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Article: [Global liver cancer incidence and mortality and future trends from 2000 to 2020: GLOBOCAN data analysis].

Wang, R H / Hu, M / Yang, Z Y / Niu, Z Y / Chen, H S / Zhou, X / Cao, G W

Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology

2023 Volume 31, Issue 3, Page(s) 271–280

Abstract: Objective: ...

Abstract	Objective:
MeSH term(s)	Humans ; Male ; Female ; Incidence ; Liver Neoplasms/epidemiology
Language	Chinese
Publishing date	2023-05-03
Publishing country	China
Document type	English Abstract ; Journal Article
ISSN	1007-3418
ISSN	1007-3418
DOI	10.3760/cma.j.cn501113-20221127-00579
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Article: [Analysis of endoscopic and pathological features of gastric adenomatous polyps and risk factors for canceration].

Niu, Z Y / Xue, Y / Zhang, J / Zhang, H J / Ding, S G

Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences

2021 Volume 53, Issue 6, Page(s) 1122–1127

Abstract: Objective: To investigate the endoscopic and pathological characteristics of gastric adenomatous polyps and to assess the potential risk factors for canceration of gastric adenomatous polyps.: Methods: The endoscopic and pathological characteristics ... ...

Abstract	Objective: To investigate the endoscopic and pathological characteristics of gastric adenomatous polyps and to assess the potential risk factors for canceration of gastric adenomatous polyps. Methods: The endoscopic and pathological characteristics of the patients with gastric adenomatous polyps from January 1, 2005 to December 31, 2019 were summarized retrospectively, and the risk factors of canceration were analyzed. Results: A total of 125 patients with gastric adenomatous polyps were included, 51.20% of whom were females. The average age was (66.7±12.3) years. 64.80% of patients with gastric adenomatous polyps equal or more than 65 years old, and only 5.60% of the patients less than 45 years old. Adenomatous polyps were mostly distributed in the corpus and antrum with 40.80% and 32.80%, respectively. The majority of them were single (90.40%) and sessile (76.81%). 65.4% of adenomatous polyps were no more than 1.0 cm in diameter, and 23.20% of patients with adenomatous polyps were combined with hyperplastic polyps and/or fundus glandular polyps, and 1.60% had both pathological types of polyps. 58.62% (17/29) patients with hyperplastic polyps and/or fundus glandular polyps had multiple polyps. 1.60% (2/125) of the patients had gastric neuroendocrine tumor of G1 stage. Synchronous gastric cancer was detected in 13.60% (17/125) of the patients with adenomatous polyps, and the proportion of low-grade intraepithelial neoplasia was 18.40% (23/125). The main types of synchronous gastric cancer were progressive (70.59%) and undifferentiated (66.67%). Chronic atrophic gastritis with intestinal metaplasia was found in 52.80% of the patients, and autoimmune gastritis accounted for 11.20%. The positive rate of Conclusion: The synchronous gastric cancer is common and the canceration of gastric adenomatous polyps is high with diameter and surface morphology as independent risk factors. We should pay attention to the identification of the pathological types of polyps and the evaluation of the whole gastric mucosa during the endoscopic examination.
MeSH term(s)	Adenomatous Polyps/epidemiology ; Aged ; Female ; Gastric Mucosa ; Humans ; Middle Aged ; Retrospective Studies ; Risk Factors ; Stomach Neoplasms/epidemiology
Language	Chinese
Publishing date	2021-12-16
Publishing country	China
Document type	Journal Article
ZDB-ID	2452593-5
ISSN	1671-167X
ISSN	1671-167X
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Article: [Kaposi sarcoma combined with severe ulcerative colitis: A case report and literature review].

Li, J / Niu, Z Y / Xue, Y / Shi, X Y / Zhang, B / Wang, Y

Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences

2020 Volume 52, Issue 2, Page(s) 373–377

Abstract: Kaposi's sarcoma (KS) is an unusual vascular tumor associated with human herpesvirus-8 (HHV-8) infection, which is common in immunosuppressors. Although extremely rare, iatrogenic (drug-related) KS can occur in human immunodeficiency virus (HIV)-negative ...

Abstract	Kaposi's sarcoma (KS) is an unusual vascular tumor associated with human herpesvirus-8 (HHV-8) infection, which is common in immunosuppressors. Although extremely rare, iatrogenic (drug-related) KS can occur in human immunodeficiency virus (HIV)-negative patients under immunosuppressive therapy. We report a 64-year-old male diagnosed with ulcerative colitis for 1 year. He was treated with methylprednisolone because of an acute severe disease flare. He presented with several popular violet lesions on the body 4 months after steroid therapy. Histological examination of skin biopsies showed Kaposi's sarcoma associated with HHV-8. The skin lesions regressed after steroid withdrawal and chemotherapy. Two key words "Kaposi's sarcoma" and "inflammatory bowel disease" were searched in Wanfang data and CNKI, but no relevant articles were found. Thirty-eight articles in English were retrieved on PubMed with the key words of ("ulcerative colitis" OR "Crohn's disease" OR "inflammatory bowel disease") AND (Kaposi sarcoma). Twenty-five cases of Kaposi's sarcoma related to inflammatory bowel disease (IBD) were reported. Including this case, the majority of 26 Kaposi's sarcoma related IBD patients were male (80.8%, 21/26). The average age was (51.1 ± 16.4) years. Twenty cases were ulcerative colitis and 6 were Crohn's disease. All the patients received immunomodulatory therapy, including glucocorticoid, azathioprine/mercaptopurine, methotrexate, cyclosporin and anti tumor necrosis factor α antibody. Thirteen cases were positive for HHV-8. There were 18 cases involving the distal ileum and colorectum only, 3 cases involving skin only, and 5 cases involving both skin and colorectum at the same time. Overall, the prognosis was good. Three patients only stopped immunosuppressive therapy, 1 received radiotherapy, 1 received chemotherapy, and 20 received surgery. Kaposi's sarcoma could be seen in IBD patients with immunomodulatory therapy. It is very important to distinguish from the skin lesions related to IBD or drug treatment. The adverse reactions of immunomodulatory therapy should not be ignored. In addition, attention should be paid to the cooperation of multi-disciplinary team, which can diagnose and treat rare cases earlier and more accurately.
MeSH term(s)	Adult ; Aged ; Colitis, Ulcerative ; Crohn Disease ; Herpesvirus 8, Human ; Humans ; Immunosuppression ; Male ; Middle Aged ; Sarcoma, Kaposi
Language	Chinese
Publishing date	2020-04-17
Publishing country	China
Document type	Case Reports ; Journal Article
ISSN	1671-167X
ISSN	1671-167X
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Article: [The drug resistance and evolution of Helicobacter pylori in adults of mainland China].

Niu, Z Y / Song, Z Q / Zhou, L Y

Zhonghua nei ke za zhi

2016 Volume 55, Issue 9, Page(s) 734–736

Language	Chinese
Publishing date	2016-09-01
Publishing country	China
Document type	Journal Article
ZDB-ID	754223-9
ISSN	0578-1426
ISSN	0578-1426
DOI	10.3760/cma.j.issn.0578-1426.2016.09.018
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Article: Dietary vitamin E improves meat quality and antioxidant capacity in broilers by upregulating the expression of antioxidant enzyme genes

Niu, Z. Y / Y. N. Min / F. Z. Liu

Journal of applied animal research. 2018 Jan. 1, v. 46, no. 1

2018

Abstract: A total of 240 one-day-old broiler chicks were divided into 3 treatments with 4 replicates of 20 birds. The birds were fed a corn–soybean meal diet supplemented with 0, 100, and 200 mg/kg vitamin E (VE), respectively. The results indicated that VE ... ...

Abstract	A total of 240 one-day-old broiler chicks were divided into 3 treatments with 4 replicates of 20 birds. The birds were fed a corn–soybean meal diet supplemented with 0, 100, and 200 mg/kg vitamin E (VE), respectively. The results indicated that VE supplementation led to a significant decrease in shear force (P < .05), and showed higher b* values and lower a* values (P < .05). Dietary supplementation with VE significantly increased VE concentration in serum compared to that in the control group (P < .05). Total antioxidant capacity activity in breast muscle or serum was increased with the increase in dietary VE supplementation in a dose-dependent manner (P < .05). Total superoxide dismutase (T-SOD) and glutathione peroxidase (GSH-Px) activity were linearly increased with the increase in dietary VE (P < .05), while malondialdehyde content decreased linearly (P < .05). The mRNA expression of SOD and GSH-Px in liver was linearly increased with the increase in dietary VE (P < .05). These findings suggest that dietary VE could increase meat quality by upregulating the expression of antioxidant enzyme genes in broilers.
Keywords	antioxidant activity ; antioxidants ; blood serum ; breast muscle ; broiler chickens ; broiler feeding ; dose response ; gene expression ; gene expression regulation ; genes ; glutathione peroxidase ; liver ; malondialdehyde ; meat quality ; messenger RNA ; superoxide dismutase ; vitamin E ; vitamin supplements
Language	English
Dates of publication	2018-0101
Size	p. 397-401.
Publishing place	Taylor & Francis
Document type	Article
ZDB-ID	1353626-6
ISSN	0974-1844 ; 0971-2119
ISSN (online)	0974-1844
ISSN	0971-2119
DOI	10.1080/09712119.2017.1309321
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Article: Effects of lysine deficiency or excess on growth and the expression of lipid metabolism genes in slow-growing broilers

Tian, D L / Chen, P P / Guo, R J / Li, Y M / Liu, F Z / Liu, R F / Min, Y N / Niu, Z Y / Wang, J J / Wang, Z P / Zi, B B

Poultry science. 2019 July 01, v. 98, no. 7

2019

Abstract: This experiment was conducted to evaluate the effects of lysine deficiency or excess on growth and the expression of lipid metabolism genes in slow-growing birds. A total of 360 one-day-old chicks were randomly divided into 3 groups, with 6 replicates of ...

Abstract	This experiment was conducted to evaluate the effects of lysine deficiency or excess on growth and the expression of lipid metabolism genes in slow-growing birds. A total of 360 one-day-old chicks were randomly divided into 3 groups, with 6 replicates of 20 birds each. The birds fed the basal diet with a total lysine 0.60% (LL), 1.00% (ML), or 1.40% (HL). The amount of lysine (ML) as the control group, LL and HL as the experimental group, the trial period last 3 wk. The results showed that compared with ML, LL significantly decreased average daily gain and average daily feed intake and remarkably increased feed conversion ratio of birds at 21 day old (P < 0.01), while the above indices in HL had no significant effects (P > 0.05). Besides, LL reduced the pectoral muscle rate (P < 0.01) and decreased the percentage of abdominal fat significantly (P < 0.05). In addition, compared with ML, the expression of fatty acid binding protein 1 (FABP1), acetyl-CoA carboxylase (ACC), malic enzyme (ME), and sterol regulatory element binding protein 1 (SREBP1c) mRNA of liver in LL was significantly decreased (P < 0.05), and the expression of cholesteryl ester transfer protein (CETP) mRNA was significantly increased (P < 0.01), whereas LL had no significant effects on the expression of peroxisome proliferator activated receptor alpha (PPARα) mRNA (P > 0.05). Moreover, compared with ML, HL significantly reduced the expression of FABP1, ACC, ME, SREBP-1c, and PPARα mRNA in the liver (P < 0.05), and had no significant effects on the expression of CETP mRNA (P > 0.05). The results of current research suggest that dietary lysine deficiency could reduce the growth and fat deposition of slow-growing broilers mainly by downregulating the expression of lipid synthesis genes.
Keywords	abdominal fat ; acetyl-CoA carboxylase ; average daily gain ; birds ; chicks ; cholesteryl ester transfer protein ; diet ; fatty acid-binding proteins ; feed conversion ; feed intake ; gene expression regulation ; genes ; lipid metabolism ; liver ; lysine ; malic enzyme ; messenger RNA ; muscles ; peroxisome proliferator-activated receptor alpha ; sterols
Language	English
Dates of publication	2019-0701
Size	p. 2927-2932.
Publishing place	Poultry Science Association, Inc.
Document type	Article
ZDB-ID	242586-5
ISSN	1525-3171 ; 0032-5791
ISSN (online)	1525-3171
ISSN	0032-5791
DOI	10.3382/ps/pez041
Database	NAL-Catalogue (AGRICOLA)

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Article: [Chemotherapy followed by allo-hematopoietic stem cell transplantation for the treatment of blastic plasmacytoid dendritic cell neoplasm: two case reports and literatures review].

Wen, S P / Wang, B Y / Xing, L N / Lu, X / Wang, F Y / Cheng, Z Y / Geng, L / Wang, Z Z / Niu, Z Y / Wang, Y / Wang, F X / Zhang, X J

Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi

2019 Volume 40, Issue 10, Page(s) 874–877

MeSH term(s)	Acute Disease ; Dendritic Cells ; Hematologic Neoplasms ; Hematopoietic Stem Cell Transplantation ; Humans ; Skin Neoplasms
Language	Chinese
Publishing date	2019-11-24
Publishing country	China
Document type	Case Reports ; Journal Article ; Review
ISSN	0253-2727
ISSN	0253-2727
DOI	10.3760/cma.j.issn.0253-2727.2019.10.017
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Article ; Online: Effects of lysine deficiency or excess on growth and the expression of lipid metabolism genes in slow-growing broilers.

Tian, D L / Guo, R J / Li, Y M / Chen, P P / Zi, B B / Wang, J J / Liu, R F / Min, Y N / Wang, Z P / Niu, Z Y / Liu, F Z

Poultry science

2019 Volume 98, Issue 7, Page(s) 2927–2932

Abstract	This experiment was conducted to evaluate the effects of lysine deficiency or excess on growth and the expression of lipid metabolism genes in slow-growing birds. A total of 360 one-day-old chicks were randomly divided into 3 groups, with 6 replicates of 20 birds each. The birds fed the basal diet with a total lysine 0.60% (LL), 1.00% (ML), or 1.40% (HL). The amount of lysine (ML) as the control group, LL and HL as the experimental group, the trial period last 3 wk. The results showed that compared with ML, LL significantly decreased average daily gain and average daily feed intake and remarkably increased feed conversion ratio of birds at 21 day old (P < 0.01), while the above indices in HL had no significant effects (P > 0.05). Besides, LL reduced the pectoral muscle rate (P < 0.01) and decreased the percentage of abdominal fat significantly (P < 0.05). In addition, compared with ML, the expression of fatty acid binding protein 1 (FABP1), acetyl-CoA carboxylase (ACC), malic enzyme (ME), and sterol regulatory element binding protein 1 (SREBP1c) mRNA of liver in LL was significantly decreased (P < 0.05), and the expression of cholesteryl ester transfer protein (CETP) mRNA was significantly increased (P < 0.01), whereas LL had no significant effects on the expression of peroxisome proliferator activated receptor alpha (PPARα) mRNA (P > 0.05). Moreover, compared with ML, HL significantly reduced the expression of FABP1, ACC, ME, SREBP-1c, and PPARα mRNA in the liver (P < 0.05), and had no significant effects on the expression of CETP mRNA (P > 0.05). The results of current research suggest that dietary lysine deficiency could reduce the growth and fat deposition of slow-growing broilers mainly by downregulating the expression of lipid synthesis genes.
MeSH term(s)	Animal Feed/analysis ; Animals ; Chickens/growth & development ; Diet/veterinary ; Gene Expression ; Lipid Metabolism/drug effects ; Lipid Metabolism/genetics ; Liver/drug effects ; Liver/metabolism ; Lysine/deficiency ; Lysine/pharmacology ; Random Allocation
Chemical Substances	Lysine (K3Z4F929H6)
Language	English
Publishing date	2019-02-12
Publishing country	England
Document type	Journal Article
ZDB-ID	242586-5
ISSN	1525-3171 ; 0032-5791
ISSN (online)	1525-3171
ISSN	0032-5791
DOI	10.3382/ps/pez041
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: [Effect of interleukin-1 beta on liver/bone/kidney alkaline phosphatase mRNA level of fibroblastic cells derived from human periodontal ligament].

Niu, Z Y

Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology

1993 Volume 28, Issue 2, Page(s) 73–4, 127

Abstract: The present study showed the effect of interleukin-1 beta (IL-1 beta) on liver/bone/kidney (L/B/K) alkaline phosphatase (ALP) mRNA level of the fibroblastic cells derived from human periodontal ligament (HPLF). The 5th to 10th passage of cultured HPLF ... ...

Abstract	The present study showed the effect of interleukin-1 beta (IL-1 beta) on liver/bone/kidney (L/B/K) alkaline phosphatase (ALP) mRNA level of the fibroblastic cells derived from human periodontal ligament (HPLF). The 5th to 10th passage of cultured HPLF were used. It was found that IL-1 beta significantly inhibited the gene expression of L/B/K ALP mRNA in the cells, and that the effect was dose-and incubation time-dependent. These results suggest that IL-1 beta may play a negative role in reparation of periodontium and periapical diseases.
MeSH term(s)	Adolescent ; Alkaline Phosphatase/biosynthesis ; Alkaline Phosphatase/genetics ; Cells, Cultured ; Child ; Fibroblasts/cytology ; Gene Expression Regulation, Enzymologic ; Humans ; Interleukin-1/pharmacology ; Periodontal Ligament/cytology ; RNA, Messenger/analysis
Chemical Substances	Interleukin-1 ; RNA, Messenger ; Alkaline Phosphatase (EC 3.1.3.1)
Language	Chinese
Publishing date	1993-03
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	1027950-7
ISSN	1002-0098
ISSN	1002-0098
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Vitamin E and vitamin C supplementation improves antioxidant status and immune function in oxidative-stressed breeder roosters by up-regulating expression of GSH-Px gene

Min, Y N / Chen, P P / Jiao, P X / Liu, F Z / Niu, Z Y / Sun, T T / Tian, D L / Wang, Z P / Zi, B B

Poultry science. 2018 Apr. 01, v. 97, no. 4

2018

Abstract: This study aimed to evaluate the effects of vitamin C and vitamin E on antioxidant capacity and immune function in oxidative-stressed breeder roosters. One hundred twenty 45-week-old Lveyang black-boned breeder roosters were randomly assigned to 5 ... ...

Abstract	This study aimed to evaluate the effects of vitamin C and vitamin E on antioxidant capacity and immune function in oxidative-stressed breeder roosters. One hundred twenty 45-week-old Lveyang black-boned breeder roosters were randomly assigned to 5 dietary treatments, including negative control group (NC), positive control group (PC), and 3 trial groups, which were fed the diets containing 300 mg/kg VC, 200 mg/kg VE, or 300 mg/kg VC and 200 mg/kg VE (VC+VE). At 47 wk of age, the positive control and trial groups were subcutaneously injected 3 times every other d with dexamethasone (DEX) 4 mg/kg of body weight, the negative control group was injected with saline. The experiment lasted for 35 d. The results showed that at 50 wk of age, average daily feed intake of birds challenged with DEX significantly increased (P < 0.05). During post-stress recovery period (52 wk of age), dietary supplemental VE or VC+VE notably increased body weight under oxidative stress (P < 0.01). Oxidative stress induced by DEX could significantly decrease superoxide dismutase (SOD), IgM, antibody titer of ND and mRNA expression of SOD or glutathion peroxidase activity (GSH-Px), increase serous malondialdehyde (MDA) (P < 0.05). Supplementation of VC or VE significantly decreased serous MDA, and increased SOD under oxidative stress (P < 0.05). Supplementation of VC or VE, or their combination significantly increased the relative expression of GSH-Px mRNA when compared to the oxidative-stressed control treatment (P < 0.05), whereas did not alleviate the relative expression of SOD mRNA (P > 0.05). Therefore, the results suggest that addition of 300 mg/kg VC, 200 mg/kg VE or their combination could improve antioxidant ability and immune performance in oxidative-stressed breeder roosters through up-regulating the expression of GSH-Px gene.
Keywords	antibodies ; antioxidant activity ; antioxidants ; ascorbic acid ; body weight ; dexamethasone ; diet ; enzyme activity ; feed intake ; gene expression ; gene expression regulation ; genes ; glutathione peroxidase ; immune response ; immunoglobulin M ; malondialdehyde ; messenger RNA ; oxidative stress ; peroxidase ; roosters ; superoxide dismutase ; vitamin E
Language	English
Dates of publication	2018-0401
Size	p. 1238-1244.
Publishing place	Poultry Science Association, Inc.
Document type	Article
ZDB-ID	242586-5
ISSN	1525-3171 ; 0032-5791
ISSN (online)	1525-3171
ISSN	0032-5791
DOI	10.3382/ps/pex417
Database	NAL-Catalogue (AGRICOLA)

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