Article ; Online: Survival and Predictive Factors of Chemotherapy With FOLFIRINOX as First-Line Therapy in Metastatic Pancreatic Cancer: A Retrospective Multicentric Analysis.
2021 Volume 50, Issue 6, Page(s) 803–806
Abstract: Objectives: The use of FOLFIRINOX (a combination of oxaliplatin, irinotecan, fluorouracil, and leucovorin) is one of the therapeutic standards in pancreatic adenocarcinoma. We analyzed progression-free survival (PFS) and overall survival (OS) and their ... ...
Abstract | Objectives: The use of FOLFIRINOX (a combination of oxaliplatin, irinotecan, fluorouracil, and leucovorin) is one of the therapeutic standards in pancreatic adenocarcinoma. We analyzed progression-free survival (PFS) and overall survival (OS) and their predictive factors in patients treated with FOLFIRINOX as first-line therapy in metastatic pancreatic cancer. Methods: This multicenter retrospective analysis included patients treated with FOLFIRINOX between 2011 and 2015. The Kaplan-Meier method was used to estimate OS and PFS. The statistical comparison for survival was performed by the log-rank test. Predictive factors were estimated in multivariate analysis with the use of a Cox model. Results: One hundred and thirty-six patients were included (74 men, 62 women; median age, 62 years [range, 29-74 years]). The median PFS was 5.97 months (95% confidence interval, 4.4-6.63 months). The median OS was 8.93 months (95% confidence interval, 7.4-10.07 months). Prognostic factors in multivariate analysis were the use of granulocyte colony-stimulating factor, which appeared to be a good prognostic factor. Dose intensity of oxaliplatin (≥74.48%) and dose intensity of bolus of fluorouracil (>6.9%) appeared as pejorative factors. Conclusions: In patients with metastatic pancreatic adenocarcinoma treated with FOLFIRINOX in first line, dose modifications at the onset of adverse effects and early use of granulocyte-colony stimulating factor seem to be associated with a better survival. |
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MeSH term(s) | Adenocarcinoma/drug therapy ; Adenocarcinoma/pathology ; Adult ; Aged ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Female ; Fluorouracil/administration & dosage ; Fluorouracil/adverse effects ; Humans ; Irinotecan/administration & dosage ; Irinotecan/adverse effects ; Kaplan-Meier Estimate ; Leucovorin/administration & dosage ; Leucovorin/adverse effects ; Male ; Middle Aged ; Multivariate Analysis ; Nausea/chemically induced ; Neoplasm Metastasis ; Neutropenia/chemically induced ; Outcome Assessment, Health Care/methods ; Outcome Assessment, Health Care/statistics & numerical data ; Oxaliplatin/administration & dosage ; Oxaliplatin/adverse effects ; Pancreatic Neoplasms/drug therapy ; Pancreatic Neoplasms/pathology ; Prognosis ; Retrospective Studies ; Vomiting/chemically induced |
Chemical Substances | Oxaliplatin (04ZR38536J) ; Irinotecan (7673326042) ; Leucovorin (Q573I9DVLP) ; Fluorouracil (U3P01618RT) |
Language | English |
Publishing date | 2021-08-02 |
Publishing country | United States |
Document type | Journal Article ; Multicenter Study |
ZDB-ID | 632831-3 |
ISSN | 1536-4828 ; 0885-3177 |
ISSN (online) | 1536-4828 |
ISSN | 0885-3177 |
DOI | 10.1097/MPA.0000000000001837 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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