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Article ; Online: Corn straw lignin - A sustainable bioinspired finish for superhydrophobic and UV-protective cellulose fabric.

Nisar, Sabeen / Raza, Zulfiqar Ali

International journal of biological macromolecules

2023 Volume 257, Issue Pt 1, Page(s) 128393

Abstract: Hydrophobic textiles have been considered extensively for self-cleaning, phase-separating, and biomedical curing applications. We focused on preparing an eco-friendly lignin-based bio-finish to develop superhydrophobic cellulose fabric under mild ... ...

Abstract	Hydrophobic textiles have been considered extensively for self-cleaning, phase-separating, and biomedical curing applications. We focused on preparing an eco-friendly lignin-based bio-finish to develop superhydrophobic cellulose fabric under mild conditions. The mass spectroscopic analysis expressed that the lignin comprised the major constituents of p-coumaryl alcohol, ferulic acid, coniferyl alcohol, and sinapyl alcohol. The surface morphological analysis indicated the formation of a regular lignin coating on the cellulose fabric. The bio-finished cellulose fabric prepared (at 2 %, w/v, lignin) expressed the maximum water contact angle (WCA) of 157.2° and remained in the hydrophobic range (119°) after ten standard washes. The treated fabric expressed the WCA values of 135.0 and 133.0° after exposure to pH 2 and 12 aqueous media, respectively. The infrared spectroscopic analysis indicated the functional chemistry of the precursors involved and possible alteration in their chemical interactions during processing. The lignin-treated cellulose was observed to be less crystalline as compared to the untreated one. Such fabric expressed acceptable comfort, sensorial properties, and thermal stability up to 333 °C. The treated fabrics could block up to 92.24 % UV-A and 98.62 % UV-B radiations. Consequently, the lignin-based finish sourced from wasted corn straw was found cost-effective and efficient for producing superhydrophobic cellulose fabric.
MeSH term(s)	Lignin ; Cellulose ; Zea mays ; Mass Spectrometry ; Spectrophotometry, Infrared ; Water
Chemical Substances	Lignin (9005-53-2) ; Cellulose (9004-34-6) ; Water (059QF0KO0R)
Language	English
Publishing date	2023-11-25
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2023.128393
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Article ; Online: Neuroimaging genetics approaches to identify new biomarkers for the early diagnosis of autism spectrum disorder.

Nisar, Sabah / Haris, Mohammad

Molecular psychiatry

2023 Volume 28, Issue 12, Page(s) 4995–5008

Abstract: Autism-spectrum disorders (ASDs) are developmental disabilities that manifest in early childhood and are characterized by qualitative abnormalities in social behaviors, communication skills, and restrictive or repetitive behaviors. To explore the ... ...

Abstract	Autism-spectrum disorders (ASDs) are developmental disabilities that manifest in early childhood and are characterized by qualitative abnormalities in social behaviors, communication skills, and restrictive or repetitive behaviors. To explore the neurobiological mechanisms in ASD, extensive research has been done to identify potential diagnostic biomarkers through a neuroimaging genetics approach. Neuroimaging genetics helps to identify ASD-risk genes that contribute to structural and functional variations in brain circuitry and validate biological changes by elucidating the mechanisms and pathways that confer genetic risk. Integrating artificial intelligence models with neuroimaging data lays the groundwork for accurate diagnosis and facilitates the identification of early diagnostic biomarkers for ASD. This review discusses the significance of neuroimaging genetics approaches to gaining a better understanding of the perturbed neurochemical system and molecular pathways in ASD and how these approaches can detect structural, functional, and metabolic changes and lead to the discovery of novel biomarkers for the early diagnosis of ASD.
MeSH term(s)	Humans ; Autism Spectrum Disorder/genetics ; Autism Spectrum Disorder/diagnosis ; Early Diagnosis ; Biomarkers ; Neuroimaging/methods ; Brain/metabolism ; Brain/diagnostic imaging ; Child
Chemical Substances	Biomarkers
Language	English
Publishing date	2023-04-17
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	1330655-8
ISSN	1476-5578 ; 1359-4184
ISSN (online)	1476-5578
ISSN	1359-4184
DOI	10.1038/s41380-023-02060-9
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Article ; Online: Correction to: Neuroimaging genetics approaches to identify new biomarkers for the early diagnosis of autism spectrum disorder.

Nisar, Sabah / Haris, Mohammad

Molecular psychiatry

2023 Volume 28, Issue 12, Page(s) 5009–5010

Language	English
Publishing date	2023-11-29
Publishing country	England
Document type	Published Erratum
ZDB-ID	1330655-8
ISSN	1476-5578 ; 1359-4184
ISSN (online)	1476-5578
ISSN	1359-4184
DOI	10.1038/s41380-023-02115-x
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Article ; Online: Photoinduced Electron Transfer-Based Glutathione-Sensing Theranostic Nanoprodrug with Self-Tracking and Real-Time Drug Release Monitoring for Cancer Treatment.

Nisar, Safiya / Starosta, Elisabeth / Elayyan, Mouhmad / Regmi, Amrit / Sui, Binglin

ACS applied materials & interfaces

2024 Volume 16, Issue 6, Page(s) 6859–6867

Abstract: The rapid development of nanomedicine has considerably advanced precision therapy for cancer treatment. Superior to traditional chemotherapy, emerging theranostic nanoprodrugs can effectively realize inherent self-tracking, targeted drug delivery, ... ...

Abstract	The rapid development of nanomedicine has considerably advanced precision therapy for cancer treatment. Superior to traditional chemotherapy, emerging theranostic nanoprodrugs can effectively realize inherent self-tracking, targeted drug delivery, stimuli-triggered drug release, and reduced systemic toxicity of chemotherapeutic drugs. However, theranostic nanoprodrugs with real-time drug release monitoring have remained rare so far. In this work, we developed a new glutathione-responsive theranostic nanoprodrug with a high drug-loading content of 59.4 wt % and an average nanoscale size of 46 nm, consisting of the anticancer drug paclitaxel and a fluorescent imaging probe with a high fluorescence quantum yield, which are linked by a disulfide-based glutathione-sensitive self-immolating linker. The strong fluorescence emission of the fluorophore enables efficacious self-tracking and sensitive fluorescence "ON-OFF" glutathione sensing. Upon encountering high-level glutathione in cancer cells, the disulfide bond is cleaved, and the resulting linker halves spontaneously collapse into cyclic small molecules at the same pace, leading to the simultaneous release of the therapeutic drug and the fluorescence-OFF imaging probe. Thereby, the drug release process is efficiently monitored by the fluorescence change in the nanoprodrug. The nanoprodrugs exerted high cytotoxicity toward various cancer cells, especially for A549 and HEK-293 cells, in which the nanoprodrugs generated better therapeutic effects than free paclitaxel. Our work demonstrated a new modality of smart theranostic nanoprodrugs for precise cancer therapy.
MeSH term(s)	Humans ; Precision Medicine ; Cell Line, Tumor ; Drug Liberation ; Electrons ; HEK293 Cells ; Paclitaxel/pharmacology ; Paclitaxel/therapeutic use ; Theranostic Nanomedicine/methods ; Optical Imaging/methods ; Glutathione/metabolism ; Disulfides/therapeutic use ; Nanoparticles/chemistry ; Neoplasms/diagnostic imaging ; Neoplasms/drug therapy
Chemical Substances	Paclitaxel (P88XT4IS4D) ; Glutathione (GAN16C9B8O) ; Disulfides
Language	English
Publishing date	2024-02-01
Publishing country	United States
Document type	Journal Article
ISSN	1944-8252
ISSN (online)	1944-8252
DOI	10.1021/acsami.3c16585
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Dual-functional etchants that simultaneously demineralize and stabilize dentin render collagen resistant to degradation for resin bonding.

Nisar, Saleha / Liu, Hang / Hass, Viviane / Wang, Yong

Dental materials : official publication of the Academy of Dental Materials

2023 Volume 39, Issue 11, Page(s) 1004–1012

Abstract: Objectives: To develop dual-functional etchants that could demineralize and stabilize dentin collagen simultaneously, and to assess the effects of these etchants on collagen crosslinking, biostability and resin bonding properties under clinically ... ...

Abstract	Objectives: To develop dual-functional etchants that could demineralize and stabilize dentin collagen simultaneously, and to assess the effects of these etchants on collagen crosslinking, biostability and resin bonding properties under clinically relevant conditions. Methods: Dual-functional etchants were prepared by mixing 56% glycolic acid and 17% phosphoric acid and adding 1% of theaflavins (TF) or proanthocyanidins from grape seed extract (GSE). The etchant without crosslinker was used as control. The prepared human dentin specimens were treated with the 3 etchants for 30 s and analyzed for chemical interaction using Fourier transform infrared spectroscopy and resistance of the demineralized layer to collagenase degradation using electron microscopy (EM). Resin-dentin interfacial bonding properties were evaluated after 24 h and after 10,000 thermocycling through microtensile bond strength (μTBS), nanoleakage and matrix metalloproteinases (MMPs) activity via in situ zymography. Statistical analysis was done using ANOVA and post- hoc Tuckey's test. Results: Compared to control, TF and GSE dual-functional etchants were able to demineralize dentin, induce collagen crosslinking and protect the demineralized layer from collagenase degradation within 30 s. High resolution EM images showed better protection with TF etchant compared to GSE. There was a significant reduction in μTBS and an increase in nanoleakage and MMPs activity in control after thermocycling (p < 0.05) while these changes weren't seen in dual-functional etchants. Significance: Dual-functional etchants, especially TF containing, provide collagen protection against degradation and result in stable μTBS and less nanoleakage and MMPs activity under clinically relevant conditions.
Language	English
Publishing date	2023-09-19
Publishing country	England
Document type	Journal Article
ZDB-ID	605995-8
ISSN	1879-0097 ; 0109-5641
ISSN (online)	1879-0097
ISSN	0109-5641
DOI	10.1016/j.dental.2023.09.002
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Article ; Online: Privacy-Conflict Resolution for Integrating Personal and Electronic Health Records in Blockchain-Based Systems.

Kormiltsyn, Aleksandr / Udokwu, Chibuzor / Dwivedi, Vimal / Norta, Alex / Nisar, Sanam

Blockchain in healthcare today

2023 Volume 6

Abstract: Integrating personal health records (PHRs) and electronic health records (EHRs) facilitates the provision of novel services to individuals, researchers, and healthcare practitioners. Simultaneously, integrating healthcare data leads to complexities ... ...

Abstract	Integrating personal health records (PHRs) and electronic health records (EHRs) facilitates the provision of novel services to individuals, researchers, and healthcare practitioners. Simultaneously, integrating healthcare data leads to complexities arising from the structural and semantic heterogeneity within the data. The subject of healthcare data evokes strong emotions due to concerns surrounding privacy breaches. Blockchain technology is employed to address the issue of patient data privacy in inter-organizational processes, as it facilitates patient data ownership and promotes transparency in its usage. At the same time, blockchain technology creates new challenges for e-healthcare systems, such as data privacy, observability, and online enforceability. This article proposes designing and formalizing automatic conflict resolution techniques in decentralized e-healthcare systems. The present study expounds upon our concepts by employing a running case study centered around preventive and personalized healthcare domains. Plain language summary: This paper suggests using blockchain technology for privacy concerns in integrating personal health records and electronic health records in decentralized e-healthcare systems. This report focuses on designing automatic conflict resolution techniques to ensure patient data ownership, transparency, and privacy in inter-organizational processes. This paper proposes designing automatic conflict resolution techniques in decentralized e-healthcare systems, which can improve inter-organizational processes in healthcare. Using blockchain technology to integrate personal and electronic health records can ensure patient data ownership and promote transparency in data usage, addressing privacy concerns in healthcare systems. This paper emphasizes the importance of data privacy and protection in healthcare systems, highlighting the need for compliance with laws and regulations. The research results, including the proof-of-concept prototype, can provide practical insights into implementing conflict resolution techniques in decentralized e-healthcare systems.
Language	English
Publishing date	2023-12-14
Publishing country	United States
Document type	Journal Article
ISSN	2573-8240
ISSN (online)	2573-8240
DOI	10.30953/bhty.v6.276
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Article ; Online: Cardiac contractility modulation: A new horizon in the management of heart failure with preserved ejection fraction (HFpEF).

Aneeq, Adnan / Jan, Muneeb / Nisar, Sibtain / Zahid, Shanzay / Kumari, Usha

Cardiovascular revascularization medicine : including molecular interventions

2023 Volume 61, Page(s) 110

Abstract: Cardiac contractility modulation (CCM) is a new therapy that has shown promising results in heart failure with preserved ejection fraction (HFpEF) management. This therapy involves the use of a device that delivers electrical signals to the heart during ... ...

Abstract	Cardiac contractility modulation (CCM) is a new therapy that has shown promising results in heart failure with preserved ejection fraction (HFpEF) management. This therapy involves the use of a device that delivers electrical signals to the heart during the refractory period, enhancing cardiac contractility without changing heart rate or rhythm. This short article explores the potential of CCM as a new horizon in the management of HFpEF, highlighting its mechanism of action, clinical trials, and future directions for research. Overall, CCM has emerged as a promising therapy for improving the outcomes of patients with HFpEF and provides hope for the development of more effective treatments in the future.
MeSH term(s)	Humans ; Stroke Volume/physiology ; Heart Failure/diagnosis ; Heart Failure/therapy ; Myocardial Contraction/physiology ; Treatment Outcome ; Heart Rate
Language	English
Publishing date	2023-11-11
Publishing country	United States
Document type	Letter
ZDB-ID	2212113-4
ISSN	1878-0938 ; 1553-8389
ISSN (online)	1878-0938
ISSN	1553-8389
DOI	10.1016/j.carrev.2023.11.007
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Article: Minimizing Viral Transmission in COVID-19 Like Pandemics: Technologies, Challenges, and Opportunities.

Nisar, Shibli / Wakeel, Abdul / Tahir, Wania / Tariq, Muhammad

IEEE sensors journal

2022 Volume 23, Issue 2, Page(s) 922–932

Abstract: Coronavirus (COVID-19) pandemic has incurred huge loss to human lives throughout the world. Scientists, researchers, and doctors are trying their best to develop and distribute the COVID-19 vaccine throughout the world at the earliest. In current ... ...

Abstract	Coronavirus (COVID-19) pandemic has incurred huge loss to human lives throughout the world. Scientists, researchers, and doctors are trying their best to develop and distribute the COVID-19 vaccine throughout the world at the earliest. In current circumstances, different tracking systems are utilized to control or stop the spread of the virus till the whole population of the world gets vaccinated. To track and trace patients in COVID-19 like pandemics, various tracking systems based on different technologies are discussed and compared in this paper. These technologies include, cellular, cyber, satellite-based radio navigation and low range wireless technologies. The main aim of this paper is to conduct a comprehensive survey that can overview all such tracking systems, which are used in minimizing the spread of COVID-19 like pandemics. This paper also highlights the shortcoming of each tracking systems and suggests new mechanisms to overcome such limitations. In addition, the authors propose some futuristic approaches to track patients in prospective pandemics, based on artificial intelligence and big data analysis. Potential research directions, challenges, and the introduction of next-generation tracking systems for minimizing the spread of prospective pandemics, are also discussed at the end.
Language	English
Publishing date	2022-04-25
Publishing country	United States
Document type	Journal Article
ISSN	1530-437X
ISSN	1530-437X
DOI	10.1109/JSEN.2022.3170521
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Article ; Online: The enigma of a subluxated globe

Devi Nivean, Pratheeba / Sayee, T. S. Mohammed / Nisar, Sonam / Madhivanan, Nivean

GMS Ophthalmology Cases - An Open Access Journal

2024 Volume 14, Page(s) 4

Abstract: Spontaneous globe subluxation (SGS) is an uncommon condition wherein the equator of the globe protrudes anteriorly beyond the eyelid aperture causing severe lagophthalmos, proptosis and exposure keratopathy. SGS can lead to an emotional disturbance ... ...

Abstract	Spontaneous globe subluxation (SGS) is an uncommon condition wherein the equator of the globe protrudes anteriorly beyond the eyelid aperture causing severe lagophthalmos, proptosis and exposure keratopathy. SGS can lead to an emotional disturbance leading to anxiety and fear, thereby affecting one’s quality of life. The patients might often be able to reduce the globe on their own, but permanent measures must be taken to prevent recurrence and vision-threatening sequelae of SGS. We present this case due to its rarity and to highlight the importance of a simple, cost-effective and cosmetically acceptable bilateral tarsorrhaphy in management of SGS.
Keywords	Medizin, Gesundheit ; spontaneous globe subluxation ; lateral tarsorrhaphy ; medical emergency ; shallow orbits
Publishing date	2024-04-19
Publisher	German Medical Science GMS Publishing House; Düsseldorf
Document type	Article ; Online
ISSN	2193-1496
ISSN (online)	2193-1496
DOI	10.3205/oc000236
Database	German Medical Science

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Article ; Online: Integrated nutrient management in spring-maize improves yield, nutrient use efficiency and minimizes greenhouse gas intensity

Nisar, Shahida / Mavi, Manpreet Singh / Singh, Jagdeep / Dey, Pradip

Archives of Agronomy and Soil Science. 2023 Nov. 10, v. 69, no. 13 p.2522-2536

2023

Abstract: Ensuring food security and simultaneously maintaining environmental integrity has become a major challenge in modern agriculture. Quantification of trade-offs between productivity, fertilizer use and greenhouse gas (GHG) emissions in agriculture is ... ...

Abstract	Ensuring food security and simultaneously maintaining environmental integrity has become a major challenge in modern agriculture. Quantification of trade-offs between productivity, fertilizer use and greenhouse gas (GHG) emissions in agriculture is important for the development of management strategies to ensure food security and environmental sustainability. The present study investigated the effect of synthetic fertilizer (SF) versus SF plus farmyard manure (FYM) in various combinations on soil fertility, grain yield and agronomic efficiency (AE) and GHG intensity (GHGI) in spring-maize for four years. A combination of 100% of the recommended NPK along with FYM (100%NPK+FYM) resulted in maximum (20–24%) increase in soil organic C content over 100%NPK alone treatment. Similarly, 100%NPK+FYM increased soil available N, P and K by 20, 73 and 33% over 100%NPK treatment. Continuous use of integrated nutrient management (INM) practices had a favourable impact on spring-maize grain yield, maximum being in 100%NPK+FYM (8.09 t ha⁻¹) and 125%NPK+FYM (8.16 t ha⁻¹) treatments. Though the grain yield between 100%NPK+FYM and 125%NPK+FYM treatments was similar, maximum AE of N, P and K and minimal GHGI was achieved in 100%NPK+FYM treatment. The results of the study indicated that application of 100%NPK+FYM in spring-maize proved to be agricultural and environmental sustainable management practice.
Keywords	agronomy ; animal manures ; environmental sustainability ; fertilizer application ; fertilizers ; food security ; grain yield ; greenhouse gases ; nutrient management ; nutrient use efficiency ; soil ; soil fertility ; soil organic carbon ; Synthetic fertilizers ; farmyard manure ; agronomic efficiency ; sustainability ; greenhouse gas emissions ; conjoint application
Language	English
Dates of publication	2023-1110
Size	p. 2522-2536.
Publishing place	Taylor & Francis
Document type	Article ; Online
ZDB-ID	1132910-5
ISSN	1476-3567 ; 0365-0340
ISSN (online)	1476-3567
ISSN	0365-0340
DOI	10.1080/03650340.2022.2160977
Database	NAL-Catalogue (AGRICOLA)

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