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  1. Book ; Thesis: Die bronchoalveoläre Lavage

    Noll, Christina

    eine hochwertige Methode zur Diagnostik der chronischen Aspiration im Kindesalter

    1996  

    Author's details vorgelegt von Christina Noll
    Language German
    Size 124 S. : Ill., graph. Darst.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Frankfurt (Main), Univ., Diss., 1997
    HBZ-ID HT007619998
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    97 D 2389 order for loan Magazin

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  2. Article ; Online: Association of retinal vessel pathology and brain atrophy in relapsing-remitting multiple sclerosis.

    Romahn, Eva Feodora / Wiltgen, Tun / Bussas, Matthias / Aly, Lilian / Wicklein, Rebecca / Noll, Christina / Berthele, Achim / Dehmelt, Vera / Mardin, Christian / Zimmer, Claus / Korn, Thomas / Hemmer, Bernhard / Kirschke, Jan S / Mühlau, Mark / Knier, Benjamin

    Frontiers in immunology

    2023  Volume 14, Page(s) 1284986

    Abstract: Background: Optical coherence tomography angiography (OCTA) allows non-invasive assessment of retinal vessel structures. Thinning and loss of retinal vessels is evident in eyes of patients with multiple sclerosis (MS) and might be associated with a ... ...

    Abstract Background: Optical coherence tomography angiography (OCTA) allows non-invasive assessment of retinal vessel structures. Thinning and loss of retinal vessels is evident in eyes of patients with multiple sclerosis (MS) and might be associated with a proinflammatory disease phenotype and worse prognosis. We investigated whether changes of the retinal vasculature are linked to brain atrophy and disability in MS.
    Material and methods: This study includes one longitudinal observational cohort (n=79) of patients with relapsing-remitting MS. Patients underwent annual assessment of the expanded disability status scale (EDSS), timed 25-foot walk, symbol digit modalities test (SDMT), retinal optical coherence tomography (OCT), OCTA, and brain MRI during a follow-up duration of at least 20 months. We investigated intra-individual associations between changes in the retinal architecture, vasculature, brain atrophy and disability. Eyes with a history of optic neuritis (ON) were excluded.
    Results: We included 79 patients with a median disease duration of 12 (interquartile range 2 - 49) months and a median EDSS of 1.0 (0 - 2.0). Longitudinal retinal axonal and ganglion cell loss were linked to grey matter atrophy, cortical atrophy, and volume loss of the putamen. We observed an association between vessel loss of the superficial vascular complex (SVC) and both grey and white matter atrophy. Both observations were independent of retinal ganglion cell loss. Moreover, patients with worsening of the EDSS and SDMT revealed a pronounced longitudinal rarefication of the SVC and the deep vascular complex.
    Discussion: ON-independent narrowing of the retinal vasculature might be linked to brain atrophy and disability in MS. Our findings suggest that retinal OCTA might be a new tool for monitoring neurodegeneration during MS.
    MeSH term(s) Humans ; Atrophy ; Brain/diagnostic imaging ; Brain/pathology ; Central Nervous System Diseases/pathology ; Multiple Sclerosis/pathology ; Multiple Sclerosis, Relapsing-Remitting/pathology ; Neurodegenerative Diseases/pathology ; Optic Neuritis/diagnostic imaging ; Optic Neuritis/pathology ; Retina/diagnostic imaging ; Retina/pathology ; Retinal Vessels/diagnostic imaging ; Retinal Vessels/pathology ; Longitudinal Studies
    Language English
    Publishing date 2023-11-28
    Publishing country Switzerland
    Document type Observational Study ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1284986
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Association of the retinal vasculature, intrathecal immunity, and disability in multiple sclerosis.

    Noll, Christina / Hiltensperger, Michael / Aly, Lilian / Wicklein, Rebecca / Afzali, Ali Maisam / Mardin, Christian / Gasperi, Christiane / Berthele, Achim / Hemmer, Bernhard / Korn, Thomas / Knier, Benjamin

    Frontiers in immunology

    2022  Volume 13, Page(s) 997043

    Abstract: Background: Optical coherence tomography angiography (OCT-A) is a novel technique allowing non-invasive assessment of the retinal vasculature. During relapsing remitting multiple sclerosis (RRMS), retinal vessel loss occurs in eyes suffering from acute ... ...

    Abstract Background: Optical coherence tomography angiography (OCT-A) is a novel technique allowing non-invasive assessment of the retinal vasculature. During relapsing remitting multiple sclerosis (RRMS), retinal vessel loss occurs in eyes suffering from acute optic neuritis and recent data suggest that retinal vessel loss might also be evident in non-affected eyes. We investigated whether alterations of the retinal vasculature are linked to the intrathecal immunity and whether they allow prognostication of the future disease course.
    Material and methods: This study includes two different patient cohorts recruited at a tertiary German academic multiple sclerosis center between 2018 and 2020 and a cohort of 40 healthy controls. A total of 90 patients with RRMS undergoing lumbar puncture and OCT-A analysis were enrolled into a cross-sectional cohort study to search for associations between the retinal vasculature and the intrathecal immune compartment. We recruited another 86 RRMS patients into a prospective observational cohort study who underwent clinical examination, OCT-A and cerebral magnetic resonance imaging at baseline and during annual follow-up visits to clarify whether alterations of the retinal vessels are linked to RRMS disease activity. Eyes with a history of optic neuritis were excluded from the analysis.
    Results: Rarefication of the superficial vascular complex occured during RRMS and was linked to higher frequencies of activated B cells and higher levels of the pro-inflammatory cytokines interferon-γ, tumor necrosis factor α and interleukin-17 in the cerebrospinal fluid. During a median follow-up of 23 (interquartile range 14 - 25) months, vessel loss within the superficial (hazard ratio [HR] 1.6 for a 1%-point decrease in vessel density, p=0.01) and deep vascular complex (HR 1.6 for a 1%-point decrease, p=0.05) was associated with future disability worsening.
    Discussion: Optic neuritis independent rarefication of the retinal vasculature might be linked to neuroinflammatory processes during RRMS and might predict a worse disease course. Thus, OCT-A might be a novel biomarker to monitor disease activity and predict future disability.
    MeSH term(s) Humans ; Multiple Sclerosis/pathology ; Cross-Sectional Studies ; Prospective Studies ; Retinal Vessels/diagnostic imaging ; Retinal Vessels/pathology ; Optic Neuritis ; Multiple Sclerosis, Relapsing-Remitting/diagnostic imaging ; Multiple Sclerosis, Relapsing-Remitting/pathology ; Disease Progression
    Language English
    Publishing date 2022-11-11
    Publishing country Switzerland
    Document type Observational Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.997043
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Dynamics of Retinal Vessel Loss After Acute Optic Neuritis in Patients With Relapsing Multiple Sclerosis.

    Aly, Lilian / Noll, Christina / Wicklein, Rebecca / Wolf, Elisabeth / Romahn, Eva Feodora / Wauschkuhn, Josphine / Hosari, Sami / Mardin, Christian / Berthele, Achim / Hemmer, Bernhard / Korn, Thomas / Knier, Benjamin

    Neurology(R) neuroimmunology & neuroinflammation

    2022  Volume 9, Issue 3

    Abstract: Background and objectives: Rarefication of the retinal vasculature as measured by optical coherence tomography angiography (OCT-A) is a novel finding in patients with multiple sclerosis (MS). This study aimed to analyze longitudinal dynamics of the ... ...

    Abstract Background and objectives: Rarefication of the retinal vasculature as measured by optical coherence tomography angiography (OCT-A) is a novel finding in patients with multiple sclerosis (MS). This study aimed to analyze longitudinal dynamics of the retinal vasculature following an acute inflammatory relapse including acute optic neuritis (ON) and to search for associations with alterations of the retinal architecture and visual function.
    Methods: This prospective longitudinal cohort study included patients with relapsing-remitting MS or clinically isolated syndrome having an acute ON (n = 20) or a non-ON relapse (n = 33). Patients underwent examinations at baseline and after 7, 14, 28, 90, and 180 days with OCT, OCT-A, and assessment of the high- (HCVA) and low-contrast visual acuity (LCVA).
    Results: Retinal vessel loss of the superficial vascular complex (SVC) evolves early after ON and reaches a plateau between 90 and 180 days (relative vessel loss 15% ± 8% [mean ± SD]). In addition, an 18% ± 18% intraindividual increase of the foveal avascular zone (FAZ) is evident within 180 days after acute ON. Both SVC thinning and FAZ enlargement were associated with worse HCVA and LCVA. Rarefication of the SVC evolved simultaneously to thinning of the common ganglion cell and inner plexiform layer (GCIP) after ON. No alterations of the deep vascular complex were seen in eyes with ON, and no alterations of the retinal vasculature were recognized in patients having acute non-ON relapses.
    Discussion: Rarefication of the SVC and growing of the FAZ evolve rapidly after ON and are linked to persistent visual disability. ON-related SVC thinning might be closely linked to GCIP atrophy and might occur due to an altered local metabolic activity within inner retinal layers.
    MeSH term(s) Humans ; Longitudinal Studies ; Multiple Sclerosis/complications ; Optic Neuritis/complications ; Prospective Studies ; Recurrence ; Retinal Vessels/diagnostic imaging ; Tomography, Optical Coherence ; Vision Disorders/complications
    Language English
    Publishing date 2022-03-17
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2767740-0
    ISSN 2332-7812 ; 2332-7812
    ISSN (online) 2332-7812
    ISSN 2332-7812
    DOI 10.1212/NXI.0000000000001159
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The OSCAR-MP Consensus Criteria for Quality Assessment of Retinal Optical Coherence Tomography Angiography.

    Wicklein, Rebecca / Yam, Charmaine / Noll, Christina / Aly, Lilian / Banze, Nicolas / Romahn, Eva Feodora / Wolf, Elisabeth / Hemmer, Bernhard / Oertel, Frederike C / Zimmermann, Hanna / Albrecht, Philipp / Ringelstein, Marius / Baumann, Carmen / Feucht, Nikolaus / Penkava, Josef / Havla, Joachim / Gernert, Jonathan A / Mardin, Christian / Vasileiou, Eleni S /
    Van Der Walt, Anneke / Al-Louzi, Omar / Cabello, Sergio / Vidal-Jordana, Angela / Krämer, Julia / Wiendl, Heinz / Preiningerova, Jana Lizrova / Ciccarelli, Olga / Garcia-Martin, Elena / Kana, Veronika / Calabresi, Peter A / Paul, Friedemann / Saidha, Shiv / Petzold, Axel / Toosy, Ahmed T / Knier, Benjamin

    Neurology(R) neuroimmunology & neuroinflammation

    2023  Volume 10, Issue 6

    Abstract: Background and objectives: Optical coherence tomography angiography (OCTA) is a noninvasive high-resolution imaging technique for assessing the retinal vasculature and is increasingly used in various ophthalmologic, neuro-ophthalmologic, and neurologic ... ...

    Abstract Background and objectives: Optical coherence tomography angiography (OCTA) is a noninvasive high-resolution imaging technique for assessing the retinal vasculature and is increasingly used in various ophthalmologic, neuro-ophthalmologic, and neurologic diseases. To date, there are no validated consensus criteria for quality control (QC) of OCTA. Our study aimed to develop criteria for OCTA quality assessment.
    Methods: To establish criteria through (1) extensive literature review on OCTA artifacts and image quality to generate standardized and easy-to-apply OCTA QC criteria, (2) application of OCTA QC criteria to evaluate interrater agreement, (3) identification of reasons for interrater disagreement, revision of OCTA QC criteria, development of OCTA QC scoring guide and training set, and (4) validation of QC criteria in an international, interdisciplinary multicenter study.
    Results: We identified 7 major aspects that affect OCTA quality: (O) obvious problems, (S) signal strength, (C) centration, (A) algorithm failure, (R) retinal pathology, (M) motion artifacts, and (P) projection artifacts. Seven independent raters applied the OSCAR-MP criteria to a set of 40 OCTA scans from people with MS, Sjogren syndrome, and uveitis and healthy individuals. The interrater kappa was substantial (κ 0.67). Projection artifacts were the main reason for interrater disagreement. Because artifacts can affect only parts of OCTA images, we agreed that prior definition of a specific region of interest (ROI) is crucial for subsequent OCTA quality assessment. To enhance artifact recognition and interrater agreement on reduced image quality, we designed a scoring guide and OCTA training set. Using these educational tools, 23 raters from 14 different centers reached an almost perfect agreement (κ 0.92) for the rejection of poor-quality OCTA images using the OSCAR-MP criteria.
    Discussion: We propose a 3-step approach for standardized quality control: (1) To define a specific ROI, (2) to assess the occurrence of OCTA artifacts according to the OSCAR-MP criteria, and (3) to evaluate OCTA quality based on the occurrence of different artifacts within the ROI. OSCAR-MP OCTA QC criteria achieved high interrater agreement in an international multicenter study and is a promising QC protocol for application in the context of future clinical trials and studies.
    MeSH term(s) Humans ; Consensus ; Fluorescein Angiography/methods ; Retina/diagnostic imaging ; Retinal Vessels ; Tomography, Optical Coherence
    Language English
    Publishing date 2023-10-09
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2767740-0
    ISSN 2332-7812 ; 2332-7812
    ISSN (online) 2332-7812
    ISSN 2332-7812
    DOI 10.1212/NXI.0000000000200169
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Book ; Thesis: Die bronchoalveoläre Lavage

    Noll, Christina

    eine hochwertige Methode zur Diagnostik der chronischen Aspiration im Kindesalter

    1996  

    Author's details vorgelegt von Christina Noll
    Language German
    Size 124, 2 S, Ill., graph. Darst, 21 cm
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Univ., Diss.--Frankfurt (Main), 1997
    Database Former special subject collection: coastal and deep sea fishing

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