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  1. Article: Mobile Pressure Calibrator for the Development of Submarine Geodetic Monitoring Systems

    Machida, Yuya / Nishida, Shuhei / Kimura, Toshinori / Araki, Eiichiro

    Journal of geophysical research. 2020 Sept., v. 125, no. 9

    2020  

    Abstract: Monitoring long‐term vertical seafloor displacements at the centimeter scale using a pressure gauge network in the seismogenic zone is key to understanding the real‐time strength of interplate coupling. The mobile pressure calibrator (MPC) was developed ... ...

    Abstract Monitoring long‐term vertical seafloor displacements at the centimeter scale using a pressure gauge network in the seismogenic zone is key to understanding the real‐time strength of interplate coupling. The mobile pressure calibrator (MPC) was developed for calibrating a seafloor pressure gauge network with a resolution of less than 1 hPa/year, equivalent to about 1 cm/year. Inherent drift of the seafloor pressure gauges is estimated by comparing the raw observations between the seafloor pressure gauges and the MPC and subsequently subtracting the long‐term pressure data. In October 2018, three in situ pressure measurements were conducted to evaluate the measurement uncertainty of the MPC. The calibrator was placed adjacent to a seafloor pressure gauge, which is installed at a depth of about 1,750 m in the Nankai Trough offshore Japan, and measured the pressure differences between the calibrator and the seafloor pressure gauge. The drift component of the pressure gauge used inside the MPC was estimated and corrected based on calibrations performed in the laboratory before and after the in situ seafloor pressure measurements. The results indicated an uncertainty of 0.04 hPa for the in situ measurements and therefore the possibility of detecting small, long‐term seafloor displacements. We continue to compare the MPC and seafloor pressure gauge deviations over intervals of several months to years and estimate the drift of the seafloor pressure gauge.
    Keywords Japan ; geodesy ; geophysics ; research ; uncertainty ; Pacific Ocean
    Language English
    Dates of publication 2020-09
    Publishing place John Wiley & Sons, Ltd
    Document type Article
    Note JOURNAL ARTICLE
    ISSN 2169-9313
    DOI 10.1029/2020JB020284
    Database NAL-Catalogue (AGRICOLA)

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  2. Article: Amendment of the status of Pontella sewelli Heinrich, 1987 as a junior synonym of P. sinica Chen & Zhang, 1965, with confirmation of female-male matching by genetic analysis (Copepoda, Calanoida)

    Francis, Sanu V / Nishida, Shuhei

    Crustaceana. , v. 91, no. 4

    2018  

    Abstract: Specimens of Pontella sinica Chen & Zhang, 1965, that were collected for the first time from the eastern Indian Ocean, are described, and a revised synonymy of the species is presented, including an amendment of P. sewelli Heinrich, 1987 as a junior ... ...

    Abstract Specimens of Pontella sinica Chen & Zhang, 1965, that were collected for the first time from the eastern Indian Ocean, are described, and a revised synonymy of the species is presented, including an amendment of P. sewelli Heinrich, 1987 as a junior synonym of P. sinica. The present specimens agree with most of the previous descriptions except for the frontal, rostral, and/or ventral eye lenses, which have been described as present in some previous studies, but proved to be all absent in the present examination. In addition, an analysis applying mitochondrial cytochrome c oxidase subunit I (mt COI) as a genetic marker confirmed matching of the female and male that were morphologically described by previous workers.
    Keywords Calanoida ; cytochrome-c oxidase ; eye lens ; females ; genetic analysis ; genetic markers ; males ; mitochondria ; Indian Ocean
    Language English
    Size p. 439-449.
    Publishing place Brill
    Document type Article
    ZDB-ID 217297-5
    ISSN 0011-216X
    ISSN 0011-216X
    DOI 10.1163/15685403-00003749
    Database NAL-Catalogue (AGRICOLA)

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  3. Article ; Online: Long-term training-dependent representation of individual finger movements in the primary motor cortex.

    Ogawa, Kenji / Mitsui, Kaoru / Imai, Fumihito / Nishida, Shuhei

    NeuroImage

    2019  Volume 202, Page(s) 116051

    Abstract: We investigated the effects of long-term training on the neural representation of individual finger movements in the primary sensorimotor cortex. One group of participants (trained group) included subjects trained in playing the piano (mean years of ... ...

    Abstract We investigated the effects of long-term training on the neural representation of individual finger movements in the primary sensorimotor cortex. One group of participants (trained group) included subjects trained in playing the piano (mean years of experience = 17.9; range = 9-26; n = 20). The other group of participants (novice group) had no prior experience (n = 20). All participants performed finger-tapping movements using either of the four digits of the hand (index, middle, ring, and little fingers). Functional magnetic resonance imaging (fMRI) was used to analyze the spatial activation patterns elicited by individual finger movements. Subsequently, we tried to classify the finger that was being moved using a multi-voxel pattern analysis (MVPA). Our results showed significantly higher-than-chance classification accuracies in both primary motor cortex (M1) and somatosensory cortex (S1) contralateral to the hand. We also found significantly lower classification accuracies for both hands in the trained group compared with the novice group in M1, without significant differences in the average signal changes and the number of activated voxels for individual fingers or overlap between digits. Representational similarity analysis (RSA) also demonstrated the differences in similarity patterns of activations between the trained and novice groups in M1. Our results indicate the modulation of neural representations of individual finger movements of M1 due to long-term training.
    MeSH term(s) Adult ; Brain Mapping ; Female ; Fingers ; Humans ; Magnetic Resonance Imaging ; Male ; Motor Activity/physiology ; Motor Cortex/physiology ; Multivariate Analysis ; Practice, Psychological ; Psychomotor Performance/physiology ; Sensorimotor Cortex/physiology ; Young Adult
    Language English
    Publishing date 2019-07-24
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1147767-2
    ISSN 1095-9572 ; 1053-8119
    ISSN (online) 1095-9572
    ISSN 1053-8119
    DOI 10.1016/j.neuroimage.2019.116051
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  4. Article ; Online: Validation of Male

    Francis, Sanu Vengasseril / Nishida, Shuhei / Nandan, Sivasankaran Bijoy

    Zoological studies

    2018  Volume 57, Page(s) e16

    Abstract: Sanu Vengasseril Francis, Shuhei Nishida, and Sivasankaran Bijoy Nandan (2018) ...

    Abstract Sanu Vengasseril Francis, Shuhei Nishida, and Sivasankaran Bijoy Nandan (2018)
    Language English
    Publishing date 2018-04-17
    Publishing country China (Republic : 1949- )
    Document type Journal Article
    ZDB-ID 2105348-0
    ISSN 1810-522X ; 1021-5506
    ISSN (online) 1810-522X
    ISSN 1021-5506
    DOI 10.6620/ZS.2018.57-16
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  5. Article: Influence of environmental parameters on habitat preference of gelatinous zooplankton in various coastal ecosystems, the Straits of Malacca

    Balqis, Siti A.R / Yusoff, Fatimah Md / Nishikawa, Jun / Lindsay, Dhugal / Nishida, Shuhei

    Regional studies in marine science. 2019 July, v. 30

    2019  

    Abstract: This study examined spatial distribution patterns of gelatinous zooplankton in three coastal areas, namely Matang mangrove area (managed mangrove area, MMA), Kuala Selangor coastal waters (reclaimed mangrove area, RMA) and Port Dickson coastal waters (a ... ...

    Abstract This study examined spatial distribution patterns of gelatinous zooplankton in three coastal areas, namely Matang mangrove area (managed mangrove area, MMA), Kuala Selangor coastal waters (reclaimed mangrove area, RMA) and Port Dickson coastal waters (a resort area, PDC). In each area, non-gelatinous and gelatinous zooplankton samples were collected by horizontal tows of a plankton net (140μm mesh size) and a Bongo net (500μm mesh size). Various environmental parameters were measured in situ (temperature, dissolved oxygen, pH, turbidity) as well as analyzed in the laboratory (nutrients, chlorophyll-a , zooplankton). Nineteen hydromedusae, two siphonophore and two ctenophore species were recorded from three different areas. Matang mangrove (MMA) had the highest number of species (19 species), followed by RMA (13 species) and PDC (9 species). Gelatinous zooplankton density and biomass were significantly higher (p < 0.05) in MMA than the other areas. Different gelatinous zooplankton groups dominated in different areas with ctenophores as the most important group (Pukia sp. formed 79.0% of total gelatinous zooplankton) in MMA. The hydromedusae (55.0% was Eirene brevigona) was the most dominant group in RMA that had high total suspended solids, and siphonophores (58.0% was Lensia subtiloides) dominated PDC characterized by high water transparency. Biotic-environmental (BIO-ENV) analysis showed significant roles of turbidity, salinity, nutrients, chlorophyll-a and non-gelatinous zooplankton (p < 0.05) in the distribution of gelatinous zooplankton in these tropical coastal ecosystems. Two-way ANOSIM (analysis of similarities) showed that there were significant differences in gelatinous zooplankton amongst the three habitats. In terms of monsoonal seasons, the gelatinous zooplankton density showed significant differences (p < 0.05) between the southwest and northeast monsoons. This study illustrated that gelatinous zooplankton diversity and density varied with the degrees of habitat disturbance and seasonal changes, implying the potential impacts of anthropogenic activities and climate change on its community structure.
    Keywords Ctenophora ; Hydrozoa ; anthropogenic activities ; biomass ; chlorophyll ; climate change ; coastal ecosystems ; coastal water ; coasts ; community structure ; dissolved oxygen ; environmental factors ; habitat destruction ; habitat preferences ; habitats ; marine science ; monsoon season ; nutrients ; oxygen ; pH ; resorts ; salinity ; seasonal variation ; temperature ; total suspended solids ; turbidity ; zooplankton
    Language English
    Dates of publication 2019-07
    Publishing place Elsevier B.V.
    Document type Article
    ISSN 2352-4855
    DOI 10.1016/j.rsma.2019.100712
    Database NAL-Catalogue (AGRICOLA)

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  6. Article ; Online: Experimental evidence characterizing pressure fluctuations at the seafloor-water interface induced by an earthquake.

    Matsumoto, Hiroyuki / Kimura, Toshinori / Nishida, Shuhei / Machida, Yuya / Araki, Eiichiro

    Scientific reports

    2018  Volume 8, Issue 1, Page(s) 16406

    Abstract: An unusual combination of a laboratory experiment and in situ measurement of pressure fluctuations during an earthquake allows us to resolve some uncertainties in bottom pressure recorders (BPRs). In situ BPRs are usually contaminated by seismic waves ... ...

    Abstract An unusual combination of a laboratory experiment and in situ measurement of pressure fluctuations during an earthquake allows us to resolve some uncertainties in bottom pressure recorders (BPRs). In situ BPRs are usually contaminated by seismic waves during earthquakes; thus uncertainty still remains in the data obtained from BPRs. We examine in situ BPR data together with pressure variations produced by a dead weight (a pressure standard) in a laboratory experiment during an earthquake. The features recorded by the in situ BPRs are analysed as part of the overall experiment. We demonstrated that a 10-kg dead weight on a piston-cylinder across an area of 10 mm
    Language English
    Publishing date 2018-11-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-018-34578-2
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  7. Article ; Online: Lipid and fatty acid/alcohol compositions of the subarctic copepods Neocalanus cristatus and Eucalanus bungii from various depths in the Oyashio region, western North Pacific.

    Yamada, Yuichiro / Nishida, Shuhei / Graeve, Martin / Kattner, Gerhard

    Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology

    2016  Volume 198, Page(s) 57–65

    Abstract: Lipids of Neocalanus cristatus and Eucalanus bungii (C3 to adults), collected in March, May, and December from various depths (0-2000m) were studied in the Oyashio region, western North Pacific. Total lipid and wax ester contents of younger N. cristatus ... ...

    Abstract Lipids of Neocalanus cristatus and Eucalanus bungii (C3 to adults), collected in March, May, and December from various depths (0-2000m) were studied in the Oyashio region, western North Pacific. Total lipid and wax ester contents of younger N. cristatus stages increased during the development, being higher in May than in March and December. Major fatty acids of younger N. cristatus were 16:0, 20:5(n-3), and 22:6(n-3) and the dominant alcohols were 16:0, 16:1(n-7), 20:1(n-9)/(n-11) and 22:1(n-11). The energy-rich 20:1 and 22:1 moieties increased from the younger to the adult stages showing the importance of lipid biosynthesis which may be advantageous for successful overwintering and reproduction at depth. The 16:4(n-1) fatty acid, characteristic of a diatom diet increased in May, particularly in the younger stages. Our results suggest that the diatom-dominated feeding mode of younger N. cristatus during the spring bloom is important for an effective accumulation of wax esters. In contrast to N. cristatus, E. bungii accumulated substantial amounts of triacylglycerols. The total lipid and triacylglycerol content increased slightly toward the older developmental stages. The major fatty acids were 16:0, 16:1(n-7), 18:1(n-9) and (n-7), and 20:5(n-3). There was no evidence of developmental or seasonal changes in the fatty acid composition. The differences in the lipid storage modes of both copepods via wax esters or triacylglycerols are species-specific but their fatty acid compositions varied according to diet and developmental stage, especially in N. cristatus. These lipid characteristics are discussed in relation to reproduction, feeding modes, diapause and overwintering strategies.
    MeSH term(s) Alcohols/chemistry ; Alcohols/metabolism ; Animals ; Copepoda/chemistry ; Copepoda/metabolism ; Energy Metabolism ; Fatty Acids/chemistry ; Fatty Acids/metabolism ; Lipid Metabolism ; Lipids/chemistry ; Pacific Ocean ; Seasons
    Chemical Substances Alcohols ; Fatty Acids ; Lipids
    Language English
    Publishing date 2016-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 121247-3
    ISSN 1879-1107 ; 0305-0491 ; 1096-4959
    ISSN (online) 1879-1107
    ISSN 0305-0491 ; 1096-4959
    DOI 10.1016/j.cbpb.2016.04.003
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  8. Article ; Online: Nanaomycin E inhibits NLRP3 inflammasome activation by preventing mitochondrial dysfunction.

    Matsui, Yudai / Takemura, Naoki / Shirasaki, Yoshitaka / Takahama, Michihiro / Noguchi, Yoshihiko / Ikoma, Kenta / Pan, Yixi / Nishida, Shuhei / Taura, Manabu / Nakayama, Akiyoshi / Funatsu, Takashi / Misawa, Takuma / Harada, Yoshie / Sunazuka, Toshiaki / Saitoh, Tatsuya

    International immunology

    2022  Volume 34, Issue 10, Page(s) 505–518

    Abstract: Nod-like receptor family pyrin domain-containing 3 (NLRP3) is a cytosolic innate immune receptor that senses organelle dysfunction induced by various stimuli, such as infectious, environmental, metabolic and drug stresses. Upon activation, NLRP3 forms an ...

    Abstract Nod-like receptor family pyrin domain-containing 3 (NLRP3) is a cytosolic innate immune receptor that senses organelle dysfunction induced by various stimuli, such as infectious, environmental, metabolic and drug stresses. Upon activation, NLRP3 forms an inflammasome with its adaptor protein apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC) and caspase-1, to trigger the release of inflammatory cytokines. The development of effective anti-inflammatory drugs targeting the NLRP3 inflammasome is in high demand as its aberrant activation often causes inflammatory diseases. Here, we found that nanaomycin A (NNM-A), a quinone-based antibiotic isolated from Streptomyces, effectively inhibited NLRP3 inflammasome-mediated inflammatory responses induced by imidazoquinolines, including imiquimod. Interestingly, its epoxy derivative nanaomycin E (NNM-E) showed a comparable inhibitory effect against the NLRP3 inflammasome-induced release of interleukin (IL)-1β and IL-18 from macrophages, with a much lower toxicity than NNM-A. NNM-E inhibited ASC oligomerization and caspase-1 cleavage, both of which are hallmarks of NLRP3 inflammasome activation. NNM-E reduced mitochondrial damage and the production of reactive oxygen species, thereby preventing the activation of the NLRP3 inflammasome. NNM-E treatment markedly alleviated psoriasis-like skin inflammation induced by imiquimod. Collectively, NNM-E inhibits NLRP3 inflammasome activation by preventing mitochondrial dysfunction with little toxicity and showed an anti-inflammatory effect in vivo. Thus, NNM-E could be a potential lead compound for developing effective and safe anti-inflammatory agents for the treatment of NLRP3 inflammasome-mediated inflammatory diseases.
    MeSH term(s) Caspase 1/metabolism ; Imiquimod/metabolism ; Imiquimod/pharmacology ; Inflammasomes ; Interleukin-1beta/metabolism ; Mitochondria/metabolism ; NLR Family, Pyrin Domain-Containing 3 Protein ; Naphthoquinones
    Chemical Substances Inflammasomes ; Interleukin-1beta ; NLR Family, Pyrin Domain-Containing 3 Protein ; Naphthoquinones ; nanaomycin E (72660-52-7) ; Caspase 1 (EC 3.4.22.36) ; Imiquimod (P1QW714R7M)
    Language English
    Publishing date 2022-06-27
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1013745-2
    ISSN 1460-2377 ; 0953-8178
    ISSN (online) 1460-2377
    ISSN 0953-8178
    DOI 10.1093/intimm/dxac028
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  9. Article: A new deep-sea benthopelagic chaetognath of the genus Bathyspadella (Chaetognatha) with ecological and molecular phylogenetic remarks

    Miyamoto, Hiroomi / Nishida, Shuhei

    Journal of natural history. 2011 Oct. 1, v. 45, no. 45-46

    2011  

    Abstract: A new chaetognath, Bathyspadella oxydentata, collected from Sagami Bay, central Japan, is described. The new species was collected from deep-sea benthopelagic habitat and is distinguished from the closely related species Bathyspadella edentata Tokioka, ... ...

    Abstract A new chaetognath, Bathyspadella oxydentata, collected from Sagami Bay, central Japan, is described. The new species was collected from deep-sea benthopelagic habitat and is distinguished from the closely related species Bathyspadella edentata Tokioka, 1939 by the presence of teeth. The phylogenetic position of the new species was examined by molecular genetic analysis using partial sequences of 18S rRNA and 16S rRNA. Although B. oxydentata shares several morphological features with both Spadellidae and Eukrohnidae, the molecular phylogeny indicates that the new species is closely related to Heterokrohnidae species.
    Keywords genetic techniques and protocols ; habitats ; new species ; phylogeny ; ribosomal RNA ; teeth ; Japan
    Language English
    Dates of publication 2011-1001
    Size p. 2785-2794.
    Publishing place Taylor & Francis
    Document type Article
    ZDB-ID 1467695-3
    ISSN 1464-5262 ; 0022-2933
    ISSN (online) 1464-5262
    ISSN 0022-2933
    DOI 10.1080/00222933.2011.602806
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  10. Article: Inhibition of inflammation-mediated DPP-4 expression by linagliptin increases M2 macrophages in atherosclerotic lesions

    Nishida, Shuhei / Matsumura, Takeshi / Senokuchi, Takafumi / Murakami-Nishida, Saiko / Ishii, Norio / Morita, Yutaro / Yagi, Yoshitaka / Motoshima, Hiroyuki / Kondo, Tatsuya / Araki, Eiichi

    Biochemical and biophysical research communications. 2020 Mar. 26, v. 524, no. 1

    2020  

    Abstract: Dipeptidyl peptidase-4 (DPP-4) inhibitors have been reported to suppress atherosclerosis progression in atherosclerotic mouse models through unclear mechanisms. In this study, we investigated the effect of the DPP-4 inhibitor, linagliptin, on macrophage ... ...

    Abstract Dipeptidyl peptidase-4 (DPP-4) inhibitors have been reported to suppress atherosclerosis progression in atherosclerotic mouse models through unclear mechanisms. In this study, we investigated the effect of the DPP-4 inhibitor, linagliptin, on macrophage polarization in vitro and in vivo.Mouse bone marrow macrophages (BMMs) were used in in vitro assays. High fat diet (HFD)-fed Apoe⁻/⁻ mice were treated orally with linagliptin (10 mg/kg⁻¹•day⁻¹) or a vehicle (water) control.In in vitro assays using BMMs, treatment with LPS and IFNγ decreased the mRNA-expression levels of alternatively activated macrophage (M2) markers, and linagliptin treatment prevented these reductions. The mRNA levels of M2 markers and the number of M2 macrophages in the aorta were higher in linagliptin groups than in control groups. Linagliptin decreased the size of atherosclerotic lesions in HFD-fed Apoe⁻/⁻ mice. Interestingly, inflammatory stimulation increased DPP-4 expression, and linagliptin suppressed these effects in BMMs. Treatment with DPP-4 small-interfering RNA (siRNA) reproduced linagliptin-mediated alteration of M2 polarization.Linagliptin increased M2 macrophage polarization by inhibiting DPP-4 expression and activity. These findings may indicate the beneficial effects of DPP-4 inhibitors on the progression of diabetic macrovascular complications.
    Keywords aorta ; atherosclerosis ; bone marrow ; high fat diet ; macrophages ; mice ; research
    Language English
    Dates of publication 2020-0326
    Size p. 8-15.
    Publishing place Elsevier Inc.
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 205723-2
    ISSN 0006-291X ; 0006-291X
    ISSN (online) 0006-291X
    ISSN 0006-291X
    DOI 10.1016/j.bbrc.2020.01.027
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