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  1. Article ; Online: Two Onnamide Analogs from the Marine Sponge Theonella conica

    Fumiaki Nakamura / Hiroshi Kimura / Nobuhiro Fusetani / Yoichi Nakao

    Molecules, Vol 28, Iss 2524, p

    Evaluation of Geometric Effects in the Polyene Systems on Biological Activity

    2023  Volume 2524

    Abstract: Two previously unreported onnamide analogs, 2 Z - and 6 Z -onnamides A ( 1 and 2 ), were isolated from the marine sponge Theonella conica collected at Amami-Oshima Is., Kagoshima Prefecture, Japan. Structures of compounds 1 and 2 were elucidated by ... ...

    Abstract Two previously unreported onnamide analogs, 2 Z - and 6 Z -onnamides A ( 1 and 2 ), were isolated from the marine sponge Theonella conica collected at Amami-Oshima Is., Kagoshima Prefecture, Japan. Structures of compounds 1 and 2 were elucidated by spectral analysis. Structure–activity relationships (SARs) for effects on histone modifications and cytotoxicity against HeLa and P388 cells were characterized. The geometry in the polyene systems of onnamides affected the histone modification levels and cytotoxicity.
    Keywords onnamides ; Theonella sp ; marine sponges ; histone modifications ; cytotoxicity ; marine natural products ; Organic chemistry ; QD241-441
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Marine Pharmacology in 2016–2017

    Alejandro M. S. Mayer / Aimee J. Guerrero / Abimael D. Rodríguez / Orazio Taglialatela-Scafati / Fumiaki Nakamura / Nobuhiro Fusetani

    Marine Drugs, Vol 19, Iss 2, p

    Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-Inflammatory, Antiprotozoal, Antituberculosis and Antiviral Activities; Affecting the Immune and Nervous Systems, and Other Miscellaneous Mechanisms of Action

    2021  Volume 49

    Abstract: The review of the 2016–2017 marine pharmacology literature was prepared in a manner similar as the 10 prior reviews of this series. Preclinical marine pharmacology research during 2016–2017 assessed 313 marine compounds with novel pharmacology reported ... ...

    Abstract The review of the 2016–2017 marine pharmacology literature was prepared in a manner similar as the 10 prior reviews of this series. Preclinical marine pharmacology research during 2016–2017 assessed 313 marine compounds with novel pharmacology reported by a growing number of investigators from 54 countries. The peer-reviewed literature reported antibacterial, antifungal, antiprotozoal, antituberculosis, and antiviral activities for 123 marine natural products, 111 marine compounds with antidiabetic and anti-inflammatory activities as well as affecting the immune and nervous system, while in contrast 79 marine compounds displayed miscellaneous mechanisms of action which upon further investigation may contribute to several pharmacological classes. Therefore, in 2016–2017, the preclinical marine natural product pharmacology pipeline generated both novel pharmacology as well as potentially new lead compounds for the growing clinical marine pharmaceutical pipeline, and thus sustained with its contributions the global research for novel and effective therapeutic strategies for multiple disease categories.
    Keywords drug ; marine ; sea ; chemical ; natural product ; pharmacology ; Biology (General) ; QH301-705.5
    Subject code 333
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Marine Pharmacology in 2012–2013

    Alejandro M. S. Mayer / Abimael D. Rodríguez / Orazio Taglialatela-Scafati / Nobuhiro Fusetani

    Marine Drugs, Vol 15, Iss 9, p

    Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-Inflammatory, Antiprotozoal, Antituberculosis, and Antiviral Activities; Affecting the Immune and Nervous Systems, and Other Miscellaneous Mechanisms of Action

    2017  Volume 273

    Abstract: The peer-reviewed marine pharmacology literature from 2012 to 2013 was systematically reviewed, consistent with the 1998–2011 reviews of this series. Marine pharmacology research from 2012 to 2013, conducted by scientists from 42 countries in addition to ...

    Abstract The peer-reviewed marine pharmacology literature from 2012 to 2013 was systematically reviewed, consistent with the 1998–2011 reviews of this series. Marine pharmacology research from 2012 to 2013, conducted by scientists from 42 countries in addition to the United States, reported findings on the preclinical pharmacology of 257 marine compounds. The preclinical pharmacology of compounds isolated from marine organisms revealed antibacterial, antifungal, antiprotozoal, antituberculosis, antiviral and anthelmitic pharmacological activities for 113 marine natural products. In addition, 75 marine compounds were reported to have antidiabetic and anti-inflammatory activities and affect the immune and nervous system. Finally, 69 marine compounds were shown to display miscellaneous mechanisms of action which could contribute to novel pharmacological classes. Thus, in 2012–2013, the preclinical marine natural product pharmacology pipeline provided novel pharmacology and lead compounds to the clinical marine pharmaceutical pipeline, and contributed significantly to potentially novel therapeutic approaches to several global disease categories.
    Keywords drug ; marine ; chemical ; metabolite ; natural product ; pharmacology ; pharmaceutical ; review ; toxicology ; pipeline ; Biology (General) ; QH301-705.5
    Subject code 333
    Language English
    Publishing date 2017-08-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article: Behavioral assay and chemical characters of female sex pheromones in the hermit crab Pagurus filholi

    Okamura, Saori / Takuma Kawaminami / Hiroshi Matsuura / Nobuhiro Fusetani / Seiji Goshima

    Journal of ethology. 2017 May, v. 35, no. 2

    2017  

    Abstract: Males of the hermit crab Pagurus filholi perform assessment behavior toward females, as a preliminary step of precopulatory guarding, during the reproductive season. It is known that such behavior is elicited by female sex pheromones, but the compounds ... ...

    Abstract Males of the hermit crab Pagurus filholi perform assessment behavior toward females, as a preliminary step of precopulatory guarding, during the reproductive season. It is known that such behavior is elicited by female sex pheromones, but the compounds involved have never been characterized in this species. Several experiments were conducted to develop a reliable bioassay along with purification procedures to identify potential compounds with pheromonal activity in Pagurus filholi. We developed a bioassay protocol to assess pheromonal activity by using an empty shell with cotton containing either artificial seawater (control) or test water. We measured and compared the time duration of male assessment behavior toward each shell if the test water contained female sex pheromones. Ultra-filtering of seawater samples potentially containing pheromones showed that the compound was <1 kDa in molecular weight. Males showed precopulatory assessment behavior toward “female conditioned” water samples treated with open column purification and eluted with MeOH, suggesting that compounds triggering male behavior were low polar molecules. Molecules with pheromonal activity were not volatile after freeze drying, effective even after heating to 90 °C, and remained active in seawater at 12 °C even after 6 days from sample collection, which suggests a rather stable characteristic of the female sex pheromones of this species.
    Keywords bioassays ; breeding season ; chemical elements ; cotton ; crabs ; females ; freeze drying ; males ; methanol ; molecular weight ; seawater ; sex pheromones
    Language English
    Dates of publication 2017-05
    Size p. 169-176.
    Publishing place Springer Japan
    Document type Article
    ZDB-ID 2020048-1
    ISSN 1439-5444 ; 0289-0771
    ISSN (online) 1439-5444
    ISSN 0289-0771
    DOI 10.1007/s10164-017-0507-y
    Database NAL-Catalogue (AGRICOLA)

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  5. Article ; Online: Marine Pharmacology in 2009–2011

    Nobuhiro Fusetani / Orazio Taglialatela-Scafati / Alejandro M. S. Mayer / Abimael D. Rodríguez

    Marine Drugs, Vol 11, Iss 7, Pp 2510-

    Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-Inflammatory, Antiprotozoal, Antituberculosis, and Antiviral Activities; Affecting the Immune and Nervous Systems, and other Miscellaneous Mechanisms of Action

    2013  Volume 2573

    Abstract: The peer-reviewed marine pharmacology literature from 2009 to 2011 is presented in this review, following the format used in the 1998–2008 reviews of this series. The pharmacology of structurally-characterized compounds isolated from marine animals, ... ...

    Abstract The peer-reviewed marine pharmacology literature from 2009 to 2011 is presented in this review, following the format used in the 1998–2008 reviews of this series. The pharmacology of structurally-characterized compounds isolated from marine animals, algae, fungi and bacteria is discussed in a comprehensive manner. Antibacterial, antifungal, antiprotozoal, antituberculosis, and antiviral pharmacological activities were reported for 102 marine natural products. Additionally, 60 marine compounds were observed to affect the immune and nervous system as well as possess antidiabetic and anti-inflammatory effects. Finally, 68 marine metabolites were shown to interact with a variety of receptors and molecular targets, and thus will probably contribute to multiple pharmacological classes upon further mechanism of action studies. Marine pharmacology during 2009–2011 remained a global enterprise, with researchers from 35 countries, and the United States, contributing to the preclinical pharmacology of 262 marine compounds which are part of the preclinical pharmaceutical pipeline. Continued pharmacological research with marine natural products will contribute to enhance the marine pharmaceutical clinical pipeline, which in 2013 consisted of 17 marine natural products, analogs or derivatives targeting a limited number of disease categories.
    Keywords drug ; marine ; chemical ; metabolite ; natural ; product ; pharmacology ; pharmaceutical ; review ; toxicology ; Biology (General) ; QH301-705.5
    Subject code 333
    Language English
    Publishing date 2013-07-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Identification of Renieramycin A as an Antileishmanial Substance in a Marine Sponge Neopetrosia sp.

    Yoichi Nakao / Takeru Shiroiwa / Shigeki Matsunaga / Shuhei Murayama / Yasuyuki Goto / Yoshitsugu Matsumoto / Nobuhiro Fusetani

    Marine Drugs, Vol 2, Iss 2, Pp 55-

    2004  Volume 62

    Abstract: Abstract: The newly developed assay system using recombinant Leishmania amazonensis expressing enhanced green fluorescent protein (La/egfp) has been applied to the screening of Japanese marine sponges for antileishmanial activity. Bioassay-guided ... ...

    Abstract Abstract: The newly developed assay system using recombinant Leishmania amazonensis expressing enhanced green fluorescent protein (La/egfp) has been applied to the screening of Japanese marine sponges for antileishmanial activity. Bioassay-guided fractionation of an active sponge Neopetrosia sp. afforded an active compound which was identified as renieramycin A by spectroscopic analysis. It inhibited La/egfp with an IC50 value of 0.2 μg/mL.
    Keywords leishmaniasis ; marine sponge ; renieramycin A ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2004-05-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Preliminary Structure-Activity Relationship on Theonellasterol, a New Chemotype of FXR Antagonist, from the Marine Sponge Theonella swinhoei

    Stefano Fiorucci / Nobuhiro Fusetani / Yoichi Nakao / Giuseppe Bifulco / Maria Giovanna Chini / Barbara Renga / Claudio D'Amore / Simona De Marino / Orazio Taglialatela-Scafati / Maria Valeria D'Auria / Valentina Sepe / Raffaella Ummarino / Angela Zampella

    Marine Drugs, Vol 10, Iss 11, Pp 2448-

    2012  Volume 2466

    Abstract: Using theonellasterol as a novel FXR antagonist hit, we prepared a series of semi-synthetic derivatives in order to gain insight into the structural requirements for exhibiting antagonistic activity. These derivatives are characterized by modification at ...

    Abstract Using theonellasterol as a novel FXR antagonist hit, we prepared a series of semi-synthetic derivatives in order to gain insight into the structural requirements for exhibiting antagonistic activity. These derivatives are characterized by modification at the exocyclic carbon-carbon double bond at C-4 and at the hydroxyl group at C-3 and were prepared from theonellasterol using simple reactions. Pharmacological investigation showed that the introduction of a hydroxyl group at C-4 as well as the oxidation at C-3 with or without concomitant modification at the exomethylene functionality preserve the ability of theonellasterol to inhibit FXR transactivation caused by CDCA. Docking analysis showed that the placement of these molecules in the FXR-LBD is well stabilized when on ring A functional groups, able to form hydrogen bonds and π interactions, are present.
    Keywords marine sponges ; Theonella swinhoei ; steroids ; theonellasterol ; nuclear receptors ; farnesoid-X-receptor ; chemical modification ; structure-activity relationship ; Biology (General) ; QH301-705.5
    Subject code 540
    Language English
    Publishing date 2012-11-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article: Identification of Renieramycin A as an Antileishmanial Substance in a Marine Sponge Neopetrosia sp.

    Yoichi Nakao / Takeru Shiroiwa / Shuhei Murayama / Shigeki Matsunaga / Yasuyuki Goto / Yoshitsugu Matsumoto / Nobuhiro Fusetani

    Abstract: Abstract: The newly developed assay system using recombinant Leishmania amazonensis expressing enhanced green fluorescent protein (La/egfp) has been applied to the screening of Japanese marine sponges for antileishmanial activity. Bioassay-guided ... ...

    Abstract Abstract: The newly developed assay system using recombinant Leishmania amazonensis expressing enhanced green fluorescent protein (La/egfp) has been applied to the screening of Japanese marine sponges for antileishmanial activity. Bioassay-guided fractionation of an active sponge Neopetrosia sp. afforded an active compound which was identified as renieramycin A by spectroscopic analysis. It inhibited La/egfp with an IC50 value of 0.2 μg/mL.
    Language English
    Document type Article
    Database AGRIS - International Information System for the Agricultural Sciences and Technology

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  9. Article: Preliminary Structure-Activity Relationship on Theonellasterol, a New Chemotype of FXR Antagonist, from the Marine Sponge Theonella swinhoei

    Valentina Sepe / Raffaella Ummarino / Maria Valeria D' / Auria / Orazio Taglialatela-Scafati / Simona De Marino / Claudio D' / Amore / Barbara Renga / Maria Giovanna Chini / Giuseppe Bifulco / Yoichi Nakao / Nobuhiro Fusetani / Stefano Fiorucci / Angela Zampella

    Abstract: Using theonellasterol as a novel FXR antagonist hit, we prepared a series of semi-synthetic derivatives in order to gain insight into the structural requirements for exhibiting antagonistic activity. These derivatives are characterized by modification at ...

    Abstract Using theonellasterol as a novel FXR antagonist hit, we prepared a series of semi-synthetic derivatives in order to gain insight into the structural requirements for exhibiting antagonistic activity. These derivatives are characterized by modification at the exocyclic carbon-carbon double bond at C-4 and at the hydroxyl group at C-3 and were prepared from theonellasterol using simple reactions. Pharmacological investigation showed that the introduction of a hydroxyl group at C-4 as well as the oxidation at C-3 with or without concomitant modification at the exomethylene functionality preserve the ability of theonellasterol to inhibit FXR transactivation caused by CDCA. Docking analysis showed that the placement of these molecules in the FXR-LBD is well stabilized when on ring A functional groups, able to form hydrogen bonds and π interactions, are present.
    Language English
    Document type Article
    Database AGRIS - International Information System for the Agricultural Sciences and Technology

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    Inter-library loan at ZB MED

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