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Article ; Online: How temperature, substrate, and stratification periods influence <i>Ilex paraguariensis</i> embryonic development

Duarte, Manoela Mendes / Walter, Letícia Siqueira / Gabira, Mônica Moreno / Porath, Cléberson / Vieira, Elisa Serra Negra / Nogueira, Antonio Carlos / Wendling, Ivar / Kratz, Dagma

Australian Journal of Botany. 2023, v. 71, no. 5 p.269-273

2023

Abstract: Aiming to develop a new stratification protocol for yerba mate seeds, we evaluated how different combinations of temperature, substrate, and period influence the embryonic development of the species, compared to fresh seeds and conventionally stratified ... ...

Abstract	Aiming to develop a new stratification protocol for yerba mate seeds, we evaluated how different combinations of temperature, substrate, and period influence the embryonic development of the species, compared to fresh seeds and conventionally stratified seeds. We measured the seeds’ moisture content and performed a tetrazolium test to evaluate embryo viability and embryonic development. Seeds’ initial moisture content was 10.1% and reached 40.6% after stratification. We observed more embryos in advanced development stages after stratification in all treatments, indicating that the protocols used were adequate for the species and have a great potential to be explored for yerba mate seedling.
Keywords	Ilex paraguariensis ; botany ; embryogenesis ; seedlings ; temperature ; tetrazolium ; viability ; water content ; yerba mate ; seed development ; seed dormancy ; seed germination ; seed viability ; seminal propagation ; stratification protocol ; tetrazolium test
Language	English
Size	p. 269-273.
Publishing place	CSIRO Publishing
Document type	Article ; Online
ISSN	0067-1924
DOI	10.1071/BT23010
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Evidence for Monocyte Reprogramming in a Long-Term Postsepsis Study.

Gritte, Raquel Bragante / Souza-Siqueira, Talita / Borges da Silva, Eliane / Dos Santos de Oliveira, Laiane Cristina / Cerqueira Borges, Rodrigo / Alves, Heloísa H de Oliveira / Masi, Laureane Nunes / Murata, Gilson Masahiro / Gorjão, Renata / Levada-Pires, Adriana Cristina / Nogueira, Antônio Carlos / Pithon-Curi, Tânia Cristina / de Azevedo, Ricardo Bentes / Soriano, Francisco Garcia / Curi, Rui / Machado, Marcel Cerqueira Cesar

Critical care explorations

2022 Volume 4, Issue 8, Page(s) e0734

Abstract: This study sought to identify monocyte alterations from septic patients after hospital discharge by evaluating gene expression of inflammatory mediators and monocyte polarization markers. It was hypothesized that sepsis reprograms the inflammatory state ... ...

Abstract	This study sought to identify monocyte alterations from septic patients after hospital discharge by evaluating gene expression of inflammatory mediators and monocyte polarization markers. It was hypothesized that sepsis reprograms the inflammatory state of monocytes, causing effects that persist after hospital discharge and influencing patient outcomes. Design: The gene expression patterns of inflammatory receptors, M1 and M2 macrophage polarization markers, NLRP3 inflammasome components, and pro- and anti-inflammatory cytokines in monocytes were assessed. Patients: Thirty-four patients from the University of São Paulo Hospital, during the acute sepsis phase (phase A), immediately after ICU discharge (phase B), and 3 months (phase C), 6 months (phase D), 1 year (phase E), and 3 years (phase F) after discharge, were included. Patients that died during phases A and B were grouped separately, and the remaining patients were collectively termed the survivor group. Measurements and main results: The gene expression of toll-like receptor ( Conclusions: Sepsis reprograms the inflammatory state of monocytes, probably contributing to postsepsis syndrome development and mortality.
Language	English
Publishing date	2022-07-29
Publishing country	United States
Document type	Journal Article
ISSN	2639-8028
ISSN (online)	2639-8028
DOI	10.1097/CCE.0000000000000734
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Endotoxemic myocardial dysfunction: subendocardial collagen deposition related to coronary driving pressure.

Soriano, Francisco Garcia / Guido, Maria Carolina / Barbeiro, Hermes Vieira / Caldini, Elia Garcia / Lorigados, Clara Batista / Nogueira, Antonio Carlos

Shock (Augusta, Ga.)

2014 Volume 42, Issue 5, Page(s) 472–479

Abstract: Sepsis impairs the autoregulation of myocardial microcirculatory blood flow, but whether this impairment is correlated with myocardial remodeling is unknown. This study investigated the role of coronary driving pressure (CDP) as a determinant of ... ...

Abstract	Sepsis impairs the autoregulation of myocardial microcirculatory blood flow, but whether this impairment is correlated with myocardial remodeling is unknown. This study investigated the role of coronary driving pressure (CDP) as a determinant of microcirculatory blood flow and myocardial fibrosis in endotoxemia and sepsis. The study is composed of two parts: a prospective experimental study and an observational clinical study. The experimental study was performed on male Wistar rats weighing 300 to 320 g. Endotoxemia was induced in rats by lipopolysaccharide (LPS) injection (10 mg·kg intraperitoneally). Hemodynamic evaluation was performed 1.5 to 24 h after LPS injection by measuring the mean arterial pressure, CDP, left ventricular end-diastolic pressure, dP/dtmax, and dP/dtmin. Microspheres were also infused into the left ventricle to measure myocardial blood flow, and myocardial tissue was histologically assessed to analyze collagen deposition. The CDP, mean arterial pressure, and myocardial blood flow were reduced by 55%, 30%, and 70%, respectively, in rats 1.5 h after LPS injection compared with phosphate buffer saline injection (P < 0.05). The CDP was significantly correlated with subendocardial blood flow (r = 0.73) and fibrosis (r = 0.8). Left ventricular function was significantly impaired in the LPS-treated rats, as demonstrated by dP/dtmax (6,155 ± 455 vs. 3,746 ± 406 mmHg·s, baseline vs. LPS; P < 0.05) and dP/dtmin (-5,858 ± 236 vs. -3,516 ± 436 mmHg·s, baseline vs. LPS; P < 0.05). The clinical study was performed on 28 patients with septic shock analyzed for CDP. The CDP data and histological slices were collected from septic patients. In addition, the clinical data demonstrated fibrosis and 45% CDP reduction in nonsurvivors compared with survivors. In conclusion, the left ventricular subendocardial blood flow was positively correlated with CDP, and higher CDP was negatively correlated with myocardial collagen deposition. Thus, early reductions in myocardial blood flow and CDP facilitate late myocardial fibrosis in rats and likely in humans.
MeSH term(s)	Adult ; Animals ; Blood Pressure/physiology ; Collagen/metabolism ; Coronary Circulation/physiology ; Cytokines/metabolism ; Endotoxemia/metabolism ; Endotoxemia/pathology ; Endotoxemia/physiopathology ; Female ; Fibrosis ; Hemodynamics/physiology ; Humans ; Male ; Matrix Metalloproteinase 2/metabolism ; Microcirculation/physiology ; Middle Aged ; Myocardium/metabolism ; Myocardium/pathology ; Rats, Wistar ; Shock, Septic/metabolism ; Shock, Septic/pathology ; Shock, Septic/physiopathology ; Thiobarbituric Acid Reactive Substances/metabolism ; Ventricular Function, Left/physiology
Chemical Substances	Cytokines ; Thiobarbituric Acid Reactive Substances ; Collagen (9007-34-5) ; Matrix Metalloproteinase 2 (EC 3.4.24.24)
Language	English
Publishing date	2014-11
Publishing country	United States
Document type	Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
ZDB-ID	1185432-7
ISSN	1540-0514 ; 1073-2322
ISSN (online)	1540-0514
ISSN	1073-2322
DOI	10.1097/SHK.0000000000000232
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Article ; Online: Frequency of subclinical thyroid dysfunction and risk factors for cardiovascular disease among women at a workplace.

Diaz-Olmos, Rodrigo / Nogueira, Antônio-Carlos / Penalva, Daniele Queirós Fucciolo / Lotufo, Paulo Andrade / Benseñor, Isabela Martins

Sao Paulo medical journal = Revista paulista de medicina

2010 Volume 128, Issue 1, Page(s) 18–23

Abstract: Context and objective: Subclinical thyroid dysfunction is very common in clinical practice and there is some evidence that it may be associated with cardiovascular disease. The aim here was to evaluate the frequencies of subclinical thyroid disease and ... ...

Abstract	Context and objective: Subclinical thyroid dysfunction is very common in clinical practice and there is some evidence that it may be associated with cardiovascular disease. The aim here was to evaluate the frequencies of subclinical thyroid disease and risk factors for cardiovascular disease among women at a workplace, and to evaluate the association between subclinical thyroid disease and cardiovascular risk factors among them. Design and setting: Cross-sectional study on 314 women aged 40 years or over who were working at Universidade de São Paulo (USP). Methods: All the women answered a questionnaire on sociodemographic characteristics and risk factors for cardiovascular disease and the Rose angina questionnaire. Anthropometric variables were measured and blood samples were analyzed for blood glucose, total cholesterol and fractions, high-sensitivity C-reactive protein, thyroid-stimulating hormone (TSH), free thyroxine (free-T4) and anti-thyroperoxidase antibodies (anti-TPO). Results: The frequencies of subclinical hypothyroidism and hyperthyroidism were, respectively, 7.3% and 5.1%. Women with subclinical thyroid disease presented higher levels of anti-TPO than did women with normal thyroid function (P = 0.01). There were no differences in sociodemographic factors and cardiovascular risk factors according to thyroid function status, except for greater sedentarism among the women with subclinical hypothyroidism. Restricting the comparison to women with subclinical hypothyroidism (TSH > 10 mIU/l) did not change the results. Conclusion: In this sample of women, there was no association between poor profile of cardiovascular risk factors and presence of subclinical thyroid disease that would justify screening at the workplace.
MeSH term(s)	Adult ; Analysis of Variance ; Antibodies/blood ; Blood Glucose/metabolism ; Brazil/epidemiology ; C-Reactive Protein/analysis ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/etiology ; Cross-Sectional Studies ; Female ; Humans ; Hyperthyroidism/complications ; Hyperthyroidism/epidemiology ; Hypothyroidism/complications ; Hypothyroidism/epidemiology ; Middle Aged ; Risk Factors ; Surveys and Questionnaires ; Thyroid Gland/physiopathology ; Thyrotropin/blood ; Thyroxine/blood ; Workplace
Chemical Substances	Antibodies ; Blood Glucose ; Thyrotropin (9002-71-5) ; C-Reactive Protein (9007-41-4) ; Thyroxine (Q51BO43MG4)
Language	English
Publishing date	2010-05-19
Publishing country	Brazil
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1203171-9
ISSN	1806-9460 ; 1516-3180 ; 0035-0362
ISSN (online)	1806-9460
ISSN	1516-3180 ; 0035-0362
DOI	10.1590/s1516-31802010000100005
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Article: Transient elevation of ST-segment due to pneumothorax and pneumopericardium.

Brandão, Rodrigo Martins / Gonçalves, Amanda Cristina Maria Aparecida / Brandão, Renata Paula Martins / de Oliveira, Lucas Fernandes / Nogueira, Antonio Carlos / Kawabata, Vitor Sérgio

Autopsy & case reports

2013 Volume 3, Issue 1, Page(s) 63–66

Abstract: ST-segment elevation, observed in the critically ill patients, almost always raises the suspicion of ischemic heart disease. However, nonischemic myocardial and non-myocardial problems in these patients may also lead to ST-segment elevation. Pneumothorax ...

Abstract	ST-segment elevation, observed in the critically ill patients, almost always raises the suspicion of ischemic heart disease. However, nonischemic myocardial and non-myocardial problems in these patients may also lead to ST-segment elevation. Pneumothorax and pneumopericardium have been rarely reported as a cause of transient ST-segment elevation. The authors report the case of a patient admitted to the emergency care unit because of a respiratory failure requiring mechanical ventilatory support. As the patient showed signs of clinical deterioration, a pneumothorax was clinically diagnosed. Chest radiography after thorax drainage also disclosed a pneumopericardium. The 12-lead electrocardiogram recorded before the thoracic drainage revealed an ST-segment elevation, which normalized after the surgical procedure. Ischemic myocardial biomarkers were negative. The authors call attention to the right-sided pneumothorax associated with pneumopericardium as an unusual cause of ST-segment elevation.
Language	English
Publishing date	2013-03-31
Publishing country	Brazil
Document type	Case Reports
ZDB-ID	2815488-5
ISSN	2236-1960
ISSN	2236-1960
DOI	10.4322/acr.2013.009
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Changes in plasma free fatty acid levels in septic patients are associated with cardiac damage and reduction in heart rate variability.

Nogueira, Antonio Carlos / Kawabata, Victor / Biselli, Paolo / Lins, Marcelo Henrique / Valeri, Carla / Seckler, Mauricio / Hoshino, Wagner / Júnior, Luiz Gonzaga / Bernik, Marcia Martins Silveira / de Andrade Machado, Juliana B / Martinez, Marina Baquerizo / Lotufo, Paulo Andrade / Caldini, Elia Garcia / Martins, Edgair / Curi, Rui / Soriano, Francisco Garcia

Shock (Augusta, Ga.)

2008 Volume 29, Issue 3, Page(s) 342–348

Abstract: Free fatty acids (FFAs) have been shown to produce alteration of heart rate variability (HRV) in healthy and diabetic individuals. Changes in HRV have been described in septic patients and in those with hyperglycemia and elevated plasma FFA levels. We ... ...

Abstract	Free fatty acids (FFAs) have been shown to produce alteration of heart rate variability (HRV) in healthy and diabetic individuals. Changes in HRV have been described in septic patients and in those with hyperglycemia and elevated plasma FFA levels. We studied if sepsis-induced heart damage and HRV alteration are associated with plasma FFA levels in patients. Thirty-one patients with sepsis were included. The patients were divided into two groups: survivors(n = 12) and nonsurvivors (n = 19). The following associations were investigated: (a) troponin I elevation and HRV reduction and (b) clinical evolution and HRV index, plasma troponin, and plasma FFA levels. Initial measurements of C-reactive protein and gravity Acute Physiology and Chronic Health Evaluation scores were similar in both groups. Overall, an increase in plasma troponin level was related to increased mortality risk. From the first day of study, the nonsurvivor group presented a reduced left ventricular stroke work systolic index and a reduced low frequency (LF) that is one of HRV indexes. The correlation coefficient for LF values and troponin was r(2) = 0.75 (P < 0.05). All patients presented elevated plasma FFA levels on the first day of the study (5.11 +/- 0.53 mg/mL), and this elevation was even greater in the nonsurvivor group compared with the survivors (6.88 +/- 0.13 vs. 3.85 +/- 0.48 mg/mL, respectively; P < 0.05). Cardiac damage was confirmed by measurement of plasma troponin I and histological analysis. Heart dysfunction was determined by left ventricular stroke work systolic index and HRV index in nonsurvivor patients. A relationship was found between plasma FFA levels, LFnu index, troponin levels, and histological changes. Plasma FFA levels emerged as possible cause of heart damage in sepsis.
MeSH term(s)	Adult ; Arrhythmias, Cardiac/blood ; Arrhythmias, Cardiac/etiology ; Arrhythmias, Cardiac/physiopathology ; Blood Glucose/metabolism ; Fatty Acids, Nonesterified/blood ; Female ; Heart Diseases/blood ; Heart Diseases/etiology ; Heart Diseases/physiopathology ; Heart Rate/physiology ; Humans ; Lipoproteins/blood ; Male ; Middle Aged ; Myocardium/pathology ; Prospective Studies ; Risk Factors ; Sepsis/blood ; Sepsis/complications ; Sepsis/mortality ; Sepsis/physiopathology ; Triglycerides/blood ; Troponin I/blood
Chemical Substances	Blood Glucose ; Fatty Acids, Nonesterified ; Lipoproteins ; Triglycerides ; Troponin I
Language	English
Publishing date	2008-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	1185432-7
ISSN	1540-0514 ; 1073-2322
ISSN (online)	1540-0514
ISSN	1073-2322
DOI	10.1097/shk.0b013e31815abbc6
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Article: Normatização dos equipamentos e das técnicas para a realização de exames de ultra-sonografia vascular.

Belem, Luciano Herman Juaçaba / Nogueira, Antonio Carlos Santos / Schettino, Claudio Domenico / Barros, Marcio Vinicius Lins / de Alcantara, Monica Luiza / Studart, Paulo Cesar de Carvalho / de Araújo, Paula Pimentel / do Amaral, Salomon Israel / Barretto, Simone / Guimarães, Jorge Ilha

Arquivos brasileiros de cardiologia

2004 Volume 82 Suppl 6, Page(s) 1–14

Title translation	Standardization of techniques and equipment for vascular ultrasonography exams .
MeSH term(s)	Aorta, Abdominal/diagnostic imaging ; Arterial Occlusive Diseases/diagnostic imaging ; Carotid Stenosis/diagnostic imaging ; Contrast Media ; Echocardiography, Doppler, Color/instrumentation ; Echocardiography, Doppler, Color/standards ; Humans ; Lower Extremity/blood supply ; Renal Artery/diagnostic imaging ; Vascular Diseases/diagnostic imaging ; Vertebral Artery/diagnostic imaging
Chemical Substances	Contrast Media
Language	Portuguese
Publishing date	2004-05-21
Publishing country	Brazil
Document type	Guideline ; Journal Article ; Practice Guideline
ZDB-ID	730261-7
ISSN	0066-782X
ISSN	0066-782X
DOI	10.1590/s0066-782x2004001200001
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Article ; Online: Normatização dos equipamentos e das técnicas para a realização de exames de ultra-sonografia vascular

Belem Luciano Herman Juaçaba / Nogueira Antonio Carlos Santos / Schettino Claudio Domenico / Barros Marcio Vinicius Lins / Alcantara Monica Luiza de / Studart Paulo Cesar de Carvalho / Araújo Paula Pimentel de / Amaral Salomon Israel do / Barretto Simone / Guimarães Jorge Ilha

Arquivos Brasileiros de Cardiologia, Vol 82, Iss suppl.6, Pp 1-

2004 Volume 14

Keywords	Diseases of the circulatory (Cardiovascular) system ; RC666-701 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Cardiovascular ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
Language	English
Publishing date	2004-01-01T00:00:00Z
Publisher	Sociedade Brasileira de Cardiologia - SBC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Myocardial perfusion by contrast echocardiography. Establishment of normal pattern of intracoronary injection and safety in humans

Morcerf Fernando / Cantisano Armando Luiz / Salek Flavia / Mendonça Carlos Alberto / Paulino Guilherme / Palheiro Flavio Cure / Nogueira Antonio Carlos / Pereira Wanderley Quarte / Moraes Álvaro

Arquivos Brasileiros de Cardiologia, Vol 72, Iss 6, Pp 682-

1999 Volume 686

Abstract: OBJECTIVE: To establish the normal pattern and safety of echocardiographic contrast in patients with no significant obstruction of epicardial coronary arteries. METHODS: 67 patients with normal coronary arteries or obstructions < 50% were selected from ... ...

Abstract	OBJECTIVE: To establish the normal pattern and safety of echocardiographic contrast in patients with no significant obstruction of epicardial coronary arteries. METHODS: 67 patients with normal coronary arteries or obstructions < 50% were selected from 277 patients who underwent coronary angiography (CA). Mean age was 56 ± 11years and 36 were males. At the end CA, echocardiographic contrast was selectively injected into each coronary artery. The parasternal short axis of the left ventricle (LV) was divided into six segments: anterior (A), antero-lateral (AL), postero-lateral (PL), posterior (P), infero-septal (IS) and antero-septal (AS). Anterolateral (ALPM) and posteromedial papillary muscles (PMPM) were also considered. The pattern and intensity of the appearance of the myocardial contrast was visually analyzed. RESULTS: The right coronary artery (RCA) was dominant in 60 patients. Contrast appearance was sudden and simultaneous in the 3 muscle layers. All segments could be contrasted after the injection in both coronary arteries. 100% of the AS, A and AL segments, 97% of the PL and 98% of the ALPM were perfused by the left coronary artery (LCA). P and IS segments were perfused by the RCA in 85% and 82%, respectively, and by a dominant LCA in 71% of the cases. The PMPM was perfused by a dominant RCA in 77% and by a dominant LCA in 86%. There were no symptoms. CONCLUSION: Intracoronary injection of the sonicated solution is a safe procedure that allows for an excellent opacification of the myocardium and can potentially be used during routine CA.
Keywords	myocardial perfusion ; echocardiography ; myocardial contrast echocardiography ; microbubbles ; Diseases of the circulatory (Cardiovascular) system ; RC666-701 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Cardiovascular ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
Subject code	610
Language	English
Publishing date	1999-01-01T00:00:00Z
Publisher	Sociedade Brasileira de Cardiologia - SBC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Morfologia do fruto, da semente e morfo-anatomia da plântula de Vitex megapotamica (Spreng.) Moldenke (Lamiaceae)

Cosmo, Nelson Luiz(Universidade Federal do Paraná Departamento de Ciências Florestais Programa de Pós-Graduação em Engenharia Florestal) / Gogosz, Alessandra Mara(Universidade Federal do Paraná Departamento de Botânica Programa de Pós-Graduação em Botânica) / Nogueira, Antônio Carlos(Universidade Federal do Paraná Departamento de Ciências Florestais) / Bona, Cleusa(Universidade Federal do Paraná Departamento de Botânica) / Kuniyoshi, Yoshiko Saito(Universidade Federal do Paraná Departamento de Ciências Florestais)

Acta Botanica Brasilica

2009/06

Abstract: Vitex megapotamica (tarumã) é espécie arbórea, decídua, com ocorrência, no Brasil, desde Minas Gerais até o Rio Grande do Sul. Visando à caracterização morfológica do fruto, da semente e morfo-anatômica da plântula, frutos desta espécie foram coletados e ...

Abstract	Vitex megapotamica (tarumã) é espécie arbórea, decídua, com ocorrência, no Brasil, desde Minas Gerais até o Rio Grande do Sul. Visando à caracterização morfológica do fruto, da semente e morfo-anatômica da plântula, frutos desta espécie foram coletados e as sementes postas para germinar em laboratório. As plântulas foram coletadas desde a protrusão da raiz até o desenvolvimento do primeiro par de eofilo. Foram realizadas medições e pesagem de frutos, e contagem do número de sementes por frutos. As características morfológicas do fruto e da semente são aqui descritas e ilustradas, assim como a morfo-anatomia da plântula. O fruto é drupóide, nuculânio, tetralocular, contendo apenas uma ou duas sementes com fina camada de endosperma e embrião axial, foliáceo. O diásporo (pirênio) é constituído pelo endocarpo mais a semente. O endocarpo lenhoso parece exercer restrição sobre a germinação das sementes desta espécie. A plântula é epigea, fanerocotiledonar, com paracotilédones elípticos, com margem inteira, e eofilos opostos, simples, elípticos, com margem serreada, apresentando tricomas tectores. Tanto o paracotilédone quanto o eofilo apresentam mesofilo heterogêneo, dorsiventral, feixe colateral em forma de arco e estômatos anomocíticos. A raiz é poliarca, com córtex parênquimático; o hipocótilo possui tricomas glandulares e não-glandulares, colo distinto, e com cerca de 20 dias encontra-se em início de crescimento secundário. Diversas das características da plântula de Vitex megapotamica estão relacionadas à sua condição de espécie heliófila.
Language	Portuguese
Document type	Article
ISSN	0102-3306
Database	AGRIS - International Information System for the Agricultural Sciences and Technology

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