safeguarding of genome integrity is a key process in all living organisms. Due to their sessile lifestyle, plants are particularly exposed to all kinds of stress conditions that could induce DNA damage. However, very few genes involved in the maintenance of genome integrity are indispensable to plants’ viability. One remarkable exception is the POLQ gene, which encodes DNA polymerase theta (Pol θ), a non‐replicative polymerase involved in trans‐lesion synthesis during DNA replication and double‐strand break (DSB) repair. The Arabidopsis tebichi (teb) mutants, deficient in Pol θ, have been reported to display severe developmental defects, leading to the conclusion that Pol θ is required for normal plant development. However, this essential role of Pol θ in plants is challenged by contradictory reports regarding the phenotypic defects of teb mutants and the recent finding that rice (Oryza sativa) null mutants develop normally. Here we show that the phenotype of teb mutants is highly variable. Taking advantage of hypomorphic mutants for the replicative DNA polymerase epsilon, which display constitutive replicative stress, we show that Pol θ allows maintenance of meristem activity when DNA replication is partially compromised. Furthermore, we found that the phenotype of Pol θ mutants can be aggravated by modifying their growth conditions, suggesting that environmental conditions impact the basal level of replicative stress and providing evidence for a link between plants’ responses to adverse conditions and mechanisms involved in the maintenance of genome integrity.
    Schlagwörter Arabidopsis ; DNA damage ; DNA replication ; DNA-directed DNA polymerase ; Oryza sativa ; genes ; lifestyle ; meristems ; phenotype ; plant development ; rice ; viability
    Sprache Englisch
    Erscheinungsverlauf 2021-06
    Umfang p. 1197-1207.
    Erscheinungsort John Wiley & Sons, Ltd
    Dokumenttyp Artikel
    Anmerkung JOURNAL ARTICLE
    ZDB-ID 1088037-9
    ISSN 1365-313X ; 0960-7412
    ISSN (online) 1365-313X
    ISSN 0960-7412
    DOI 10.1111/tpj.15295
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  5. Artikel ; Online: Distinctive and complementary roles of E2F transcription factors during plant replication stress responses.

    Nisa, Maherun / Eekhout, Thomas / Bergis, Clara / Pedroza-Garcia, Jose-Antonio / He, Xiaoning / Mazubert, Christelle / Vercauteren, Ilse / Cools, Toon / Brik-Chaouche, Rim / Drouin-Wahbi, Jeannine / Chmaiss, Layla / Latrasse, David / Bergounioux, Catherine / Vandepoele, Klaas / Benhamed, Moussa / De Veylder, Lieven / Raynaud, Cécile

    Molecular plant

    2023  Band 16, Heft 8, Seite(n) 1269–1282

    Abstract: Survival of living organisms is fully dependent on their maintenance of genome integrity, being permanently threatened by replication stress in proliferating cells. Although the plant DNA damage response (DDR) regulator SOG1 has been demonstrated to cope ...

    Abstract Survival of living organisms is fully dependent on their maintenance of genome integrity, being permanently threatened by replication stress in proliferating cells. Although the plant DNA damage response (DDR) regulator SOG1 has been demonstrated to cope with replication defects, accumulating evidence points to other pathways functioning independent of SOG1. Here, we report the roles of the Arabidopsis E2FA and EF2B transcription factors, two well-characterized regulators of DNA replication, in plant response to replication stress. Through a combination of reverse genetics and chromatin immunoprecipitation approaches, we show that E2FA and E2FB share many target genes with SOG1, providing evidence for their involvement in the DDR. Analysis of double- and triple-mutant combinations revealed that E2FB, rather than E2FA, plays the most prominent role in sustaining plant growth in the presence of replication defects, either operating antagonistically or synergistically with SOG1. Conversely, SOG1 aids in overcoming the replication defects of E2FA/E2FB-deficient plants. Collectively, our data reveal a complex transcriptional network controlling the replication stress response in which E2Fs and SOG1 act as key regulatory factors.
    Mesh-Begriff(e) Arabidopsis Proteins/genetics ; Arabidopsis Proteins/metabolism ; Arabidopsis/metabolism ; Transcription Factors/metabolism ; E2F Transcription Factors/genetics ; E2F Transcription Factors/metabolism ; Gene Expression Regulation, Plant/genetics
    Chemische Substanzen Arabidopsis Proteins ; Transcription Factors ; E2F Transcription Factors ; SOG1 protein, Arabidopsis
    Sprache Englisch
    Erscheinungsdatum 2023-07-06
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2393618-6
    ISSN 1752-9867 ; 1674-2052
    ISSN (online) 1752-9867
    ISSN 1674-2052
    DOI 10.1016/j.molp.2023.07.002
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  6. Artikel ; Online: Distinctive and complementary roles of E2F transcription factors during plant replication stress responses

    Nisa, Maherun / Eekhout, Thomas / Bergis, Clara / Pedroza-Garcia, Jose-Antonio / He, Xiaoning / Mazubert, Christelle / Vercauteren, Ilse / Cools, Toon / Brik-Chaouche, Rim / Drouin-Wahbi, Jeannine / Chmaiss, Layla / Latrasse, David / Bergounioux, Catherine / Vandepoele, Klaas / Benhamed, Moussa / De Veylder, Lieven / Raynaud, Cécile

    Molecular Plant. 2023 July 06,

    2023  

    Abstract: Survival of living organisms is fully dependent on their maintenance of genome integrity, being permanently threatened by replication stress in proliferating cells. Although the plant DNA damage response (DDR) regulator SOG1 has been demonstrated to cope ...

    Abstract Survival of living organisms is fully dependent on their maintenance of genome integrity, being permanently threatened by replication stress in proliferating cells. Although the plant DNA damage response (DDR) regulator SOG1 has been demonstrated to cope with replication defects, accumulating evidence points to other pathways functioning independent of SOG1. Here, we report the roles of the Arabidopsis E2FA and EF2B transcription factors, two well-characterized regulators of DNA replication, in plant response to replication stress. Through a combination of reverse genetics and chromatin immunoprecipitation approaches, we show that E2FA and E2FB share many target genes with SOG1, providing evidence for their involvement in the DDR. Analysis of double- and triple-mutant combinations revealed that E2FB, rather than E2FA, plays the most prominent role in sustaining plant growth in the presence of replication defects, either operating antagonistically or synergistically with SOG1. Conversely, SOG1 aids in overcoming the replication defects of E2FA/E2FB-deficient plants. Collectively, our data reveal a complex transcriptional network controlling the replication stress response in which E2Fs and SOG1 act as key regulatory factors.
    Schlagwörter Arabidopsis ; DNA damage ; DNA replication ; chromatin immunoprecipitation ; genome ; plant growth ; plant response ; reverse genetics ; stress response ; transcription (genetics) ; replication stress ; E2F ; SOG1 ; cell cycle
    Sprache Englisch
    Erscheinungsverlauf 2023-0706
    Erscheinungsort Elsevier Inc.
    Dokumenttyp Artikel ; Online
    Anmerkung Pre-press version
    ZDB-ID 2393618-6
    ISSN 1752-9867 ; 1674-2052
    ISSN (online) 1752-9867
    ISSN 1674-2052
    DOI 10.1016/j.molp.2023.07.002
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  7. Artikel ; Online: Maize ATR safeguards genome stability during kernel development to prevent early endosperm endocycle onset and cell death.

    Pedroza-Garcia, Jose Antonio / Eekhout, Thomas / Achon, Ignacio / Nisa, Maher-Un / Coussens, Griet / Vercauteren, Ilse / Van den Daele, Hilde / Pauwels, Laurens / Van Lijsebettens, Mieke / Raynaud, Cécile / De Veylder, Lieven

    The Plant cell

    2021  Band 33, Heft 8, Seite(n) 2662–2684

    Abstract: The ataxia-telangiectasia mutated (ATM) and ATM and Rad3-related (ATR) kinases coordinate the DNA damage response. The roles described for Arabidopsis thaliana ATR and ATM are assumed to be conserved over other plant species, but molecular evidence is ... ...

    Abstract The ataxia-telangiectasia mutated (ATM) and ATM and Rad3-related (ATR) kinases coordinate the DNA damage response. The roles described for Arabidopsis thaliana ATR and ATM are assumed to be conserved over other plant species, but molecular evidence is scarce. Here, we demonstrate that the functions of ATR and ATM are only partially conserved between Arabidopsis and maize (Zea mays). In both species, ATR and ATM play a key role in DNA repair and cell cycle checkpoint activation, but whereas Arabidopsis plants do not suffer from the absence of ATR under control growth conditions, maize mutant plants accumulate replication defects, likely due to their large genome size. Moreover, contrarily to Arabidopsis, maize ATM deficiency does not trigger meiotic defects, whereas the ATR kinase appears to be crucial for the maternal fertility. Strikingly, ATR is required to repress premature endocycle onset and cell death in the maize endosperm. Its absence results in a reduction of kernel size, protein and starch content, and a stochastic death of kernels, a process being counteracted by ATM. Additionally, while Arabidopsis atr atm double mutants are viable, no such mutants could be obtained for maize. Therefore, our data highlight that the mechanisms maintaining genome integrity may be more important for vegetative and reproductive development than previously anticipated.
    Mesh-Begriff(e) Arabidopsis/genetics ; Arabidopsis Proteins/genetics ; Ataxia Telangiectasia Mutated Proteins/genetics ; CRISPR-Cas Systems ; Cell Death/genetics ; DNA Breaks, Double-Stranded ; DNA Repair/genetics ; DNA Replication/genetics ; Endosperm/cytology ; Endosperm/genetics ; Genomic Instability ; Mutation ; Plant Cells ; Plant Proteins/genetics ; Plant Proteins/metabolism ; Plants, Genetically Modified ; Seeds/cytology ; Seeds/genetics ; Seeds/growth & development ; Zea mays/cytology ; Zea mays/genetics ; Zea mays/growth & development
    Chemische Substanzen Arabidopsis Proteins ; Plant Proteins ; ATR protein, Arabidopsis (EC 2.7.1.-) ; Ataxia Telangiectasia Mutated Proteins (EC 2.7.11.1)
    Sprache Englisch
    Erscheinungsdatum 2021-06-04
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 623171-8
    ISSN 1532-298X ; 1040-4651
    ISSN (online) 1532-298X
    ISSN 1040-4651
    DOI 10.1093/plcell/koab158
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Z 4952: Hefte anzeigen

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