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  1. Article ; Online: Podocyte Ercc1 is indispensable for glomerular integrity.

    Hama, Eriko Yoshida / Nakamichi, Ran / Hishikawa, Akihito / Kihara, Miho / Abe, Takaya / Yoshimoto, Norifumi / Nishimura, Erina Sugita / Itoh, Hiroshi / Hayashi, Kaori

    Biochemical and biophysical research communications

    2024  Volume 704, Page(s) 149713

    Abstract: As life expectancy continues to increase, age-related kidney diseases are becoming more prevalent. Chronic kidney disease (CKD) is not only a consequence of aging but also a potential accelerator of aging process. Here we report the pivotal role of ... ...

    Abstract As life expectancy continues to increase, age-related kidney diseases are becoming more prevalent. Chronic kidney disease (CKD) is not only a consequence of aging but also a potential accelerator of aging process. Here we report the pivotal role of podocyte ERCC1, a DNA repair factor, in maintaining glomerular integrity and a potential effect on multiple organs. Podocyte-specific ERCC1-knockout mice developed severe proteinuria, glomerulosclerosis, and renal failure, accompanied by a significant increase in glomerular DNA single-strand breaks (SSBs) and double-strand breaks (DSBs). ERCC1 gene transfer experiment in the knockout mice attenuated proteinuria and glomerulosclerosis with reduced DNA damage. Notably, CD44
    MeSH term(s) Humans ; Mice ; Animals ; Podocytes/metabolism ; Kidney Glomerulus/metabolism ; Kidney Diseases/metabolism ; Mice, Knockout ; Proteinuria/genetics ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; Endonucleases/genetics ; Endonucleases/metabolism
    Chemical Substances Ercc1 protein, mouse (EC 3.1.-) ; DNA-Binding Proteins ; Endonucleases (EC 3.1.-)
    Language English
    Publishing date 2024-02-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 205723-2
    ISSN 1090-2104 ; 0006-291X ; 0006-291X
    ISSN (online) 1090-2104 ; 0006-291X
    ISSN 0006-291X
    DOI 10.1016/j.bbrc.2024.149713
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 116: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: DNA-damaged podocyte-CD8 T cell crosstalk exacerbates kidney injury by altering DNA methylation.

    Nakamichi, Ran / Hishikawa, Akihito / Chikuma, Shunsuke / Yoshimura, Akihiko / Sasaki, Takashi / Hashiguchi, Akinori / Abe, Takaya / Tokuhara, Tomoko / Yoshimoto, Norifumi / Nishimura, Erina Sugita / Hama, Eriko Yoshida / Azegami, Tatsuhiko / Nakayama, Takashin / Hayashi, Kaori / Itoh, Hiroshi

    Cell reports

    2023  Volume 42, Issue 4, Page(s) 112302

    Abstract: Recent epigenome-wide studies suggest an association between blood DNA methylation and kidney function. However, the pathological importance remains unclear. Here, we show that the homing endonuclease I-PpoI-induced DNA double-strand breaks in kidney ... ...

    Abstract Recent epigenome-wide studies suggest an association between blood DNA methylation and kidney function. However, the pathological importance remains unclear. Here, we show that the homing endonuclease I-PpoI-induced DNA double-strand breaks in kidney glomerular podocytes cause proteinuria, glomerulosclerosis, and tubulointerstitial fibrosis with DNA methylation changes in blood cells as well as in podocytes. Single-cell RNA-sequencing analysis reveals an increase in cytotoxic CD8
    MeSH term(s) Humans ; Podocytes/metabolism ; DNA Methylation/genetics ; CD8-Positive T-Lymphocytes/metabolism ; NK Cell Lectin-Like Receptor Subfamily K/metabolism ; Kidney/metabolism ; Proteinuria/genetics ; Proteinuria/metabolism ; Proteinuria/pathology ; Renal Insufficiency, Chronic/pathology ; DNA Damage ; DNA/metabolism
    Chemical Substances NK Cell Lectin-Like Receptor Subfamily K ; DNA (9007-49-2)
    Language English
    Publishing date 2023-03-28
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2023.112302
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: DNA-damaged podocyte-CD8 T cell crosstalk exacerbates kidney injury by altering DNA methylation.

    Nakamichi, Ran / Hishikawa, Akihito / Chikuma, Shunsuke / Yoshimura, Akihiko / Sasaki, Takashi / Hashiguchi, Akinori / Abe, Takaya / Tokuhara, Tomoko / Yoshimoto, Norifumi / Nishimura, Erina Sugita / Hama, Eriko Yoshida / Azegami, Tatsuhiko / Nakayama, Takashin / Hayashi, Kaori / Itoh, Hiroshi

    Cell reports

    2023  Volume 42, Issue 5, Page(s) 112427

    Language English
    Publishing date 2023-04-19
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2023.112427
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Clinical significance of serum urea-to-creatinine ratio in patients undergoing peritoneal dialysis.

    Tonomura, Shun / Uchiyama, Kiyotaka / Nakayama, Takashin / Mitsuno, Ryunosuke / Kojima, Daiki / Hama, Eriko Yoshida / Nagasaka, Tomoki / Nishimura, Erina Sugita / Kusahana, Ei / Takahashi, Rina / Yoshimoto, Norifumi / Yamaguchi, Shintaro / Morimoto, Kohkichi / Yoshida, Tadashi / Hayashi, Kaori / Kanda, Takeshi / Washida, Naoki / Itoh, Hiroshi

    Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy

    2023  Volume 27, Issue 6, Page(s) 1103–1112

    Abstract: Introduction: We aimed to determine the correlation between the serum urea-to-creatinine ratio and residual kidney function (RKF) in patients undergoing peritoneal dialysis (PD), as well as its predictive value for PD-related outcomes.: Methods: This ...

    Abstract Introduction: We aimed to determine the correlation between the serum urea-to-creatinine ratio and residual kidney function (RKF) in patients undergoing peritoneal dialysis (PD), as well as its predictive value for PD-related outcomes.
    Methods: This study included a cross-sectional study to assess the correlation between serum urea-to-creatinine ratio and RKF in 50 patients on PD and a retrospective cohort study to assess the association between serum urea-to-creatinine ratio and PD-related outcomes in 122 patients who initiated PD.
    Results: Serum urea-to-creatinine ratios had significant positive correlations with renal Kt/V and creatinine clearance values (r = 0.60, p < 0.001 and r = 0.61, p < 0.001, respectively). Additionally, serum urea-to-creatinine ratio was significantly associated with a lower risk of transfer to hemodialysis or PD/hemodialysis hybrid therapy (hazard ratio: 0.84, 95% confidence interval: 0.75-0.95).
    Conclusion: The serum urea-to-creatinine ratio can be an indicator of RKF and a prognostic factor in patients undergoing PD.
    MeSH term(s) Humans ; Creatinine ; Kidney Failure, Chronic/therapy ; Retrospective Studies ; Clinical Relevance ; Cross-Sectional Studies ; Peritoneal Dialysis ; Urea
    Chemical Substances Creatinine (AYI8EX34EU) ; Urea (8W8T17847W)
    Language English
    Publishing date 2023-06-22
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2119809-3
    ISSN 1744-9987 ; 1091-6660 ; 1744-9979
    ISSN (online) 1744-9987
    ISSN 1091-6660 ; 1744-9979
    DOI 10.1111/1744-9987.14030
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5208: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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