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Article ; Online: Fragile lip in a patient with macroglossia due to hemodialysis-associated amyloidosis.

Shiratori, Tohru / Nishimura, Masahiro / Horitani, Yusuke

JA clinical reports

2024 Volume 10, Issue 1, Page(s) 1

Language	English
Publishing date	2024-01-10
Publishing country	Germany
Document type	Letter
ISSN	2363-9024
ISSN (online)	2363-9024
DOI	10.1186/s40981-024-00686-4
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Article ; Online: Feasibility and perceptions of a benzodiazepine deprescribing quality improvement initiative for primary care providers in Japan.

Nishimura, Masahiro / Teo, Alan R / Mochizuki, Takahiro / Fujiwara, Naoki / Nakamura, Masakazu / Yamashita, Daisuke

BMC primary care

2024 Volume 25, Issue 1, Page(s) 35

Abstract: Background: Quality improvement (QI) initiatives in primary care in Japan are rare. One crucial area for QI is the appropriate prescription of benzodiazepines due to the large and growing elderly population in the country.: Objective: This study ... ...

Abstract	Background: Quality improvement (QI) initiatives in primary care in Japan are rare. One crucial area for QI is the appropriate prescription of benzodiazepines due to the large and growing elderly population in the country. Objective: This study aimed to determine the feasibility and other perceptions of a Benzodiazepine receptor agonist medications (BZRAs) deprescribing QI initiative for primary care providers (PCPs) in Japanese primary care clinics. Design: A qualitative study within a QI initiative. Participants: We recruited 11 semi-public clinics and 13 providers in Japan to participate in a BZRAs deprescribing initiative from 2020 to 2021. After stratifying the clinics according to size, we randomly allocated implementation clinics to either an Audit only or an Audit plus Coaching group. Interventions: For the Audit, we presented clinics with two BZRAs-related indicators. We provided monthly web-based meetings for the Coaching to support their QI activities. Approach: After the nine-month initiative, we conducted semi-structured interviews and used content analysis to identify themes. We organized the themes and assessed the key factors of implementation using the Consolidated Framework for Implementation Research (CFIR) framework. Key results: Audit plus Coaching was perceived as more valuable than Audit only intervention. Participants expressed intellectual curiosity about the QI initiative from resources outside their clinic. However, adopting a team-based QI approach in a small clinic was perceived as challenging, and selecting the indicators was important for meaningful QI. Conclusion: The small size of the clinic could be a potential barrier, but enhancing academic curiosity may facilitate QI initiatives in primary care in Japan. Further implementation trials are needed to evaluate the possibility of QI with more various indicators and a more extended period of time.
MeSH term(s)	Humans ; Aged ; Benzodiazepines/therapeutic use ; Japan ; Deprescriptions ; Feasibility Studies ; Quality Improvement ; Receptors, GABA-A ; Primary Health Care
Chemical Substances	Benzodiazepines (12794-10-4) ; Receptors, GABA-A
Language	English
Publishing date	2024-01-24
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2731-4553
ISSN (online)	2731-4553
DOI	10.1186/s12875-024-02270-2
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Article ; Online: Structural basis for p53 binding to its nucleosomal target DNA sequence.

Nishimura, Masahiro / Takizawa, Yoshimasa / Nozawa, Kayo / Kurumizaka, Hitoshi

PNAS nexus

2022 Volume 1, Issue 4, Page(s) pgac177

Abstract: The tumor suppressor p53 functions as a pioneer transcription factor that binds a nucleosomal target DNA sequence. However, the mechanism by which p53 binds to its target DNA in the nucleosome remains elusive. Here we report the cryo-electron microscopy ... ...

Abstract	The tumor suppressor p53 functions as a pioneer transcription factor that binds a nucleosomal target DNA sequence. However, the mechanism by which p53 binds to its target DNA in the nucleosome remains elusive. Here we report the cryo-electron microscopy structures of the p53 DNA-binding domain and the full-length p53 protein complexed with a nucleosome containing the 20 base-pair target DNA sequence of p53 (p53BS). In the p53-nucleosome structures, the p53 DNA-binding domain forms a tetramer and specifically binds to the p53BS DNA, located near the entry/exit region of the nucleosome. The nucleosomal position of the p53BS DNA is within the genomic p21 promoter region. The p53 binding peels the DNA from the histone surface, and drastically changes the DNA path around the p53BS on the nucleosome. The C-terminal domain of p53 also binds to the DNA around the center and linker DNA regions of the nucleosome, as revealed by hydroxyl radical footprinting. These results provide important structural information for understanding the mechanism by which p53 binds the nucleosome and changes the chromatin structure for gene activation.
Language	English
Publishing date	2022-09-04
Publishing country	England
Document type	Journal Article
ISSN	2752-6542
ISSN (online)	2752-6542
DOI	10.1093/pnasnexus/pgac177
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Article ; Online: Simultaneous Inflation of Both Cuffs of an EZ-Blocker Device Facilitates Selective Endobronchial Isolation.

Goto, Marina / Aoyama, Kazuyoshi / Nishimura, Masahiro / Takeda, Takao

Journal of cardiothoracic and vascular anesthesia

2022 Volume 36, Issue 8 Pt B, Page(s) 3429–3430

MeSH term(s)	Humans ; Intubation, Intratracheal ; One-Lung Ventilation
Language	English
Publishing date	2022-04-06
Publishing country	United States
Document type	Letter ; Research Support, Non-U.S. Gov't
ZDB-ID	1067317-9
ISSN	1532-8422 ; 1053-0770
ISSN (online)	1532-8422
ISSN	1053-0770
DOI	10.1053/j.jvca.2022.03.039
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Article ; Online: Effect of weekend hospitalization on the duration of fasting in patients with aspiration pneumonia.

Hasumi, Yuki / Hirota, Yoshito / Nishimura, Masahiro

Journal of general and family medicine

2022 Volume 23, Issue 5, Page(s) 336–342

Abstract: Background: Decreased swallowing function is an important risk factor for the development of aspiration pneumonia. A previous study reported that a long duration of fasting decreased swallowing function and increased mortality. The purpose of this study ...

Abstract	Background: Decreased swallowing function is an important risk factor for the development of aspiration pneumonia. A previous study reported that a long duration of fasting decreased swallowing function and increased mortality. The purpose of this study is to clarify the relationship between weekend hospitalization and fasting duration in older patients with aspiration pneumonia. Methods: In this retrospective cohort study using hospital claims data and electronic medical record data between April 1, 2018, and March 31, 2020, 238 patients hospitalized for aspiration pneumonia were enrolled. Patients admitted from Monday to Friday were defined as the weekday admission group, and patients admitted on Saturday, Sunday, and holidays were defined as the weekend admission group. The primary endpoint was the duration of fasting. Multiple regression analysis was performed with age, gender, place of living, Functional Oral Intake Scale before admission, severity of pneumonia, and weekend admission as the independent variables. Results: There were 41 patients in the weekend admission group and 103 patients in the weekday admission group. The baseline characteristics of the two groups were similar. There was a median difference in the fasting duration of 23.3 h; the fasting duration in the weekend admission group was significantly longer than the weekday admission group by 20.03 h (95% confidence interval: 2.81-37.25) in the multiple regression analysis. Conclusions: Weekend hospitalization was significantly associated with a longer fasting duration in patients hospitalized for aspiration pneumonia. There is a need to establish a system to enable early meal initiation for patients admitted on weekends.
Language	English
Publishing date	2022-06-13
Publishing country	Japan
Document type	Journal Article
ISSN	2189-7948
ISSN (online)	2189-7948
DOI	10.1002/jgf2.564
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Article: Impact of Surface Changes and Microbial Adhesion on Mucosal Surface Finishing of Resin Denture Bases by Shot Blast Polishing Using Viscoelastic Media.

Yamashita, Yusuke / Nishi, Yasuhiro / Murakami, Mamoru / Harada, Kae / Nishimura, Masahiro

Materials (Basel, Switzerland)

2022 Volume 15, Issue 6

Abstract: Surface changes and microbiological effects following shot blast polishing with viscoelastic media of the mucosal surface of resin denture bases were examined. Average surface roughness (Ra) and the depth of surface removal of specimens were measured ... ...

Abstract	Surface changes and microbiological effects following shot blast polishing with viscoelastic media of the mucosal surface of resin denture bases were examined. Average surface roughness (Ra) and the depth of surface removal of specimens were measured over time, and the clinical number of microbial adhesions on the mucosal surface of dentures was clinically assessed. The results obtained showed no changes in Ra after 20 s of polishing, Ra of <0.2 µm, and a depth of surface removal < 20 µm. This method of finishing did not affect the fit of the mucosal surface of the dentures. Furthermore, the adhesion of microorganisms to the mucosal surface of dentures was significantly suppressed. Shot blast polishing with viscoelastic media is useful for finishing the mucosal surface of resin denture bases.
Language	English
Publishing date	2022-03-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma15062275
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Article ; Online: Piper retrofractum extract and its component piperine promote lymphangiogenesis via an AKT- and ERK-dependent mechanism.

Ishii, Masakazu / Miyata, Haruka / Ikeda, Nao / Tagawa, Takashi / Nishimura, Masahiro

Journal of food biochemistry

2022 Volume 46, Issue 9, Page(s) e14233

Abstract: Administration of Piper retrofractum extract (PRE) has been reported to alleviate edema, but the mechanism underlying this effect is unknown. Promotion of lymphangiogenesis is known to improve lymphedema, but the effect of PRE on lymphangiogenesis ... ...

Abstract	Administration of Piper retrofractum extract (PRE) has been reported to alleviate edema, but the mechanism underlying this effect is unknown. Promotion of lymphangiogenesis is known to improve lymphedema, but the effect of PRE on lymphangiogenesis remains unclear. In the present study, we investigated whether PRE and specifically, piperine, the main component of PRE, can induce lymphangiogenesis. Treatments with PRE and piperine significantly promoted the proliferation, migration, and tube formation in human dermal lymphatic microvascular endothelial cells (HDLECs) but had no effect on the expression of lymphangiogenic factors. Furthermore, PRE and piperine significantly promoted the phosphorylation of the AKT and ERK proteins in HDLECs, and pretreatment with AKT and ERK inhibitors significantly attenuated the PRE- and piperine-induced lymphangiogenesis. These results indicate that PRE and piperine promote lymphangiogenesis via an AKT- and ERK-dependent mechanism. PRACTICAL APPLICATIONS: The lymphatic system plays various roles such as maintaining tissue fluid homeostasis, immune defense, and metabolism. Disruption of the lymphatic system results in insufficient fluid drainage, which causes edema. Currently, there are no effective treatments for lymphedema; therefore, the development of novel treatment strategies is desirable. In this study, we showed that PRE and its main component piperine promote lymphangiogenesis in lymphatic endothelial cells. Therefore, PRE has the potential to be used as a novel functional food for relieving lymphedema.
MeSH term(s)	Alkaloids ; Benzodioxoles ; Endothelial Cells/metabolism ; Humans ; Lymphangiogenesis ; Lymphedema/drug therapy ; Lymphedema/metabolism ; Piper ; Piperidines ; Plant Extracts/metabolism ; Plant Extracts/pharmacology ; Polyunsaturated Alkamides ; Proto-Oncogene Proteins c-akt/genetics ; Proto-Oncogene Proteins c-akt/metabolism
Chemical Substances	Alkaloids ; Benzodioxoles ; Piperidines ; Plant Extracts ; Polyunsaturated Alkamides ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; piperine (U71XL721QK)
Language	English
Publishing date	2022-05-13
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	433846-7
ISSN	1745-4514 ; 0145-8884
ISSN (online)	1745-4514
ISSN	0145-8884
DOI	10.1111/jfbc.14233
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Article ; Online: Purple sweet potato leaf extracts suppress adipogenic differentiation of human bone marrow-derived mesenchymal stem cells.

Ishii, Masakazu / Ikeda, Nao / Miyata, Haruka / Takahashi, Manami / Nishimura, Masahiro

Journal of food biochemistry

2022 Volume 46, Issue 2, Page(s) e14057

Abstract: Purple sweet potato (Ipomoea batatas L.) leaf extract (PSPLE) is known to exhibit various biological effects. However, the anti-adipogenic effects of PSPLE on mesenchymal stem cells (MSCs) remain unknown. In the present study, we investigated the effect ... ...

Abstract	Purple sweet potato (Ipomoea batatas L.) leaf extract (PSPLE) is known to exhibit various biological effects. However, the anti-adipogenic effects of PSPLE on mesenchymal stem cells (MSCs) remain unknown. In the present study, we investigated the effect of PSPLE on the adipogenic differentiation of human bone marrow MSCs. PSPLE treatment significantly reduced lipid accumulation and triglyceride levels during adipogenic differentiation. PSPLE suppressed the expression of PPARγ and C/EBPα, which are the master transcription factors orchestrating adipogenesis; moreover, it inhibited the expression of adiponectin, adipocyte protein 2 (aP2), and lipoprotein lipase (LPL), which are downstream target genes involved in adipogenic differentiation. Furthermore, PSPLE treatment suppressed glucose transporter 4 expression and intracellular glucose uptake and significantly inhibited the adipogenic differentiation induced factor-stimulated Akt signaling activation. These results indicate that PSPLE suppresses the differentiation of undifferentiated MSCs into adipocyte lineages and inhibits the terminal differentiation from preadipocytes into mature adipocytes. PRACTICAL APPLICATION: The increase in the prevalence of obesity worldwide is a problem today. Obesity is induced by an excessive accumulation of adipocytes and causes obesity-related diseases, such as diabetes, hypertension, and hyperlipidemia. Natural compounds derived from plants and fruits have a variety of biological activities and are expected to exert therapeutic effects against various diseases. This study shows that purple sweet potato (Ipomoea batatas L.) leaf extract (PSPLE) suppresses adipogenesis of bone marrow-derived mesenchymal stem cells. Thus, PSPLE may be a novel functional food for controlling obesity.
MeSH term(s)	Adipogenesis ; Bone Marrow ; Humans ; Ipomoea batatas ; Mesenchymal Stem Cells ; Plant Extracts/metabolism ; Plant Extracts/pharmacology
Chemical Substances	Plant Extracts
Language	English
Publishing date	2022-01-16
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	433846-7
ISSN	1745-4514 ; 0145-8884
ISSN (online)	1745-4514
ISSN	0145-8884
DOI	10.1111/jfbc.14057
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Article ; Online: Efficacy of chitinase-3-like protein 1 as an

Komabashiri, Naohiro / Suehiro, Fumio / Ishii, Masakazu / Nishimura, Masahiro

Regenerative therapy

2021 Volume 18, Page(s) 38–50

Abstract: Introduction: Maxillary/mandibular bone marrow stromal cells (MBMSCs) are a useful cell source for bone regeneration in the oral and maxillofacial region. To further ensure the clinical application of MBMSCs in bone regenerative therapy, it is important ...

Abstract	Introduction: Maxillary/mandibular bone marrow stromal cells (MBMSCs) are a useful cell source for bone regeneration in the oral and maxillofacial region. To further ensure the clinical application of MBMSCs in bone regenerative therapy, it is important to determine the bone formation capacity of MBMSCs before transplantation. The aim of this study is to identify the molecular marker that determines the Methods: The cell growth, cell surface antigens, Results: The cell growth, and Conclusion: Our study indicates that the
Language	English
Publishing date	2021-03-27
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2835333-X
ISSN	2352-3204 ; 2352-3204
ISSN (online)	2352-3204
ISSN	2352-3204
DOI	10.1016/j.reth.2021.03.004
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Article: Purple sweet potato leaf extracts suppress adipogenic differentiation of human bone marrow–derived mesenchymal stem cells

Ishii, Masakazu / Ikeda, Nao / Miyata, Haruka / Takahashi, Manami / Nishimura, Masahiro

Journal of food biochemistry. 2022 Feb., v. 46, no. 2

2022

Abstract: Purple sweet potato (Ipomoea batatas L.) leaf extract (PSPLE) is known to exhibit various biological effects. However, the anti‐adipogenic effects of PSPLE on mesenchymal stem cells (MSCs) remain unknown. In the present study, we investigated the effect ... ...

Abstract	Purple sweet potato (Ipomoea batatas L.) leaf extract (PSPLE) is known to exhibit various biological effects. However, the anti‐adipogenic effects of PSPLE on mesenchymal stem cells (MSCs) remain unknown. In the present study, we investigated the effect of PSPLE on the adipogenic differentiation of human bone marrow MSCs. PSPLE treatment significantly reduced lipid accumulation and triglyceride levels during adipogenic differentiation. PSPLE suppressed the expression of PPARγ and C/EBPα, which are the master transcription factors orchestrating adipogenesis; moreover, it inhibited the expression of adiponectin, adipocyte protein 2 (aP2), and lipoprotein lipase (LPL), which are downstream target genes involved in adipogenic differentiation. Furthermore, PSPLE treatment suppressed glucose transporter 4 expression and intracellular glucose uptake and significantly inhibited the adipogenic differentiation induced factor‐stimulated Akt signaling activation. These results indicate that PSPLE suppresses the differentiation of undifferentiated MSCs into adipocyte lineages and inhibits the terminal differentiation from preadipocytes into mature adipocytes. PRACTICAL APPLICATION: The increase in the prevalence of obesity worldwide is a problem today. Obesity is induced by an excessive accumulation of adipocytes and causes obesity‐related diseases, such as diabetes, hypertension, and hyperlipidemia. Natural compounds derived from plants and fruits have a variety of biological activities and are expected to exert therapeutic effects against various diseases. This study shows that purple sweet potato (Ipomoea batatas L.) leaf extract (PSPLE) suppresses adipogenesis of bone marrow–derived mesenchymal stem cells. Thus, PSPLE may be a novel functional food for controlling obesity.
Keywords	Ipomoea batatas ; adipocytes ; adipogenesis ; adiponectin ; bone marrow ; diabetes ; functional foods ; glucose ; glucose transporters ; humans ; hyperlipidemia ; hypertension ; leaf extracts ; leaves ; lipoprotein lipase ; obesity ; sweet potatoes ; therapeutics ; triacylglycerols
Language	English
Dates of publication	2022-02
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	JOURNAL ARTICLE
ZDB-ID	433846-7
ISSN	1745-4514 ; 0145-8884
ISSN (online)	1745-4514
ISSN	0145-8884
DOI	10.1111/jfbc.14057
Database	NAL-Catalogue (AGRICOLA)

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