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  1. Article ; Online: Is it necessary to avoid all legumes in legume allergy?

    Kakleas, Konstantinos / Luyt, David / Foley, Gary / Noimark, Lee

    Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology

    2020  Volume 31, Issue 7, Page(s) 848–851

    MeSH term(s) Adolescent ; Child ; Child, Preschool ; Cross Reactions ; Fabaceae/immunology ; Food Hypersensitivity/diagnosis ; Food Hypersensitivity/immunology ; Humans ; Infant ; Retrospective Studies ; Skin Tests/methods ; United Kingdom
    Language English
    Publishing date 2020-05-27
    Publishing country England
    Document type Letter
    ZDB-ID 1057059-7
    ISSN 1399-3038 ; 0905-6157 ; 0906-5784
    ISSN (online) 1399-3038
    ISSN 0905-6157 ; 0906-5784
    DOI 10.1111/pai.13275
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    Zs.A 3096: Show issues Location:
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  2. Article ; Online: Lip Dose Challenges in Food Allergy: Current Practice and Diagnostic Utility in the United Kingdom.

    Vazquez-Ortiz, Marta / Ludman, Siân / Aston, Antony / Noimark, Lee / Turner, Paul J

    The journal of allergy and clinical immunology. In practice

    2019  Volume 7, Issue 8, Page(s) 2770–2774.e3

    Abstract: Background: Lip dose challenges (LDCs) are often performed as an initial step before oral food challenges (OFCs). However, guidance on how to perform and interpret LDCs is unclear, and data are lacking regarding the diagnostic accuracy of LDCs.: ... ...

    Abstract Background: Lip dose challenges (LDCs) are often performed as an initial step before oral food challenges (OFCs). However, guidance on how to perform and interpret LDCs is unclear, and data are lacking regarding the diagnostic accuracy of LDCs.
    Objective: To investigate current practice with respect to LDCs among UK allergy health care professionals, and to evaluate the diagnostic utility of LDCs in children undergoing OFCs for IgE-mediated food allergy.
    Methods: We used an electronic survey to assess the use of LDCs by UK Allergy clinics. Separately, we prospectively recruited children undergoing "low-risk" OFCs for suspected IgE-mediated food allergy from 2 large specialist allergy units in London. LDC was performed 30 minutes before the OFC, by applying the food to the inner lip for 30 seconds. Objective symptoms were considered a positive outcome. All patients subsequently proceeded to OFC regardless of LDC outcome, and outcome assessed according to PRACTALL consensus.
    Results: We received 147 responses to the online survey, representing 67% of registered pediatric allergy clinics in the United Kingdom. Eighty percent of respondents (representing 81% of responding centers) included LDC as the first step of OFC in routine clinical practice. There was a wide variation in both how LDCs were performed and interpreted, with one-third not proceeding to OFC if LDC resulted in subjective symptoms. In the prospective study, 198 children (mean age, 7 years) with conclusive OFCs were included. Foods tested were tree nuts (30%), peanut (16.6%), egg (16%), fish (10.5%), milk (6%), shrimp (4%), and other (16.9%). There were 12 positive LDCs (1 of which triggered systemic symptoms: generalized urticaria) and 31 positive OFCs. Two children with positive LDCs went on to have a negative diagnostic OFC. Sensitivity of LDC was 32%, specificity 98%, with a false-negative rate of 68%.
    Conclusions: Most UK allergy clinics included LDC as an initial step during OFC, despite a wide variation in how LDCs are performed and interpreted, which raises major concerns about the reproducibility and the validity of the test. We found that LDC had poor sensitivity as an alternative or initial step to formal OFC.
    MeSH term(s) Adolescent ; Attitude of Health Personnel ; Child ; Child, Preschool ; Food Hypersensitivity/diagnosis ; Health Personnel ; Humans ; Immunologic Tests/methods ; Infant ; Lip ; Surveys and Questionnaires ; United Kingdom
    Language English
    Publishing date 2019-05-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2019.04.037
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    Zs.A 7086: Show issues Location:
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  3. Article ; Online: Nutritional problems related to food allergy in childhood.

    Noimark, Lee / Cox, Helen E

    Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology

    2008  Volume 19, Issue 2, Page(s) 188–195

    Abstract: Food allergy is becoming an increasing problem worldwide with an estimated 6-8% of children affected at some point in their childhood. The perceived prevalence of food allergy is even higher with an estimated 20% of children adhering to some form of ... ...

    Abstract Food allergy is becoming an increasing problem worldwide with an estimated 6-8% of children affected at some point in their childhood. The perceived prevalence of food allergy is even higher with an estimated 20% of children adhering to some form of elimination diet. Against this background, accurate diagnosis is essential to prevent the imposition of unnecessarily restrictive diets on young children. Raising clinical awareness amongst health professionals as to the clinical characteristics, epidemiology, investigation, and management of food allergic disorders is key to tackling this growing problem. In this article, three separate cases of children with poor nutrition and secondary morbidity are presented, highlighting the varying scenarios in which these conditions can be encountered. In the first child, the features clinically displayed were hypocalcemic seizures and rickets due to prolonged breast feeding, poor weaning, and inadequate dietary supplementation. The second case reveals the dangers of complementary diagnostic allergy testing leading to poor nutrition as a consequence of an unsupervised elimination diet. The last report describes a child with multiple food allergies, failure to thrive, and protein losing enteropathy to highlight the diversity of nutritional problems faced by allergists and to underline the importance of specialist dietetic input in the management of a child with food allergy.
    MeSH term(s) Anemia, Iron-Deficiency/diet therapy ; Anemia, Iron-Deficiency/etiology ; Asthma/complications ; Asthma/drug therapy ; Breast Feeding/adverse effects ; Calcium, Dietary/administration & dosage ; Child, Preschool ; Dermatitis, Atopic/etiology ; Diagnosis, Differential ; Diarrhea/etiology ; Diarrhea/therapy ; Dietary Supplements ; Failure to Thrive/diet therapy ; Failure to Thrive/etiology ; Female ; Follow-Up Studies ; Food Hypersensitivity/complications ; Humans ; Hypocalcemia/complications ; Hypocalcemia/diet therapy ; Infant ; Iron, Dietary/administration & dosage ; Male ; Nutrition Disorders/complications ; Nutrition Disorders/diagnosis ; Nutrition Disorders/diet therapy ; Rickets/diet therapy ; Rickets/etiology ; Seizures/etiology ; Vitamin D/administration & dosage
    Chemical Substances Calcium, Dietary ; Iron, Dietary ; Vitamin D (1406-16-2)
    Language English
    Publishing date 2008-03
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 1057059-7
    ISSN 1399-3038 ; 0905-6157 ; 0906-5784
    ISSN (online) 1399-3038
    ISSN 0905-6157 ; 0906-5784
    DOI 10.1111/j.1399-3038.2007.00700.x
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  4. Article ; Online: Assessment of infant outgrowth of cow’s milk allergy in relation to the faecal microbiome and metaproteome

    Hendrickx, Diana / An, Ran / Boeren, Sjef / Mutte, Sumanth / Chatchatee, Pantipa / Nowak-Wegrzyn, Anna / Lange, Lars / Benjaponpitak, Suwat / Wee Chong, Kok / Sangsupawanich, Pasuree / van Ampting, Marleen / Oude Nijhuis, Manon / Harthoorn, Lucien / Langford, Jane / Knol, Jan / Knipping, Karen / Garssen, Johan / Trendelenburg, Valerie / Pesek, Robert /
    Davis, Carla / Muraro, Antonella / Erlewyn-Lajeunesse, Mich / Fox, Adam / Michaelis, Louise / Beyer, Kirsten / Noimark, Lee / Stiefel, Gary / Schauer, Uwe / Hamelmann, Eckard / Peroni, Diego / Boner, Attilio / Lambert, Jolanda / Belzer, Clara

    Scientific Reports

    2023  Volume 13, Issue 1

    Abstract: Previous studies provide evidence for an association between modifications of the gut microbiota in early life and the development of food allergies. We studied the faecal microbiota composition (16S rRNA gene amplicon sequencing) and faecal microbiome ... ...

    Abstract Previous studies provide evidence for an association between modifications of the gut microbiota in early life and the development of food allergies. We studied the faecal microbiota composition (16S rRNA gene amplicon sequencing) and faecal microbiome functionality (metaproteomics) in a cohort of 40 infants diagnosed with cow’s milk allergy (CMA) when entering the study. Some of the infants showed outgrowth of CMA after 12 months, while others did not. Faecal microbiota composition of infants was analysed directly after CMA diagnosis (baseline) as well as 6 and 12 months after entering the study. The aim was to gain insight on gut microbiome parameters in relation to outgrowth of CMA. The results of this study show that microbiome differences related to outgrowth of CMA can be mainly identified at the taxonomic level of the 16S rRNA gene, and to a lesser extent at the protein-based microbial taxonomy and functional protein level. At the 16S rRNA gene level outgrowth of CMA is characterized by lower relative abundance of Lachnospiraceae at baseline and lower Bacteroidaceae at visit 12 months.
    Keywords Life Science
    Language English
    Publishing country nl
    Document type Article ; Online
    ZDB-ID 2615211-3
    ISSN 2045-2322
    ISSN 2045-2322
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Tolerance development in cow's milk–allergic infants receiving amino acid–based formula

    Chatchatee, Pantipa / Nowak-Wegrzyn, Anna / Lange, Lars / Benjaponpitak, Suwat / Chong, Kok Wee / Sangsupawanich, Pasuree / van Ampting, Marleen T.J. / Oude Nijhuis, Manon M. / Harthoorn, Lucien F. / Langford, Jane E. / Knol, Jan / Knipping, Karen / Garssen, Johan / Trendelenburg, Valerie / Pesek, Robert / Davis, Carla M. / Muraro, Antonella / Erlewyn-Lajeunesse, Mich / Fox, Adam T. /
    Michaelis, Louise J. / Beyer, Kirsten / Noimark, Lee / Stiefel, Gary / Schauer, Uwe / Hamelman / Peroni, Diego / Boner

    Journal of Allergy and Clinical Immunology

    A randomized controlled trial

    2022  Volume 149, Issue 2

    Abstract: Background: Tolerance development is an important clinical outcome for infants with cow's milk allergy. Objective: This multicenter, prospective, randomized, double-blind, controlled clinical study (NTR3725) evaluated tolerance development to cow's milk ( ...

    Abstract Background: Tolerance development is an important clinical outcome for infants with cow's milk allergy. Objective: This multicenter, prospective, randomized, double-blind, controlled clinical study (NTR3725) evaluated tolerance development to cow's milk (CM) and safety of an amino acid–based formula (AAF) including synbiotics (AAF-S) comprising prebiotic oligosaccharides (oligofructose, inulin) and probiotic Bifidobacterium breve M-16V in infants with confirmed IgE-mediated CM allergy. Methods: Subjects aged ≤13 months with IgE-mediated CM allergy were randomized to receive AAF-S (n = 80) or AAF (n = 89) for 12 months. Stratification was based on CM skin prick test wheal size and study site. After 12 and 24 months, CM tolerance was evaluated by double-blind, placebo-controlled food challenge. A logistic regression model used the all-subjects randomized data set. Results: At baseline, mean ± SD age was 9.36 ± 2.53 months. At 12 and 24 months, respectively, 49% and 62% of subjects were CM tolerant (AAF-S 45% and 64%; AAF 52% and 59%), and not differ significantly between groups. During the 12-month intervention, the number of subjects reporting at least 1 adverse event did not significantly differ between groups; however, fewer subjects required hospitalization due to serious adverse events categorized as infections in the AAF-S versus AAF group (9% vs 20%; P = .036). Conclusions: After 12 and 24 months, CM tolerance was not different between groups and was in line with natural outgrowth. Results suggest that during the intervention, fewer subjects receiving AAF-S required hospitalization due to infections.
    Keywords Cow's milk allergy ; amino acid–based formula ; infection ; oral tolerance ; prebiotics ; probiotics ; synbiotics
    Subject code 610
    Language English
    Publishing country nl
    Document type Article ; Online
    ZDB-ID 121011-7
    ISSN 1085-8725 ; 1097-6825 ; 0091-6749
    ISSN (online) 1085-8725 ; 1097-6825
    ISSN 0091-6749
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Uh III Zs.92: Show issues Location:
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  6. Article ; Online: Urinary prostanoids in preschool wheeze.

    Grigg, Jonathan / Whitehouse, Abigail / Pandya, Hitesh / Turner, Stephen / Griffiths, Christopher J / Vulliamy, Tom / T Walton, Robert / Price, David B / Sanak, Marek / Holloway, John W / Noimark, Lee / Lesosky, Maia / Brugha, Rossa / Koh, Lee / Nwokoro, Chinedu

    The European respiratory journal

    2017  Volume 49, Issue 2

    MeSH term(s) Asthma/urine ; Case-Control Studies ; Child, Preschool ; Creatinine/urine ; Dermatitis, Atopic/urine ; Dinoprostone/urine ; Female ; Humans ; Inflammation ; Male ; Prostaglandin D2/urine ; Prostaglandins/urine ; Respiratory Sounds/physiopathology ; Urinalysis
    Chemical Substances Prostaglandins ; Creatinine (AYI8EX34EU) ; Dinoprostone (K7Q1JQR04M) ; Prostaglandin D2 (RXY07S6CZ2)
    Language English
    Publishing date 2017-02-02
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.01390-2016
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  7. Article: Temporomandibular joint destruction in mucolipidosis type III necessitating gastrostomy insertion.

    Zolkipli, Zarzuela / Noimark, Lee / Cleary, Maureen A / Owens, Cathy / Vellodi, Ashok

    European journal of pediatrics

    2005  Volume 164, Issue 12, Page(s) 772–774

    Abstract: Unlabelled: Mucolipidosis III is a genetically heterogeneous lysosomal disorder characterised by progressive symptoms and signs, the commonest being skeletal pain due to bony destruction. We describe a patient who developed severe destruction of the ... ...

    Abstract Unlabelled: Mucolipidosis III is a genetically heterogeneous lysosomal disorder characterised by progressive symptoms and signs, the commonest being skeletal pain due to bony destruction. We describe a patient who developed severe destruction of the temporomandibular joints leading to difficulties with speech and feeding, necessitating gastrostomy insertion.
    Conclusion: Temporomandibular joint involvement has not been previously reported in mucolipidosis III.
    MeSH term(s) Adolescent ; Female ; Gastrostomy ; Humans ; Mucolipidoses/complications ; Temporomandibular Joint Disorders/etiology ; Temporomandibular Joint Disorders/physiopathology
    Language English
    Publishing date 2005-12
    Publishing country Germany
    Document type Case Reports ; Journal Article
    ZDB-ID 194196-3
    ISSN 1432-1076 ; 0340-6199 ; 0943-9676
    ISSN (online) 1432-1076
    ISSN 0340-6199 ; 0943-9676
    DOI 10.1007/s00431-005-1727-7
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