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Article: Epidermoid cyst of the testis: A report of three cases.

Usui, Kimitsugu / Yamashita, Ryo / Sakura, Yuma / Nakamura, Masafumi / Shinsaka, Hideo / Matsuzaki, Masato / Niwakawa, Masashi

Clinical case reports

2024 Volume 12, Issue 4, Page(s) e8577

Abstract: Testicular epidermoid cysts have characteristic findings. Testicular tumor markers are negative in patients with epidermoid cysts. Clear margins and sole and small testicular tumors (20 mm or less) suggest the possibility of epidermoid cyst. Testicular- ... ...

Abstract	Testicular epidermoid cysts have characteristic findings. Testicular tumor markers are negative in patients with epidermoid cysts. Clear margins and sole and small testicular tumors (20 mm or less) suggest the possibility of epidermoid cyst. Testicular-sparing surgery with intraoperative frozen section examination should be performed when suspecting epidermoid cysts. Testicular epidermoid cysts are rare tumors that account for 1% of all testicular tumors and are often clinically misdiagnosed as malignant lesions. We report three cases of epidermoid cysts. The chief manifestations were scrotal induration in two patients and pruritus scrotum in one. The median age of the patients was 23 years (18-30). All tumors were determined to be sole lesions (<20 mm in diameter). Testing for tumor markers in all patients revealed negative results. We could not rule out malignancy; hence, we performed high inguinal orchiectomy in all cases. Histologically, the inner walls of the cysts were lined with stratified squamous epithelium; their contents were keratinized. All patients were diagnosed with epidermoid cysts.
Language	English
Publishing date	2024-03-31
Publishing country	England
Document type	Case Reports
ZDB-ID	2740234-4
ISSN	2050-0904
ISSN	2050-0904
DOI	10.1002/ccr3.8577
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Article ; Online: Effectiveness of adjuvant chemotherapy for patients who undergo radical cystectomy without neoadjuvant chemotherapy: A retrospective cohort study of 115 advanced bladder cancer patients with pathological lymph node classification.

Sakura, Yuma / Yamashita, Ryo / Notsu, Akifumi / Usui, Kimitsugu / Shinsaka, Hideo / Nakamura, Masafumi / Matsuzaki, Masato / Niwakawa, Masashi

International journal of urology : official journal of the Japanese Urological Association

2024

Abstract: Objectives: We investigated the clinical outcomes of radical cystectomy without cisplatin-based neoadjuvant chemotherapy (NAC) and identified factors affecting the effectiveness of cisplatin-based adjuvant chemotherapy (AC).: Methods: Between ... ...

Abstract	Objectives: We investigated the clinical outcomes of radical cystectomy without cisplatin-based neoadjuvant chemotherapy (NAC) and identified factors affecting the effectiveness of cisplatin-based adjuvant chemotherapy (AC). Methods: Between September 2002 and February 2020, 288 bladder cancer patients who did not receive NAC underwent radical cystectomy. We retrospectively analyzed the recurrence rates, primary recurrence sites, recurrence-free survival (RFS), and overall survival (OS) of 115 advanced bladder cancer patients (pT3-4 or pN1-3) who were divided into the AC and observation groups. Subgroup analysis was performed, focusing on pathological stage. Results: In total, 51 patients received AC, and 64 patients were observed. The median follow-up duration was 95 months. The recurrence rate was lower in the AC group than in the observation group (35.3% vs. 54.7%, p = 0.041). The rate of recurrences in the lymph node area (dissection site and proximal lymph nodes) was lower in the AC group (9.8% vs. 26.6%; p = 0.031). In the subgroup analysis of patients with pN1, the probability of RFS and OS was higher in the AC group than in the observation group. The hazard ratio for RFS and OS was 0.243 (95% confidence interval [CI]: 0.077-0.768) and 0.259 (95% CI: 0.082-0.816), respectively. The 5-year RFS and OS were significantly higher in the AC group (80.0% and 79.4%) than in the observation group (35.7% and 42.9%; p < 0.008 and p < 0.012, respectively). Conclusions: AC improved RFS and OS in patients with pN1 disease who did not receive NAC and should be considered for this population.
Language	English
Publishing date	2024-04-12
Publishing country	Australia
Document type	Journal Article
ZDB-ID	1328401-0
ISSN	1442-2042 ; 0919-8172
ISSN (online)	1442-2042
ISSN	0919-8172
DOI	10.1111/iju.15465
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Article: [Radiation therapy for locally advanced prostate cancer].

Niwakawa, Masashi

Nihon rinsho. Japanese journal of clinical medicine

2011 Volume 69 Suppl 5, Page(s) 424–426

MeSH term(s)	Chemotherapy, Adjuvant ; Gonadotropin-Releasing Hormone/therapeutic use ; Humans ; Male ; Prostatic Neoplasms/drug therapy ; Prostatic Neoplasms/radiotherapy
Chemical Substances	Gonadotropin-Releasing Hormone (33515-09-2)
Language	Japanese
Publishing date	2011-06
Publishing country	Japan
Document type	Journal Article ; Review
ZDB-ID	390903-7
ISSN	0047-1852
ISSN	0047-1852
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Zs.A 429: Show issues

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Article ; Online: [ANALYSIS OF THE ASSOCIATION BETWEEN IMMUNE-RELATED ADVERSE EVENTS AND THE EFFICACY OF PEMBROLIZUMAB IN PATIENTS WITH METASTATIC UROTHELIAL CARCINOMA].

Hashizume, Akihito / Yamashita, Ryo / Shinsaka, Hideo / Nakamura, Masafumi / Matsuzaki, Masato / Niwakawa, Masashi

Nihon Hinyokika Gakkai zasshi. The japanese journal of urology

2022 Volume 112, Issue 4, Page(s) 179–184

Abstract: Objectives) We evaluated the association between immune-related adverse events (irAEs) and the efficacy of pembrolizumab therapy in patients with metastatic urothelial carcinoma. (Methods) Data of 42 patients with metastatic urothelial carcinoma treated ...

Abstract	(Objectives) We evaluated the association between immune-related adverse events (irAEs) and the efficacy of pembrolizumab therapy in patients with metastatic urothelial carcinoma. (Methods) Data of 42 patients with metastatic urothelial carcinoma treated with pembrolizumab between May 2018 and February 2020 were retrospectively analyzed to determine the association between irAEs and objective response rate (ORR), progression-free survival (PFS), and overall survival (OS). (Results) IrAEs were observed in 19 patients (45.2%). Objective response was observed in 15 patients (35.7%). Thirteen (68.4%) of 19 patients who experienced irAEs showed an objective response, whereas two (8.70%) of 23 patients who did not experience irAEs (odds ratio: 15.0, 95% confidence interval [CI]: 1.70-738, P=0.006). PFS and OS in the irAE group were longer than those in the non-irAE group (PFS: hazard ratio: 0.24, 95% CI: 0.11-0.54, P<0.001; OS: hazard ratio: 0.11, 95% CI: 0.03-0.37, P<0.001). (Conclusions) During pembrolizumab treatment, the occurrence of irAEs was significantly associated with higher response and survival prolongation in patients with metastatic urothelial carcinoma.
Language	Japanese
Publishing date	2022-10-20
Publishing country	Japan
Document type	English Abstract ; Journal Article
ZDB-ID	958552-7
ISSN	1884-7110 ; 0021-5287 ; 0369-3988
ISSN (online)	1884-7110
ISSN	0021-5287 ; 0369-3988
DOI	10.5980/jpnjurol.112.179
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Zs.A 275: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 653: Show issues

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Article ; Online: The occurrence of high-grade complications after radical cystectomy worsens oncological outcomes in patients with bladder cancer.

Yamashita, Ryo / Nakamura, Masafumi / Notsu, Akifumi / Hashizume, Akihito / Shinsaka, Hideo / Matsuzazki, Masato / Niwakawa, Masashi

International urology and nephrology

2019 Volume 52, Issue 3, Page(s) 475–480

Abstract: Purpose: Reports frequently describe the worsening of oncologic outcome in patients who developed high-grade complications after curative surgery for esophageal, gastric, and breast cancers. We investigated the extent of this correlation in patients ... ...

Abstract	Purpose: Reports frequently describe the worsening of oncologic outcome in patients who developed high-grade complications after curative surgery for esophageal, gastric, and breast cancers. We investigated the extent of this correlation in patients with bladder cancer after radical cystectomy (RC). Methods: During 2002-2017, we performed 326 RC and urinary diversion procedures and collected data regarding complications in these patients within 90 days postoperatively. We evaluated the severity of complications based on the modified Clavien-Dindo classification (grades 0-5). Grade ≥ 3 complications were considered high grade. After adjusting for confounding factors using a Cox regression model, we calculated the hazard ratios (HRs) for high-grade complications associated with recurrence-free survival (RFS) and cancer-specific survival (CSS). Results: During a median follow-up period of 61 months, 38 patients (12%) developed high-grade complications (grade ≥ 3). The main causes (76%) of high-grade complications were gastrointestinal and infection problems. The RFS and CSS differed significantly between patients with high-grade complications and those without complications. After adjusting for confounding factors in the multivariate analysis, high-grade complications remained a significant risk factor for both RFS [HR 2.11; 95% confidence interval (CI) 1.07-4.15, p = 0.030] and CSS (HR 2.74; 95% CI 1.05-7.14, p = 0.039). Conclusions: High-grade complications after RC led to worse RFS and CSS outcomes, similar to those observed in patients with other cancers. A large-scale study is needed to further verify these findings, and discussions of knowledge and experiences are required to reduce the incidence of postoperative high-grade complications.
MeSH term(s)	Cystectomy/adverse effects ; Cystectomy/methods ; Cystectomy/statistics & numerical data ; Female ; Gastrointestinal Diseases/epidemiology ; Gastrointestinal Diseases/etiology ; Gastrointestinal Diseases/therapy ; Humans ; Infections/epidemiology ; Infections/etiology ; Infections/therapy ; Kaplan-Meier Estimate ; Male ; Middle Aged ; Postoperative Complications/diagnosis ; Postoperative Complications/epidemiology ; Postoperative Complications/therapy ; Prognosis ; Risk Assessment/methods ; Risk Factors ; Severity of Illness Index ; Treatment Outcome ; Urinary Bladder Neoplasms/pathology ; Urinary Bladder Neoplasms/surgery ; Urinary Diversion/methods
Language	English
Publishing date	2019-11-22
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	204048-7
ISSN	1573-2584 ; 0301-1623 ; 0042-1162
ISSN (online)	1573-2584
ISSN	0301-1623 ; 0042-1162
DOI	10.1007/s11255-019-02341-9
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Zs.A 733: Show issues

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Article ; Online: Radiotherapy combined with zoledronate can reduce skeletal-related events in renal cell carcinoma patients with bone metastasis.

Hosaka, Seiichi / Katagiri, Hirohisa / Niwakawa, Masashi / Harada, Hideyuki / Wasa, Junji / Murata, Hideki / Takahashi, Mitsuru

International journal of clinical oncology

2018 Volume 23, Issue 6, Page(s) 1127–1133

Abstract: Background: Skeletal-related events (SRE) are common in patients with renal cell carcinoma (RCC) that includes bone metastasis. The purpose of this study was to clarify the effectiveness of zoledronate with and without sunitinib, combined with ... ...

Abstract	Background: Skeletal-related events (SRE) are common in patients with renal cell carcinoma (RCC) that includes bone metastasis. The purpose of this study was to clarify the effectiveness of zoledronate with and without sunitinib, combined with radiotherapy, for the treatment of bone metastasis from RCC. Methods: We retrospectively analyzed 62 RCC patients with bone metastasis, who had been treated with radiotherapy at our institution. We divided the study cohort into two groups: patients treated with radiotherapy alone (RT; n = 27) and those treated with radiotherapy combined with zoledronate (RT + Z; n = 35). We investigated the overall survival and post-irradiation (PI)-SRE-free rate for each group, as well as the effect of sunitinib in the RT + Z treatment group. In addition, we determined treatment effectiveness by imaging assessments and relative response rates. Results: There was no significant difference in the survival rates between the RT and RT + Z treatment groups (p = 0.11). However, the PI-SRE-free rate in the RT + Z group was significantly higher than that in the RT group (p = 0.02). The PI-SRE-free rate was significantly higher in patients who were treated with sunitinib after radiotherapy than in those who were treated without sunitinib (p = 0.03). However, there was no significant difference in the relative response rates, as assessed by imaging, in each group. Conclusion: Radiotherapy combined with zoledronate is an effective treatment for RCC with bone metastasis to prevent PI-SRE. Sunitinib may reduce PI-SRE if used after radiotherapy and combined with zoledronate.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Bone Neoplasms/secondary ; Bone Neoplasms/therapy ; Carcinoma, Renal Cell/pathology ; Carcinoma, Renal Cell/therapy ; Chemoradiotherapy ; Female ; Fractures, Spontaneous/prevention & control ; Humans ; Kidney Neoplasms/pathology ; Kidney Neoplasms/therapy ; Male ; Middle Aged ; Retrospective Studies ; Spinal Cord Compression/prevention & control ; Sunitinib/administration & dosage ; Survival Rate ; Treatment Outcome ; Zoledronic Acid/administration & dosage
Chemical Substances	Zoledronic Acid (6XC1PAD3KF) ; Sunitinib (V99T50803M)
Language	English
Publishing date	2018-06-29
Publishing country	Japan
Document type	Journal Article
ZDB-ID	1400227-9
ISSN	1437-7772 ; 1341-9625
ISSN (online)	1437-7772
ISSN	1341-9625
DOI	10.1007/s10147-018-1310-7
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Zs.A 4828: Show issues

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Article ; Online: Bacillus Calmette-Guérin treatment of urothelial carcinoma arising in the ileal neobladder after radical cystectomy.

Yamashita, Ryo / Matsuzaki, Masato / Niwakawa, Masashi / Ito, Ichiro

International journal of urology : official journal of the Japanese Urological Association

2014 Volume 21, Issue 3, Page(s) 333–334

Abstract: In January 2005, a 66-year-old man underwent radical cystectomy and ileal neobladder reconstruction for invasive bladder cancer. A total of 3 years after the cystectomy, left-side ureteral cancer was diagnosed, and a nephroureterectomy was carried out in ...

Abstract	In January 2005, a 66-year-old man underwent radical cystectomy and ileal neobladder reconstruction for invasive bladder cancer. A total of 3 years after the cystectomy, left-side ureteral cancer was diagnosed, and a nephroureterectomy was carried out in May 2008. In October 2011, he complained of asymptomatic macroscopic hematuria. We detected multiple papillary pedunculated and broad-based tumors in the left side and the dome of the neobladder. The patient underwent transurethral resection of the bladder tumor, and a pathological diagnosis of high-grade pTa urothelial carcinoma was made. A total of 4 months later, tumors recurred in the right side and anterior wall of the neobladder. We carried out transurethral resection of the bladder tumor again; the pathological diagnosis was high-grade pTa urothelial carcinoma with carcinoma in situ. Bacillus Calmette-Guérin instillation was carried out seven times into the neobladder, without any severe side-effects. Tumor recurrence was not observed up to 8 months after bacillus Calmette-Guérin treatment.
MeSH term(s)	Adjuvants, Immunologic/therapeutic use ; Aged ; BCG Vaccine/therapeutic use ; Carcinoma, Transitional Cell/drug therapy ; Carcinoma, Transitional Cell/surgery ; Cystectomy ; Humans ; Ileum/transplantation ; Male ; Neoplasms, Second Primary/drug therapy ; Urinary Bladder/surgery ; Urinary Bladder Neoplasms/drug therapy ; Urinary Bladder Neoplasms/surgery ; Urinary Diversion
Chemical Substances	Adjuvants, Immunologic ; BCG Vaccine
Language	English
Publishing date	2014-03
Publishing country	Australia
Document type	Case Reports ; Journal Article
ZDB-ID	1328401-0
ISSN	1442-2042 ; 0919-8172
ISSN (online)	1442-2042
ISSN	0919-8172
DOI	10.1111/iju.12268
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Zs.MO 278: Show issues

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Article ; Online: Incidence and location of perioperative deep vein thrombosis in patients with bladder cancer undergoing radical cystectomy.

Yamashita, Ryo / Nakamura, Masafumi / Okayama, Yukiko / Kawase, Mizuki / Muraoka, Nao / Fujita, Ayano / Notsu, Akifumi / Asakura, Koiku / Hashizume, Akihito / Shinsaka, Hideo / Matsuzaki, Masato / Niwakawa, Masashi / Oya, Mototsugu

International journal of urology : official journal of the Japanese Urological Association

2021 Volume 29, Issue 3, Page(s) 259–264

Abstract: Objectives: To determine the incidence and location of lower extremity deep vein thrombosis in patients undergoing radical cystectomy.: Methods: We performed radical cystectomy in 137 patients with bladder cancer between August 2014 and February 2020. ...

Abstract	Objectives: To determine the incidence and location of lower extremity deep vein thrombosis in patients undergoing radical cystectomy. Methods: We performed radical cystectomy in 137 patients with bladder cancer between August 2014 and February 2020. Since 2014, we have had a policy to screen for deep vein thrombosis using lower extremity ultrasonography both before and after radical cystectomy. We determined the incidence and location of deep vein thrombosis and classified it as either proximal or distal type. Furthermore, we explored the incidence of pulmonary embolism within 3 months after radical cystectomy. Results: After excluding six patients with a lack of ultrasonographic data, we evaluated 131 patients. Preoperative deep vein thrombosis (one proximal and 17 distal) was diagnosed in 18 patients (14%) with no symptoms. Postoperative deep vein thrombosis was diagnosed in 41 patients (31%; three proximal and 38 distal), of whom 26 (63%) had new-onset deep vein thrombosis after cystectomy. Three patients, two with proximal and one with distal type deep vein thrombosis, developed nonfatal pulmonary embolism postoperatively. Multivariate analysis showed that preoperative D-dimer levels (odds ratio 5.35, 95% confidence interval 1.74-16.50; P < 0.003), type of urinary diversion (ileal neobladder; odds ratio 11.15, 95% confidence interval 2.16-57.55; P = 0.004), and preoperative deep vein thrombosis (odds ratio 15.93, 95% confidence interval 3.82-66.30; P < 0.001) were significant risk factors for postoperative deep vein thrombosis. Conclusions: Pre- and post-radical cystectomy whole-leg ultrasonography can lead to an early perioperative diagnosis and immediate treatment of proximal deep vein thrombosis, thereby potentially preventing fatal pulmonary embolism.
MeSH term(s)	Cystectomy/adverse effects ; Humans ; Incidence ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology ; Postoperative Complications/surgery ; Urinary Bladder Neoplasms/complications ; Urinary Diversion/adverse effects ; Venous Thrombosis/diagnostic imaging ; Venous Thrombosis/epidemiology ; Venous Thrombosis/etiology
Language	English
Publishing date	2021-12-09
Publishing country	Australia
Document type	Journal Article
ZDB-ID	1328401-0
ISSN	1442-2042 ; 0919-8172
ISSN (online)	1442-2042
ISSN	0919-8172
DOI	10.1111/iju.14760
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Zs.A 4460: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 278: Show issues

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Article ; Online: Comparison of clinical features between immune-related sclerosing cholangitis and hepatitis.

Takinami, Masaki / Ono, Akira / Kawabata, Takanori / Mamesaya, Nobuaki / Kobayashi, Haruki / Omori, Shota / Wakuda, Kazushige / Kenmotsu, Hirotsugu / Naito, Tateaki / Murakami, Haruyasu / Endo, Masahiro / Kiyohara, Yoshio / Yasui, Hirofumi / Niwakawa, Masashi / Takahashi, Toshiaki

Investigational new drugs

2021 Volume 39, Issue 6, Page(s) 1716–1723

Abstract: Background Immune-related hepatotoxicity is often regarded as immune-related hepatitis (irHepatitis) despite including immune-related sclerosing cholangitis (irSC). This study examined the clinical differences between irSC and irHepatitis. Methods A ... ...

Abstract	Background Immune-related hepatotoxicity is often regarded as immune-related hepatitis (irHepatitis) despite including immune-related sclerosing cholangitis (irSC). This study examined the clinical differences between irSC and irHepatitis. Methods A single-center retrospective study of 530 consecutive patients who received immunotherapy between August 2014 and April 2020 was performed. IrSC and irHepatitis were respectively defined as the radiological presence and absence of bile duct dilation and wall thickness. Results Forty-one patients (7.7%) developed immune-related hepatotoxicity. A CT scan was performed on 12 patients, including 11 of 12 with ≥ grade 3 aminotransferase elevations. IrSC and irHepatitis were diagnosed in 4 (0.8%) and 8 (1.5%) patients, respectively. All the irSC patients had been treated with anti-PD-1. IrHepatitis was more common among patients receiving anti-CTLA-4 than among those receiving anti-PD-1/PD-L1 inhibitors (14%, 7/50 vs. 0.2%, 1/480, P < 0.001). A ≥ grade 2 alkaline phosphatase (ALP) elevation resulting in a cholestatic pattern was seen in all 4 irSC patients. Among the irSC patients, 3 (3/4, 75%) developed ≥ grade 3 aminotransferases elevation. The median duration from the start of immunotherapy until ≥ grade 2 liver enzymes elevation was 257 and 55.5 days in irSC and irHepatitis patients. The median times for progression from grade 2 to 3 liver enzyme elevation were 17.5 and 0 days, respectively. Conclusions IrSC and irHepatitis have different characteristics in the class of immune checkpoint inhibitor and onset pattern. Radiological examination for the diagnosis of irSC should be considered for patients with ≥ grade 2 ALP elevation resulting in a cholestatic pattern. (Registration number J2020-36, Date of registration June 3, 2020).
MeSH term(s)	Aged ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Cholangitis, Sclerosing/chemically induced ; Cholangitis, Sclerosing/diagnostic imaging ; Cholangitis, Sclerosing/immunology ; Cholangitis, Sclerosing/pathology ; Female ; Hepatitis/diagnostic imaging ; Hepatitis/etiology ; Hepatitis/immunology ; Hepatitis/pathology ; Humans ; Immune Checkpoint Inhibitors/adverse effects ; Immune Checkpoint Inhibitors/therapeutic use ; Male ; Middle Aged ; Neoplasms/drug therapy ; Retrospective Studies ; Tomography, X-Ray Computed ; Transaminases/blood
Chemical Substances	Immune Checkpoint Inhibitors ; Transaminases (EC 2.6.1.-)
Language	English
Publishing date	2021-05-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	604895-x
ISSN	1573-0646 ; 0167-6997
ISSN (online)	1573-0646
ISSN	0167-6997
DOI	10.1007/s10637-021-01136-z
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Article ; Online: Impact of Mutations in Subunit Genes of the Mammalian SWI/SNF Complex on Immunological Tumor Microenvironment.

Hozumi, Chikako / Iizuka, Akira / Ikeya, Tomoatsu / Miyata, Haruo / Maeda, Chie / Ashizawa, Tadashi / Nagashima, Takeshi / Urakami, Kenichi / Shimoda, Yuji / Ohshima, Keiichi / Muramatsu, Koji / Sugino, Takashi / Shiomi, Akio / Ohde, Yasuhisa / Bando, Etsuro / Furukawa, Kenichiro / Sugiura, Teiichi / Mukaigawa, Takashi / Nishimura, Seiichiro /

Hirashima, Yasuyuki / Mitsuya, Koichi / Yoshikawa, Shusuke / Tsubosa, Yasuhiro / Katagiri, Hirohisa / Niwakawa, Masashi / Yamaguchi, Ken / Kenmotsu, Hirotsugu / Akiyama, Yasuto

Cancer genomics & proteomics

2023 Volume 21, Issue 1, Page(s) 88–101

Abstract: Background/aim: Recently, inactivating somatic mutations of SWI/SNF chromatin-remodeling genes in cancers have been reported. However, few studies have been performed regarding the immunological analysis of the tumor microenvironment (TME) in chromatin ... ...

Abstract	Background/aim: Recently, inactivating somatic mutations of SWI/SNF chromatin-remodeling genes in cancers have been reported. However, few studies have been performed regarding the immunological analysis of the tumor microenvironment (TME) in chromatin remodeling complex gene-mutated tumors. In the present study, we identified cancer patients harboring various mammalian SWI/SNF complex mutations and investigated the immunological features in those mutated cancers. Patients and methods: Cancer patients harboring any type of chromatin remodeling complex gene mutation were selected and clinicopathological features were compared between chromatin remodeling complex gene expression-low and expression-high groups. Specifically, expression levels of immune response-associated genes and cancer-associated genes were compared between the SMARCA4 expression-low and expression-high groups using volcano plot analysis. Results: Among cancers harboring PBRM1, SAMRACA4 and ARID2 gene mutations, T-cell marker and mature B-cell marker genes were up-regulated in the tumor. Specifically, T-cell effector genes (CD8B, CD40LG), central memory marker genes (CD27, CCR7) and mature B-cell marker genes (CD20, CD38, CD79 and IRF4) were up-regulated, and cancer-associated genes including MYB, MYC and AURKB genes were down-regulated in the SMARCA4 expression-low group. Remarkably, heatmap of gene expression and immunohistochemistry (IHC) data demonstrated that the tertiary lymphoid structure (TLS) gene signature of mature B cells was up-regulated in SMACA4 gene-mutated stomach cancers. Conclusion: These results suggest that immune tumor microenvironment status, such as mature B cell recruitment featuring the TLS gene signature and immune activation mediated by cancer signal down-regulation, might contribute to the classification of SMARCA4 gene-mutated tumors as immune checkpoint blockade therapy-sensitive target tumors.
MeSH term(s)	Animals ; Humans ; Tumor Microenvironment/genetics ; Mutation ; Neoplasms/genetics ; Mammals ; DNA Helicases/genetics ; Nuclear Proteins/genetics ; Transcription Factors/genetics
Chemical Substances	SMARCA4 protein, human (EC 3.6.1.-) ; DNA Helicases (EC 3.6.4.-) ; Nuclear Proteins ; Transcription Factors
Language	English
Publishing date	2023-10-27
Publishing country	Greece
Document type	Journal Article
ZDB-ID	2144517-5
ISSN	1790-6245 ; 1109-6535
ISSN (online)	1790-6245
ISSN	1109-6535
DOI	10.21873/cgp.20432
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In stock of ZB MED Cologne/Königswinter

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In stock of ZB MED Cologne/Königswinter

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In stock of ZB MED Cologne/Königswinter

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In stock of ZB MED Cologne/Königswinter

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In stock of ZB MED Cologne/Königswinter

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In stock of ZB MED Cologne/Königswinter

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In stock of ZB MED Cologne/Königswinter

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