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  1. Article: Effects of cardiac rehabilitation with motion assistance from a wearable cyborg hybrid assistive limb on patients with chronic heart failure: a randomized controlled trial with a one-year follow-up.

    Watanabe, Hiroki / Koike, Akira / Kato, Hidenori / Kawamatsu, Naoto / Ichinohe, Takako / Machino, Takeshi / Nishi, Isao / Kawamoto, Hiroaki / Sankai, Yoshiyuki / Ieda, Masaki

    Journal of physical therapy science

    2023  Volume 35, Issue 2, Page(s) 114–120

    Abstract: Purpose] We have recently reported that using a wearable cyborg hybrid assistive limb improved the isometric knee extensor muscle strength of patients with chronic heart failure. Here, we investigated the long-term effects of a lumbar-type hybrid ... ...

    Abstract [Purpose] We have recently reported that using a wearable cyborg hybrid assistive limb improved the isometric knee extensor muscle strength of patients with chronic heart failure. Here, we investigated the long-term effects of a lumbar-type hybrid assistive limb for patients with chronic heart failure. [Participants and Methods] A total of 28 hospitalized patients with chronic heart failure (mean age, 73.1 ± 13.8 years) were randomly assigned to two groups: the hybrid assistive limb group or the control group, in which they performed a sit-to-stand exercise with or without the hybrid assistive limb, respectively. The cardiac rehabilitation therapy included this intervention, which was performed as many times as possible for 5-30 minutes per day for 6-10 days. Clinical assessments like lower-limb muscle strength, walking ability, etc., were measured before and after the intervention. Cardiac events were followed up for up to a year after discharge. [Results] No adverse events occurred during the study period in either group. In terms of long-term effects, the incidence of cardiac events was 23% and 45% in the hybrid assistive limb and the control groups, respectively. [Conclusion] Hybrid assistive limb-assisted exercise therapy may be a safe and feasible cardiac rehabilitation tool in patients with chronic heart failure. The lumbar-type wearable cyborg hybrid assistive limb may have a positive effect on heart failure prognosis by adding long-term exercise therapy.
    Language English
    Publishing date 2023-02-01
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2038898-6
    ISSN 0915-5287
    ISSN 0915-5287
    DOI 10.1589/jpts.35.114
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: [The Role of the Microbiology Laboratory in Healthcare-Associated Infection Control].

    Nishi, Isao / Hidaka, Yoh

    Rinsho byori. The Japanese journal of clinical pathology

    2016  Volume 64, Issue 3, Page(s) 338–344

    Abstract: Healthcare-associated infection control aims to protect patients and health care workers from infections. For successful control, it is important not to transmit pathogens and resistant bacteria as well as not to create new resistant bacteria. Preventing ...

    Abstract Healthcare-associated infection control aims to protect patients and health care workers from infections. For successful control, it is important not to transmit pathogens and resistant bacteria as well as not to create new resistant bacteria. Preventing the transmission of pathogens and resistant bacteria involves the reliable implementation of preventative measures for specific pathways in response to the causative microorganism. Appropriate information from the microbiology laboratory promotes the thorough implementation of prevention measures. This laboratory also makes it possible to promptly understand data on infections for the whole hospital. Therefore, in addition to the normal reporting of results, surveillance reports of infectious agents, such as drug-resistant bacteria, acid-fast bacilli smear-positive patients, and influenza virus antigen-positive patients must be immediately reported to the infection control team (ICT), which is the unit responsible for infection control. In addition, it is important to provide information on the detection of resistant bacteria and antimicrobial susceptibility rates to clinical staff and promote the development of systems in which new resistant bacteria are not created.
    MeSH term(s) Clinical Laboratory Techniques/methods ; Cross Infection/microbiology ; Cross Infection/prevention & control ; Humans ; Infection Control
    Language Japanese
    Publishing date 2016-03
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 604196-6
    ISSN 0047-1860 ; 0485-1404
    ISSN 0047-1860 ; 0485-1404
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Genomic Characterization of ESBL- and Carbapenemase-Positive Enterobacteriaceae Co-harboring

    Nakamura, Akihiro / Nakamura, Tatsuya / Niki, Makoto / Kuchibiro, Tomokazu / Nishi, Isao / Komatsu, Masaru

    Frontiers in microbiology

    2021  Volume 12, Page(s) 665432

    Abstract: Worldwide spread of Enterobacteriaceae resistant to colistin, a polypeptide antibacterial drug for last-resort treatment of carbapenemase-producing Enterobacteriaceae (CPE) infections, is concerning. This study aimed to elucidate colistin MICs and ... ...

    Abstract Worldwide spread of Enterobacteriaceae resistant to colistin, a polypeptide antibacterial drug for last-resort treatment of carbapenemase-producing Enterobacteriaceae (CPE) infections, is concerning. This study aimed to elucidate colistin MICs and molecular characteristics of
    Language English
    Publishing date 2021-08-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2021.665432
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Liver abscess caused by Gram-negative spiral bacilli.

    Hagiya, Hideharu / Kimura, Keigo / Nishi, Isao / Tomono, Kazunori

    JMM case reports

    2018  Volume 5, Issue 7, Page(s) e005155

    Language English
    Publishing date 2018-06-08
    Publishing country England
    Document type Case Reports
    ZDB-ID 2755673-6
    ISSN 2053-3721
    ISSN 2053-3721
    DOI 10.1099/jmmcr.0.005155
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Multiplex Real-Time PCR Assay for Six Major Carbapenemase Genes

    Yoshioka, Nori / Hagiya, Hideharu / Deguchi, Matsuo / Hamaguchi, Shigeto / Kagita, Masanori / Nishi, Isao / Akeda, Yukihiro / Tomono, Kazunori

    Pathogens. 2021 Mar. 01, v. 10, no. 3

    2021  

    Abstract: The global dissemination of carbapenemase-producing Enterobacteriaceae (CPE) is a major concern in public health. Due to the existence of the diversity of carbapenemases, development of an easily available, cost-effective multiplex detection assay for ... ...

    Abstract The global dissemination of carbapenemase-producing Enterobacteriaceae (CPE) is a major concern in public health. Due to the existence of the diversity of carbapenemases, development of an easily available, cost-effective multiplex detection assay for CPE is required worldwide. Using clinically available and reliable equipment, COBAS® z480 (Roche Diagnostics K.K., Tokyo, Japan), we developed a multiplex real-time PCR assay for the detection of two combinations of carbapenemases; first, blaNDM, blaKPC, and blaIMP (Set 1), and second, blaGES, blaOXA₋₄₈, and blaVIM (Set 2). We constructed standard curves for each carbapenemase gene using serial dilutions of DNA standards, then applied reference or clinical isolates with each carbapenemase gene to this assay. The multiplex assay showed satisfactory accuracy to detect CPE genes, with the correlation coefficients of greater than 0.99 for all genotypes. The assay appropriately differentiated the reference or clinical strains harboring each carbapenemase gene without cross reactivity. Lastly, the assay successfully detected multiple genes without false-positive reactions by applying six clinical isolates carrying both NDM and OXA-48-like carbapenemase genes. Major advantages of our assay include multiplicity, simple operation, robustness, and speed (1 h). We believe that the multiplex assay potentially contributes to early diagnosis of CPE with a diverse genetic background.
    Keywords DNA ; Enterobacteriaceae ; Japan ; beta-lactamase ; cost effectiveness ; cross reaction ; diagnostic techniques ; early diagnosis ; equipment ; genes ; genetic background ; public health ; quantitative polymerase chain reaction
    Language English
    Dates of publication 2021-0301
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    Note NAL-light
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens10030276
    Database NAL-Catalogue (AGRICOLA)

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  6. Article ; Online: Evaluation of the VITEK2 AST-XN17 card for the detection of carbapenemase-producing Enterobacterales in isolates primarily producing metallo β-lactamase.

    Kuchibiro, Tomokazu / Komatsu, Masaru / Yamasaki, Katsutoshi / Nakamura, Tatsuya / Niki, Makoto / Nishio, Hisaaki / Kida, Kaneyuki / Ohama, Masanobu / Nakamura, Akihiro / Nishi, Isao

    European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology

    2022  Volume 41, Issue 5, Page(s) 723–732

    Abstract: Carbapenemase-producing Enterobacterales (CPE) are not always resistant to carbapenem antimicrobial susceptibility testing (AST) and can be difficult to detect. With the newly created VITEK2 AST-XN17 card, the types of antibiotics measured in AST can be ... ...

    Abstract Carbapenemase-producing Enterobacterales (CPE) are not always resistant to carbapenem antimicrobial susceptibility testing (AST) and can be difficult to detect. With the newly created VITEK2 AST-XN17 card, the types of antibiotics measured in AST can be increased. In this study, we evaluated the detectability of CPE using the results of AST with multiple antimicrobial agents with additional measurements of the AST-XN17 card. In addition, we evaluated the CPE detectability of comments on CPE using the VITEK2 Advance Expert System (AES). In total, 169 Enterobacterales samples, including 76 non-CPE and 93 CPE, collected from multiple medical institutions in the Kinki region of Japan, were used in this investigation. AST with VITEK2 was performed by adding the AST-XN17 card in addition to the AST-N268 or AST-N404 card. Measurement results were identified using cutoff values, primarily Clinical and Laboratory Standards Institute breakpoints, and the CPE detection capability of each antibiotic was evaluated in several terms, including sensitivity and specificity. The drugs highly sensitive to CPE detection were faropenem (FRPM) > 2 µg/mL at 100% and meropenem > 0.25 µg/mL at 98.9%; the highest specificity to CPE detection was for avibactam/ceftazidime (AVI/CAZ) > 8 µg/mL at 100%. The sensitivity and specificity of each card in the AES output were 86.2% and 94.7% for AST-N404 and AST-XN17 and 91.5% and 90.8% for AST-N268 and AST-XN17, respectively. AST using the VITEK2 AST-XN17 card is a useful test method of screening for CPE.
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Bacterial Proteins ; Humans ; Meropenem ; Microbial Sensitivity Tests ; beta-Lactamases
    Chemical Substances Anti-Bacterial Agents ; Bacterial Proteins ; beta-Lactamases (EC 3.5.2.6) ; carbapenemase (EC 3.5.2.6) ; Meropenem (FV9J3JU8B1)
    Language English
    Publishing date 2022-02-24
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 603155-9
    ISSN 1435-4373 ; 0934-9723 ; 0722-2211
    ISSN (online) 1435-4373
    ISSN 0934-9723 ; 0722-2211
    DOI 10.1007/s10096-022-04424-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Early clinical experience of radiofrequency catheter ablation using an audiovisual telesupport system.

    Shinoda, Yasutoshi / Sato, Akira / Adach, Toru / Nishi, Isao / Nogami, Akihiko / Aonuma, Kazutaka / Ieda, Masaki

    Heart rhythm

    2020  Volume 17, Issue 5 Pt B, Page(s) 870–875

    Abstract: Background: An audiovisual telesupport system that enables real-time audiovisual communications between 2 long-distance hospitals is one method of telemedicine. The usefulness and safety of radiofrequency catheter ablation (RFCA) using an audiovisual ... ...

    Abstract Background: An audiovisual telesupport system that enables real-time audiovisual communications between 2 long-distance hospitals is one method of telemedicine. The usefulness and safety of radiofrequency catheter ablation (RFCA) using an audiovisual telesupport system has not been well established.
    Objective: The purpose of this study was to evaluate the effectiveness and safety of RFCA using an audiovisual telesupport system.
    Methods: An audiovisual telesupport system using a strictly secured virtual network was established between Kamisu Saiseikai Hospital (operator with 10 years' experience and 800 procedures) and the University of Tsukuba (advisor with >20 years' experience and 8000 procedures). We evaluated 19 initial consecutive patients who underwent RFCA using this system for tachyarrhythmia: 10 with atrial fibrillation (AF), 5 with paroxysmal supraventricular tachycardia (PSVT), 3 with premature ventricular contraction (PVC), and 1 with atrial flutter. Electrophysiological and procedural characteristics were retrospectively assessed.
    Results: Acute success was achieved in all 19 patients without any major complications, with the advisor's audiovisual assistance. Mean procedure time and fluoroscopic time were 161 ± 44 minutes and 24 ± 14 minutes for AF, 110 ± 17 minutes and 28 ± 8 minutes for PVC, and 132 ± 19 minutes and 32 ± 2 minutes for PSVT, respectively. There was no recurrence of clinical arrhythmia in 17 of the 19 patients (89%) during 13 ± 9 month follow-up.
    Conclusion: An audiovisual telesupport system for RFCA is a useful and safe method that enabled the electrophysiologist with limited human resources to make an optimal decision regarding procedural strategy and endpoint with the remote advisor's audiovisual assistance.
    MeSH term(s) Catheter Ablation/methods ; Equipment Design ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Reproducibility of Results ; Surgery, Computer-Assisted/methods ; Tachycardia, Paroxysmal/diagnosis ; Tachycardia, Paroxysmal/physiopathology ; Tachycardia, Paroxysmal/surgery ; Tachycardia, Supraventricular/diagnosis ; Tachycardia, Supraventricular/physiopathology ; Tachycardia, Supraventricular/surgery ; Telemedicine/instrumentation ; Time Factors ; Video Recording/instrumentation
    Language English
    Publishing date 2020-04-30
    Publishing country United States
    Document type Journal Article ; Multicenter Study
    ZDB-ID 2229357-7
    ISSN 1556-3871 ; 1547-5271
    ISSN (online) 1556-3871
    ISSN 1547-5271
    DOI 10.1016/j.hrthm.2020.01.018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Temporal shifts in the predominant carbapenemase gene types among carbapenemase-producing

    Sakamoto, Noriko / Laolerd, Warawut / Akeda, Yukihiro / Sugawara, Yo / Motooka, Daisuke / Yamamoto, Norihisa / Takeuchi, Dan / Shanmugakani, Rathina Kumar / Nishi, Isao / Suzuki, Masato / Shibayama, Keigo / Iida, Tetsuya / Santanirand, Pitak / Tomono, Kazunori / Hamada, Shigeyuki

    Journal of medical microbiology

    2023  Volume 72, Issue 6

    Abstract: Introduction. ...

    Abstract Introduction.
    MeSH term(s) Humans ; Klebsiella pneumoniae/genetics ; Carbapenem-Resistant Enterobacteriaceae/genetics ; Thailand/epidemiology ; Phylogeny ; Enterobacteriaceae Infections/epidemiology ; beta-Lactamases/genetics ; Bacterial Proteins/genetics ; Microbial Sensitivity Tests
    Chemical Substances carbapenemase (EC 3.5.2.6) ; beta-Lactamases (EC 3.5.2.6) ; Bacterial Proteins
    Language English
    Publishing date 2023-06-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 218356-0
    ISSN 1473-5644 ; 0022-2615
    ISSN (online) 1473-5644
    ISSN 0022-2615
    DOI 10.1099/jmm.0.001711
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Roseomonas mucosa

    Kimura, Keigo / Hagiya, Hideharu / Nishi, Isao / Yoshida, Hisao / Tomono, Kazunori

    IDCases

    2018  Volume 14, Page(s) e00469

    Abstract: ... ...

    Abstract Roseomonas
    Language English
    Publishing date 2018-11-13
    Publishing country Netherlands
    Document type Journal Article ; Case Reports
    ZDB-ID 2745454-X
    ISSN 2214-2509
    ISSN 2214-2509
    DOI 10.1016/j.idcr.2018.e00469
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Multiplex Real-Time PCR Assay for Six Major Carbapenemase Genes.

    Yoshioka, Nori / Hagiya, Hideharu / Deguchi, Matsuo / Hamaguchi, Shigeto / Kagita, Masanori / Nishi, Isao / Akeda, Yukihiro / Tomono, Kazunori

    Pathogens (Basel, Switzerland)

    2021  Volume 10, Issue 3

    Abstract: The global dissemination of carbapenemase- ... ...

    Abstract The global dissemination of carbapenemase-producing
    Language English
    Publishing date 2021-03-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens10030276
    Database MEDical Literature Analysis and Retrieval System OnLINE

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