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  1. Book ; Online: Drug Repositioning: Current Advances and Future Perspectives

    Nishimura, Yuhei / Hara, Hideaki

    2019  

    Keywords Therapeutics. Pharmacology ; Science (General)
    Size 1 electronic resource (153 p.)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT020101976
    ISBN 9782889456963 ; 288945696X
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article: [Regulation of adipose progenitors and fibro-adipogenic progenitors through primary cilia].

    Nishimura, Yuhei

    Nihon yakurigaku zasshi. Folia pharmacologica Japonica

    2024  

    Abstract: The primary cilium, an antenna-like structure of cell membrane, detects various signals and regulates cellular functions such as proliferation and differentiation. The impairment of primary cilium is associated with the etiologies of diseases including ... ...

    Abstract The primary cilium, an antenna-like structure of cell membrane, detects various signals and regulates cellular functions such as proliferation and differentiation. The impairment of primary cilium is associated with the etiologies of diseases including cancer, obesity, and congenital anomalies. In this review, novel functions of trichoplein, a suppressor of ciliogenesis, on the regulation of adipose progenitors and fibro-adipogenic progenitors are focused. Trichoplein-knockout mice show resistance to high-fat diet-induced obesity and accelerated regeneration after skeletal muscle injury. The primary cilia of adipose progenitors from trichoplein-knockout mice are elongated, leading to the inhibitions of the accumulation of lipid raft to the base of primary cilia and the phosphorylation of AKT. The primary cilia of fibro-adipogenic progenitors from trichoplein-knockout mice are also elongated, causing the increased expression of IL-13 through IL-33 receptor signaling. These mechanisms are involved in the resistance to diet-induced obesity and improved regeneration. These findings suggest that targeting the primary cilia of specific cells may be a novel therapeutic approach through modulating cellular functions.
    Language Japanese
    Publishing date 2024-04-26
    Publishing country Japan
    Document type English Abstract ; Journal Article
    ZDB-ID 1097532-9
    ISSN 1347-8397 ; 0015-5691
    ISSN (online) 1347-8397
    ISSN 0015-5691
    DOI 10.1254/fpj.23108
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 439: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Technology using simulated microgravity.

    Nishimura, Yusuke

    Regenerative therapy

    2023  Volume 24, Page(s) 318–323

    Abstract: The human body experiences constant stimulation from Earth's gravity, and the absence of gravity leads to various impacts at the cellular and tissue levels. Simulated microgravity (s-μg) has been employed on Earth to investigate these effects, ... ...

    Abstract The human body experiences constant stimulation from Earth's gravity, and the absence of gravity leads to various impacts at the cellular and tissue levels. Simulated microgravity (s-μg) has been employed on Earth to investigate these effects, circumventing the challenges of conducting experiments in space and providing an opportunity to understand the influence of microgravity on living organisms. Research focusing on stem cells and utilizing s-μg has enhanced our understanding of how microgravity affects stem cell morphology, migration, proliferation, and differentiation. Studies have used systems such as rotating wall vessels, random positioning machines, and clinostats. By uncovering the mechanisms underlying the observed changes in these studies, there is potential to identify therapeutic targets that regulate stem cell function and explore a range of applications, including stem cell-based regenerative medicine. This review will focus on the features of each device designed to simulate microgravity on Earth, as well as the stem cell experiments performed with those devices.
    Language English
    Publishing date 2023-08-22
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2835333-X
    ISSN 2352-3204 ; 2352-3204
    ISSN (online) 2352-3204
    ISSN 2352-3204
    DOI 10.1016/j.reth.2023.08.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: [An attempt toward outcome-based education in medical pharmacology].

    Nishimura, Yuhei

    Nihon yakurigaku zasshi. Folia pharmacologica Japonica

    2023  Volume 158, Issue 6, Page(s) 434–439

    Abstract: The Japan Accreditation Council for Medical Education is the organization to evaluate medical education programs at each university based on the World Federation for Medical Education Global Standards for Quality Improvement. The practice of outcome- ... ...

    Abstract The Japan Accreditation Council for Medical Education is the organization to evaluate medical education programs at each university based on the World Federation for Medical Education Global Standards for Quality Improvement. The practice of outcome-based education is one of the most important points in the evaluation. Each university is required to clarify learning outcomes, which are the qualities and abilities that students should acquire at the time of graduation, and the curriculums and the framework of evaluations to achieve the learning outcomes. With the publicization of common achievement tests for medical students prior to clinical clerkship, medical students can perform medical treatments during clinical clerkship except for the issuance of prescriptions. However, to properly issue prescriptions as a resident soon after passing the national examination for medical practitioners, medical students should acquire the qualities and abilities not only to understand the pathophysiology of disease and the pharmacological actions of therapeutic drugs but also comprehensively to grasp the relationships between the patient, family, and society. Therefore, pharmacology is inevitably involved in many learning outcomes as a hub in the horizontal integration of basic medicine and the vertical integration of basic medicine, behavioral science, social medicine, and clinical medicine. In this paper, I look at pharmacology education at the Mie University School of Medicine from the perspective of outcome-based education and consider the role that pharmacology should play in the evaluation of medical education programs.
    MeSH term(s) Humans ; Curriculum ; Education, Medical ; Students, Medical ; Learning ; Japan
    Language Japanese
    Publishing date 2023-11-01
    Publishing country Japan
    Document type English Abstract ; Journal Article
    ZDB-ID 1097532-9
    ISSN 1347-8397 ; 0015-5691
    ISSN (online) 1347-8397
    ISSN 0015-5691
    DOI 10.1254/fpj.23043
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 439: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Plastid Nucleoids: Insights into Their Shape and Dynamics.

    Nishimura, Yoshiki

    Plant & cell physiology

    2023  Volume 65, Issue 4, Page(s) 551–559

    Abstract: Chloroplasts/plastids are unique organelles found in plant cells and some algae and are responsible for performing essential functions such as photosynthesis. The plastid genome, consisting of circular and linear DNA molecules, is packaged and organized ... ...

    Abstract Chloroplasts/plastids are unique organelles found in plant cells and some algae and are responsible for performing essential functions such as photosynthesis. The plastid genome, consisting of circular and linear DNA molecules, is packaged and organized into specialized structures called nucleoids. The composition and dynamics of these nucleoids have been the subject of intense research, as they are critical for proper plastid functions and development. In this mini-review, recent advances in understanding the organization and regulation of plastid nucleoids are overviewed, with a focus on the various proteins and factors that regulate the shape and dynamics of nucleoids, including DNA-binding proteins and membrane anchorage proteins. The dynamic nature of nucleoid organization, which is influenced by a variety of developmental cues and the cell cycle, is also examined.
    MeSH term(s) Plastids/genetics ; Plastids/metabolism ; Chloroplasts/metabolism ; Chloroplasts/genetics ; Plant Proteins/metabolism ; Plant Proteins/genetics ; Plants/genetics ; Plants/metabolism
    Language English
    Publishing date 2023-08-12
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 208907-5
    ISSN 1471-9053 ; 0032-0781
    ISSN (online) 1471-9053
    ISSN 0032-0781
    DOI 10.1093/pcp/pcad090
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 79/710: Show issues

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  6. Article: Daptomycin-Related Rhabdomyolysis Complicated by Severe Hyperkalemia and Acute Kidney Injury.

    Nishimura, Yoshito

    Cureus

    2022  Volume 14, Issue 9, Page(s) e29764

    Abstract: We describe a case of a 65-year-old man who presented with progressive generalized weakness. He was started on daptomycin for methicillin-resistant Staphylococcus aureus (MRSA) right fifth metatarsal osteomyelitis. Laboratory testing revealed severe ... ...

    Abstract We describe a case of a 65-year-old man who presented with progressive generalized weakness. He was started on daptomycin for methicillin-resistant Staphylococcus aureus (MRSA) right fifth metatarsal osteomyelitis. Laboratory testing revealed severe hyperkalemia of 7.5 mEq/L (normal range: 3.3-5.1) and acute kidney injury (AKI) stage 1 associated with a substantial elevation in serum creatine kinase (CK). He had been on a high-intensity statin for years, and daptomycin was switched to linezolid, and statin was held as daptomycin-related rhabdomyolysis was suspected. Our case highlights the importance of seeking alternatives to daptomycin for patients on chronic statins.
    Language English
    Publishing date 2022-09-29
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.29764
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Primary Care, Burnout, and Patient Safety: Way to Eliminate Avoidable Harm.

    Nishimura, Yoshito

    International journal of environmental research and public health

    2022  Volume 19, Issue 16

    Abstract: Patient safety has been a big theme in the area of global health, as represented by the resolution of the World Health Organization (WHO) on "Global action on patient safety" in 2019 and the recently published "Global Patient Safety Action Plan 2021-2030 ...

    Abstract Patient safety has been a big theme in the area of global health, as represented by the resolution of the World Health Organization (WHO) on "Global action on patient safety" in 2019 and the recently published "Global Patient Safety Action Plan 2021-2030 [...].
    MeSH term(s) Burnout, Professional/prevention & control ; Humans ; Patient Safety ; Primary Health Care ; World Health Organization
    Language English
    Publishing date 2022-08-16
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph191610112
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Current status and future prospects of decellularized kidney tissue.

    Nishimura, Yusuke

    Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs

    2022  Volume 26, Issue 3, Page(s) 171–175

    Abstract: End-stage renal disease (ESRD) is characterized by progressive loss of kidney function, which can result in damage to various tissues and organs. Dialysis therapy and kidney transplantation are currently the only therapeutic options available for ... ...

    Abstract End-stage renal disease (ESRD) is characterized by progressive loss of kidney function, which can result in damage to various tissues and organs. Dialysis therapy and kidney transplantation are currently the only therapeutic options available for patients with ESRD. In the case of kidney transplantation, organ shortage and high organ rejection have increased the need for novel treatment modalities. Therefore, organ regeneration employing decellularization technology has emerged as a viable alternative to conventional organ transplantation. In this technology, organs are decellularized using physical, chemical, or biological means to create a natural scaffold and foundation for cell seeding. After in vivo transplantation, this scaffold can be recellularized using stem cells or adult differentiated cells, resulting in a functional organ devoid of immune response. This review focuses on the primary agents used for renal decellularization and the current status of kidney regeneration using decellularization.
    MeSH term(s) Humans ; Kidney ; Tissue Scaffolds/chemistry ; Tissue Engineering/methods ; Regeneration ; Kidney Failure, Chronic/surgery ; Extracellular Matrix/chemistry
    Language English
    Publishing date 2022-09-22
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 1463555-0
    ISSN 1619-0904 ; 1434-7229
    ISSN (online) 1619-0904
    ISSN 1434-7229
    DOI 10.1007/s10047-022-01366-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5024: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Impacts of workplace verbal aggression classified via text mining on workers' mental health.

    Nishimura, Y / Matsumoto, S / Sasaki, T / Kubo, T

    Occupational medicine (Oxford, England)

    2024  Volume 74, Issue 2, Page(s) 186–192

    Abstract: Background: Exposure to workplace aggression adversely affects workers' health; however, little is known regarding the impact of specific types of verbal content.: Aims: We aimed to examine the relationship between exposure to several types of ... ...

    Abstract Background: Exposure to workplace aggression adversely affects workers' health; however, little is known regarding the impact of specific types of verbal content.
    Aims: We aimed to examine the relationship between exposure to several types of aggressive words at work and the victim's depressive symptoms and sleep disturbance using text mining.
    Methods: We conducted a longitudinal survey with 800 workers in wholesale and retail companies; of which, 500 responded to the follow-up survey. The Centre for Epidemiologic Studies-Depression Scale and Pittsburgh Sleep Quality Index were filled out by the participants, and their responses were analysed by logistic regression to evaluate the risk of depression or sleep problems. We collected exact aggressive words encountered at work over the past year as a dependent variable and classified it into four types using text mining, such as words criticizing one's performance.
    Results: The follow-up rate was 63%. Exposure to words threatening one's life showed a significant relationship with the risk of depression (odds ratio [OR] = 13.94, 95% confidence interval [CI] = 1.76-110.56). The exposure to words criticizing one's job performance is significantly related to the risk of sleep disturbance (OR = 5.56, 95% CI = 2.08-14.88).
    Conclusions: These findings suggest that different contents of verbal aggression can have different impacts on workers' health. This indicates that not only overtly threatening and abusive language but also words related to one's performance can be a risk factor for workers, depending on how they are delivered. To mitigate the adverse effects, promoting effective communication and cultivating psychological detachment from work may be beneficial.
    MeSH term(s) Humans ; Mental Health ; Aggression ; Workplace ; Surveys and Questionnaires ; Sleep Wake Disorders ; Data Mining
    Language English
    Publishing date 2024-02-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 1103950-4
    ISSN 1471-8405 ; 0962-7480
    ISSN (online) 1471-8405
    ISSN 0962-7480
    DOI 10.1093/occmed/kqae009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 426: Show issues Location:
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  10. Conference proceedings ; Online: Coseismic and postseismic deformation associated with the 17th Century megathrust earthquake along the Kuril Trench estimated by diatom analysis

    Nishimura, Y. / Chiba, T.

    XXVIII General Assembly of the International Union of Geodesy and Geophysics (IUGG)

    2023  

    Abstract: A method to construct the history of past crustal deformation based on diatom analysis was developed, and the amount of coseismic and postseismic deformation associated with the 17th Century megathrust earthquake in Toberi marsh, Tokachi, Hokkaido, was ... ...

    Abstract A method to construct the history of past crustal deformation based on diatom analysis was developed, and the amount of coseismic and postseismic deformation associated with the 17th Century megathrust earthquake in Toberi marsh, Tokachi, Hokkaido, was estimated. The cores including the tsunami deposits at an altitude of 2.5-3.0 m (TP) inferred that subside trend continued before the earthquake and it turned to uplift trend after the event. Since both of the trends are gradual, the coseismic deformation does not seem to be significant. On the other hand, Pseudopodosira kosugii, which distributes the intertidal to supratidal zone, is most abundant on the horizon of the tsunami deposits. Present habitat distribution of Pseudopodosira kosugii in the same marsh revealed that the upper distribution limit and mode were 0.8 to 1.3 m (TP) and -0.2 to 0.3 m (TP), respectively. Prehistorical uplift can be estimated from the current elevation of the limit and the mode of this diatom in the core. The amount of the uplift in Toberi march after the 17th Century event was ca. 1.5 m. That was constrained by using both the distribution limit and the mode of cores from five survey points in the marsh. Information about the crustal deformation after the 17th Century event is useful for the evaluation of source models of the earthquakes that is used for tsunami hazard assessment along the Pacific coast of Hokkaido.
    Subject code 550
    Language English
    Publishing date 2023-07-11
    Publishing country de
    Document type Conference proceedings ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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