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  1. Article: Challenges and complexities in evaluating severe acute respiratory syndrome coronavirus 2 molecular diagnostics during the COVID-19 pandemic.

    Scott, Lesley E / Noble, Lara D / Singh-Moodley, Ashika / Kahamba, Trish / Hardie, Diana R / Preiser, Wolfgang / Stevens, Wendy S

    African journal of laboratory medicine

    2022  Volume 11, Issue 1, Page(s) 1429

    Language English
    Publishing date 2022-04-26
    Publishing country South Africa
    Document type Journal Article
    ZDB-ID 2708535-1
    ISSN 2225-2010 ; 2225-2002
    ISSN (online) 2225-2010
    ISSN 2225-2002
    DOI 10.4102/ajlm.v11i1.1429
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Evaluation of the Abbott m2000 RealTime human immunodeficiency virus type 1 (HIV-1) assay for HIV load monitoring in South Africa compared to the Roche Cobas AmpliPrep-Cobas Amplicor, Roche Cobas AmpliPrep-Cobas TaqMan HIV-1, and BioMerieux NucliSENS EasyQ HIV-1 assays.

    Scott, Lesley E / Noble, Lara D / Moloi, Jackie / Erasmus, Linda / Venter, Willem D F / Stevens, Wendy

    Journal of clinical microbiology

    2009  Volume 47, Issue 7, Page(s) 2209–2217

    Abstract: The implementation of antiretroviral therapy demands the need for increased access to viral load (VL) monitoring. Newer real-time VL testing technologies are faster and have larger dynamic ranges and fully automated extraction to benefit higher ... ...

    Abstract The implementation of antiretroviral therapy demands the need for increased access to viral load (VL) monitoring. Newer real-time VL testing technologies are faster and have larger dynamic ranges and fully automated extraction to benefit higher throughputs in resource-poor environments. The Abbott RealTime human immunodeficiency virus type 1 (HIV-1) assay was evaluated as a new option for testing for HIV-1 subtype C in South Africa, and its performance was compared to the performance of existing assays (the Cobas AmpliPrep-Cobas TaqMan HIV-1, version 1, assay; the AmpliPrep-Cobas Monitor standard HIV-1 assay; and the NucliSENS EasyQ-EasyMag HIV-1 assay) in a high-throughput laboratory. The total precision of the RealTime HIV-1 assay was acceptable over all viral load ranges. This assay compared most favorably with the Cobas AmpliPrep-Cobas TaqMan HIV-1 assay (R(2) = 0.904), with a low standard deviation of difference being detected (0.323 copies/ml). The bias against comparator assays ranged from -0.001 copies/ml to -0.228 copies/ml. Variability in the reporting of VLs for a 20-member subtype panel compared to the variability of other assays was noted with subtypes G and CRF02-AG. The RealTime HIV-1 assay can test 93 samples per day with minimal manual preparation, less staff, and the minimization of contamination through automation. This assay is suitable for HIV-1 subtype C VL quantification in South Africa.
    MeSH term(s) HIV Infections/virology ; HIV-1/isolation & purification ; Humans ; Molecular Diagnostic Techniques/methods ; Reagent Kits, Diagnostic ; South Africa ; Viral Load/methods
    Chemical Substances Reagent Kits, Diagnostic
    Language English
    Publishing date 2009-05-06
    Publishing country United States
    Document type Comparative Study ; Evaluation Study ; Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 390499-4
    ISSN 1098-660X ; 0095-1137
    ISSN (online) 1098-660X
    ISSN 0095-1137
    DOI 10.1128/JCM.01761-08
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1188: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Can oral fluid testing be used to replace blood-based HIV rapid testing to improve access to diagnosis in South Africa?

    Scott, Lesley E / Noble, Lara D / Langeveldt, Margaret / Jentsch, Ute / Francois Venter, Willem Daniel / Stevens, Wendy

    Journal of acquired immune deficiency syndromes (1999)

    2011  Volume 51, Issue 5, Page(s) 646–8; author reply 648–9

    MeSH term(s) AIDS Serodiagnosis/methods ; AIDS Serodiagnosis/statistics & numerical data ; Cohort Studies ; Developing Countries ; Enzyme-Linked Immunosorbent Assay ; HIV Infections/diagnosis ; HIV Infections/virology ; HIV-1/classification ; Health Services Accessibility ; Humans ; Saliva/virology ; Sensitivity and Specificity ; South Africa
    Language English
    Publishing date 2011-06-16
    Publishing country United States
    Document type Comparative Study ; Evaluation Study ; Letter ; Research Support, U.S. Gov't, Non-P.H.S. ; Comment
    ZDB-ID 645053-2
    ISSN 1944-7884 ; 1077-9450 ; 1525-4135 ; 0897-5965 ; 0894-9255
    ISSN (online) 1944-7884 ; 1077-9450
    ISSN 1525-4135 ; 0897-5965 ; 0894-9255
    DOI 10.1097/QAI.0b013e3181a448ac
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2442: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

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  4. Article: Evaluation of the Abbott m2000 RealTime Human Immunodeficiency Virus Type 1 (HIV-1) Assay for HIV Load Monitoring in South Africa Compared to the Roche Cobas AmpliPrep-Cobas Amplicor, Roche Cobas AmpliPrep-Cobas TaqMan HIV-1, and BioMerieux NucliSENS EasyQ HIV-1 Assays

    Scott, Lesley E / Noble, Lara D / Moloi, Jackie / Erasmus, Linda / Venter, Willem D.F / Stevens, Wendy

    Journal of clinical microbiology JCM. 2009 July, v. 47, no. 7

    2009  

    Abstract: The implementation of antiretroviral therapy demands the need for increased access to viral load (VL) monitoring. Newer real-time VL testing technologies are faster and have larger dynamic ranges and fully automated extraction to benefit higher ... ...

    Abstract The implementation of antiretroviral therapy demands the need for increased access to viral load (VL) monitoring. Newer real-time VL testing technologies are faster and have larger dynamic ranges and fully automated extraction to benefit higher throughputs in resource-poor environments. The Abbott RealTime human immunodeficiency virus type 1 (HIV-1) assay was evaluated as a new option for testing for HIV-1 subtype C in South Africa, and its performance was compared to the performance of existing assays (the Cobas AmpliPrep-Cobas TaqMan HIV-1, version 1, assay; the AmpliPrep-Cobas Monitor standard HIV-1 assay; and the NucliSENS EasyQ-EasyMag HIV-1 assay) in a high-throughput laboratory. The total precision of the RealTime HIV-1 assay was acceptable over all viral load ranges. This assay compared most favorably with the Cobas AmpliPrep-Cobas TaqMan HIV-1 assay (R² = 0.904), with a low standard deviation of difference being detected (0.323 copies/ml). The bias against comparator assays ranged from -0.001 copies/ml to -0.228 copies/ml. Variability in the reporting of VLs for a 20-member subtype panel compared to the variability of other assays was noted with subtypes G and CRF02-AG. The RealTime HIV-1 assay can test 93 samples per day with minimal manual preparation, less staff, and the minimization of contamination through automation. This assay is suitable for HIV-1 subtype C VL quantification in South Africa.
    Language English
    Dates of publication 2009-07
    Size p. 2209-2217.
    Publishing place American Society for Microbiology
    Document type Article
    ZDB-ID 390499-4
    ISSN 1098-660X ; 0095-1137
    ISSN (online) 1098-660X
    ISSN 0095-1137
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1188: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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