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Article ; Online: Transaortic cryoablation of uncommon atrioventricular nodal reentrant tachycardia after Senning and Rastelli operations.

Toyohara, Keiko / Kudo, Yoshimichi / Nishimura, Tomomi / Shoda, Morio

Pacing and clinical electrophysiology : PACE

2021 Volume 44, Issue 7, Page(s) 1287–1291

Abstract: A 36-years-old woman with a congenital corrected transposition of the great arteries, who underwent Senning and Rastelli operations, was admitted with a symptomatic supraventricular tachycardia. During an electrophysiological study, uncommon ... ...

Abstract	A 36-years-old woman with a congenital corrected transposition of the great arteries, who underwent Senning and Rastelli operations, was admitted with a symptomatic supraventricular tachycardia. During an electrophysiological study, uncommon atrioventricular (AV) nodal reentrant tachycardia was induced. The coronary veins and coronary sinus did not connect to the systemic venous atrium. The His bundle electrogram (HBE) was recorded at the anterior septum of the mitral valve via the aorta. The target of ablation was the site of the earliest atrial activation during the tachycardia, 5 mm posterior to the AV node, and a successful cryoablation was performed using a transaortic approach. Both the antegrade and retrograde conduction of the slow AV nodal pathway was eliminated.
MeSH term(s)	Adult ; Aorta ; Cardiac Surgical Procedures/methods ; Cryosurgery/methods ; Female ; Humans ; Tachycardia, Atrioventricular Nodal Reentry/surgery
Language	English
Publishing date	2021-03-23
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	424437-0
ISSN	1540-8159 ; 0147-8389
ISSN (online)	1540-8159
ISSN	0147-8389
DOI	10.1111/pace.14219
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Zs.A 1466: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Periportal hepatocyte proliferation at midgestation governs maternal glucose homeostasis in mice.

Kozuki, Satoshi / Kabata, Mio / Sakurai, Satoko / Iwaisako, Keiko / Nishimura, Tomomi / Toi, Masakazu / Yamamoto, Takuya / Toyoshima, Fumiko

Communications biology

2023 Volume 6, Issue 1, Page(s) 1226

Abstract: The maternal liver is challenged by metabolic demands throughout pregnancy. However, hepatocyte dynamics and their physiological significance in pregnancy remain unclear. Here, we show in mice that hepatocyte proliferation is spatiotemporally regulated ... ...

Abstract	The maternal liver is challenged by metabolic demands throughout pregnancy. However, hepatocyte dynamics and their physiological significance in pregnancy remain unclear. Here, we show in mice that hepatocyte proliferation is spatiotemporally regulated in each liver lobular zone during pregnancy, with transient proliferation of periportal and pericentral hepatocytes during mid and late gestation, respectively. Using adeno-associated virus (AAV)-8-mediated expression of the cell cycle inhibitor p21 in hepatocytes, we show that inhibition of hepatocyte proliferation during mid, but not late, gestation impairs liver growth. Transcriptionally, genes involved in glucose/glycogen metabolism are downregulated in late pregnancy when midgestational hepatocyte proliferation is attenuated. In addition, hepatic glycogen storage is abolished, with concomitant elevated blood glucose concentrations, glucose intolerance, placental glycogen deposition, and fetal overgrowth. Laser capture microdissection and RNA-seq analysis of each liver lobular zone show zone-specific changes in the transcriptome during pregnancy and identify genes that are periportally expressed at midgestation, including the hyaluronan-mediated motility receptor (Hmmr). Knockdown of Hmmr in hepatocytes by AAV8-shHmmr suppresses periportal hepatocyte proliferation at midgestation and induces impaired hepatic glycogen storage, glucose intolerance, placental glycogen deposition and fetal overgrowth. Our results suggest that periportal hepatocyte proliferation during midgestation is critical for maternal glycogen metabolism and fetal size.
MeSH term(s)	Humans ; Mice ; Pregnancy ; Female ; Animals ; Liver Glycogen/metabolism ; Placenta/metabolism ; Glucose Intolerance/genetics ; Glucose Intolerance/metabolism ; Diabetes, Gestational ; Fetal Macrosomia/metabolism ; Glucose/metabolism ; Glycogen/metabolism ; Hepatocytes/metabolism ; Homeostasis ; Cell Proliferation
Chemical Substances	Liver Glycogen ; Glucose (IY9XDZ35W2) ; Glycogen (9005-79-2)
Language	English
Publishing date	2023-12-04
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2399-3642
ISSN (online)	2399-3642
DOI	10.1038/s42003-023-05614-3
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Article ; Online: Impact of preoperative electrophysiological intervention on occurrence of peri/postoperative supraventricular tachycardia following Fontan surgery.

Takeuchi, Daiji / Toyohara, Keiko / Kudo, Yoshimichi / Nishimura, Tomomi / Shoda, Morio

Heart rhythm

2020 Volume 18, Issue 1, Page(s) 34–40

Abstract: Background: Little is known about the effects of preoperative electrophysiological study (EPS) and catheter ablation (CA) in Fontan surgery candidates with supraventricular tachycardia (SVT).: Objective: The purpose of this study was to investigate ... ...

Abstract	Background: Little is known about the effects of preoperative electrophysiological study (EPS) and catheter ablation (CA) in Fontan surgery candidates with supraventricular tachycardia (SVT). Objective: The purpose of this study was to investigate the clinical impact of EPS-guided intervention in Fontan surgery candidates with preceding SVT events. Methods: A total of 109 consecutive patients with a history of SVT before Fontan surgery were divided into 3 groups: 44 in whom EPS with CA was attempted (CA group); 21 in whom EPS without CA was attempted (EPS group); and 44 in whom EPS was not performed (N group). The incidence and diagnosis of SVT, acute success rate of CA, and risk factors of peri/postoperative SVT were retrospectively investigated. Results: The total incidence of SVT within 1 year after Fontan surgery was 34% (n = 37), with 91% of cases occurring within 1 month. Among the 71 SVT incidences diagnosed with EPS, 31 were atrioventricular reentrant tachycardias (AVRTs) involving twin atrioventricular nodes, 12 were atrioventricular nodal reentrant tachycardias, 12 were atrial tachycardias, 7 were orthodromic AVRTs via the accessory pathway, 7 were atrial flutters, and 2 were junctional tachycardias. The acute success rate of CA was 91% (48/53). The rate of peri/postoperative atrioventricular reciprocating SVT was significantly lower in the CA group than in the N or EPS group (11% vs 43% or 43%; P <.05). No/unsuccessful CA significantly increased the risk of peri/postoperative SVT in multivariate analysis (odds ratio 4.43; 95% confidence interval 1.69-11.59). Conclusion: Preoperative CA reduces peri/postoperative SVT occurrence in Fontan surgery candidates at high risk for SVT.
MeSH term(s)	Accessory Atrioventricular Bundle/physiopathology ; Adolescent ; Catheter Ablation ; Child ; Child, Preschool ; Electrophysiologic Techniques, Cardiac/methods ; Female ; Follow-Up Studies ; Fontan Procedure/adverse effects ; Heart Defects, Congenital/surgery ; Humans ; Incidence ; Japan/epidemiology ; Male ; Perioperative Period ; Postoperative Period ; Retrospective Studies ; Risk Factors ; Tachycardia, Supraventricular/epidemiology ; Tachycardia, Supraventricular/etiology ; Tachycardia, Supraventricular/physiopathology
Language	English
Publishing date	2020-08-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	2229357-7
ISSN	1556-3871 ; 1547-5271
ISSN (online)	1556-3871
ISSN	1547-5271
DOI	10.1016/j.hrthm.2020.08.003
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Article ; Online: Transvenous shock-only implantable cardioverter defibrillator after an atrio-pulmonary Fontan surgery.

Toyohara, Keiko / Yagishita, Daigo / Kudo, Yoshimichi / Nishimura, Tomomi / Takeuchi, Daiji / Tomizawa, Yasuko / Shoda, Morio

Pacing and clinical electrophysiology : PACE

2020 Volume 44, Issue 1, Page(s) 181–184

Abstract: A 42-year-old woman with tricuspid atresia who underwent a Fontan surgery (atrio-pulmonary connection) was admitted to our hospital due to symptomatic ventricular tachycardia (VT). A defibrillation lead was implanted in a distal site of a coronary vein ... ...

Abstract	A 42-year-old woman with tricuspid atresia who underwent a Fontan surgery (atrio-pulmonary connection) was admitted to our hospital due to symptomatic ventricular tachycardia (VT). A defibrillation lead was implanted in a distal site of a coronary vein since there was no usual entry to the ventricle. Ventricular pacing was impossible due to the high threshold, however, good sensing was obtained. Three years later, she felt palpitations and a subsequent shock therapy while climbing stairs. The cardioverter data showed that an appropriate cardioversion therapy successfully converted VT to normal rhythm.
MeSH term(s)	Adult ; Defibrillators, Implantable ; Female ; Fontan Procedure ; Humans ; Postoperative Complications/physiopathology ; Postoperative Complications/therapy ; Tachycardia, Ventricular/physiopathology ; Tachycardia, Ventricular/therapy
Language	English
Publishing date	2020-11-27
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	424437-0
ISSN	1540-8159 ; 0147-8389
ISSN (online)	1540-8159
ISSN	0147-8389
DOI	10.1111/pace.14128
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Zs.A 1466: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article: Successful catheter ablation of ventricular tachycardia in a patient with congenitally corrected transposition of great arteries after double switch operation.

Toyohara, Keiko / Nishimura, Tomomi / Nakanishi, Toshio / Shoda, Morio

SpringerPlus

2016 Volume 5, Page(s) 341

Abstract: Ventricular tachycardia (VT) may cause sudden death late after repair of congenital heart disease. Radiofrequency catheter ablation (CA) of VT can be effective but may be hampered by hypertrophied myocardium or prosthetic material. A 33-year-old man with ...

Abstract	Ventricular tachycardia (VT) may cause sudden death late after repair of congenital heart disease. Radiofrequency catheter ablation (CA) of VT can be effective but may be hampered by hypertrophied myocardium or prosthetic material. A 33-year-old man with congenitally corrected transposition of the great arteries (ccTGA) had undergone a double switch operation (DSO) with the combined Mustard and Rastelli procedures when he was 10 years old. He developed sustained VT 16 years after the surgery. An electrophysiological study was performed using a 3D mapping system. During the VT, abnormal fragmented potentials were identified in the right ventricular side near the patch of ventricular septal defect. Radiofrequency energy was delivered at the site with changes in the QRS morphology. Electroanatomical mapping of the left ventricle was performed via a retrograde transaortic approach. Successful ablation of the fractionated potentials was likewise achieved on the left side. We report, to our knowledge, the first case of a successful radiofrequency CA of VT in a patient with ccTGA after a DSO. A slow conduction zone, which was proved to be part of the tachycardia substrate, existed around the patch of ventricular septal defect. Fragmented activities during VT were recorded from both ventricles. The tachycardia circuit was eliminated after ablating the right and left sides of the ventricular septal defect patch.
Language	English
Publishing date	2016-03-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2661116-8
ISSN	2193-1801
ISSN	2193-1801
DOI	10.1186/s40064-016-1903-4
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Article ; Online: Time-series blood cytokine profiles correlate with treatment responses in triple-negative breast cancer patients.

Saldajeno, Don Pietro / Kawaoka, Shinpei / Masuda, Norikazu / Tanaka, Sunao / Bando, Hiroko / Nishimura, Tomomi / Kadoya, Takayuki / Yamanaka, Takashi / Imoto, Shigeru / Velaga, Ravindranath M / Tamura, Nobuko / Aruga, Tomoyuki / Ikeda, Kazushi / Fukui, Yukiko / Maeshima, Yurina / Takada, Masahiro / Suzuki, Eiji / Ueno, Takayuki / Ogawa, Seishi /

Haga, Hironori / Ohno, Shinji / Morita, Satoshi / Kawaguchi, Kosuke / Toi, Masakazu

British journal of cancer

2024 Volume 130, Issue 6, Page(s) 1023–1035

Abstract: Background: Triple-negative breast cancer (TNBC) is the most heterogeneous breast cancer subtype. Partly due to its heterogeneity, it is currently challenging to stratify TNBC patients and predict treatment outcomes.: Methods: In this study, we ... ...

Abstract	Background: Triple-negative breast cancer (TNBC) is the most heterogeneous breast cancer subtype. Partly due to its heterogeneity, it is currently challenging to stratify TNBC patients and predict treatment outcomes. Methods: In this study, we examined blood cytokine profiles of TNBC patients throughout treatments (pre-treatment, during chemotherapy, pre-surgery, and 1 year after the surgery in a total of 294 samples). We analyzed the obtained cytokine datasets using weighted correlation network analyses, protein-protein interaction analyses, and logistic regression analyses. Results: We identified five cytokines that correlate with good clinical outcomes: interleukin (IL)-1α, TNF-related apoptosis-inducing ligand (TRAIL), Stem Cell Factor (SCF), Chemokine ligand 5 (CCL5 also known as RANTES), and IL-16. The expression of these cytokines was decreased during chemotherapy and then restored after the treatment. Importantly, patients with good clinical outcomes had constitutively high expression of these cytokines during treatments. Protein-protein interaction analyses implicated that these five cytokines promote an immune response. Logistic regression analyses revealed that IL-1α and TRAIL expression levels at pre-treatment could predict treatment outcomes in our cohort. Conclusion: We concluded that time-series cytokine profiles in breast cancer patients may be useful for understanding immune cell activity during treatment and for predicting treatment outcomes, supporting precision medicine. Trial registration: The study has been registered with the University Hospital Medical Information Network Clinical Trials Registry ( http://www.umin.ac.jp/ctr/index-j.htm ) with the unique trial number UMIN000023162. The association Japan Breast Cancer Research Group trial number is JBCRG-22. The clinical outcome of the JBCRG-22 study was published in Breast Cancer Research and Treatment on 25 March 2021. https://doi.org/10.1007/s10549-021-06184-w .
MeSH term(s)	Humans ; Triple Negative Breast Neoplasms/drug therapy ; Triple Negative Breast Neoplasms/metabolism ; Cytokines/metabolism ; Chemokines ; Treatment Outcome ; Japan
Chemical Substances	Cytokines ; Chemokines
Language	English
Publishing date	2024-01-18
Publishing country	England
Document type	Journal Article
ZDB-ID	80075-2
ISSN	1532-1827 ; 0007-0920
ISSN (online)	1532-1827
ISSN	0007-0920
DOI	10.1038/s41416-023-02527-0
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Article ; Online: Transvenous biventricular pacing in double-inlet left ventricle following ventricular septation and atrioventricular valve replacement.

Takeuchi, Daiji / Yagishita, Daigo / Toyohara, Keiko / Nishimura, Tomomi / Park, In-Sam / Shoda, Morio

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology

2017 Volume 19, Issue 12, Page(s) 1987

MeSH term(s)	Adult ; Atrial Fibrillation/diagnostic imaging ; Atrial Fibrillation/etiology ; Atrial Fibrillation/physiopathology ; Atrial Fibrillation/therapy ; Cardiac Pacing, Artificial/methods ; Computed Tomography Angiography ; Coronary Angiography/methods ; Disease Progression ; Equipment Design ; Heart Defects, Congenital/diagnostic imaging ; Heart Defects, Congenital/physiopathology ; Heart Defects, Congenital/surgery ; Heart Failure/diagnostic imaging ; Heart Failure/etiology ; Heart Failure/physiopathology ; Heart Failure/therapy ; Heart Valve Prosthesis ; Heart Valve Prosthesis Implantation/adverse effects ; Heart Valve Prosthesis Implantation/instrumentation ; Humans ; Male ; Pacemaker, Artificial ; Recovery of Function ; Treatment Outcome ; Tricuspid Valve/diagnostic imaging ; Tricuspid Valve/physiopathology ; Tricuspid Valve/transplantation ; Ventricular Function, Left ; Ventricular Function, Right
Language	English
Publishing date	2017-04-11
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	1449879-0
ISSN	1532-2092 ; 1099-5129
ISSN (online)	1532-2092
ISSN	1099-5129
DOI	10.1093/europace/euw322
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Zs.A 5434: Show issues

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Article ; Online: Antipsychotics-containing regimen as an alternative to standard antiemetics for delayed nausea induced by highly emetogenic chemotherapy.

Ishiguro, Hiroshi / Kawaguchi, Kosuke / Nishimura, Tomomi / Toi, Masakazu

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

2013 Volume 31, Issue 10, Page(s) 1377–1378

MeSH term(s)	Antiemetics/administration & dosage ; Antineoplastic Agents/adverse effects ; Female ; Humans ; Male ; Nausea/prevention & control
Chemical Substances	Antiemetics ; Antineoplastic Agents
Language	English
Publishing date	2013-04-01
Publishing country	United States
Document type	Comment ; Letter
ZDB-ID	604914-x
ISSN	1527-7755 ; 0732-183X
ISSN (online)	1527-7755
ISSN	0732-183X
DOI	10.1200/JCO.2012.47.2951
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Zs.A 1847: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: A homeobox protein, NKX6.1, up-regulates interleukin-6 expression for cell growth in basal-like breast cancer cells.

Li, Wenzhao / Itou, Junji / Tanaka, Sunao / Nishimura, Tomomi / Sato, Fumiaki / Toi, Masakazu

Experimental cell research

2016 Volume 343, Issue 2, Page(s) 177–189

Abstract: Among breast cancer subtypes, basal-like breast cancer is particularly aggressive, and research on the molecules involved in its pathology might contribute to therapy. In this study, we found that expression of NKX6.1, a homeobox transcription factor, is ...

Abstract	Among breast cancer subtypes, basal-like breast cancer is particularly aggressive, and research on the molecules involved in its pathology might contribute to therapy. In this study, we found that expression of NKX6.1, a homeobox transcription factor, is higher in basal-like breast cancer than in other subtypes. In loss-of-function experiments on basal-like breast cancer cell lines, NKX6.1-depleted cells exhibited reduced cell growth. Because cytokine interleukin-6 (IL-6) is expressed in basal-like breast cancer, and increases cell growth, we analyzed expression levels of IL6, an IL-6 gene, and observed reduced IL6 expression in NKX6.1-depleted cells. In a reporter assay, IL6 promoter activity was reduced by loss of NKX6.1 function. A pull-down assay showed that NKX6.1 binds to the proximal region in IL6 promoter. These results indicate that NKX6.1 directly up-regulates IL6 expression. To investigate further, we established cells with forced expression of IL-6. We observed that exogenous IL-6 expression restored the reduced cell growth of NKX6.1-depleted cells. Furthermore, orthotopic xenografts showed that NKX6.1-depleted cells lost the capacity for tumor formation. We therefore conclude that NKX6.1 is a factor for IL-6-regulated growth and tumor formation in basal-like breast cancer. Our findings facilitate profound understanding of basal-like breast cancer, and the development of suitable therapy.
MeSH term(s)	Animals ; Base Sequence ; Breast Neoplasms/genetics ; Breast Neoplasms/pathology ; Carcinogenesis/pathology ; Cell Line, Tumor ; Cell Proliferation ; Feedback, Physiological ; Female ; Gene Expression Regulation, Neoplastic ; Homeodomain Proteins/metabolism ; Humans ; Interleukin-6/genetics ; Interleukin-6/metabolism ; Mice, Inbred NOD ; Mice, SCID ; Models, Biological ; Promoter Regions, Genetic ; Up-Regulation/genetics
Chemical Substances	Homeodomain Proteins ; Interleukin-6 ; NKX6-1 protein, human
Language	English
Publishing date	2016-05-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	1493-x
ISSN	1090-2422 ; 0014-4827
ISSN (online)	1090-2422
ISSN	0014-4827
DOI	10.1016/j.yexcr.2016.03.023
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Article ; Online: Long-Term Efficacy of Implantable Cardioverter Defibrillator in Repaired Tetralogy of Fallot　- Role of Anti-tachycardia Pacing.

Henmi, Ryuta / Ejima, Koichiro / Yagishita, Daigo / Iwanami, Yuji / Nishimura, Tomomi / Takeuchi, Daiji / Toyohara, Keiko / Shoda, Morio / Hagiwara, Nobuhisa

Circulation journal : official journal of the Japanese Circulation Society

2017 Volume 81, Issue 2, Page(s) 165–171

Abstract: Background: Tetralogy of Fallot (TOF) is one of the common congenital heart diseases (CHD) in implantable cardioverter defibrillator (ICD) recipients, but few studies have reported the long-term outcomes of and the anti-tachycardia pacing (ATP) efficacy ...

Abstract	Background: Tetralogy of Fallot (TOF) is one of the common congenital heart diseases (CHD) in implantable cardioverter defibrillator (ICD) recipients, but few studies have reported the long-term outcomes of and the anti-tachycardia pacing (ATP) efficacy in repaired TOF.Methods and Results:Twenty-one repaired TOF patients with an ICD implanted between April 2003 and March 2015 were investigated retrospectively. ICD therapy and clinical outcome were analyzed. Mean patient age was 39±11 years; 62% were male; and mean age at repair surgery was 9.4±6.8 years. During a median follow-up of 5.6 years (range, 2.6-8.4 years), no patients died. Appropriate ATP were delivered in 11 patients (52%), with appropriate shocks in 5 patients (24%) and inappropriate shocks in 5 patients (24%). The success rate of ATP was 98% for fast ventricular tachycardia (VT; cycle length ≤320 ms) and 98% for slow VT (cycle length >320 ms). ATP effectiveness increased from 81.5% with the first ATP attempt to 93.7% with the second ATP attempt, to 97.5% with the third ATP attempt, and to 98.6% with the fourth or successive ATP attempt (P<0.0001, Cochran-Armitage trend test). Conclusions: ATP was highly effective in repaired TOF regardless of VT cycle length. Multiple ATP attempts could have an important role in VT termination, and the novel subcutaneous ICD without ATP capability should be used carefully.
MeSH term(s)	Adenosine Triphosphate/therapeutic use ; Adult ; Cardiac Pacing, Artificial ; Case-Control Studies ; Defibrillators, Implantable/standards ; Female ; Humans ; Longitudinal Studies ; Male ; Middle Aged ; Retrospective Studies ; Tachycardia, Ventricular/physiopathology ; Tetralogy of Fallot/drug therapy ; Tetralogy of Fallot/surgery ; Treatment Outcome
Chemical Substances	Adenosine Triphosphate (8L70Q75FXE)
Language	English
Publishing date	2017-01-25
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2068090-9
ISSN	1347-4820 ; 1346-9843
ISSN (online)	1347-4820
ISSN	1346-9843
DOI	10.1253/circj.CJ-16-0932
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