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Article ; Online: CD36: The Bridge between Lipids and Tumors.

Zhou, Xuan / Su, Manman / Lu, Jungu / Li, Deming / Niu, Xinhui / Wang, Yi

2024 Volume 29, Issue 2

Abstract: It has been found that the development of some cancers can be attributed to obesity, which is associated with the excessive intake of lipids. Cancer cells undergo metabolic reprogramming, shifting from utilizing glucose to fatty acids (FAs) for energy. ... ...

Abstract	It has been found that the development of some cancers can be attributed to obesity, which is associated with the excessive intake of lipids. Cancer cells undergo metabolic reprogramming, shifting from utilizing glucose to fatty acids (FAs) for energy. CD36, a lipid transporter, is highly expressed in certain kinds of cancer cells. High expressions of CD36 in tumor cells triggers FA uptake and lipid accumulation, promoting rapid tumor growth and initiating metastasis. Meanwhile, immune cells in the tumor microenvironment overexpress CD36 and undergo metabolic reprogramming. CD36-mediated FA uptake leads to lipid accumulation and has immunosuppressive effects. This paper reviews the types of FAs associated with cancer, high expressions of CD36 that promote cancer development and progression, effects of CD36 on different immune cells in the tumor microenvironment, and the current status of CD36 as a therapeutic target for the treatment of tumors with high CD36 expression.
MeSH term(s)	Humans ; Neoplasms ; Fatty Acids/metabolism ; CD36 Antigens/genetics ; CD36 Antigens/metabolism ; Obesity ; Biological Transport ; Tumor Microenvironment
Chemical Substances	Fatty Acids ; CD36 Antigens
Language	English
Publishing date	2024-01-21
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules29020531
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Zs.MO 81: Show issues

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Article ; Online: Research Progress of Bioactive Components in

Lu, Jungu / Su, Manman / Zhou, Xuan / Li, Deming / Niu, Xinhui / Wang, Yi

Molecules (Basel, Switzerland)

2024 Volume 29, Issue 6

Abstract: The species ... ...

Abstract	The species in
MeSH term(s)	Animals ; Mice ; Basidiomycota/chemistry ; Agaricales/chemistry ; Antioxidants/pharmacology ; Phellinus ; Polyphenols
Chemical Substances	Antioxidants ; Polyphenols
Language	English
Publishing date	2024-03-07
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules29061195
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Article ; Online: Selective membrane wrapping on differently sized nanoparticles regulated by clathrin assembly: A computational model.

Li, Ye / Zhang, Man / Niu, Xinhui / Yue, Tongtao

Colloids and surfaces. B, Biointerfaces

2022 Volume 214, Page(s) 112467

Abstract: Nanoparticles (NPs) enter cells via multiple pathways, all of which are NP size dependent. Previous studies indicated that the clathrin-mediated endocytosis has different selectivity for the NP size, but the regulatory mechanism remains unclear and ... ...

Abstract	Nanoparticles (NPs) enter cells via multiple pathways, all of which are NP size dependent. Previous studies indicated that the clathrin-mediated endocytosis has different selectivity for the NP size, but the regulatory mechanism remains unclear and difficult to study at the molecular scale in vivo. By means of computer simulation, here we design membrane wrapping on differently sized NPs with mimic clathrin assembly at the opposite membrane side. With relatively large NPs readily wrapped by a pure membrane as manifested, clathrin modulates the process and tunes the size selectivity. Although finite curvature can be generated by cage-like clathrin assembly to facilitate membrane wrapping on relatively small NPs, the clathrin assemblage has a certain range of size, which is mismatched with larger NPs. Besides, the local membrane patch is rigidified by clathrin to increase the barrier of membrane wrapping on larger NPs. Competition of these items determines whether membrane wrapping on NPs is promoted or suppressed, and can be tuned by the NP-membrane adhesion strength, clathrin concentration, and inter-NP distance. Our results highlight the significance of complex environment in altering the nature of NP interaction with cell membranes, and are expected to help design NPs for biomedical applications requiring precise control of NP uptake or cell membrane attachment.
MeSH term(s)	Cell Membrane/metabolism ; Clathrin/metabolism ; Computer Simulation ; Endocytosis ; Nanoparticles/metabolism
Chemical Substances	Clathrin
Language	English
Publishing date	2022-03-18
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1500523-9
ISSN	1873-4367 ; 0927-7765
ISSN (online)	1873-4367
ISSN	0927-7765
DOI	10.1016/j.colsurfb.2022.112467
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Article: Selective membrane wrapping on differently sized nanoparticles regulated by clathrin assembly: a computational model

Li, Ye / Zhang, Man / Niu, Xinhui / Yue, Tongtao

Colloids and surfaces. 2022 Mar. 15,

2022

Abstract	Nanoparticles (NPs) enter cells via multiple pathways, all of which are NP size dependent. Previous studies indicated that the clathrin-mediated endocytosis has different selectivity for the NP size, but the regulatory mechanism remains unclear and difficult to study at the molecular scale in vivo. By means of computer simulation, here we design membrane wrapping on differently sized NPs with mimic clathrin assembly at the opposite membrane side. With relatively large NPs readily wrapped by a pure membrane as manifested, clathrin modulates the process and tunes the size selectivity. Although finite curvature can be generated by cage-like clathrin assembly to facilitate membrane wrapping on relatively small NPs, the clathrin assemblage has a certain range of size, which is mismatched with larger NPs. Besides, the local membrane patch is rigidified by clathrin to increase the barrier of membrane wrapping on larger NPs. Competition of these items determines whether membrane wrapping on NPs is promoted or suppressed, and can be tuned by the NP-membrane adhesion strength, clathrin concentration, and inter-NP distance. Our results highlight the significance of complex environment in altering the nature of NP interaction with cell membranes, and are expected to help design NPs for biomedical applications requiring precise control of NP uptake or cell membrane attachment.
Keywords	adhesion ; bioinformatics ; cell membranes ; clathrin ; computer simulation ; endocytosis
Language	English
Dates of publication	2022-0315
Publishing place	Elsevier B.V.
Document type	Article
Note	Pre-press version
ZDB-ID	1500523-9
ISSN	1873-4367 ; 0927-7765
ISSN (online)	1873-4367
ISSN	0927-7765
DOI	10.1016/j.colsurfb.2022.112467
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Article ; Online: ESR1

Liu, Junying / Yuan, Shouli / Niu, Xinhui / Kelleher, Robbie / Sheridan, Helen

Aging

2022 Volume 14, Issue 21, Page(s) 8595–8614

Abstract: Alzheimer's disease (AD) accounts for approximately 60% of dementia cases worldwide. Advanced age is the most significant risk factor for AD and approximately two-thirds of cases relate to women. While the previous meta-analysis suggests that estrogen ... ...

Abstract	Alzheimer's disease (AD) accounts for approximately 60% of dementia cases worldwide. Advanced age is the most significant risk factor for AD and approximately two-thirds of cases relate to women. While the previous meta-analysis suggests that estrogen receptor (ESR) genetic polymorphisms are closely associated with dementia, the implications of this observation on a molecular level are not entirely understood. Our study explores this intricate molecular puzzle through the use of a variety of bioinformatics tools. Initially, we attempted to elucidate mechanisms underlying breast cancer development by identifying the high-throughput dataset of
MeSH term(s)	Female ; Humans ; Alzheimer Disease/genetics ; Amyloid Precursor Protein Secretases ; Aspartic Acid Endopeptidases ; Breast Neoplasms ; Molecular Docking Simulation ; Neuroinflammatory Diseases ; Estrogen Receptor alpha/metabolism
Chemical Substances	Amyloid Precursor Protein Secretases (EC 3.4.-) ; Aspartic Acid Endopeptidases (EC 3.4.23.-) ; Estrogen Receptor alpha
Language	English
Publishing date	2022-11-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1945-4589
ISSN (online)	1945-4589
DOI	10.18632/aging.204359
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Article ; Online: A computational study of the influence of nanoparticle shape on clathrin-mediated endocytosis.

Li, Ye / Zhang, Man / Zhang, Yezhuo / Niu, Xinhui / Liu, Zhendan / Yue, Tongtao / Zhang, Wen

Journal of materials chemistry. B

2023 Volume 11, Issue 27, Page(s) 6319–6334

Abstract: Nanoparticles have been widely used in biomedical applications such as gene/drug delivery, molecular imaging and diagnostics. Among the physicochemical properties, shape is a vital design parameter for tuning the cell uptake of nanoparticles. However, ... ...

Abstract	Nanoparticles have been widely used in biomedical applications such as gene/drug delivery, molecular imaging and diagnostics. Among the physicochemical properties, shape is a vital design parameter for tuning the cell uptake of nanoparticles. However, the regulatory mechanism remains elusive due to the complexity of the cell membrane and multiple pathways of cell uptake. Therefore, in this computational study, we design and clarify cell membrane wrapping on different shaped nanoparticles (sphere, rod and disk) with a clathrin assembly to model the clathrin-mediated endocytosis, which is an important pathway of nanoparticle cell uptake. Our simulations revealed that the clathrin-mediated endocytosis is shape sensitive for nanoparticles. Spherical nanoparticles are easier to be wrapped by the membrane with the self-assembly of clathrins than the other shaped nanoparticles with the same volume, and the efficiency declines with the increase in the nanoparticle shape anisotropy. Furthermore, simulation results showed clear evidence that rotation is one of the typical characteristics determining the kinetics of clathrin-mediated endocytosis of shaped nanoparticles. Especially for rod nanoparticles with high aspect ratios, nanoparticle rotation occurs in both the invagination and wrapping stages, which is different from the case without clathrins. The size and shape mismatch between the clathrin-mediated vesicle and the nanoparticle determines how the nanoparticle rotates and is wrapped by the membrane. In addition, the wrapping time of nanoparticles depends not only on the shape of the nanoparticle but also on its initial orientation and size, the rate of clathrin self-assembly and the surface tension of the membrane. These results provide insights into the interplay between cell membrane wrapping and clathrin assembly, where the nanoparticle shape matters. Understanding the dynamics mechanism of clathrin-mediated endocytosis of nanoparticles will help to design targeted nanomedicines with an improved efficacy.
MeSH term(s)	Endocytosis ; Cell Membrane/chemistry ; Nanoparticles/chemistry ; Clathrin/analysis ; Clathrin/metabolism ; Computer Simulation
Chemical Substances	Clathrin
Language	English
Publishing date	2023-07-12
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2702241-9
ISSN	2050-7518 ; 2050-750X
ISSN (online)	2050-7518
ISSN	2050-750X
DOI	10.1039/d3tb00322a
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Article ; Online: Salinomycin-Loaded High-Density Lipoprotein Exerts Promising Anti-Ovarian Cancer Effects by Inhibiting Epithelial-Mesenchymal Transition.

Zou, Miao / Yin, Xirui / Zhou, Xuan / Niu, Xinhui / Wang, Yi / Su, Manman

International journal of nanomedicine

2022 Volume 17, Page(s) 4059–4071

Abstract: Background: Effective treatments for ovarian cancer remain elusive, and survival rates have long been considered grim. Ovarian cancer stem cells (OCSCs) and epithelial-mesenchymal transition (EMT) are associated with cancer progression and metastasis, ... ...

Abstract	Background: Effective treatments for ovarian cancer remain elusive, and survival rates have long been considered grim. Ovarian cancer stem cells (OCSCs) and epithelial-mesenchymal transition (EMT) are associated with cancer progression and metastasis, as well as drug resistance and eventual treatment failure. Salinomycin (Sal) has an extensive effect on a variety of cancer stem cells (CSCs); however, its poor water solubility and toxicity to healthy tissues at high doses limit further research into its potential as an anti-cancer drug. We proposed a therapeutic strategy by constructing a tumor-targeting carrier that mimics high-density lipoprotein (HDL) to synthesize salinomycin-loaded high-density lipoprotein (S-HDL). This strategy helps reduce the side effects of salinomycin, thereby improving its clinical benefits. Methods: OCSCs were isolated from ovarian cancer cells (OCCs) and the uptake of HDL nanoparticles was observed using laser confocal microscopes. After the cell viability analysis revealed the inhibitory effect of S-HDL on OCCs and OCSCs, the main biological processes influenced by S-HDL were predicted with a transcriptome sequencing analysis and verified in vitro and in vivo. Results: Cellular uptake analysis showed that the HDL delivery system was able to significantly enhance the uptake of Sal by OCCs, tentatively validating the targeting role of recombinant HDL, so that S-HDL could reduce the toxicity of Sal and increase its anti-ovarian cancer effects. Conversely, S-HDL could exert anti-ovarian cancer effects by inhibiting the proliferation of OCCs and OCSCs, promoting apoptosis, blocking EMT, and suppressing stemness and angiogenesis-related protein expression in vitro and in vivo. Conclusion: S-HDL had stronger anti-ovarian cancer effects than unencapsulated Sal. Thus, it may be a potential agent for ovarian cancer treatment in the future.
MeSH term(s)	Carcinoma, Ovarian Epithelial ; Cell Line, Tumor ; Epithelial-Mesenchymal Transition ; Female ; Humans ; Lipoproteins, HDL ; Ovarian Neoplasms/drug therapy ; Ovarian Neoplasms/pathology ; Pyrans
Chemical Substances	Lipoproteins, HDL ; Pyrans ; salinomycin (62UXS86T64)
Language	English
Publishing date	2022-09-08
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2364941-0
ISSN	1178-2013 ; 1176-9114
ISSN (online)	1178-2013
ISSN	1176-9114
DOI	10.2147/IJN.S380598
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Article ; Online: Genome-Wide Identification and Analysis of the

Liu, Xian / Liu, Zhiguo / Niu, Xinhui / Xu, Qian / Yang, Long

International journal of molecular sciences

2019 Volume 20, Issue 23

Abstract: NONEXPRESSOR OF PATHOGENESIS-RELATED GENES 1 (NPR1), and its paralogues NPR3 and NPR4, are bona fide salicylic acid (SA) receptors and play critical regulatory roles in plant immunity. However, comprehensive identification and analysis of ... ...

Abstract	NONEXPRESSOR OF PATHOGENESIS-RELATED GENES 1 (NPR1), and its paralogues NPR3 and NPR4, are bona fide salicylic acid (SA) receptors and play critical regulatory roles in plant immunity. However, comprehensive identification and analysis of the
MeSH term(s)	Amino Acids/genetics ; Bread ; Chromosomes, Plant/genetics ; Gene Expression Profiling/methods ; Gene Expression Regulation, Plant/genetics ; Genes, Plant/genetics ; Genome, Plant/genetics ; Genome-Wide Association Study/methods ; Multigene Family/genetics ; Phylogeny ; Plant Immunity/genetics ; Plant Proteins/genetics ; Promoter Regions, Genetic/genetics ; Stress, Physiological/genetics ; Transcriptome/genetics ; Triticum/genetics
Chemical Substances	Amino Acids ; Plant Proteins
Language	English
Publishing date	2019-11-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms20235974
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Article ; Online: The Molecular Mechanism of Multiple Organ Dysfunction and Targeted Intervention of COVID-19 Based on Time-Order Transcriptomic Analysis.

Zou, Miao / Su, Xiaoyun / Wang, Luoying / Yi, Xingcheng / Qiu, Yue / Yin, Xirui / Zhou, Xuan / Niu, Xinhui / Wang, Liuli / Su, Manman

Frontiers in immunology

2021 Volume 12, Page(s) 729776

Abstract: Coronavirus disease 2019 (COVID-19) pandemic is caused by the novel coronavirus that has spread rapidly around the world, leading to high mortality because of multiple organ dysfunction; however, its underlying molecular mechanism is unknown. To ... ...

Abstract	Coronavirus disease 2019 (COVID-19) pandemic is caused by the novel coronavirus that has spread rapidly around the world, leading to high mortality because of multiple organ dysfunction; however, its underlying molecular mechanism is unknown. To determine the molecular mechanism of multiple organ dysfunction, a bioinformatics analysis method based on a time-order gene co-expression network (TO-GCN) was performed. First, gene expression profiles were downloaded from the gene expression omnibus database (GSE161200), and a TO-GCN was constructed using the breadth-first search (BFS) algorithm to infer the pattern of changes in the different organs over time. Second, Gene Ontology enrichment analysis was used to analyze the main biological processes related to COVID-19. The initial gene modules for the immune response of different organs were defined as the research object. The STRING database was used to construct a protein-protein interaction network of immune genes in different organs. The PageRank algorithm was used to identify five hub genes in each organ. Finally, the Comparative Toxicogenomics Database played an important role in exploring the potential compounds that target the hub genes. The results showed that there were two types of biological processes: the body's stress response and cell-mediated immune response involving the lung, trachea, and olfactory bulb (olf) after being infected by COVID-19. However, a unique biological process related to the stress response is the regulation of neuronal signals in the brain. The stress response was heterogeneous among different organs. In the lung, the regulation of DNA morphology, angiogenesis, and mitochondrial-related energy metabolism are specific biological processes related to the stress response. In particular, an effect on tracheal stress response was made by the regulation of protein metabolism and rRNA metabolism-related biological processes, as biological processes. In the olf, the distinctive stress responses consist of neural signal transmission and brain behavior. In addition, myeloid leukocyte activation and myeloid leukocyte-mediated immunity in response to COVID-19 can lead to a cytokine storm. Immune genes such as
MeSH term(s)	Antiviral Agents/therapeutic use ; Brain/metabolism ; Brain/virology ; COVID-19/complications ; COVID-19/drug therapy ; COVID-19/genetics ; COVID-19/virology ; Gene Expression Profiling ; Gene Ontology ; Humans ; Lung/metabolism ; Lung/virology ; Multiple Organ Failure/drug therapy ; Multiple Organ Failure/etiology ; Multiple Organ Failure/genetics ; Multiple Organ Failure/metabolism ; Olfactory Bulb/metabolism ; Olfactory Bulb/virology ; Protein Interaction Maps ; SARS-CoV-2/physiology ; Trachea/metabolism ; Trachea/virology ; Transcriptome
Chemical Substances	Antiviral Agents
Language	English
Publishing date	2021-08-24
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2021.729776
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