Article ; Online: Post-translational modifications of vimentin reflect different pathological processes associated with non-small cell lung cancer and chronic obstructive pulmonary disease.
2019 Volume 10, Issue 63, Page(s) 6829–6841
Abstract: Introduction: Vimentin has shown to be highly implicated in cancer initiation and progression. Vimentin is often a target of post-translational modifications (PTMs) which can be disease specific, thus targeting these specific modifications can be of ... ...
Abstract | Introduction: Vimentin has shown to be highly implicated in cancer initiation and progression. Vimentin is often a target of post-translational modifications (PTMs) which can be disease specific, thus targeting these specific modifications can be of high biomarker potential. In this study we set out to evaluate the biological relevance and serum biomarker potential of citrullinated vimentin (VICM) and non-citrullinated vimentin (VIM) in non-small cell lung cancer (NSCLC) and chronic obstructive pulmonary disease (COPD). Methods: A competitive ELISA targeting VIM was developed and quantified in serum from patients with NSCLC and COPD. VIM was compared with levels of VICM in the same indications. Results: VIM was significantly increased in NSCLC ( Conclusions: These findings suggest a biomarker potential of VIM in NSCLC. Our findings also indicate that PTMs of vimentin are highly relevant and that targeting these modifications can have differential biomarker potential. |
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Language | English |
Publishing date | 2019-11-26 |
Publishing country | United States |
Document type | Journal Article |
ZDB-ID | 2560162-3 |
ISSN | 1949-2553 ; 1949-2553 |
ISSN (online) | 1949-2553 |
ISSN | 1949-2553 |
DOI | 10.18632/oncotarget.27332 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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