Article: Whole-Genome Sequencing of a Colistin-Resistant
Antibiotics (Basel, Switzerland)
2022 Volume 11, Issue 5
Abstract: Background: Acinetobacter baumannii: Methods: An antimicrobial susceptibility test, conventional PCR, quantitative real-time PCR, phenotypic evaluation of the efflux pump, and whole-genome sequencing and analysis were performed on the isolate.: ... ...
| Abstract | Background: Acinetobacter baumannii Methods: An antimicrobial susceptibility test, conventional PCR, quantitative real-time PCR, phenotypic evaluation of the efflux pump, and whole-genome sequencing and analysis were performed on the isolate. Results: The antimicrobial susceptibility pattern revealed a resistance to piperacillin/tazobactam, ceftazidime, cefepime, cefotaxime/ceftriaxone, imipenem, meropenem, gentamycin, ciprofloxacin, trimethoprim/sulfamethoxazole, tigecycline, and colistin. A broth microdilution test confirmed the colistin resistance. Conventional PCR and quantitative real-time PCR investigations revealed the presence of Conclusions: The mosaic of the virulence factors coupled with the resistance-associated genes and the phenotypic resistance profile highlights the risk that this strain is at this South African tertiary health facility. |
|---|---|
| Language | English |
| Publishing date | 2022-04-28 |
| Publishing country | Switzerland |
| Document type | Journal Article |
| ZDB-ID | 2681345-2 |
| ISSN | 2079-6382 |
| ISSN | 2079-6382 |
| DOI | 10.3390/antibiotics11050594 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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