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  1. Article: A fluorinated dialkoxide-based magnesium-ion electrolyte

    Herb, Jake T / Nist-Lund, Carl A / Arnold, Craig B

    Journal of materials chemistry A. 2017 May 3, v. 5, no. 17

    2017  

    Abstract: Efficient large scale electrochemical energy storage systems, such as those based on multivalent ions, are a prerequisite for the realization of intermittent renewable energy sources. From the perspectives of both cost and environmental concerns, it is ... ...

    Abstract Efficient large scale electrochemical energy storage systems, such as those based on multivalent ions, are a prerequisite for the realization of intermittent renewable energy sources. From the perspectives of both cost and environmental concerns, it is of critical importance that components of these systems are synthesized using sustainable chemical processes starting from their initial conception. Herein, we report on a fluorinated dialkoxide-based magnesium-ion electrolyte that is synthesized through an atom-efficient and scalable process without the use of any metal alkyls. The electrolyte composition results in high solution conductivity (4.77 mS cm−1 at 26.3 °C), low overpotentials, ca. 100% coulombic efficiency for electrodeposition/dissolution, and good performance in full battery cells using Chevrel phase Mo6S8.
    Keywords batteries ; electrochemistry ; energy ; green chemistry ; ions ; renewable energy sources ; sulfides
    Language English
    Dates of publication 2017-0503
    Size p. 7801-7805.
    Publishing place The Royal Society of Chemistry
    Document type Article
    ZDB-ID 2702232-8
    ISSN 2050-7496 ; 2050-7488
    ISSN (online) 2050-7496
    ISSN 2050-7488
    DOI 10.1039/c7ta01578j
    Database NAL-Catalogue (AGRICOLA)

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  2. Article ; Online: Publisher Correction: Improved TMC1 gene therapy restores hearing and balance in mice with genetic inner ear disorders.

    Nist-Lund, Carl A / Pan, Bifeng / Patterson, Amy / Asai, Yukako / Chen, Tianwen / Zhou, Wu / Zhu, Hong / Romero, Sandra / Resnik, Jennifer / Polley, Daniel B / Géléoc, Gwenaelle S / Holt, Jeffrey R

    Nature communications

    2019  Volume 10, Issue 1, Page(s) 734

    Abstract: The original version of this Article contained errors in Fig. 5. In panels i and j the three rightmost x-axis labels inadvertently read 'Tmc1' instead of 'Tmc2'. These errors have been corrected in both the PDF and HTML versions of the Article. ...

    Abstract The original version of this Article contained errors in Fig. 5. In panels i and j the three rightmost x-axis labels inadvertently read 'Tmc1' instead of 'Tmc2'. These errors have been corrected in both the PDF and HTML versions of the Article.
    Language English
    Publishing date 2019-02-08
    Publishing country England
    Document type Journal Article ; Published Erratum
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-019-08716-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Improved TMC1 gene therapy restores hearing and balance in mice with genetic inner ear disorders.

    Nist-Lund, Carl A / Pan, Bifeng / Patterson, Amy / Asai, Yukako / Chen, Tianwen / Zhou, Wu / Zhu, Hong / Romero, Sandra / Resnik, Jennifer / Polley, Daniel B / Géléoc, Gwenaelle S / Holt, Jeffrey R

    Nature communications

    2019  Volume 10, Issue 1, Page(s) 236

    Abstract: Fifty percent of inner ear disorders are caused by genetic mutations. To develop treatments for genetic inner ear disorders, we designed gene replacement therapies using synthetic adeno-associated viral vectors to deliver the coding sequence for ... ...

    Abstract Fifty percent of inner ear disorders are caused by genetic mutations. To develop treatments for genetic inner ear disorders, we designed gene replacement therapies using synthetic adeno-associated viral vectors to deliver the coding sequence for Transmembrane Channel-Like (Tmc) 1 or 2 into sensory hair cells of mice with hearing and balance deficits due to mutations in Tmc1 and closely related Tmc2. Here we report restoration of function in inner and outer hair cells, enhanced hair cell survival, restoration of cochlear and vestibular function, restoration of neural responses in auditory cortex and recovery of behavioral responses to auditory and vestibular stimulation. Secondarily, we find that inner ear Tmc gene therapy restores breeding efficiency, litter survival and normal growth rates in mouse models of genetic inner ear dysfunction. Although challenges remain, the data suggest that Tmc gene therapy may be well suited for further development and perhaps translation to clinical application.
    MeSH term(s) Animals ; Deafness/genetics ; Deafness/therapy ; Genetic Predisposition to Disease ; Genetic Therapy/methods ; Hair Cells, Auditory/physiology ; Hair Cells, Vestibular/physiology ; Hearing Loss/genetics ; Hearing Loss/therapy ; Labyrinth Diseases/genetics ; Labyrinth Diseases/therapy ; Membrane Proteins/genetics ; Mice ; Mice, Mutant Strains
    Chemical Substances Membrane Proteins ; TMC1 protein, mouse
    Language English
    Publishing date 2019-01-22
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-018-08264-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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