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  1. Article: Nutrition Trends in Kidney Transplant Recipients: the Importance of Dietary Monitoring and Need for Evidence-Based Recommendations.

    Nolte Fong, Joy V / Moore, Linda W

    Frontiers in medicine

    2018  Volume 5, Page(s) 302

    Abstract: Many physiological properties of the renal system influence nutrient metabolism, elimination, and homeostasis. Kidney failure poses significant challenges to maintaining adequate nutrition, most of which transplantation ameliorates. Comprehensive ... ...

    Abstract Many physiological properties of the renal system influence nutrient metabolism, elimination, and homeostasis. Kidney failure poses significant challenges to maintaining adequate nutrition, most of which transplantation ameliorates. Comprehensive recommendations for managing nutritional derangements for patients with chronic kidney disease and end stage renal disease exist; however, there are only sparse guidelines for post-transplant malnutrition and adverse outcomes. Not only are guidelines limited, but little is known about dietary trends of post-kidney transplant recipients. This review describes guidelines for prevalent metabolic and nutritional complications post-kidney transplantation and also evaluates changes in caloric intake and diet composition after transplantation. This topic is important because nutrition influences allograft function and a number of cardiovascular risk factors including blood pressure, dyslipidemia, weight, and diabetes. In addition, many dietary recommendations and modifiable lifestyle changes should be tailored for specific complications of transplant patients, namely immunosuppression side effects, dietary restrictions, and electrolyte imbalances.
    Language English
    Publishing date 2018-10-31
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2018.00302
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Precision Nutrition Model Predicts Glucose Control of Overweight Females Following the Consumption of Potatoes High in Resistant Starch.

    Nolte Fong, Joy V / Miketinas, Derek / Moore, Linda W / Nguyen, Duc T / Graviss, Edward A / Ajami, Nadim / Patterson, Mindy A

    Nutrients

    2022  Volume 14, Issue 2

    Abstract: Individual glycemic responses following dietary intake result from complex physiological processes, and can be influenced by physical properties of foods, such as increased resistant starch (RS) from starch retrogradation. Predictive equations are needed ...

    Abstract Individual glycemic responses following dietary intake result from complex physiological processes, and can be influenced by physical properties of foods, such as increased resistant starch (RS) from starch retrogradation. Predictive equations are needed to provide personalized dietary recommendations to reduce chronic disease development. Therefore, a precision nutrition model predicting the postprandial glucose response (PPGR) in overweight women following the consumption of potatoes was formulated. Thirty overweight women participated in this randomized crossover trial. Participants consumed 250 g of hot (9.2 g RS) or cold (13.7 g RS) potatoes on two separate occasions. Baseline characteristics included demographics, 10-day dietary records, body composition, and the relative abundance (RA) and α-diversity of gut microbiota. Elastic net regression using 5-fold cross-validation predicted PPGR after potato intake. Most participants (70%) had a favorable PPGR to the cold potato. The model explained 32.2% of the variance in PPGR with the equation: 547.65 × (0 [if cold, high-RS potato], ×1, if hot, low-RS potato]) + (BMI [kg/m
    MeSH term(s) Adult ; Area Under Curve ; Blood Glucose/metabolism ; Body Mass Index ; Cross-Over Studies ; Diet ; Faecalibacterium ; Female ; Gastrointestinal Microbiome ; Glycemic Index ; Humans ; Models, Biological ; Nutritional Status ; Obesity/blood ; Obesity/microbiology ; Overweight/blood ; Overweight/microbiology ; Postprandial Period ; Resistant Starch/pharmacology ; Solanum tuberosum/chemistry ; Vegetables/chemistry ; Young Adult
    Chemical Substances Blood Glucose ; Resistant Starch
    Language English
    Publishing date 2022-01-09
    Publishing country Switzerland
    Document type Clinical Trial ; Journal Article ; Observational Study ; Validation Study
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu14020268
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  3. Article ; Online: Metastatic gastric cancer target lesion complete response with Claudin18.2-CAR T cells.

    Botta, Gregory P / Chao, Joseph / Ma, Hong / Hahn, Michael / Sierra, Gloria / Jia, Jie / Hendrix, Amanda Y / Nolte Fong, Joy V / Ween, Audrey / Vu, Peter / Miller, Aaron / Choi, Michael / Heyman, Benjamin / Daniels, Gregory A / Kaufman, Dan / Jamieson, Catriona / Li, Zonghai / Cohen, Ezra

    Journal for immunotherapy of cancer

    2024  Volume 12, Issue 2

    Abstract: Treatment of hematologic malignancies with patient-derived anti-CD19 chimeric antigen receptor (CAR) T-cells has demonstrated long-term remissions for patients with otherwise treatment-refractory advanced leukemia and lymphoma. Conversely, CAR T-cell ... ...

    Abstract Treatment of hematologic malignancies with patient-derived anti-CD19 chimeric antigen receptor (CAR) T-cells has demonstrated long-term remissions for patients with otherwise treatment-refractory advanced leukemia and lymphoma. Conversely, CAR T-cell treatment of solid tumors, including advanced gastric cancer (GC), has proven more challenging due to on-target off-tumor toxicities, poor tumor T-cell infiltration, inefficient CAR T-cell expansion, immunosuppressive tumor microenvironments, and demanding preconditioning regimens. We report the exceptional results of autologous Claudin18.2-targeted CAR T cells (CT041) in a patient with metastatic GC, who had progressed on four lines of combined systemic chemotherapy and immunotherapy. After two CT041 infusions, the patient had target lesion complete response and sustained an 8-month overall partial response with only minimal ascites. Moreover, tumor-informed circulating tumor DNA (ctDNA) reductions coincided with rapid CAR T-cell expansion and radiologic response. No severe toxicities occurred, and the patient's quality of life significantly improved. This experience supports targeting Claudin18.2-positive GC with CAR T-cell therapy and helps to validate ctDNA as a biomarker in CAR T-cell therapy.
    MeSH term(s) Humans ; Receptors, Antigen, T-Cell ; Stomach Neoplasms/therapy ; Quality of Life ; T-Lymphocytes ; Receptors, Chimeric Antigen ; Pathologic Complete Response ; Antigens, CD19 ; Leukemia ; Tumor Microenvironment
    Chemical Substances Receptors, Antigen, T-Cell ; Receptors, Chimeric Antigen ; Antigens, CD19
    Language English
    Publishing date 2024-02-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2719863-7
    ISSN 2051-1426 ; 2051-1426
    ISSN (online) 2051-1426
    ISSN 2051-1426
    DOI 10.1136/jitc-2023-007927
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Precision Nutrition Model Predicts Glucose Control of Overweight Females Following the Consumption of Potatoes High in Resistant Starch

    Nolte Fong, Joy V. / Miketinas, Derek / Moore, Linda W. / Nguyen, Duc T. / Graviss, Edward A. / Ajami, Nadim / Patterson, Mindy A.

    Nutrients. 2022 Jan. 09, v. 14, no. 2

    2022  

    Abstract: Individual glycemic responses following dietary intake result from complex physiological processes, and can be influenced by physical properties of foods, such as increased resistant starch (RS) from starch retrogradation. Predictive equations are needed ...

    Abstract Individual glycemic responses following dietary intake result from complex physiological processes, and can be influenced by physical properties of foods, such as increased resistant starch (RS) from starch retrogradation. Predictive equations are needed to provide personalized dietary recommendations to reduce chronic disease development. Therefore, a precision nutrition model predicting the postprandial glucose response (PPGR) in overweight women following the consumption of potatoes was formulated. Thirty overweight women participated in this randomized crossover trial. Participants consumed 250 g of hot (9.2 g RS) or cold (13.7 g RS) potatoes on two separate occasions. Baseline characteristics included demographics, 10-day dietary records, body composition, and the relative abundance (RA) and α-diversity of gut microbiota. Elastic net regression using 5-fold cross-validation predicted PPGR after potato intake. Most participants (70%) had a favorable PPGR to the cold potato. The model explained 32.2% of the variance in PPGR with the equation: 547.65 × (0 [if cold, high-RS potato], ×1, if hot, low-RS potato]) + (BMI [kg/m²] × 40.66)—(insoluble fiber [g] × 49.35) + (Bacteroides [RA] × 8.69)—(Faecalibacterium [RA] × 73.49)—(Parabacteroides [RA] × 42.08) + (α-diversity × 110.87) + 292.52. This model improves the understanding of baseline characteristics that explain interpersonal variation in PPGR following potato intake and offers a tool to optimize dietary recommendations for a commonly consumed food.
    Keywords Bacteroides ; body composition ; chronic diseases ; cold ; cross-over studies ; demographic statistics ; equations ; food intake ; glucose ; glycemic control ; insoluble fiber ; intestinal microorganisms ; models ; overweight ; potatoes ; resistant starch ; retrogradation ; variance
    Language English
    Dates of publication 2022-0109
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2518386-2
    ISSN 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu14020268
    Database NAL-Catalogue (AGRICOLA)

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  5. Article ; Online: The Rise of the Machines: Will They Fulfill the Restoration Promise?

    Nolte Fong, Joy V / Saharia, Ashish / Hobeika, Mark / Podder, Hemangshu / Ghobrial, R Mark

    Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society

    2020  Volume 26, Issue 12, Page(s) 1568–1570

    MeSH term(s) Humans ; Liver Transplantation ; Living Donors ; Perfusion
    Language English
    Publishing date 2020-11-30
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2006866-9
    ISSN 1527-6473 ; 1527-6465
    ISSN (online) 1527-6473
    ISSN 1527-6465
    DOI 10.1002/lt.25912
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4702: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
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  6. Article: Transplant Oncology: An Evolving Field in Cancer Care.

    Abdelrahim, Maen / Esmail, Abdullah / Abudayyeh, Ala / Murakami, Naoka / Saharia, Ashish / McMillan, Robert / Victor, David / Kodali, Sudha / Shetty, Akshay / Nolte Fong, Joy V / Moore, Linda W / Heyne, Kirk / Gaber, A Osama / Ghobrial, Rafik Mark

    Cancers

    2021  Volume 13, Issue 19

    Abstract: Transplant oncology is an emerging concept of cancer treatment with a promising prospective outcome. The application of oncology, transplant medicine, and surgery to improve patients' survival and quality of life is the core of transplant oncology. ... ...

    Abstract Transplant oncology is an emerging concept of cancer treatment with a promising prospective outcome. The application of oncology, transplant medicine, and surgery to improve patients' survival and quality of life is the core of transplant oncology. Hepatobiliary malignancies have been treated by liver transplantation (LT) with significant improved outcome. In addition, as the liver is the most common site of metastasis for colorectal cancer (CRC), patients with CRC who have stable unresectable liver metastases are good candidates for LT, and initial studies have shown improved survival compared to palliative systemic therapy. The indications of LT for hepatobiliary malignancies have been slowly expanded over the years in a stepwise manner; however, they have only been shown to improve patient survival in the setting of limited systemic therapy options. This review illustrates the concept and history of transplant oncology as an evolving field for the management of hepatocellular carcinoma, intrahepatic biliary cancer, and liver-only metastasis of non-hepatobiliary carcinoma. The utility of immunotherapy in the transplant setting is discussed as well as the feasibility of using circulating tumor DNA for surveillance post-transplantation.
    Language English
    Publishing date 2021-09-29
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers13194911
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  7. Article ; Online: Successful Kidney Transplantation Is Associated With Weight Gain From Truncal Obesity and Insulin Resistance.

    Workeneh, Biruh / Moore, Linda W / Nolte Fong, Joy V / Shypailo, Roman / Gaber, A Osama / Mitch, William E

    Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation

    2019  Volume 29, Issue 6, Page(s) 548–555

    Abstract: Objective: The objective of this study is to compare changes in body composition, lifestyle factors, and metabolic responses occurring in living kidney transplant recipient patients after transplantation.: Design and methods: The study was a single- ... ...

    Abstract Objective: The objective of this study is to compare changes in body composition, lifestyle factors, and metabolic responses occurring in living kidney transplant recipient patients after transplantation.
    Design and methods: The study was a single-site, prospective, observational study. To identify metabolic responses during the initial years after transplantation, we obtained state-of-the-art, high-resolution measurements of body composition from a 4-compartment model using dual-energy X-ray absorptiometry, air displacement plethysmography, and total body potassium and nitrogen counters. We also assessed dietary recalls and actigraphy before transplantation and 3- and 12-month after transplantation. The study was conducted at a quaternary care hospital outpatient transplant center and a United States Department of Agriculture Agricultural Research Service center. Thirty-one adults receiving a living donor kidney allograft were studied. The main outcome measures were change in body composition at 3 months and 1 year after transplantation, and this was correlated with the occurrence of insulin resistance.
    Results: In patients receiving a successful kidney transplant from living donors treated with standard immunosuppression, significant increases in body weight were detected at 3 and 12 months after transplantation (2.2 kg, P = .03 and 6.6 kg, P < .0001, respectively). Weight gain was principally due to adipose tissue accumulation in the truncal region. There was no increase in muscle mass or fluid accumulation. Weight gain was not associated with changes in resting energy expenditure or physical activity. Notably, increases in visceral and subcutaneous adipose tissue were positively correlated with insulin resistance.
    Conclusion: Successful transplantation was associated with increased insulin resistance and weight gain without increases in muscle or fluid. This metabolic pattern suggests potential interventions that could prevent or mitigate the consequences of adipose tissue accumulation in transplant recipients.
    MeSH term(s) Adult ; Body Composition/physiology ; Energy Metabolism ; Exercise ; Female ; Humans ; Insulin Resistance/physiology ; Kidney Transplantation ; Living Donors ; Male ; Middle Aged ; Obesity/physiopathology ; Prospective Studies ; Treatment Outcome ; Weight Gain/physiology
    Language English
    Publishing date 2019-03-07
    Publishing country United States
    Document type Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 1080003-7
    ISSN 1532-8503 ; 1051-2276
    ISSN (online) 1532-8503
    ISSN 1051-2276
    DOI 10.1053/j.jrn.2019.01.009
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3273: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
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  8. Article ; Online: Donation after circulatory death liver transplantation: An in-depth analysis and propensity score-matched comparison.

    Hobeika, Mark J / Saharia, Ashish / Mobley, Constance M / Menser, Terri / Nguyen, Duc T / Graviss, Edward A / McMillan, Robert R / Podder, Hemangshu / Nolte Fong, Joy V / Jones, Stephen L / Yi, Stephanie G / Elshawwaf, Mahmoud / Gaber, Ahmed O / Ghobrial, Rafik M

    Clinical transplantation

    2021  Volume 35, Issue 6, Page(s) e14304

    Abstract: Background: Careful donor-recipient matching and reduced ischemia times have improved outcomes following donation after circulatory death (DCD) liver transplantation (LT). This study examines a single-center experience with DCD LT including high-acuity ... ...

    Abstract Background: Careful donor-recipient matching and reduced ischemia times have improved outcomes following donation after circulatory death (DCD) liver transplantation (LT). This study examines a single-center experience with DCD LT including high-acuity and hospitalized recipients.
    Methods: DCD LT outcomes were compared to a propensity score-matched (PSM) donation after brain death (DBD) LT cohort (1:4); 32 DCD LT patients and 128 PSM DBD LT patients transplanted from 2008 to 2018 were included. Analyses included Kaplan-Meier estimates and Cox proportional hazards models examining patient and graft survival.
    Results: Median MELD score in the DCD LT cohort was 22, with median MELD of 27 for DCD LT recipients with decompensated cirrhosis. No difference in mortality or graft loss was found (p < .05) between DCD LT and PSM DBD LT at 3 years post-transplant, nor was DCD an independent risk factor for patient or graft survival. Post-LT severe acute kidney injury was similar in both groups. Ischemic-type biliary lesions (ITBL) occurred in 6.3% (n = 2) of DCD LT recipients, resulting in 1 graft loss and 1 death.
    Conclusion: This study supports that DCD LT outcomes can be similar to DBD LT, with a low rate of ITBL, in a cohort including high-acuity recipients. Strict donor selection criteria, ischemia time minimization, and avoiding futile donor/recipient combinations are essential considerations.
    MeSH term(s) Brain Death ; Death ; Graft Survival ; Humans ; Liver Transplantation ; Propensity Score ; Retrospective Studies ; Tissue Donors ; Tissue and Organ Procurement ; Treatment Outcome
    Language English
    Publishing date 2021-04-13
    Publishing country Denmark
    Document type Journal Article
    ZDB-ID 639001-8
    ISSN 1399-0012 ; 0902-0063
    ISSN (online) 1399-0012
    ISSN 0902-0063
    DOI 10.1111/ctr.14304
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    Zs.A 2204: Show issues Location:
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