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Article ; Online: A nerve-preserving strategy for endoscopic submucosal dissection of superficial pharyngeal cancers.

Fukuchi, Takehide / Hirasawa, Kingo / Ikeda, Ryosuke / Nishio, Masafumi / Kobayashi, Ryosuke / Sato, Chiko / Maeda, Shin

Endoscopy

2023 Volume 55, Issue S 01, Page(s) E910–E911

MeSH term(s)	Humans ; Endoscopic Mucosal Resection ; Pharyngeal Neoplasms/surgery ; Carcinoma, Squamous Cell ; Treatment Outcome ; Retrospective Studies
Language	English
Publishing date	2023-07-13
Publishing country	Germany
Document type	Journal Article
ZDB-ID	80120-3
ISSN	1438-8812 ; 0013-726X
ISSN (online)	1438-8812
ISSN	0013-726X
DOI	10.1055/a-2109-0561
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Zs.A 669: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 162: Show issues

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Article ; Online: Clinical course of small gastric subepithelial lesion less than 20 mm diagnosed by endoscopic ultrasound-guided fine-needle aspiration.

Kobayashi, Ryosuke / Hirasawa, Kingo / Ozeki, Yuichiro / Sawada, Atsushi / Nishio, Masafumi / Sato, Chiko / Miwa, Haruo / Kaneko, Takashi / Sugimori, Kazuya / Maeda, Shin

Journal of gastroenterology and hepatology

2024

Abstract: Background and aim: Gastrointestinal stromal tumors (GISTs) are treated as malignant gastric subepithelial lesions (SELs), and resection is recommended. However, small gastric SELs < 20 mm with no malignant features are monitored without ... ...

Abstract	Background and aim: Gastrointestinal stromal tumors (GISTs) are treated as malignant gastric subepithelial lesions (SELs), and resection is recommended. However, small gastric SELs < 20 mm with no malignant features are monitored without histopathological examination, and the frequency of malignancy is unknown. This study aimed to clarify the clinicopathological findings and clinical course of gastric SELs < 20 mm measured by endoscopic ultrasound (EUS). Methods: This retrospective cohort study included consecutive patients with small gastric SELs < 20 mm diagnosed using EUS at a tertiary referral center between 2009 and 2021. The clinical course after diagnosis using EUS-guided fine-needle aspiration (EUS-FNA) was reviewed. Results: Among 333 patients with small gastric SELs, 104 patients with 105 lesions underwent EUS-FNA. The pathological diagnosis was confirmed in 87 patients. GISTs were the most common pathology (47%). Among the 87 patients, 43 underwent therapeutic interventions, including tumor resection and chemotherapy. In groups of tumor resection, the pathological tumor size on the resected specimen was significantly larger than the size measured by EUS (19.5 mm vs 15.0 mm, P < 0.001), and 37% of resected SELs were 20 mm or over. No recurrence was observed after tumor resection during a mean follow-up period of 40 months. Conclusions: Approximately 40% of small gastric SELs were malignant tumors, such as GIST, with most of them requiring treatment. Additionally, considering that the EUS measurement is 5 mm smaller than the pathological tumor diameter, further examinations, such as systematic EUS-FNA, may be required for SEL, including those smaller than 20 mm.
Language	English
Publishing date	2024-03-07
Publishing country	Australia
Document type	Journal Article
ZDB-ID	632882-9
ISSN	1440-1746 ; 0815-9319
ISSN (online)	1440-1746
ISSN	0815-9319
DOI	10.1111/jgh.16534
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Zs.A 2180: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 299: Show issues

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Article ; Online: Impact of endoscopy intervals on metachronous gastric cancer after endoscopic submucosal dissection: Comparison between 1 year and half-a-year.

Ozeki, Yuichiro / Hirasawa, Kingo / Sawada, Atsushi / Ikeda, Ryosuke / Nishio, Masafumi / Fukuchi, Takehide / Kobayashi, Ryosuke / Sato, Chiko / Maeda, Shin

Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society

2023 Volume 36, Issue 3, Page(s) 332–340

Abstract: Objectives: Japanese guidelines recommend posttreatment endoscopy once or twice a year after endoscopic submucosal dissection (ESD) for early gastric cancer. However, the impact of endoscopy intervals on metachronous gastric cancer (MGC) remains unclear, ...

Abstract	Objectives: Japanese guidelines recommend posttreatment endoscopy once or twice a year after endoscopic submucosal dissection (ESD) for early gastric cancer. However, the impact of endoscopy intervals on metachronous gastric cancer (MGC) remains unclear, especially the difference between 1-year and half-a-year intervals. We aimed to investigate this difference. Methods: This study retrospectively investigated 2429 patients who underwent gastric ESD between May 2001 and June 2019 at our hospital. Patients who developed MGC were classified based on those who underwent the previous endoscopy within at least 7 months (short-interval group) and within 8-13 months (regular-interval group). Propensity score matching (PSM) was used to adjust for possible confounders. The primary outcome was the proportion of MGC beyond curative ESD criteria established in the guidelines. Results: A total of 216 eligible patients developed MGC. The short- and regular-interval groups included 43 and 173 patients, respectively. Overall, no patients in the short-interval group had MGC beyond curative ESD criteria, while 27 patients in the regular-interval group did. The proportion of MGC beyond curative ESD criteria was significantly lower in the short-interval group than in the regular-interval group before (P = 0.003) and after (P = 0.028) PSM. Although not significant, the short-interval group tended to have a higher stomach preservation rate than the regular-interval group (P = 0.093). Conclusion: Our study indicated a possible benefit of biannual surveillance endoscopy in the early post-ESD period.
MeSH term(s)	Humans ; Stomach Neoplasms/diagnosis ; Stomach Neoplasms/surgery ; Stomach Neoplasms/epidemiology ; Endoscopic Mucosal Resection ; Retrospective Studies ; Gastroscopy ; Treatment Outcome ; Gastric Mucosa/surgery
Language	English
Publishing date	2023-06-15
Publishing country	Australia
Document type	Journal Article
ZDB-ID	1171589-3
ISSN	1443-1661 ; 0915-5635
ISSN (online)	1443-1661
ISSN	0915-5635
DOI	10.1111/den.14599
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Zs.A 3854: Show issues

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Article ; Online: Novel gastric endoscopic submucosal dissection training model enhances the endoscopic submucosal dissection skills of trainees: a multicenter comparative study.

Mitsui, Tomohiro / Sunakawa, Hironori / Yoda, Yusuke / Nishio, Masafumi / Kondo, Shinpei / Hamanaka, Jun / Tokoro, Chikako / Nakajo, Keiichiro / Maeda, Shin / Yano, Tomonori / Hirasawa, Kingo

Surgical endoscopy

2024

Abstract: Background: Endoscopic submucosal dissection (ESD) requires high endoscopic technical skills, and trainees should develop effective training methods. In collaboration with KOTOBUKI Medical, we developed the G-Master, which is a non-animal training model ...

Abstract	Background: Endoscopic submucosal dissection (ESD) requires high endoscopic technical skills, and trainees should develop effective training methods. In collaboration with KOTOBUKI Medical, we developed the G-Master, which is a non-animal training model that can simulate various parts of gastric ESD. We aimed to clarify the usefulness of the G-Master for inexperienced ESD trainees. Methods: We collected data from the first 5 gastric ESD cases conducted by 15 inexperienced ESD trainees at 5 participating centers between 2018 and 2022. The participants were divided into two groups: the G-Master training and non-G-Master training groups. Outcome measurements, such as procedural speed, perforation rate, self-completion rate, and en bloc resection rate, were compared between the two groups retrospectively. Results: A total of 75 gastric ESD cases were included in this study. The G-Master training group included 25 cases performed by 5 trainees, whereas the non-G-Master training group included 50 cases performed by 10 trainees. The median procedural speed for all cases was significantly faster in the G-Master training group than in the non-G-Master training group. Moreover, the procedural speed was linearly improved from the initial to the last cases in the lower location in the G-Master training group compared with the non-G-Master training group. In addition, although there was no significant difference, the G-Master training group showed lower rates of perforation and a lesser need to transition to expert operators than the non-G-Master training group. Conclusion: The G-Master could improve the ESD skills of inexperienced ESD trainees.
Language	English
Publishing date	2024-04-15
Publishing country	Germany
Document type	Journal Article
ZDB-ID	639039-0
ISSN	1432-2218 ; 0930-2794
ISSN (online)	1432-2218
ISSN	0930-2794
DOI	10.1007/s00464-024-10838-3
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Zs.A 2214: Show issues

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Article: A nerve-preserving strategy for endoscopic submucosal dissection of superficial pharyngeal cancers

Fukuchi, Takehide / Hirasawa, Kingo / Ikeda, Ryosuke / Nishio, Masafumi / Kobayashi, Ryosuke / Sato, Chiko / Maeda, Shin

Endoscopy

2023 Volume 55, Issue S 01, Page(s) E910–E911

Language	English
Publishing date	2023-07-13
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	80120-3
ISSN	1438-8812 ; 0013-726X
ISSN (online)	1438-8812
ISSN	0013-726X
DOI	10.1055/a-2109-0561
Database	Thieme publisher's database

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Zs.A 669: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 162: Show issues

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Article ; Online: Learning curve analysis for duodenal endoscopic submucosal dissection: A single-operator experience.

Ozeki, Yuichiro / Hirasawa, Kingo / Sawada, Atsushi / Ikeda, Ryosuke / Nishio, Masafumi / Fukuchi, Takehide / Kobayashi, Ryosuke / Sato, Chiko / Maeda, Shin

Journal of gastroenterology and hepatology

2022 Volume 37, Issue 11, Page(s) 2131–2137

Abstract: Background and aims: Superficial duodenal epithelial tumors are emerging targets for endoscopic submucosal dissection (ESD). However, it is unknown how competence is achieved in duodenal ESD. This study aimed to elucidate the learning curve for duodenal ...

Abstract	Background and aims: Superficial duodenal epithelial tumors are emerging targets for endoscopic submucosal dissection (ESD). However, it is unknown how competence is achieved in duodenal ESD. This study aimed to elucidate the learning curve for duodenal ESD. Methods: This retrospective observational study included 100 consecutive patients who underwent duodenal ESD by a single endoscopist between March 2014 and September 2021. The primary outcome was to define the learning curve for duodenal ESD by an endoscopist with sufficient non-duodenal ESD experience. Cumulative sum (CUSUM) curve analysis was used to assess the learning curve in terms of procedural speed. Comparative analyses of phases identified using the CUSUM method were performed. Results: In total, 98 patients were included in the analysis. Evaluation of the cumulative sum curve revealed four distinct phases in the graph: phase I, cases 1-25 (learning phase); phase II, cases 26-47 (proficiency phase); phase III, cases 48-72 (mastery phase); and phase IV, cases 73-98 (after introduction of general anesthesia). The median procedural speed was significantly faster in phase II than in phase I (11.1 mm Conclusions: Duodenal ESD requires 25 cases to gain proficiency and 50 to achieve mastery even for an endoscopist with extensive non-duodenal ESD experience.
MeSH term(s)	Humans ; Learning Curve ; Endoscopic Mucosal Resection/adverse effects ; Endoscopic Mucosal Resection/methods ; Clinical Competence ; Retrospective Studies ; Duodenal Neoplasms/surgery ; Treatment Outcome
Language	English
Publishing date	2022-09-13
Publishing country	Australia
Document type	Observational Study ; Journal Article
ZDB-ID	632882-9
ISSN	1440-1746 ; 0815-9319
ISSN (online)	1440-1746
ISSN	0815-9319
DOI	10.1111/jgh.15995
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 2180: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Cervical esophageal adenocarcinoma of intestinal type in ectopic gastric mucosa.

Ikeda, Ryosuke / Hirasawa, Kingo / Ozeki, Yuichiro / Sawada, Atsushi / Nishio, Masafumi / Fukuchi, Takehide / Sato, Chiko / Maeda, Shin

DEN open

2022 Volume 3, Issue 1, Page(s) e141

Abstract: A 45-year-old man underwent esophagogastroduodenoscopy because of symptoms of laryngopharyngeal discomfort. We found a protruded reddish lesion adjacent to the ectopic gastric mucosa (EGM) in the cervical esophagus, and a biopsy revealed that it was a ... ...

Abstract	A 45-year-old man underwent esophagogastroduodenoscopy because of symptoms of laryngopharyngeal discomfort. We found a protruded reddish lesion adjacent to the ectopic gastric mucosa (EGM) in the cervical esophagus, and a biopsy revealed that it was a tubular adenocarcinoma. We diagnosed the patient with intramucosal cancer and performed endoscopic submucosal dissection. Esophageal endoscopic submucosal dissection was performed under general anesthesia using a conventional procedure. The resected tumor measured 23 × 14 mm and was adjacent to the EGM. Histologically, the tumor cells showed moderately well-differentiated adenocarcinoma confined to the muscularis mucosa with no lymphovascular infiltration. Immunohistochemically, the tumor cells were positive for intestinal markers, namely MUC2 and CD10, and negative for gastric markers, namely MUC5AC and MUC6. The patient had no post-endoscopy submucosal dissection stenosis and remained disease-free without local recurrence. EGM of the cervical esophagus develops from the columnar epithelium during embryonic development. There are few reports on endoscopic submucosal dissection for mucosal cancer. Of these, immunostaining was performed in three cases. All were positive for MUC5AC and MUC6 and negative for MUC2 and CD10. Usually, EGM shows gastric type epithelium, but occasional cases with intestinal metaplasia, which show positivity for MUC2 and CD10, have been reported. Therefore, we consider this to be an extremely rare case of esophageal adenocarcinoma arising from intestinal metaplasia within the EGM.
Language	English
Publishing date	2022-06-18
Publishing country	Australia
Document type	Case Reports
ISSN	2692-4609
ISSN (online)	2692-4609
DOI	10.1002/deo2.141
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Article ; Online: Predictors of severe submucosal fibrosis during endoscopic submucosal dissection in patients with ulcerative colitis: Retrospective cohort study.

Nishio, Masafumi / Hirasawa, Kingo / Saigusa, Yusuke / Atsusaka, Reo / Azuma, Daisuke / Ozeki, Yuichiro / Sawada, Atsushi / Ikeda, Ryosuke / Fukuchi, Takehide / Kobayashi, Ryosuke / Sato, Chiko / Ogashiwa, Tsuyoshi / Inayama, Yoshiaki / Kunisaki, Reiko / Maeda, Shin

Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society

2023 Volume 36, Issue 2, Page(s) 172–181

Abstract: Objectives: Severe submucosal fibrosis is a crucial technical difficulty encountered during endoscopic submucosal dissection (ESD) in patients with ulcerative colitis (UC). We aimed to identify predictors of severe submucosal fibrosis in patients with ... ...

Abstract	Objectives: Severe submucosal fibrosis is a crucial technical difficulty encountered during endoscopic submucosal dissection (ESD) in patients with ulcerative colitis (UC). We aimed to identify predictors of severe submucosal fibrosis in patients with UC. Methods: We retrospectively included 55 tumors resected using ESD from 48 consecutive patients with UC. We analyzed the clinicopathological characteristics and treatment outcomes between the F0/1 (none to mild submucosal fibrosis) group (n = 28) and F2 (severe submucosal fibrosis) group (n = 27). Results: No significant difference was found between the F0/1 and F2 groups in en bloc resection rate (100% vs. 96%, P = 0.49), the R0 resection rate (100% vs. 93%, P = 0.24), and the dissection speed (0.18 vs. 0.13 cm Conclusion: Long UC duration and scarring background mucosa were predictors of severe submucosal fibrosis associated with perforation during ESD.
MeSH term(s)	Humans ; Endoscopic Mucosal Resection/adverse effects ; Colitis, Ulcerative/surgery ; Colitis, Ulcerative/pathology ; Retrospective Studies ; Cicatrix/pathology ; Oral Submucous Fibrosis ; Risk Factors ; Fibrosis ; Colorectal Neoplasms/surgery ; Treatment Outcome
Language	English
Publishing date	2023-05-17
Publishing country	Australia
Document type	Journal Article
ZDB-ID	1171589-3
ISSN	1443-1661 ; 0915-5635
ISSN (online)	1443-1661
ISSN	0915-5635
DOI	10.1111/den.14570
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Zs.A 3854: Show issues

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Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
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ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Appropriate Preconception Corticosteroid-Free Remission Period in Pregnant Women With Ulcerative Colitis.

Ikeda, Aya / Kunisaki, Reiko / Aoki, Shigeru / Yaguchi, Katsuki / Madarame, Akira / Nishio, Masafumi / Ogashiwa, Tsuyoshi / Nakamori, Yoshinori / Kimura, Hideaki / Suzuki, Ryoichi / Saigusa, Yusuke / Maeda, Shin

Inflammatory bowel diseases

2023 Volume 30, Issue 5, Page(s) 726–734

Abstract: Background: In women with inflammatory bowel disease, at least 3 months of preconception corticosteroid-free remission (CFREM) is recommended by experts in current consensus statements. However, data are lacking on the appropriate preconception ... ...

Abstract	Background: In women with inflammatory bowel disease, at least 3 months of preconception corticosteroid-free remission (CFREM) is recommended by experts in current consensus statements. However, data are lacking on the appropriate preconception remission period. We investigated the appropriate preconception CFREM period in women with ulcerative colitis to reduce maternal disease activity and adverse pregnancy outcomes (ie, preterm birth, low birth weight, and small for gestational age). Methods: We retrospectively examined 141 pregnancies in women with ulcerative colitis at 2 institutions. We categorized the patients into 3 subgroups by their preconception CFREM period (≥3 months, >0 to <3 months, and non-CFREM). We also investigated disease activity during pregnancy and postpartum and adverse pregnancy outcomes in each group. Results: During pregnancy, the rate of active disease was significantly lower in the ≥3 months and >0 to <3 months CFREM groups compared with that in the non-CFREM group (P < .001 and P = .0257, respectively). Postpartum, the rate of active disease was significantly lower in the ≥3 months CFREM group compared with that in the non-CFREM group (P = .0087). The preconception CFREM period of ≥3 months was an independent inhibitory factor for active disease during pregnancy and postpartum (adjusted odds ratio, 0.15; P = .0035; and adjusted odds ratio, 0.33; P = .027, respectively). Adverse pregnancy outcomes were less common in the >3 months CFREM group compared with those in the other groups, but this difference was not significant. Conclusions: A preconception CFREM period of more than 3 months may be appropriate for better maternal and adverse pregnancy outcomes, as recommended in consensus statements.
MeSH term(s)	Humans ; Pregnancy ; Female ; Colitis, Ulcerative/drug therapy ; Retrospective Studies ; Adult ; Pregnancy Outcome ; Pregnancy Complications ; Remission Induction ; Preconception Care/methods ; Infant, Newborn ; Adrenal Cortex Hormones/therapeutic use ; Premature Birth ; Young Adult ; Postpartum Period
Chemical Substances	Adrenal Cortex Hormones
Language	English
Publishing date	2023-01-25
Publishing country	England
Document type	Journal Article ; Multicenter Study
ZDB-ID	1340971-2
ISSN	1536-4844 ; 1078-0998
ISSN (online)	1536-4844
ISSN	1078-0998
DOI	10.1093/ibd/izac270
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Article ; Online: To Be in Remission or in Corticosteroid-free Remission: That Is the Question for Women With Inflammatory Bowel Disease at Conception.

Kunisaki, Reiko / Ikeda, Aya / Yaguchi, Katsuki / Onishi, Misa / Shibui, Shunsuke / Nishida, Daisuke / Madarame, Akira / Toritani, Kenichiro / Nakamori, Yoshinori / Nishio, Masafumi / Ogashiwa, Tsuyoshi / Fujii, Ayako / Kimura, Hideaki / Suzuki, Ryoichi / Aoki, Shigeru / Maeda, Shin

Inflammatory bowel diseases

2023 Volume 29, Issue 6, Page(s) e20–e21

MeSH term(s)	Pregnancy ; Female ; Humans ; Colitis, Ulcerative ; Pregnant Women ; Inflammatory Bowel Diseases/drug therapy ; Crohn Disease ; Adrenal Cortex Hormones/therapeutic use
Chemical Substances	Adrenal Cortex Hormones
Language	English
Publishing date	2023-03-06
Publishing country	England
Document type	Editorial ; Comment
ZDB-ID	1340971-2
ISSN	1536-4844 ; 1078-0998
ISSN (online)	1536-4844
ISSN	1078-0998
DOI	10.1093/ibd/izad023
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