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  1. Article ; Online: Thrombolysis for ECMO oxygenator thrombosis.

    Taccone, Fabio Silvio / Nobile, Leda / Annoni, Filippo

    Critical care (London, England)

    2023  Volume 27, Issue 1, Page(s) 142

    MeSH term(s) Humans ; Extracorporeal Membrane Oxygenation ; Oxygenators ; Thrombosis/drug therapy ; Fibrinolysis ; Thrombolytic Therapy
    Language English
    Publishing date 2023-04-14
    Publishing country England
    Document type Letter
    ZDB-ID 2041406-7
    ISSN 1466-609X ; 1364-8535
    ISSN (online) 1466-609X
    ISSN 1364-8535
    DOI 10.1186/s13054-023-04433-6
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    Zs.A 5517: Show issues Location:
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  2. Article ; Online: Ketone Bodies after Cardiac Arrest: A Narrative Review and the Rationale for Use.

    Annoni, Filippo / Gouvea Bogossian, Elisa / Peluso, Lorenzo / Su, Fuhong / Moreau, Anthony / Nobile, Leda / Casu, Stefano Giuseppe / Sterchele, Elda Diletta / Calabro, Lorenzo / Salvagno, Michele / Oddo, Mauro / Taccone, Fabio Silvio

    Cells

    2024  Volume 13, Issue 9

    Abstract: Cardiac arrest survivors suffer the repercussions of anoxic brain injury, a critical factor influencing long-term prognosis. This injury is characterised by profound and enduring metabolic impairment. Ketone bodies, an alternative energetic resource in ... ...

    Abstract Cardiac arrest survivors suffer the repercussions of anoxic brain injury, a critical factor influencing long-term prognosis. This injury is characterised by profound and enduring metabolic impairment. Ketone bodies, an alternative energetic resource in physiological states such as exercise, fasting, and extended starvation, are avidly taken up and used by the brain. Both the ketogenic diet and exogenous ketone supplementation have been associated with neuroprotective effects across a spectrum of conditions. These include refractory epilepsy, neurodegenerative disorders, cognitive impairment, focal cerebral ischemia, and traumatic brain injuries. Beyond this, ketone bodies possess a plethora of attributes that appear to be particularly favourable after cardiac arrest. These encompass anti-inflammatory effects, the attenuation of oxidative stress, the improvement of mitochondrial function, a glucose-sparing effect, and the enhancement of cardiac function. The aim of this manuscript is to appraise pertinent scientific literature on the topic through a narrative review. We aim to encapsulate the existing evidence and underscore the potential therapeutic value of ketone bodies in the context of cardiac arrest to provide a rationale for their use in forthcoming translational research efforts.
    MeSH term(s) Ketone Bodies/metabolism ; Humans ; Heart Arrest/metabolism ; Animals ; Diet, Ketogenic
    Chemical Substances Ketone Bodies
    Language English
    Publishing date 2024-05-04
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells13090784
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  3. Article: Monocentric, Retrospective Study on Infectious Complications within One Year after Solid-Organ Transplantation at a Belgian University Hospital.

    Van Den Daele, Céline / Martiny, Delphine / Etienne, Isabelle / Kemlin, Delphine / Roussoulières, Ana / Sokolow, Youri / Germanova, Desislava / Gustot, Thierry / Nobile, Leda / Hites, Maya

    Microorganisms

    2024  Volume 12, Issue 4

    Abstract: The epidemiology, diagnostic methods and management of infectious complications after solid-organ transplantation (SOT) are evolving. The aim of our study is to describe current infectious complications in the year following SOT and risk factors for ... ...

    Abstract The epidemiology, diagnostic methods and management of infectious complications after solid-organ transplantation (SOT) are evolving. The aim of our study is to describe current infectious complications in the year following SOT and risk factors for their development and outcome. We conducted a retrospective study in adult SOT recipients in a Belgian university hospital between 2018 and 2019. We gathered demographic characteristics, comorbidities leading to transplantation, clinical, microbiological, surgery-specific and therapeutic data concerning infectious episodes, and survival status up to one year post-transplantation. Two-hundred-and-thirty-one SOT recipients were included (90 kidneys, 79 livers, 35 lungs, 19 hearts and 8 multiple organs). We observed 381 infections in 143 (62%) patients, due to bacteria (235 (62%)), viruses (67 (18%)), and fungi (32 (8%)). Patients presented a median of two (1-5) infections, and the first infection occurred during the first six months. Nineteen (8%) patients died, eleven (58%) due to infectious causes. Protective factors identified against developing infection were obesity [OR [IC]: 0.41 [0.19-0.89];
    Language English
    Publishing date 2024-04-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms12040755
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  4. Article ; Online: Belgian patients of the European Registry for Hidradenitis Suppurativa (ERHS-Be): data, scores and phenotypes since 2015.

    Heudens, Stephanie / Sarkis, Anne-Sophie / Daoud, Mathieu / Daxhelet, Mathilde / Benhadou, Farida / Suppa, Mariano / Nobile, Laura / Karama, Jalila / Njimi, Hassane / White, Jonathan M / Del Marmol, Veronique

    Dermatology (Basel, Switzerland)

    2024  

    Abstract: Introduction Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease, characterized by painful and recurrent lesions in apocrine gland-bearing skin areas. It is a heterogeneous disease, which makes assessment and data collection difficult. ... ...

    Abstract Introduction Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease, characterized by painful and recurrent lesions in apocrine gland-bearing skin areas. It is a heterogeneous disease, which makes assessment and data collection difficult. Questionnaires with detailed items, such as the Belgian European Registry for Hidradenitis Suppurativa (ERHS-Be), are useful to study HS and its associated comorbidities. The aim of this registry is to uncover new factors associated with HS, understand HS patients' clinical profiles and efficacy of treatments. Material and methods The ERHS-Be registry is based on questionnaires, with sections for socio-demographic data, medical and HS history, clinical examination and treatment plan. It allows identification of different clinical phenotypes and automatic calculation of severity scores. Results At present, 606 patients are included in the ERHS-Be (67% women, 33% men). Mean age at first visit is 38.5 years. Tobacco use is present in 72.6% of patients. A family history of HS is noted in 42% of patients. Comorbidities are documented in this cohort: depression is present in 43.8% of patients, arthritis in 27.8%, obesity in 31.5%, hypertension in 10.6%, diabetes mellitus in 6.4% and dyslipidemia in 12.4%. Moreover, 7.7% of patients suffer from IBD and 27.4% have a pilonidal sinus. History of severe acne is found in 32.1% of patients and psoriasis in 9.3%. Thirteen percent of women in our cohort suffer from polycystic ovarian syndrome. Severity of disease is quantified in 533 patients: for instance, Hurley I, II and III scores proportions are respectively 32.3%, 52.7% and 15%, while the mean IHS4 score is 5.2. This registry also enables determination of relative phenotype proportions in our cohort, according to different classifications. Conclusion The ERHS-Be questionnaires allow systematic and larger data collection, including detailed comorbidities, phenotypes and severity of disease. Analysis of this large database will contribute to a better understanding and management of HS, at a time where new therapeutic options are becoming available.
    Language English
    Publishing date 2024-04-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1099692-8
    ISSN 1421-9832 ; 1018-8665
    ISSN (online) 1421-9832
    ISSN 1018-8665
    DOI 10.1159/000538804
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  5. Article ; Online: Drug reaction with eosinophilia and systemic symptoms syndrome in a patient with COVID-19.

    Herman, A / Matthews, M / Mairlot, M / Nobile, L / Fameree, L / Jacquet, L-M / Baeck, M

    Journal of the European Academy of Dermatology and Venereology : JEADV

    2020  Volume 34, Issue 12, Page(s) e768–e700

    MeSH term(s) COVID-19/complications ; Drug Hypersensitivity Syndrome/etiology ; Humans ; Male ; Middle Aged
    Keywords covid19
    Language English
    Publishing date 2020-08-13
    Publishing country England
    Document type Case Reports ; Letter
    ZDB-ID 1128828-0
    ISSN 1468-3083 ; 0926-9959
    ISSN (online) 1468-3083
    ISSN 0926-9959
    DOI 10.1111/jdv.16838
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    Zs.A 3492: Show issues Location:
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    Zs.MO 413: Show issues

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  6. Article ; Online: A practical approach to the use of targeted temperature management after cardiac arrest.

    Annoni, Filippo / Donadello, Katia / Nobile, Leda / Taccone, Fabio S

    Minerva anestesiologica

    2020  Volume 86, Issue 10, Page(s) 1103–1110

    Abstract: Among comatose survivors after cardiac arrest, target temperature management (TTM) is considered the most effective treatment to reduce the consequences of postanoxic brain injury. Several international guidelines have thus incorporated TTM in the ... ...

    Abstract Among comatose survivors after cardiac arrest, target temperature management (TTM) is considered the most effective treatment to reduce the consequences of postanoxic brain injury. Several international guidelines have thus incorporated TTM in the management of the postresuscitation phase. However, despite extremely promising results in animal models and in randomized trials including selected patient cohorts, TTM benefits on neurological outcome have been questioned. Moreover, TTM potential side effects have raised some concerns on its wide application in all cardiac arrest patients in different healthcare systems. There is indeed still relatively large uncertainty concerning some practical aspects related to TTM application, such as: A) how to select patients who will benefit the most from TTM; B) the optimal time to initiate TTM; C) the best target temperature; D) the most effective methods to provide TTM; E) the length of the cooling phase; and F) the optimal rewarming rate and fever control strategies. The purpose of this manuscript is to review and discuss the most recent advances in TTM use after cardiac arrest and to give some proposals on how to deal with all these relevant practical questions.
    MeSH term(s) Body Temperature ; Coma ; Heart Arrest/therapy ; Humans ; Hypothermia, Induced ; Rewarming ; Treatment Outcome
    Language English
    Publishing date 2020-05-28
    Publishing country Italy
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 123584-9
    ISSN 1827-1596 ; 0026-4717 ; 0375-9393
    ISSN (online) 1827-1596
    ISSN 0026-4717 ; 0375-9393
    DOI 10.23736/S0375-9393.20.14399-2
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    Zs.A 516: Show issues Location:
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    Zs.MO 192: Show issues

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  7. Book: Democrazie senza futuro

    Nobile, Liliana

    la riflessione politica di Derrida e di Rorty

    (Filosofie ; 222)

    2012  

    Author's details Liliana Nobile
    Series title Filosofie ; 222
    Keywords Democracy/History ; Democracy/Philosophy
    Language Italian
    Size 119 S., 21 cm
    Publisher Mimesis
    Publishing place Milano etc.
    Document type Book
    Note Includes bibliographical references ; Jacques Derrida (1930- 2004); Richard Rorty (1931-2007), philosophers
    ISBN 9788857514338 ; 8857514331
    Database Former special subject collection: coastal and deep sea fishing

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  8. Article ; Online: Osteomielitis crónica multifocal recurrente: caso clínico pediátrico.

    Battaglioni, Cristina G / Rispolo Klubek, Daniela / Nobile, Luis

    Archivos argentinos de pediatria

    2018  Volume 116, Issue 5, Page(s) e679–e683

    Abstract: Chronic recurrent multifocal osteomyelitis has recently been classified as an autoinflammatory disorder characterized by episodes of systemic inflammation including serological signs of inflammation occurring in the absence of autoantibodies or pathogen ... ...

    Title translation Chronic recurrent multifocal osteomyelitis: pediatric clinical case.
    Abstract Chronic recurrent multifocal osteomyelitis has recently been classified as an autoinflammatory disorder characterized by episodes of systemic inflammation including serological signs of inflammation occurring in the absence of autoantibodies or pathogen agents. The insidious onset of pain with swelling and tenderness localized over the affected bones are the main manifestations. The metaphysis and epiphyses of the long bones, clavicle and vertebrae are affected. We report a male patient aged 2 years and 2 months with osteomyelitis with lytic destruction in two different single sites with a year difference between the episodes. Histological examination of the bone showed inflammation and chronic osteomyelitis, excluding the existence of infectious osteomyelitis, neoplasm and myeloproliferative disease. Clinical symptoms improved under treatment with nonsteroidal anti-inflammatory drugs. Considering chronic recurrent multifocal osteomyelitis may shorten time to diagnosis in order to avoid potentially unnecessary prolonged courses of intravenous antibiotics, complementary studies and multiple biopsies.
    MeSH term(s) Anti-Inflammatory Agents, Non-Steroidal/therapeutic use ; Child, Preschool ; Diagnosis, Differential ; Humans ; Inflammation/diagnosis ; Inflammation/drug therapy ; Inflammation/pathology ; Male ; Osteomyelitis/diagnosis ; Osteomyelitis/drug therapy ; Osteomyelitis/pathology ; Time Factors ; Treatment Outcome
    Chemical Substances Anti-Inflammatory Agents, Non-Steroidal
    Language Spanish
    Publishing date 2018-09-08
    Publishing country Argentina
    Document type Case Reports ; Journal Article
    ZDB-ID 424449-7
    ISSN 1668-3501 ; 0325-0075 ; 0004-0487
    ISSN (online) 1668-3501
    ISSN 0325-0075 ; 0004-0487
    DOI 10.5546/aap.2018.e679
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  9. Article: Safety and Effectiveness of Carbon Dioxide Removal CO2RESET Device in Critically Ill Patients.

    Taccone, Fabio Silvio / Rinaldi, Simone / Annoni, Filippo / Nobile, Leda / Di Nardo, Matteo / Maccieri, Jessica / Aliberti, Anna / Malfertheiner, Maximilan Valentin / Marudi, Andrea / Broman, Lars Mikael / Belliato, Mirko

    Membranes

    2023  Volume 13, Issue 7

    Abstract: Background: In this retrospective study, we report the effectiveness and safety of a dedicated extracorporeal carbon dioxide removal (ECCO: Methods: Adult patients on mechanical ventilation due to acute respiratory distress syndrome (ARDS) or ... ...

    Abstract Background: In this retrospective study, we report the effectiveness and safety of a dedicated extracorporeal carbon dioxide removal (ECCO
    Methods: Adult patients on mechanical ventilation due to acute respiratory distress syndrome (ARDS) or decompensated chronic obstructive pulmonary disease (dCOPD), who were treated with a dedicated ECCO
    Results: Over a three-year period, 11 patients received ECCO
    Conclusions: In this study, a dedicated ECCO
    Language English
    Publishing date 2023-07-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2614641-1
    ISSN 2077-0375
    ISSN 2077-0375
    DOI 10.3390/membranes13070686
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  10. Article ; Online: The effect of increased positive end expiratory pressure on brain tissue oxygenation and intracranial pressure in acute brain injury patients.

    Gouvea Bogossian, Elisa / Cantos, Joaquin / Farinella, Anita / Nobile, Leda / Njimi, Hassane / Coppalini, Giacomo / Diosdado, Alberto / Salvagno, Michele / Oliveira Gomes, Fernando / Schuind, Sophie / Anderloni, Marco / Robba, Chiara / Taccone, Fabio Silvio

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 16657

    Abstract: Cerebral hypoxia is an important cause of secondary brain injury. Improving systemic oxygenation may increase brain tissue oxygenation ( ... ...

    Abstract Cerebral hypoxia is an important cause of secondary brain injury. Improving systemic oxygenation may increase brain tissue oxygenation (PbtO
    MeSH term(s) Humans ; Intracranial Pressure/physiology ; Retrospective Studies ; Brain Injuries/therapy ; Brain Injuries/complications ; Brain ; Positive-Pressure Respiration ; Oxygen
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2023-10-03
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-43703-9
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