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Article ; Online: Update on the treatment of cancer cachexia.

Nishie, Kenichi / Nishie, Tomomi / Sato, Seiichi / Hanaoka, Masayuki

2023 Volume 28, Issue 9, Page(s) 103689

Abstract: Cancer cachexia is a complex multifaceted syndrome involving functional impairment and changes in body composition that cannot be reversed by nutritional support. Cancer cachexia is characterized by decreased skeletal muscle mass, increased lipolysis, ... ...

Abstract	Cancer cachexia is a complex multifaceted syndrome involving functional impairment and changes in body composition that cannot be reversed by nutritional support. Cancer cachexia is characterized by decreased skeletal muscle mass, increased lipolysis, and decreased food intake. Cancer cachexia decreases chemotherapy tolerance as well as quality of life. However, because no fully effective interventions are available, cancer cachexia remains an unmet need in cancer treatment. In recent years, several discoveries and treatments for cancer cachexia have been studied, and guidelines have been published. We believe that the development of effective strategies for the diagnosis and treatment of cancer cachexia will lead to breakthroughs in cancer treatment.
MeSH term(s)	Humans ; Cachexia/drug therapy ; Cachexia/etiology ; Quality of Life ; Anorexia/etiology ; Neoplasms/complications
Language	English
Publishing date	2023-06-28
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1324988-5
ISSN	1878-5832 ; 1359-6446
ISSN (online)	1878-5832
ISSN	1359-6446
DOI	10.1016/j.drudis.2023.103689
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Zs.A 4725: Show issues

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Article ; Online: Effectiveness of neuromuscular electrical stimulation in patients with acute exacerbation of chronic obstructive pulmonary disease: A systematic review and meta-analysis.

Okura, Kazuki / Nonoyama, Tadayoshi / Shibuya, Manaka / Yamamoto, Shuhei / Kawachi, Shohei / Nishie, Kenichi / Nakayama, Katsutoshi

Physiotherapy research international : the journal for researchers and clinicians in physical therapy

2024 Volume 29, Issue 2, Page(s) e2076

Abstract: Background and purpose: This study aimed to investigate the effectiveness and acceptability of neuromuscular electrical stimulation (NMES) in patients with acute exacerbation of chronic obstructive pulmonary disease (COPD).: Methods: We conducted a ... ...

Abstract	Background and purpose: This study aimed to investigate the effectiveness and acceptability of neuromuscular electrical stimulation (NMES) in patients with acute exacerbation of chronic obstructive pulmonary disease (COPD). Methods: We conducted a systematic review and meta-analysis to investigate the effectiveness and accessibility of NMES and compared them with usual care in patients with acute exacerbation of COPD by searching databases such as MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials published up to April 2022. Randomized controlled trials (RCTs) involving patients with COPD who were treated within 3 weeks of acute exacerbation onset were included. The risk of bias was assessed using the RoB 2 tools. We pooled limb muscle strength and adverse events and performed a comparison between NMES and usual care. The quality of evidence was assessed using the Grading of Recommendations, Assessment, Development, and Evaluation approach. Results: Five RCTs, including 168 patients, met the eligibility criteria. The meta-analysis showed that limb muscle strength was significantly higher in the NMES group (four studies with 148 patients; standardized mean difference, 0.95; 95% confidence interval, 0.60-1.30; p < 0.001). The quality of evidence was very low due to the risk of bias within the studies, imprecision of the estimates, and small number of studies. Any adverse events served as outcomes in three studies (86 patients), although no adverse events occurred. Conclusion: NMES is safe for patients with acute exacerbation of COPD and may maintain and improve limb muscle strength; however, the quality of evidence was very low.
MeSH term(s)	Humans ; Pulmonary Disease, Chronic Obstructive/therapy ; Databases, Factual ; Muscle Strength ; Electric Stimulation
Language	English
Publishing date	2024-02-27
Publishing country	United States
Document type	Meta-Analysis ; Systematic Review ; Journal Article ; Review
ZDB-ID	1432038-1
ISSN	1471-2865 ; 1358-2267
ISSN (online)	1471-2865
ISSN	1358-2267
DOI	10.1002/pri.2076
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Zs.A 5028: Show issues

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Article ; Online: High-intensity interval training versus moderate-intensity continuous training in patients with heart failure: a systematic review and meta-analysis.

Okamura, Masatsugu / Shimizu, Masashi / Yamamoto, Shuhei / Nishie, Kenichi / Konishi, Masaaki

Heart failure reviews

2023 Volume 28, Issue 5, Page(s) 1113–1128

Abstract: The effects of high-intensity interval training (HIIT) in patients with heart failure (HF) remain controversial. This systematic review and meta-analysis aimed to examine the efficacy of HIIT versus moderate-intensity continuous aerobic training (MCT) on ...

Abstract	The effects of high-intensity interval training (HIIT) in patients with heart failure (HF) remain controversial. This systematic review and meta-analysis aimed to examine the efficacy of HIIT versus moderate-intensity continuous aerobic training (MCT) on exercise tolerance in patients with HF. We searched for studies published up to 4 March 2022 in Embase, MEDLINE, PubMed, and the Cochrane Library with no limitations on data, language, or publication status. We included randomized controlled trials comparing the efficacy of HIIT and MCT on peak oxygen uptake (VO
MeSH term(s)	Humans ; High-Intensity Interval Training ; Heart Failure/therapy ; Body Mass Index
Language	English
Publishing date	2023-06-05
Publishing country	United States
Document type	Meta-Analysis ; Systematic Review ; Journal Article ; Review
ZDB-ID	1336499-6
ISSN	1573-7322 ; 1382-4147
ISSN (online)	1573-7322
ISSN	1382-4147
DOI	10.1007/s10741-023-10316-3
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Article: Anamorelin for cancer cachexia.

Nishie, Kenichi / Sato, Seiichi / Hanaoka, Masayuki

Drugs of today (Barcelona, Spain : 1998)

2021 Volume 58, Issue 3, Page(s) 97–104

Abstract: Cancer anorexia-cachexia syndrome is a multifactorial condition characterized by significant weight loss due to muscle loss. It is associated with functional impairment, changes in body composition and nutritional disorders. Ghrelin receptors are ... ...

Abstract	Cancer anorexia-cachexia syndrome is a multifactorial condition characterized by significant weight loss due to muscle loss. It is associated with functional impairment, changes in body composition and nutritional disorders. Ghrelin receptors are involved in the release of growth hormone (GH) in the pituitary gland and increase appetite via the hypothalamus. The secretion of GH from the pituitary gland stimulates the liver to secrete insulin-like growth factor 1 (IGF-1), which promotes muscle protein synthesis. Anamorelin is a ghrelin receptor agonist used to treat cancer cachexia. It promotes GH secretion via ghrelin receptor activation and increases appetite, resulting in increased muscle mass and weight. Clinical trials of anamorelin have demonstrated a significant increase in lean body mass index, improved cachexia and no significant increase in serious adverse events. The present review describes the processes leading to the approval of anamorelin in Japan, focusing on pharmacology, metabolism, efficacy, safety and clinical trials.
MeSH term(s)	Anorexia/drug therapy ; Anorexia/etiology ; Cachexia/drug therapy ; Cachexia/etiology ; Cachexia/metabolism ; Humans ; Hydrazines/adverse effects ; Neoplasms/complications ; Neoplasms/drug therapy ; Oligopeptides
Chemical Substances	Hydrazines ; Oligopeptides ; anamorelin (DD5RBA1NKF)
Language	English
Publishing date	2021-12-30
Publishing country	Spain
Document type	Journal Article ; Review
ISSN	1699-3993
ISSN	1699-3993
DOI	10.1358/dot.2022.58.3.3381585
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Article ; Online: Cochrane corner: Positive airway pressure therapy for the treatment of central sleep apnoea associated with heart failure.

Yamamoto, Shuhei / Yamaga, Takayoshi / Kawachi, Shohei / Shibuya, Manaka / Nishie, Kenichi

Heart (British Cardiac Society)

2021

Language	English
Publishing date	2021-02-10
Publishing country	England
Document type	Journal Article
ZDB-ID	1303417-0
ISSN	1468-201X ; 1355-6037
ISSN (online)	1468-201X
ISSN	1355-6037
DOI	10.1136/heartjnl-2020-317888
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Ui IV Zs.40: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 112: Show issues

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Article ; Online: Does physiotherapy after rotator cuff repair require supervision by a physical therapist?: a meta-analysis.

Karasuyama, Masaki / Gotoh, Masafumi / Oike, Takuya / Nishie, Kenichi / Shibuya, Manaka / Nakamura, Hidehiro / Ohzono, Hiroki / Kawakami, Junichi

Clinics in shoulder and elbow

2023 Volume 26, Issue 3, Page(s) 296–301

Abstract: Background: A supervised physiotherapy program (SPP) is a standard regimen after surgical rotator cuff repair (RCR); however, the effect of a home-based exercise program (HEP), as an alternative, on postoperative functional recovery remains unclear. ... ...

Abstract	Background: A supervised physiotherapy program (SPP) is a standard regimen after surgical rotator cuff repair (RCR); however, the effect of a home-based exercise program (HEP), as an alternative, on postoperative functional recovery remains unclear. Therefore, the purpose of this meta-analysis was to compare the functional effects of SPP and HEP after RCR. Methods: We searched electronic databases including Central, Medline, and Embase in April 2022. The primary outcomes included the Constant score, American Shoulder and Elbow Surgeons score, University of California Los Angeles shoulder score, and pain score. Secondary outcomes included range of motion, muscle strength, retear rate, and patient satisfaction rate. A meta-analysis using random-effects models was performed on the pooled results to determine the significance. Results: The initial database search yielded 848 records, five of which met our criteria. Variables at 3 months after surgery were successfully analyzed, including the Constant score (mean difference, -8.51 points; 95% confidence interval [CI], -32.72 to 15.69; P=0.49) and pain score (mean difference, 0.02 cm; 95% CI, -2.29 to 2.33; P=0.99). There were no significant differences between the SPP and HEP. Other variables were not analyzed owing to the lack of data. Conclusions: Our data showed no significant differences between SSP and HEP with regard to the Constant and pain scores at 3 months after RCR. These results suggest that HEP may be an alternative regimen after RCR. Level of evidence: I.
Language	English
Publishing date	2023-07-04
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	3031244-9
ISSN	2288-8721 ; 2383-8337
ISSN (online)	2288-8721
ISSN	2383-8337
DOI	10.5397/cise.2022.01410
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Article ; Online: The effectiveness of supplemental oxygen during exercise training in patients with chronic obstructive pulmonary disease who show severe exercise-induced desaturation: a protocol for a meta-regression analysis and systematic review.

Kawachi, Shohei / Yamamoto, Shuhei / Nishie, Kenichi / Yamaga, Takayoshi / Shibuya, Manaka / Sakai, Yasunari / Fujimoto, Keisaku

Systematic reviews

2021 Volume 10, Issue 1, Page(s) 110

Abstract: Background: Supplemental oxygen during exercise training is used to increase the training effect of an exercise program in patients with chronic obstructive pulmonary disease (COPD) who show exercise-induced desaturation. Exercise-induced desaturation ... ...

Abstract	Background: Supplemental oxygen during exercise training is used to increase the training effect of an exercise program in patients with chronic obstructive pulmonary disease (COPD) who show exercise-induced desaturation. Exercise-induced desaturation is not clearly defined in the guidelines; however, it is generally defined in clinical studies as a decrease in SpO Methods: We will first assess the effectiveness of supplemental oxygen during exercise training in COPD. The main outcome is the change in exercise tolerance before and after the intervention, indicated by the 6-min walking distance, the walking distance, or the walking time in incremental shuttle walking test, and analyzed as the standardized mean difference (SMD). The quality and risk of bias in individual studies will be assessed using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) system and risk-of-bias tool (RoB ver.2). If statistical heterogeneity in terms of the effectiveness of exercise tolerance is shown, we will conduct meta-regression analyses to examine the association between the effectiveness of exercise training with supplemental oxygen and severity of exercise-induced desaturation at baseline. Discussion: One strength of this study is that it is a systematic review with meta-regression analysis to elucidate the effectiveness of supplemental oxygen during exercise training in patients with COPD who show severe exercise-induced desaturation. Furthermore, we will assess the severity of exercise-induced desaturation for which exercise training with supplemental oxygen is effective, the influence of acute effects at baseline, and the effect of supplemental oxygen on adverse events. Systematic review registration: Registration number, UMIN000039960.
MeSH term(s)	Exercise ; Exercise Test ; Exercise Tolerance ; Humans ; Oxygen ; Pulmonary Disease, Chronic Obstructive/therapy ; Regression Analysis ; Systematic Reviews as Topic
Chemical Substances	Oxygen (S88TT14065)
Language	English
Publishing date	2021-04-14
Publishing country	England
Document type	Journal Article
ZDB-ID	2662257-9
ISSN	2046-4053 ; 2046-4053
ISSN (online)	2046-4053
ISSN	2046-4053
DOI	10.1186/s13643-021-01667-9
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Article ; Online: Pulmonary Rehabilitation for Patients After COPD Exacerbation.

Shibuya, Manaka / Yamamoto, Shuhei / Kobayashi, Shuken / Nishie, Kenichi / Yamaga, Takayoshi / Kawachi, Shohei / Matsunaga, Atsuhiko

Respiratory care

2021 Volume 67, Issue 3, Page(s) 360–369

Abstract: Background: The aim of this study was to clarify the effectiveness of pulmonary rehabilitation in patients after exacerbations of COPD and to explore the initiation timing of pulmonary rehabilitation.: Methods: Systematic review and meta-analysis ... ...

Abstract	Background: The aim of this study was to clarify the effectiveness of pulmonary rehabilitation in patients after exacerbations of COPD and to explore the initiation timing of pulmonary rehabilitation. Methods: Systematic review and meta-analysis were performed to assess the effects of pulmonary rehabilitation in subjects with exacerbations of COPD on mortality and readmission compared with usual care. We searched for studies published up to October 2020 in MEDLINE, Embase, Cochrane Library, and other sources. Risk of bias was assessed for the randomization process, deviations from intended interventions, missing outcome data, outcome measurements, and selection of the reported result using the Risk of Bias 2 tool. We pooled mortality and readmission data and performed comparisons between pulmonary rehabilitation and usual care. The subgroup analysis compared pulmonary rehabilitation at different start times (early: ≤ 1 week from admission; and late: > 1 week from admission). Results: We identified 10 randomized trials (1,056 participants). Our meta-analysis showed a clinically relevant reduction in readmission up to 3-6 months after pulmonary rehabilitation in both early group (4 trials, 190 subjects; risk ratio [RR] 0.58, [95% CI 0.34-0.99]) and late group (3 trials, 281 subjects; RR 0.48, [95% CI 0.32-0.71]). However, pulmonary rehabilitation had no significant effect on mortality 1 y later compared with usual care (4 trials, 765 subjects; RR 1.27, [95% CI 0.91-1.79]). Conclusions: Pulmonary rehabilitation showed short-term effects for subjects with exacerbations of COPD even if initiated within 1 week; however, further study is required to determine its long-term effects.
MeSH term(s)	Disease Progression ; Hospitalization ; Humans ; Pulmonary Disease, Chronic Obstructive/rehabilitation ; Quality of Life
Language	English
Publishing date	2021-12-07
Publishing country	United States
Document type	Journal Article ; Meta-Analysis ; Review ; Systematic Review
ZDB-ID	603252-7
ISSN	1943-3654 ; 0098-9142 ; 0020-1324
ISSN (online)	1943-3654
ISSN	0098-9142 ; 0020-1324
DOI	10.4187/respcare.09066
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Article ; Online: Successful Radiotherapy of Primary Malignant Peripheral Nerve Sheath Tumor of the Lung.

Yanagisawa, Katsuya / Nishie, Kenichi / Takahashi, Hidekazu / Sano, Kenji / Takei, Kazuyoshi / Yamamoto, Hiroshi / Koizumi, Tomonobu / Hanaoka, Masayuki

Internal medicine (Tokyo, Japan)

2022 Volume 61, Issue 6, Page(s) 883–886

Abstract: A 71-year-old man presented with cough and bloody sputum. Computed tomography showed a mass in the lower lobe of the left lung. Histological findings in biopsy tissue revealed a malignant peripheral nerve sheath tumor (MPNST). The patient was diagnosed ... ...

Abstract	A 71-year-old man presented with cough and bloody sputum. Computed tomography showed a mass in the lower lobe of the left lung. Histological findings in biopsy tissue revealed a malignant peripheral nerve sheath tumor (MPNST). The patient was diagnosed with primary lung MPNST based on a systemic examination. Although initial chemotherapy treatment with doxorubicin failed to control the disease, radiotherapy considerably shrank the tumor. Primary lung MPNSTs are rare, and there is no established treatment for inoperable cases. This case suggests that radiotherapy is a treatment option for primary lung MPNST.
MeSH term(s)	Aged ; Doxorubicin/therapeutic use ; Humans ; Lung ; Male ; Nerve Sheath Neoplasms/diagnostic imaging ; Nerve Sheath Neoplasms/radiotherapy ; Neurofibrosarcoma/radiotherapy ; Tomography, X-Ray Computed
Chemical Substances	Doxorubicin (80168379AG)
Language	English
Publishing date	2022-03-15
Publishing country	Japan
Document type	Case Reports ; Journal Article
ZDB-ID	32371-8
ISSN	1349-7235 ; 0021-5120 ; 0918-2918
ISSN (online)	1349-7235
ISSN	0021-5120 ; 0918-2918
DOI	10.2169/internalmedicine.8143-21
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Zs.A 240: Show issues

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Article ; Online: Positive airway pressure therapy for the treatment of central sleep apnoea associated with heart failure.

Yamamoto, Shuhei / Yamaga, Takayoshi / Nishie, Kenichi / Nagata, Chie / Mori, Rintaro

The Cochrane database of systematic reviews

2019 Volume 12, Page(s) CD012803

Abstract: Background: Ischaemic heart disease including heart failure is the most common cause of death in the world, and the incidence of the condition is rapidly increasing. Heart failure is characterised by symptoms such as fatigue and breathlessness during ... ...

Abstract	Background: Ischaemic heart disease including heart failure is the most common cause of death in the world, and the incidence of the condition is rapidly increasing. Heart failure is characterised by symptoms such as fatigue and breathlessness during light activity, as well as disordered breathing during sleep. In particular, sleep disordered breathing (SDB), including central sleep apnoea (CSA) and obstructive sleep apnoea (OSA), is highly prevalent in people with chronic heart failure. A previous meta-analysis demonstrated that positive airway pressure (PAP) therapy dramatically increased the survival rate of people with heart failure who had CSA, and thus could contribute to improving the prognosis of these individuals. However, recent trials found that adaptive servo-ventilation (ASV) including PAP therapy had a higher risk of all-cause mortality and cardiovascular mortality. A meta-analysis that included recent trials was therefore needed. Objectives: To assess the effects of positive airway pressure therapy for people with heart failure who experience central sleep apnoea. Search methods: We searched the Cochrane Central Register of Controlled Trials (CENTRAL) in the Cochrane Library, MEDLINE, Embase, and Web of Science Core Collection on 7 February 2019 with no limitations on date, language, or publication status. We also searched two clinical trials registers in July 2019 and checked the reference lists of primary studies. Selection criteria: We excluded cross-over trials and included individually randomised controlled trials, reported as full-texts, those published as abstract only, and unpublished data. Data collection and analysis: Two review authors independently extracted outcome data from the included studies. We double-checked that data had been entered correctly by comparing the data presented in the systematic review with study reports. We analysed dichotomous data as risk ratios (RRs) with 95% confidence intervals (CIs) and continuous data as mean difference (MD) or standardised mean difference (SMD) with 95% CIs. Furthermore, we performed subgroup analysis in the ASV group or continuous PAP group separately. We used GRADEpro GDT software to assess the quality of evidence as it relates to those studies that contribute data to the meta-analyses for the prespecified outcomes. Main results: We included 16 randomised controlled trials involving a total of 2125 participants. The trials evaluated PAP therapy consisting of ASV or continuous PAP therapy for 1 to 31 months. Many trials included participants with heart failure with reduced ejection fraction. Only one trial included participants with heart failure with preserved ejection fraction. We are uncertain about the effects of PAP therapy on all-cause mortality (RR 0.81, 95% CI 0.54 to 1.21; participants = 1804; studies = 6; I Authors' conclusions: The effect of PAP therapy on all-cause mortality was uncertain. In addition, although we found evidence that PAP therapy did not reduce the risk of cardiac-related mortality and rehospitalisation, there was some indication of an improvement in quality of life for heart failure patients with CSA. Furthermore, the evidence was insufficient to determine whether adverse events were more common with PAP than with usual care. These findings were limited by low- or very low-quality evidence. PAP therapy may be worth considering for individuals with heart failure to improve quality of life.
MeSH term(s)	Heart Failure/complications ; Humans ; Positive-Pressure Respiration/methods ; Quality of Life ; Randomized Controlled Trials as Topic ; Sleep Apnea, Central/etiology ; Sleep Apnea, Central/therapy ; Sleep Apnea, Obstructive/etiology ; Sleep Apnea, Obstructive/therapy
Language	English
Publishing date	2019-12-04
Publishing country	England
Document type	Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't ; Systematic Review
ISSN	1469-493X
ISSN (online)	1469-493X
DOI	10.1002/14651858.CD012803.pub2
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