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Article ; Online: Knowledge of Helminthiasis of People Living in Slum Areas of Bandung District, Indonesia

Lia Faridah / Nisa Fauziah / Riyadi Adrizain

Majalah Kedokteran Bandung, Vol 53, Iss 4, Pp 223-

2021 Volume 228

Abstract: Among the most prevalent infections worldwide, Soil-Transmitted Helminth (STH) infection is the one that affects the poorest and most deprived populations. Data from the WHO shows that more than 1.5 billion people are affected by soil-transmitted ... ...

Abstract	Among the most prevalent infections worldwide, Soil-Transmitted Helminth (STH) infection is the one that affects the poorest and most deprived populations. Data from the WHO shows that more than 1.5 billion people are affected by soil-transmitted helminth diseases globally. In 2010, it was estimated that 819.0 million, 464.6 million, and 438.9 million people around the world were infected with Ascaris lumbricoides, Trichuris trichiura, and hookworms (Ancylostoma duodenale and Necator americanus), respectively, with the Southeast Asia as the region with the highest prevalence of STH. Children’s awareness and knowledge of helminthiasis are essential to reduce the STH infection prevalence. Unfortunately, evaluation on children’s understanding of helminthiasis is still scarce. This study was intended to measure children's knowledge of STH infections and its prevention, especially prevention measures at home, in Bandung District, Indonesia. This study was conducted in March 2021 on 506 children who lived in 15 different subdistricts in Bandung District. Data were collected through a questionnaire that was used for face-to-face interviews with the children. All data were recorded in RedCap apps for further analysis. It was demonstrated in this study that children in Bandung District generally have low-to-medium knowledge on helminthiasis prevention, symptoms, and treatment (85%). Thus, there is an urgent need for an education program on helminthiasis to complement the deworming measures conducted by the local government.
Keywords	helminthiasis ; knowledge ; population ; Medicine ; R
Subject code	360
Language	English
Publishing date	2021-12-01T00:00:00Z
Publisher	Universitas Padjajaran
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The Prevalence and Clinical Characteristics of Patients with Invasive Fungal Infections at Dr. Hasan Sadikin General Hospital in 2020–2022

Ariella Alessandro / Nisa Fauziah / Imam Megantara / Rudi Wisaksana / Intan Mauli Warma Dewi

Jurnal Penyakit Dalam Indonesia, Vol 10, Iss 4, Pp 199-

2023 Volume 206

Abstract: Introduction. Invasive fungal infection (IFI) is increasingly common in patients at risk, especially those with impaired immune response. In Indonesia, there is currently a low prevalence of IFI which may be influenced by challenges in diagnosis. This ... ...

Abstract	Introduction. Invasive fungal infection (IFI) is increasingly common in patients at risk, especially those with impaired immune response. In Indonesia, there is currently a low prevalence of IFI which may be influenced by challenges in diagnosis. This study aimed to determine the prevalence and clinical characteristics of IFI patients in Dr. Hasan Sadikin Hospital in Bandung, Indonesia. Methods. This cross-sectional study was conducted at Dr. Hasan Sadikin Hospital. Data were collected using medical records of IFI patients diagnosed between 2020 and 2022 which were selected using total sampling method. Demographic data, clinical symptoms, radiological appearance, and laboratory results were recorded. Results. The prevalence of IFI in Dr. Hasan Sadikin Hospital between 2020 and 2022 was 0,04% (40 per 100,000 patients). The most common cause of invasive fungal infection was Cryptococcus spp. and Candida spp. Fever and loss of consciousness were the two most common signs and symptoms found in this study. HIV/AIDS was present in 51,4% of cases. The diagnostic test was mostly done with cryptococcal antigen (CrAg) examination. Lung involvement was common, appearing as consolidation, infiltration, and ground glass opacity in the lungs. The mortality rate of IFI patients was 51,4%. Conclusions. The prevalence of IFI in Dr. Hasan Sadikin Hospital was quite low, with HIV/AIDS as the most common risk factor. However, there was a high mortality rate found this study is high. Thus, timely diagnosis and antifungal treatment induction should be considered to improve the outcome of invasive fungal infection patients.
Keywords	invasive fungal disease ; invasive fungal infection ; Internal medicine ; RC31-1245
Subject code	610
Language	Indonesian
Publishing date	2023-12-01T00:00:00Z
Publisher	Department of Internal Medicine, Faculty of Medicine Universitas Indonesia-Cipto Mangunkusumo Hospital
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Arbovirus Detection of Adult Female Aedes aegypti for Dengue Surveillance

Lia Faridah / Savira Ekawardhani / Nisa Fauziah / Imam Damar Djati / Ramadhani Eka Putra / Kozo Watanabe

Global Medical & Health Communication, Vol 11, Iss

a Cohort Study in Bandung City, Indonesia

2023 Volume 3

Abstract: Dengue surveillance is an important activity to prevent dengue outbreaks. This activity becomes a significant challenge for the region with limited logistic capabilities. Developing a simple mathematical model to predict the possibility of dengue ... ...

Abstract	Dengue surveillance is an important activity to prevent dengue outbreaks. This activity becomes a significant challenge for the region with limited logistic capabilities. Developing a simple mathematical model to predict the possibility of dengue incidence provides a reliable early warning system. This study compared the correlation between vector (adult female Aedes aegypti) and arbovirus detection on a vector to dengue incidence, which generalized linear mixed models tested. The incidence of adult female Aedes aegypti and dengue fever cases were interpolated through third-power inverse distance weighting (IDW). A spatial correlation between female Aedes aegypti incidence and dengue incidence was obtained from polynomial regression. Collection sites were 16 villages in Bandung city, one of the significant dengue endemic areas in January–December 2017. A total of 8,402 mosquitoes of Aedes aegypti, Aedes albopictus, and Culex sp., with 17% belonging to Aedes aegypti as the subject of the dengue virus (DENV) infection test. Data analysis only showed a weak correlation between the numbers of adult female Aedes aegypti and dengue incidence. On the other hand, there is no correlation between positive dengue infection of vector and dengue incidence. This study highlights the importance of constant arbovirus surveillance and integrated surveillance methods on all possible dengue vectors to develop an early warning system for dengue incidence.
Keywords	aedes aegypti ; arbovirus detection ; dengue ; indonesia ; surveillance ; Medicine ; R ; Medicine (General) ; R5-920
Subject code	616
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	Universitas Islam Bandung
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Oral Administration of Piperine as Curative and Prophylaxis Reduces Parasitaemia in Plasmodium berghei ANKA-Infected Mice

Shafia Khairani / Nisa Fauziah / Hesti Lina Wiraswati / Ramdan Panigoro / Endang Yuni Setyowati / Afiat Berbudi

Journal of Tropical Medicine, Vol

2022 Volume 2022

Abstract: Malaria remains a public health problem and a leading cause of death worldwide. Consequently, the discovery of novel agents, including substances from medicinal plants, is urgently needed. Piper nigrum has long been used by the community in the treatment ...

Abstract	Malaria remains a public health problem and a leading cause of death worldwide. Consequently, the discovery of novel agents, including substances from medicinal plants, is urgently needed. Piper nigrum has long been used by the community in the treatment of the symptoms of malaria. In a previous study, Piper nigrum was demonstrated to exhibit promising antiplasmodial activity against Plasmodium falciparum 3D7 and INDO strains. The aim of this study was to further investigate the antimalarial activity (curative and prophylactic) of piperine (a major isolated constituent of Piper nigrum) in Plasmodium berghei ANKA-infected mice. Piperine 10, 20, and 40 mg/kg body weight (bw), artesunate 5 mg/kg bw, and DMSO were administered orally for four days to different groups of Swiss Webster mice. Then, mice were monitored for parasitaemia, body weight, rectal temperature, survival rate, and clinical parameters. Piperine 40 mg/kg bw in curative and prophylactic tests had the maximum parasitaemia chemosuppression of 79.21% and 58.8% (p < 0.05), respectively, with a significant effect on the survival rate compared with control animals. In the curative test, piperine 40 mg/kg bw reduced the mean clinical score compared with the control group. Additionally, piperine showed an ability to protect organs (lungs, liver, spleen, and kidneys) from some damage in a dose-dependent manner. This study can be used as a basis for further discovery of novel chemotherapeutic or chemoprophylactic compounds.
Keywords	Arctic medicine. Tropical medicine ; RC955-962
Subject code	630
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Mosquito Nets Use in South Central Timor District is Significantly Liked to Incidence of Malaria

Nisa Fauziah / Reyhan Luthfierza Fauzan / Naufal Fakhri Nugraha / Lia Faridah / Jontari Hutagalung

Majalah Kedokteran Bandung, Vol 54, Iss 1, Pp 44-

2022 Volume 50

Abstract: Ninety percent of malaria cases in Indonesia come from Papua, West Papua, and East Nusa Tenggara provinces. The country has declared a target of malaria elimination by 2030. Malaria elimination efforts have been performed through case finding, treatment, ...

Abstract	Ninety percent of malaria cases in Indonesia come from Papua, West Papua, and East Nusa Tenggara provinces. The country has declared a target of malaria elimination by 2030. Malaria elimination efforts have been performed through case finding, treatment, surveillance, and risk factor prevention and control. Personal protection is crucial in preventing and reducing the risk for malaria infection. This study aimed to assess the significance of personal protection against mosquitoes in eastern Indonesia. This was a cross-sectional study using the secondary data from a previous study of malaria in eastern Indonesia in 2013–2014. Data were collected using a questionnaires and direct observation and analyzed using the chi-square with α 0.05 and 95% CI. A total of 551 data were collected (180 positive vs 371 negative). The use of mosquito nets at night (p-value: 0.038; OR: 3.127) has a significant relationship with the incidence of malaria while the use of ventilation screen (p-value: 0.191; OR: 0.839), vector shelter (p-value: 0.493; OR: 0.852), and mosquito repellent (p-value: 0.564; OR: 1.585) did not have significant relationships to the incidence of malaria. Mass distribution of mosquito nets by the local governments can constitute one of the efforts to prevent and control malaria in South Central Timor District.
Keywords	malaria ; mosquito nets ; south central timor district ; Medicine ; R
Subject code	950
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	Universitas Padjajaran
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Effectiveness of Various Mosquito Repellent Solutions to Control Mosquito Population

Lia Faridah / Christian Albert / Nisa Fauziah

Global Medical & Health Communication, Vol 7, Iss

2019 Volume 1

Abstract: The vector-borne disease is a disease caused by an organism that can transmit disease between human or animal to human. In Indonesia, several vector-borne diseases are a burden of the government including dengue fever, chikungunya, filariasis, and ... ...

Abstract	The vector-borne disease is a disease caused by an organism that can transmit disease between human or animal to human. In Indonesia, several vector-borne diseases are a burden of the government including dengue fever, chikungunya, filariasis, and malaria. The attractive baited lethal ovitrap (ALOT) is a novel strategy to alleviate mosquito populations in three main actions: attraction, an adulticide, and larvacide. Research using plant infusion can attract mosquitoes to lay their eggs is needed. This study aims to compare the effectiveness of the mosquito repellent solution using materials from organic waste in Bandung. This study was a quantitative analytic study with a quasi-experimental design conducted in the Faculty of Medicine Universitas Padjadjaran area in October 2016–July 2017. Research subjects are mosquito eggs in a solution which placed at 25 different places for every solution. The analysis was performed using Kruskal-Wallis test followed by the Dunn test. The result of the Kruskal-Wallis test indicates the difference of effectiveness of each solution (p<0.05). Based on the results of the Dunn test, the most significant difference found in the solution of wood shavings with the vegetable waste solution and the solution of wood shavings with corn straw (p<0.05). In conclusion, there is a difference in the effectiveness of the mosquito repellent solutions and the most attractive solution for mosquitoes to oviposit is the corn straw solution. EFEKTIVITAS BERBAGAI LARUTAN PENARIK NYAMUK UNTUK MENGONTROL POPULASI NYAMUK Penyakit tular vektor adalah penyakit yang disebabkan oleh organisme yang dapat mentransmisikan penyakit antarmanusia atau hewan ke manusia. Di Indonesia, terdapat beberapa penyakit tular vektor yang masih menjadi beban pemerintah, di antaranya demam berdarah, chikungunya, penyakit kaki gajah, dan malaria. Attractive baited lethal ovitrap (ALOT) merupakan strategi baru untuk menurunkan populasi nyamuk dalam tiga aksi utama, yaitu attraction, adulticide, dan larvacide. Penelitian ...
Keywords	Effectiveness ; efektivitas ; larutan penarik nyamuk ; mosquito repellent solution ; mosquito population ; populasi nyamuk ; Medicine ; R ; Medicine (General) ; R5-920
Language	English
Publishing date	2019-04-01T00:00:00Z
Publisher	Universitas Islam Bandung
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The Potential use of a Curcumin-Piperine Combination as an Antimalarial Agent

Shafia Khairani / Nisa Fauziah / Hesti Lina Wiraswati / Ramdan Panigoro / Endang Yuni Setyowati / Afiat Berbudi

Journal of Tropical Medicine, Vol

A Systematic Review

2021 Volume 2021

Abstract: Malaria remains a significant global health problem, but the development of effective antimalarial drugs is challenging due to the parasite’s complex life cycle and lack of knowledge about the critical specific stages. Medicinal plants have been ... ...

Abstract	Malaria remains a significant global health problem, but the development of effective antimalarial drugs is challenging due to the parasite’s complex life cycle and lack of knowledge about the critical specific stages. Medicinal plants have been investigated as adjuvant therapy for malaria, so this systematic review summarizes 46 primary articles published until December 2020 that discuss curcumin and piperine as antimalarial agents. The selected articles discussed their antioxidant, anti-inflammatory, and antiapoptosis properties, as well as their mechanism of action against Plasmodium species. Curcumin is a potent antioxidant, damages parasite DNA, and may promote an immune response against Plasmodium by increasing reactive oxygen species (ROS), while piperine is also a potent antioxidant that potentiates the effects of curcumin. Hence, combining these compounds is likely to have the same effect as chloroquine, that is, attenuate and restrict parasite development, thereby reducing parasitemia and increasing host survival. This systematic review presents new information regarding the development of a curcumin-piperine combination for future malaria therapy.
Keywords	Arctic medicine. Tropical medicine ; RC955-962
Subject code	572
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Is Rapid Dengue Test Necessary at Primary Health Centre? A Study in Bandung City, Indonesia

Lia Faridah / Nisa Fauziah / Savira Ekawardhani / Riyadi Riyadi / Kozo Watanabe

Journal of Clinical and Diagnostic Research, Vol 13, Iss 7, Pp DC20-DC

2019 Volume 23

Abstract: Introduction: Dengue is one of the most common arthropodborne viral disease in the tropical and subtropical regions of the world. The disease is a burden in terms of morbidity, mortality and economic aspect. There is no specific drug for dengue infection ...

Abstract	Introduction: Dengue is one of the most common arthropodborne viral disease in the tropical and subtropical regions of the world. The disease is a burden in terms of morbidity, mortality and economic aspect. There is no specific drug for dengue infection yet and the availability of a vaccine is limited in most of the Indonesia’s endemic areas. In endemic areas, most of dengue fever cases clinically resemble other diseases such as malaria, typhus, or just flu-like syndrome. Early verification of suspected dengue outbreaks is very important, allowing better public health response that leads to a proper clinical care. Unfortunately, the use of dengue Rapid Diagnostic Tests (RDTs) is still rare at first level of the health care provider in Indonesia, where the country has the policy of a gradual health service supported by the National Health Insurance (NHI). Aim: The study measured the usefulness of dengue RDT at the Primary Health Centre (PHC) in endemic areas. Materials and Methods: DENV NS1 antigen test kit (NS1 RDT) was used to detect dengue fever for all acute fever patients at three sites of PHC which had high dengue case history. Dengue fever 2017 report was used as comparative data for the analysis. The collected data were analysed using an independent t-test. Results: A total of 237 blood samples from patients with acute fever were collected from Sukajadi, Neglasari and Padasuka PHC. Fifty-one samples out of 237 (21.5%) were positive with the DENV NS1 antigen test. The number of reported dengue case before and after the implementation of DENV NS1 antigen test increased significantly (p<0.05) for each PHC; Sukajadi (p=0.01), Neglasari (p=0.01) and Padasuka (p=0.03). Conclusion: NS1 RDT effectively increased the diagnosed and reported cases when used in the PHCs. Hence, we strongly suggest that government should make a policy that supports the use of NS1 RDT at the PHCs for the early detection of dengue infection, since those PHCs are the spearheads in the implementation of health care programs in ...
Keywords	diagnosis ; fever ; outbreaks ; southeast asia ; Medicine ; R
Subject code	360
Language	English
Publishing date	2019-07-01T00:00:00Z
Publisher	JCDR Research and Publications Private Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Potential Vector Shelter for Malaria in South Central Timor Regency in Indonesia

Nisa Fauziah / Arie Galih Mohamad / Naufal Fakhri Nugraha / Lia Faridah / Jontari Hutagalung

Majalah Kedokteran Bandung, Vol 52, Iss

2020 Volume 4

Abstract: More than half of the areas in East Nusa Tenggara province, a province in the eastern part of Indonesia, are planned to be free from malaria by the end of 2030. However, one of the critical indicators for malaria elimination is still lacking, i.e. ... ...

Abstract	More than half of the areas in East Nusa Tenggara province, a province in the eastern part of Indonesia, are planned to be free from malaria by the end of 2030. However, one of the critical indicators for malaria elimination is still lacking, i.e. vectors’ environment and breeding place indicators. South Central Timor (SCT) District is one of the areas with the highest Annual Parasite Incidence (API) >2‰ with the majority of the population works as farmers. The purpose of this study was to capture the relationship between environmental factors and the prevalence of malaria. This study was a cross-sectional analytic retrospective study using data from a previous malaria study conducted in August 2013 to September 2014 in 5 sub-districts of SCT district. All respondents were selected using the systematic random sampling approach from the population of healthy people. Data were collected using a standard questionnaire and an observation environment form. Malaria was confirmed through microscopic and Polymerase Chain Reaction (PCR) examinations. Data were then analyzed using the bivariate and multivariate analysis with 95% CI and α:0.05. Of 357 data collected, 35% (125/357) were malaria positive based on PCR examination. Two variables (living nearby lagoon and nearby rice field) were significant (p-value<0.05) as vector shelters for Anopheles sp. Thus, these have to be included as inputs to formulate effective and efficient malaria elimination strategies and programs in 2030.
Keywords	malaria prevalence ; south central timor regency ; vector shelter ; Medicine ; R
Language	English
Publishing date	2020-12-01T00:00:00Z
Publisher	Universitas Padjajaran
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Evaluation of Health Information System (HIS) in The Surveillance of Dengue in Indonesia

Lia Faridah / Fedri Ruluwedrata Rinawan / Nisa Fauziah / Wulan Mayasari / Angga Dwiartama / Kozo Watanabe

International Journal of Environmental Research and Public Health, Vol 17, Iss 5, p

Lessons from Case in Bandung, West Java

2020 Volume 1795

Abstract: This study was performed to evaluate the health information system regarding the dengue surveillance system in Indonesia. Major obstacles to the implementation of an effective health information system regarding dengue cases in Bandung are examined, and ... ...

Abstract	This study was performed to evaluate the health information system regarding the dengue surveillance system in Indonesia. Major obstacles to the implementation of an effective health information system regarding dengue cases in Bandung are examined, and practical suggestions on measures to overcome them are discussed. The study utilized a mixed-method research design using qualitative approaches: document analysis, key informants and focus group interviews. Thirty key informants were selected, comprised of policymakers, senior managers, and staff at the Ministry of Health. Data from documents and transcripts were evaluated through a modified Institutional Analysis and Development (IAD) framework described by Ostrom. Through this study, we have identified several issues that hinder the effective implementation of the health information system in the case of dengue in Bandung. In the end, we propose several recommendations for reform that encompasses motivational, strategic, and structural approaches to each component of the analysis. Through evaluation of the health information system for dengue surveillance in Indonesia, we conclude that well-coordination in multi-level governance in a country as large as Indonesia is the key in the implementation of the health information system in different levels of agencies. Furthermore, the adaptability of human resources in adopting a new information system also plays an important part.
Keywords	dengue surveillance ; health information system ; bandung ; Medicine ; R
Subject code	360
Language	English
Publishing date	2020-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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