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  1. AU="Noda, Haruna"
  2. AU="Raoul, Cédric"
  3. AU=Wissing Silke AU=Wissing Silke
  4. AU="Chun-Lin Yang"
  5. AU="Romine, Kyle A"
  6. AU="Cunsolo, Vincenzo"
  7. AU="Ba, Aboubacar"
  8. AU="Prisca, Mirandolina"
  9. AU="Perez, Tate"
  10. AU="Bakkaloglu, Sevan"
  11. AU="Guernieri, Rebecca L"
  12. AU="Xing, Z Y"
  13. AU="Yu-Heng Cheng"
  14. AU=Freeman Richard B Jr
  15. AU="Wang, Qi-En"
  16. AU="Mallamaci, M"
  17. AU="Turk, Yael R"
  18. AU="Tinto, Monica"
  19. AU="Selvendiran, Karuppaiyah" AU="Selvendiran, Karuppaiyah"
  20. AU="Enns, Murray W"
  21. AU="Yaohua Yang" AU="Yaohua Yang"

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  1. Artikel ; Online: The histone demethylase Utx controls CD8

    Noda, Haruna / Suzuki, Junpei / Matsuoka, Yuko / Matsumoto, Akira / Kuwahara, Makoto / Kamei, Yoshiaki / Takada, Yasutsugu / Yamashita, Masakatsu

    Cancer science

    2023  Band 114, Heft 7, Seite(n) 2787–2797

    Abstract: ... ...

    Abstract CD8
    Mesh-Begriff(e) Mice ; Animals ; CD8-Positive T-Lymphocytes/metabolism ; Epigenesis, Genetic ; Histone Demethylases/genetics ; Histone Demethylases/metabolism ; Gene Expression Regulation ; Histones/metabolism
    Chemische Substanzen Histone Demethylases (EC 1.14.11.-) ; Histones ; Utx protein, mouse (EC 1.14.11.-)
    Sprache Englisch
    Erscheinungsdatum 2023-04-17
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2115647-5
    ISSN 1349-7006 ; 1349-7006
    ISSN (online) 1349-7006
    ISSN 1349-7006
    DOI 10.1111/cas.15814
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Computer-Aided Detection of Quantitative Signatures for Breast Fibroepithelial Tumors Using Label-Free Multi-Photon Imaging.

    Kobayashi-Taguchi, Kana / Saitou, Takashi / Kamei, Yoshiaki / Murakami, Akari / Nishiyama, Kanako / Aoki, Reina / Kusakabe, Erina / Noda, Haruna / Yamashita, Michiko / Kitazawa, Riko / Imamura, Takeshi / Takada, Yasutsugu

    Molecules (Basel, Switzerland)

    2022  Band 27, Heft 10

    Abstract: Fibroadenomas (FAs) and phyllodes tumors (PTs) are major benign breast tumors, pathologically classified as fibroepithelial tumors. Although the clinical management of PTs differs from FAs, distinction by core needle biopsy diagnoses is still challenging. ...

    Abstract Fibroadenomas (FAs) and phyllodes tumors (PTs) are major benign breast tumors, pathologically classified as fibroepithelial tumors. Although the clinical management of PTs differs from FAs, distinction by core needle biopsy diagnoses is still challenging. Here, a combined technique of label-free imaging with multi-photon microscopy and artificial intelligence was applied to detect quantitative signatures that differentiate fibroepithelial lesions. Multi-photon excited autofluorescence and second harmonic generation (SHG) signals were detected in tissue sections. A pixel-wise semantic segmentation method using a deep learning framework was used to separate epithelial and stromal regions automatically. The epithelial to stromal area ratio and the collagen SHG signal strength were investigated for their ability to distinguish fibroepithelial lesions. An image segmentation analysis with a pixel-wise semantic segmentation framework using a deep convolutional neural network showed the accurate separation of epithelial and stromal regions. A further investigation, to determine if scoring the epithelial to stromal area ratio and the SHG signal strength within the stromal area could be a marker for differentiating fibroepithelial tumors, showed accurate classification. Therefore, molecular and morphological changes, detected through the assistance of computational and label-free multi-photon imaging techniques, enable us to propose quantitative signatures for epithelial and stromal alterations in breast tissues.
    Mesh-Begriff(e) Artificial Intelligence ; Breast Neoplasms/pathology ; Computers ; Diagnosis, Differential ; Female ; Fibroadenoma/diagnostic imaging ; Fibroadenoma/pathology ; Humans ; Neoplasms, Fibroepithelial/diagnosis
    Sprache Englisch
    Erscheinungsdatum 2022-05-23
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules27103340
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.MO 81: Hefte anzeigen

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  3. Artikel: Non-traumatic bilateral rectus sheath hematoma during septic disseminated intravascular coagulation.

    Taguchi, Kana / Kamei, Yoshiaki / Kusakabe, Erina / Yamashita, Michiko / Noda, Haruna / Aoki, Reina / Nishiyama, Kanako / Murakami, Akari / Tanaka, Hiroaki / Matsuda, Megumi / Kido, Teruhito / Sato, Norio / Takada, Yasutsugu

    Radiology case reports

    2022  Band 17, Heft 5, Seite(n) 1737–1740

    Abstract: A non-traumatic abdominal wall hematoma is rare, and occurs occasionally due to coughing, physical activity, or antithrombotic/anticoagulant therapy. The condition is usually unilateral; however, rare bilateral cases have been reported. Here, we report a ...

    Abstract A non-traumatic abdominal wall hematoma is rare, and occurs occasionally due to coughing, physical activity, or antithrombotic/anticoagulant therapy. The condition is usually unilateral; however, rare bilateral cases have been reported. Here, we report a rare case of a non-traumatic bilateral rectus sheath hematoma. The patient was a 60-year-old woman who was urgently admitted to our hospital due to the occurrence of pneumonia during postoperative chemotherapy for breast cancer. Because she exhibited disseminated intravascular coagulation, a therapy with antibacterial agents, thrombomodulin alpha, and catecholamines was initiated. During hospitalization, hemorrhagic shock due to hematomas in both rectus abdominis muscles was observed without any discernible cause. Subsequent emergency angioembolization was successful, and abdominal computed tomography performed 3 months after the onset of the rectus sheath hematoma confirmed a reduction in the hematoma size.
    Sprache Englisch
    Erscheinungsdatum 2022-03-24
    Erscheinungsland Netherlands
    Dokumenttyp Case Reports
    ZDB-ID 2406300-9
    ISSN 1930-0433
    ISSN 1930-0433
    DOI 10.1016/j.radcr.2022.02.074
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel: [A Case of Breast Cancer during Pregnancy Treated with Neoadjuvant Chemotherapy during Pregnancy].

    Okujima, Kumiko / Aoki, Reina / Takemoto, Kana / Takaoka, Megumi / Kusakabe, Erina / Shidahara, Tomohiro / Noda, Haruna / Taguchi, Kana / Nishiyama, Kanako / Murakami, Akari / Yamashita, Michiko / Kamei, Yoshiaki / Takada, Yasutsugu

    Gan to kagaku ryoho. Cancer & chemotherapy

    2022  Band 49, Heft 3, Seite(n) 289–292

    Abstract: Although breast cancer during pregnancy is relatively rare, the number of such cases has risen in recent years owing to an increase in mean childbirth age and the increasing prevalence of breast cancer. Here we report the case of a 37-year-old breast ... ...

    Abstract Although breast cancer during pregnancy is relatively rare, the number of such cases has risen in recent years owing to an increase in mean childbirth age and the increasing prevalence of breast cancer. Here we report the case of a 37-year-old breast cancer patient who received neoadjuvant chemotherapy during pregnancy. The woman previously consulted an outside physician after noting a mass in her right breast at 25 weeks' gestation. Breast ultrasonography revealed a right breast tumor and axillary lymphadenopathy. A histopathological examination indicated right breast cancer and axillary lymph node metastasis. She was referred to our department for pregnancy management. Chest X-rays and abdominal ultrasonography were utilized in the search for metastases. She received 2 courses of doxorubicin and cyclophosphamide(AC)therapy during pregnancy and gave birth via cesarean section at 35 weeks' gestation. After delivery, the AC was resumed. The patient completed a total of 4 courses of AC followed by 4 courses of docetaxel (dosed every 3 weeks). She underwent total right mastectomy and axillary dissection; because the tumor was BRCA2 mutation-positive, a risk-reducing salpingo- oophorectomy was also performed. Adjuvant therapy included radiotherapy and tamoxifen but no luteinizing hormone- releasing hormone agonists. At the time of this writing more than 1 year post-surgery, she has not experienced recurrence; although the infant has a congenital clubfoot, she suffers from no other cognitive or developmental delays.
    Mesh-Begriff(e) Adult ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Breast Neoplasms/drug therapy ; Breast Neoplasms/pathology ; Breast Neoplasms/surgery ; Cesarean Section ; Female ; Humans ; Mastectomy ; Neoadjuvant Therapy ; Pregnancy
    Sprache Japanisch
    Erscheinungsdatum 2022-03-15
    Erscheinungsland Japan
    Dokumenttyp Case Reports ; Journal Article
    ZDB-ID 604842-0
    ISSN 0385-0684
    ISSN 0385-0684
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.B 2573: Hefte anzeigen Standort:
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  5. Artikel: A Case of a Rapidly Growing Granulocyte Colony-Stimulating Factor-Producing Squamous Cell Carcinoma of the Breast.

    Noda, Haruna / Yamashita, Michiko / Murakami, Akari / Okujima, Kumiko / Takemoto, Kana / Takaoka, Megumi / Kusakabe, Erina / Aoki, Reina / Taguchi, Kana / Nishiyama, Kanako / Kitazawa, Riko / Kamei, Yoshiaki / Takada, Yasutsugu

    Case reports in oncology

    2021  Band 14, Heft 2, Seite(n) 1175–1181

    Abstract: A 34-year-old woman with a rapidly growing right breast mass visited our hospital. The mass was diagnosed as a right breast cancer (cT3N1M0 stage ⦀A). Her serum leucocyte count and C-reactive protein levels were high, and she had persistent fever. ... ...

    Abstract A 34-year-old woman with a rapidly growing right breast mass visited our hospital. The mass was diagnosed as a right breast cancer (cT3N1M0 stage ⦀A). Her serum leucocyte count and C-reactive protein levels were high, and she had persistent fever. However, serum procalcitonin and β-D-glucan levels were normal, and no apparent infection focus was detected, although her serum granulocyte colony-stimulating factor (G-CSF) level was markedly elevated to 42.7 pg/mL. Therefore, a G-CSF-producing breast cancer was suspected. A pathological analysis of the surgical specimen revealed a squamous cell carcinoma of the breast (pT2N0 [i+] M0 stage ∥A). Right mastectomy (with the resection of the pectoralis major muscle), axillary lymph node dissection, and split layer grafting were performed. The leucocyte count and serum G-CSF level decreased on postoperative day (POD) 1 and normalized on POD 6. As adjuvant chemotherapy, 4 cycles of a combination chemotherapy with adriamycin and cyclophosphamide and 12 cycles of weekly paclitaxel were administered. After chemotherapy, the patient also underwent postmastectomy radiotherapy. Currently, 30 months after surgery, the patient is alive and well with neither progression nor distant metastasis. G-CSF-producing breast cancers tend to rapidly grow such as in the current case; thus, surgery should be performed immediately, followed by appropriate adjuvant treatment.
    Sprache Englisch
    Erscheinungsdatum 2021-08-06
    Erscheinungsland Switzerland
    Dokumenttyp Case Reports
    ZDB-ID 2458961-5
    ISSN 1662-6575
    ISSN 1662-6575
    DOI 10.1159/000518244
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel: Metaplastic carcinoma of the breast and BRCA1 germline mutation: a case report and review.

    Yamashita, Michiko / Kamei, Yoshiaki / Murakami, Akari / Ozaki, Erina / Okujima, Kumiko / Takemoto, Kana / Takaoka, Megumi / Tsukamoto, Daiki / Kusakabe, Erina / Shidahara, Tomoyuki / Noda, Haruna / Aoki, Reina / Taguchi, Kana / Nishiyama, Kanako / Eguchi, Mariko / Takada, Yasutsugu

    Hereditary cancer in clinical practice

    2021  Band 19, Heft 1, Seite(n) 3

    Abstract: Background: Metaplastic carcinoma of the breast consists of both invasive ductal carcinoma and metaplastic carcinoma. This rare subtype of cancer has a poor prognosis. The development of metaplastic breast cancer and relationship with BRCA1 are not well ...

    Abstract Background: Metaplastic carcinoma of the breast consists of both invasive ductal carcinoma and metaplastic carcinoma. This rare subtype of cancer has a poor prognosis. The development of metaplastic breast cancer and relationship with BRCA1 are not well known. Here, we report a rare case of germline BRCA1 mutation-positive breast cancer with chondroid metaplasia.
    Case presentation: A 39-year-old Japanese woman with a family history of breast cancer in her mother and ovarian cancer in her maternal grandmother consulted at our hospital with a left breast mass. Needle biopsy for the mass was performed, leading to a diagnosis of invasive breast cancer with chondroid metaplasia. We performed left mastectomy + sentinel lymph node biopsy + tissue expander insertion and replaced with a silicone implant later. Pathological examination revealed that the patient had triple-negative breast cancer. Four courses of doxorubicin+ cyclophosphamide therapy were performed as adjuvant therapy after surgery. We performed genetic counseling and genetic testing, and the results suggested the germline BRCA1 mutation 307 T> A (L63*). She has currently lived without a relapse for 2 years post-surgery.
    Conclusions: There have been only 6 cases of metaplastic breast carcinoma with germline BRCA1 mutations including our case. Patients with BRCA1 mutations may develop basal-like subtypes or M type of triple-negative breast cancer besides metaplastic breast cancers.
    Sprache Englisch
    Erscheinungsdatum 2021-01-06
    Erscheinungsland Poland
    Dokumenttyp Journal Article
    ZDB-ID 2252512-9
    ISSN 1897-4287 ; 1731-2302
    ISSN (online) 1897-4287
    ISSN 1731-2302
    DOI 10.1186/s13053-020-00162-x
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 6407: Hefte anzeigen Standort:
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  7. Artikel ; Online: Clinicopathological significance of MAML2 gene split in mucoepidermoid carcinoma.

    Noda, Haruna / Okumura, Yoshihide / Nakayama, Takahisa / Miyabe, Satoru / Fujiyoshi, Yukio / Hattori, Hideo / Shimozato, Kazuo / Inagaki, Hiroshi

    Cancer science

    2012  Band 104, Heft 1, Seite(n) 85–92

    Abstract: CRTC1-MAML2 and CRTC3-MAML2 fusions have been associated with favorable clinicopathological features of mucoepidermoid carcinomas. However, the significance of the MAML2 gene split has not been fully clarified. In the present study, 95 mucoepidermoid ... ...

    Abstract CRTC1-MAML2 and CRTC3-MAML2 fusions have been associated with favorable clinicopathological features of mucoepidermoid carcinomas. However, the significance of the MAML2 gene split has not been fully clarified. In the present study, 95 mucoepidermoid carcinomas (paraffin-embedded materials) were analyzed for CRTC1-MAML2 and CRTC3-MAML2 fusions by RT-PCR and for the MAML2 gene split by FISH. Quantitative RT-PCR for the CRTC1-MAML2 transcript was performed in selected cases. MLL gene involvement, which has been reported in some leukemia cases, was examined by FISH in fusion partner-unknown cases. CRTC1-MAML2 and CRTC3-MAML2 fusions were detected in 37 and 6 cases, respectively. The MAML2 gene split was detected in 62 cases, which included all CRTC1/3-MAML2 fusion-positive cases. The level of CRTC1-MAML2 transcript expression was highly variable, and its clinicopathological impact was unclear. The MLL gene split was not detected. Mucoepidermoid carcinomas negative for CRTC1/3-MAML2 and positive for the MAML2 gene split (n = 19) showed favorable clinicopathological tumor features similar to those positive for CRTC1/3-MAML2 fusions. Compared with negative cases (n = 33), mucoepidermoid carcinomas positive for the MAML2 split (n = 62) were associated with lower patient age, a mild female predilection, a smaller tumor size, less frequent nodal metastasis, a lower clinical stage, a lower histological grade, and longer overall and disease-free survival. The MAML2 gene split emerged as an independent prognostic factor for both overall and disease-free survival in multivariate prognostic analysis. The presence of the MAML2 gene split defines a distinct mucoepidermoid carcinoma subset that is associated clinicopathologically with favorable tumor features.
    Mesh-Begriff(e) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Carcinoma, Mucoepidermoid/genetics ; Carcinoma, Mucoepidermoid/pathology ; Child ; DNA-Binding Proteins/genetics ; Disease-Free Survival ; Female ; Gene Expression Regulation, Neoplastic ; Gene Fusion ; Histone-Lysine N-Methyltransferase ; Humans ; In Situ Hybridization, Fluorescence ; Lymphatic Metastasis/genetics ; Male ; Middle Aged ; Myeloid-Lymphoid Leukemia Protein/genetics ; Nuclear Proteins/genetics ; Oncogene Proteins, Fusion/genetics ; Trans-Activators ; Transcription Factors/genetics ; Young Adult
    Chemische Substanzen CRTC1 protein, human ; CRTC3 protein, human ; DNA-Binding Proteins ; KMT2A protein, human ; MAML2 protein, human ; Nuclear Proteins ; Oncogene Proteins, Fusion ; Trans-Activators ; Transcription Factors ; Myeloid-Lymphoid Leukemia Protein (149025-06-9) ; Histone-Lysine N-Methyltransferase (EC 2.1.1.43)
    Sprache Englisch
    Erscheinungsdatum 2012-11-08
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2115647-5
    ISSN 1349-7006 ; 1347-9032
    ISSN (online) 1349-7006
    ISSN 1347-9032
    DOI 10.1111/cas.12039
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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