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Article: Associations of phase angle with platelet-activating factor metabolism and related dietary factors in healthy volunteers.

Detopoulou, Paraskevi / Fragopoulou, Elizabeth / Nomikos, Tzortzis / Antonopoulou, Smaragdi

2023 Volume 10, Page(s) 1237086

Abstract: Introduction: Phase angle (PA) is derived from bioelectrical impedance analysis (BIA). It reflects cell membrane function and decreases in disease. It is affected by inflammation, oxidative stress, and diet. Platelet-activating factor (PAF) is a potent ... ...

Abstract	Introduction: Phase angle (PA) is derived from bioelectrical impedance analysis (BIA). It reflects cell membrane function and decreases in disease. It is affected by inflammation, oxidative stress, and diet. Platelet-activating factor (PAF) is a potent inflammatory lipid mediator. Its levels, along with the activity of its metabolic enzymes, including CDP-choline:1-alkyl-2-acetyl- Methods: In healthy subjects, PAF, its metabolic enzyme activity, and erythrocyte fatty acids were measured, while desaturases were estimated. Food-frequency questionnaires and recalls were used, and food groups, macronutrient intake, MedDietScore, and DAC were assessed. Lifestyle and biochemical variables were collected. DXA and BIA measurements were performed. Results: Lp-PLA Conclusion: PA is associated with PAF levels and Lp-PLA
Language	English
Publishing date	2023-11-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2776676-7
ISSN	2296-861X
ISSN	2296-861X
DOI	10.3389/fnut.2023.1237086
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Article ; Online: Effect of a 6-Week Preseason Training Protocol on Physiological and Muscle Damage Markers in High-Level Female and Male Basketball Players.

Mexis, Dimitrios / Nomikos, Tzortzis / Mitsopoulos, Nikolaos / Kostopoulos, Nikolaos

Sports (Basel, Switzerland)

2023 Volume 11, Issue 11

Abstract: This study aimed to investigate the effects of a 6-week preseason functional and plyometric fitness training protocol, on physiological and biochemical markers of performance and exercise-induced muscle damage, and to compare the response of these ... ...

Abstract	This study aimed to investigate the effects of a 6-week preseason functional and plyometric fitness training protocol, on physiological and biochemical markers of performance and exercise-induced muscle damage, and to compare the response of these markers between high-level female and male basketball players. The sample of the study consisted of 19 professional athletes (10 male; 9 female) competing in two different teams. The examined markers were body mass, BMI, fat percentage, speed, acceleration, explosiveness, vertical jumping ability, creatine kinase (CK) and lactate dehydrogenase (LDH). The preseason training period improved speed, acceleration, explosiveness and vertical jumping ability (~1-8%) and led to significant fat percentage reductions in both groups equivalently. CK and LDH increased similarly in both groups, and the percentage increases were higher for CK compared to LDH. Further investigation and a larger sample size are required in order to determine an approach that is more capable of maximizing performance without causing any possible injuries that may be related to muscle damage.
Language	English
Publishing date	2023-11-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704239-X
ISSN	2075-4663 ; 2075-4663
ISSN (online)	2075-4663
ISSN	2075-4663
DOI	10.3390/sports11110229
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Article ; Online: Type IIx muscle fibers are related to poor body composition, glycemic and lipidemic blood profiles in young females: the protective role of type I and IIa muscle fibers.

Methenitis, Spyridon / Nomikos, T / Mpampoulis, T / Kontou, E / Evangelidou, E / Papadopoulos, C / Papadimas, G / Terzis, G

European journal of applied physiology

2023 Volume 124, Issue 2, Page(s) 585–594

Abstract: Purpose: The aim of the present study was to investigate the association between muscle fiber composition, body composition, resting glycemic-lipidemic blood profiles, in apparently healthy, young, active females.: Methods: Thirty-four young healthy ... ...

Abstract	Purpose: The aim of the present study was to investigate the association between muscle fiber composition, body composition, resting glycemic-lipidemic blood profiles, in apparently healthy, young, active females. Methods: Thirty-four young healthy female volunteers were allocated into two groups, depending on their Vastus Lateralis type IIx muscle fibers percent cross-sectional area (%CSA; H: high type IIx %CSA; L: low type IIx %CSA). Body composition was determined via dual-energy X-ray absorptiometry. Venous blood samples were collected for the determination of resting serum glucose, Insulin, Apo-A1, HOMA-IR, triglycerides (TG), total cholesterol (TC), High-density lipoprotein (HDL-C), and Low-density lipoprotein (LDL-C) concentrations. Nutritional intake was also evaluated. Results: Individuals of the H group have significantly higher body mass, body fat percentage-mass, and resting blood indices of glycemic and lipidemic profiles, compared to those of L group (p < 0.001). Increased type IIx and low type I, IIa muscle fibers %CSAs were linked with poorer body composition, glycemic and lipidemic blood profiles (r: - 0.722 to 0.740, p < 0.001). Linear regression analyses revealed that the impact of muscle fibers %CSA (B coefficients ranged between - 0.700 and 0.835) on the above parameters, was at least, of the same or even of greater magnitude as that of body composition and daily nutritional intake (B: - 0.700 to 0.666). Conclusion: Increased type IIx and low Type I, IIa %CSAs are associated with poorer body composition and glycemic-lipidemic profiles in young healthy females. The contribution of the muscle fiber %CSA on health status seems to be comparable to that of nutrition and body composition.
MeSH term(s)	Humans ; Female ; Muscle Fibers, Skeletal/physiology ; Body Composition ; Quadriceps Muscle/physiology ; Insulin ; Nutritional Status
Chemical Substances	Insulin
Language	English
Publishing date	2023-09-01
Publishing country	Germany
Document type	Journal Article
ZDB-ID	124793-1
ISSN	1439-6327 ; 1432-1025 ; 0301-5548 ; 1439-6319
ISSN (online)	1439-6327 ; 1432-1025
ISSN	0301-5548 ; 1439-6319
DOI	10.1007/s00421-023-05302-4
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Article ; Online: Effect of Pre-Season Training on Physiological and Biochemical Indices in Basketball Players-A Systematic Review.

Mexis, Dimitrios / Nomikos, Tzortzis / Kostopoulos, Nikolaos

Sports (Basel, Switzerland)

2022 Volume 10, Issue 6

Abstract: The pre-season period in basketball includes all the physiological attributes that the players need to work on and develop, in order to sustain a full season workload. The monitoring of the effectiveness of pre-season training is based on a variety of ... ...

Abstract	The pre-season period in basketball includes all the physiological attributes that the players need to work on and develop, in order to sustain a full season workload. The monitoring of the effectiveness of pre-season training is based on a variety of biochemical and physiological indices; however, it is still unclear how pre-season training affects those markers. Therefore, this study aimed to analyze the effects of pre-season training on biochemical and physiological markers. A search was performed in five large scientific databases (Pubmed (Medline), Scopus, Science-Direct, Sport-Discus (EBSCO), Semantic Scholar) and produced 7081 results, which after removing duplicates and applying inclusion and exclusion criteria, resulted in 28 published scientific articles being included in this review. The most important findings suggested that the majority of the studies used a 6- or an 8-week pre-season training protocol, because these protocols have shown significant positive effects over the years. In addition, the plyometric training protocols that were used by many studies have been found to be beneficial for basketball athletes for many physiological parameters. Furthermore, the evaluation of biochemical markers can be a very useful tool in monitoring and managing fatigue, which is an essential part of modifying the training process, in order to maximize performance.
Language	English
Publishing date	2022-05-26
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2704239-X
ISSN	2075-4663 ; 2075-4663
ISSN (online)	2075-4663
ISSN	2075-4663
DOI	10.3390/sports10060085
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Article ; Online: The emerging role of skeletal muscle as a modulator of lipid profile the role of exercise and nutrition.

Nomikos, Tzortzis / Methenitis, Spyridon / Panagiotakos, Demosthenes B

Lipids in health and disease

2022 Volume 21, Issue 1, Page(s) 81

Abstract: The present article aims to discuss the hypothesis that skeletal muscle per se but mostly its muscle fiber composition could be significant determinants of lipid metabolism and that certain exercise modalities may improve metabolic dyslipidemia by ... ...

Abstract	The present article aims to discuss the hypothesis that skeletal muscle per se but mostly its muscle fiber composition could be significant determinants of lipid metabolism and that certain exercise modalities may improve metabolic dyslipidemia by favorably affecting skeletal muscle mass, fiber composition and functionality. It discusses the mediating role of nutrition, highlights the lack of knowledge on mechanistic aspects of this relationship and proposes possible experimental directions in this field.
MeSH term(s)	Exercise/physiology ; Lipid Metabolism ; Lipids ; Muscle Fibers, Skeletal/metabolism ; Muscle, Skeletal/metabolism
Chemical Substances	Lipids
Language	English
Publishing date	2022-08-30
Publishing country	England
Document type	Journal Article
ZDB-ID	2091381-3
ISSN	1476-511X ; 1476-511X
ISSN (online)	1476-511X
ISSN	1476-511X
DOI	10.1186/s12944-022-01692-0
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Article: Pumpkin Seed Extracts Inhibit Proliferation and Induce Autophagy in PC-3 Androgen Insensitive Prostate Cancer Cells

Nomikos, Tzortzis / Gioti, Katerina / Tsoukala, Magafoula / Tenta, Roxane

Journal of medicinal food. 2021 May 11,

2021

Abstract: Pumpkin seed is a rich source of polyphenols and other bioactive compounds that may act as chemopreventive agents against cancer. In this study, five different extracts of pumpkin seeds were evaluated for their ability to affect proliferation and ... ...

Abstract	Pumpkin seed is a rich source of polyphenols and other bioactive compounds that may act as chemopreventive agents against cancer. In this study, five different extracts of pumpkin seeds were evaluated for their ability to affect proliferation and autophagy on PC-3 prostate cancer cells. All extracts (water [W], methanolic, acetone, ethylacetate, and polar lipid [PL]) inhibited cell proliferation in a dose-dependent manner. Treatment of cells with the PL extract increased cell distribution in the S phase, whereas PL and W extracts induced autophagy significantly. Moreover, PL extract induced a remarkable increase of glutathione and oxidized glutathione levels, whereas nitrite and hydrogen peroxide levels were not altered. In conclusion, pumpkin seed extracts affect PC-3 cell viability, oxidative parameters, and autophagic mechanism, thus demonstrating their potential pharmacological use.
Keywords	acetone ; androgens ; autophagy ; cell proliferation ; cell viability ; chemoprevention ; dose response ; ethyl acetate ; functional foods ; glutathione ; hydrogen peroxide ; interphase ; lipids ; nitrites ; polyphenols ; prostatic neoplasms ; pumpkins
Language	English
Dates of publication	2021-0511
Publishing place	Mary Ann Liebert, Inc.
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	1427365-2
ISSN	1557-7600 ; 1096-620X
ISSN (online)	1557-7600
ISSN	1096-620X
DOI	10.1089/jmf.2020.0200
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Exercise and Nutrition Strategies for Combating Sarcopenia and Type 2 Diabetes Mellitus in Older Adults.

Argyropoulou, Dionysia / Geladas, Nikolaos D / Nomikos, Tzortzis / Paschalis, Vassilis

Journal of functional morphology and kinesiology

2022 Volume 7, Issue 2

Abstract: Medical and technology development have drastically the improved quality of life and, consequently, life expectancy. Nevertheless, the more people who enter the third-age, the more geriatric syndromes expand in the elderly. Sarcopenia and Type 2 diabetes ...

Abstract	Medical and technology development have drastically the improved quality of life and, consequently, life expectancy. Nevertheless, the more people who enter the third-age, the more geriatric syndromes expand in the elderly. Sarcopenia and Type 2 diabetes mellitus (T2DM) are common diseases among the elderly and the literature has extensively studied these two diseases separately. Recent evidence, however, revealed that there is a bidirectional relationship between sarcopenia and T2DM. The aims of the present review were: (1) to present diet and exercise interventions for the management of sarcopenia and T2DM and (2) identify which diet and exercise interventions can be used simultaneously in order to effectively deal with these two disorders. Exercise and a balanced diet are used as effective countermeasures for combating sarcopenia and T2DM in older adults based on their bidirectional relationship. Lifestyle changes such as exercise and a balanced diet seem to play an important role in the remission of the diseases. Results showed that chronic exercise can help towards glycemic regulation as well as decrease the incidence rate of muscle degradation, while diet interventions which focus on protein or amino acids seem to successfully treat both disorders. Despite the fact that there are limited studies that deal with both disorders, it seems that a combined exercise regime (aerobic and resistance) along with protein intake > 1gr/kg/d is the safest strategy to follow in order to manage sarcopenia and T2DM concurrently.
Language	English
Publishing date	2022-06-08
Publishing country	Switzerland
Document type	Journal Article ; Review
ISSN	2411-5142
ISSN (online)	2411-5142
DOI	10.3390/jfmk7020048
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Article: Can Exercise-Induced Muscle Damage Be a Good Model for the Investigation of the Anti-Inflammatory Properties of Diet in Humans?

Methenitis, Spyridon / Stergiou, Ioanna / Antonopoulou, Smaragdi / Nomikos, Tzortzis

Biomedicines

2021 Volume 9, Issue 1

Abstract: Subclinical, low-grade, inflammation is one of the main pathophysiological mechanisms underlying the majority of chronic and non-communicable diseases. Several methodological approaches have been applied for the assessment of the anti-inflammatory ... ...

Abstract	Subclinical, low-grade, inflammation is one of the main pathophysiological mechanisms underlying the majority of chronic and non-communicable diseases. Several methodological approaches have been applied for the assessment of the anti-inflammatory properties of nutrition, however, their impact in human body remains uncertain, because of the fact that the majority of the studies reporting anti-inflammatory effect of dietary patterns, have been performed under laboratory settings and/or in animal models. Thus, the extrapolation of these results to humans is risky. It is therefore obvious that the development of an inflammatory model in humans, by which we could induce inflammatory responses to humans in a regulated, specific, and non-harmful way, could greatly facilitate the estimation of the anti-inflammatory properties of diet in a more physiological way and mechanistically relevant way. We believe that exercise-induced muscle damage (EIMD) could serve as such a model, either in studies investigating the homeostatic responses of individuals under inflammatory stimuli or for the estimation of the anti-inflammatory or pro-inflammatory potential of dietary patterns, foods, supplements, nutrients, or phytochemicals. Thus, in this review we discuss the possibility of exercise-induced muscle damage being an inflammation model suitable for the assessment of the anti-inflammatory properties of diet in humans.
Language	English
Publishing date	2021-01-05
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines9010036
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Article ; Online: Acute Antiplatelet Effects of an Oleocanthal-Rich Olive Oil in Type II Diabetic Patients: A Postprandial Study.

Katsa, Maria Efthymia / Ketselidi, Kleopatra / Kalliostra, Marianna / Ioannidis, Anastasios / Rojas Gil, Andrea Paola / Diamantakos, Panagiotis / Melliou, Eleni / Magiatis, Prokopios / Nomikos, Tzortzis

International journal of molecular sciences

2024 Volume 25, Issue 2

Abstract: Postprandial dysmetabolism is a common entity of type 2 diabetes mellitus (T2DM) and may act as a daily stressor of the already dysfunctional diabetic platelets. This study aims to investigate whether oleocanthal-rich olive oils (OO), incorporated into a ...

Abstract	Postprandial dysmetabolism is a common entity of type 2 diabetes mellitus (T2DM) and may act as a daily stressor of the already dysfunctional diabetic platelets. This study aims to investigate whether oleocanthal-rich olive oils (OO), incorporated into a carbohydrate-rich meal, can affect postprandial dysmetabolism and platelet aggregation. Oleocanthal is a cyclooxygenase inhibitor with putative antiplatelet properties. In this randomized, single-blinded, crossover study, ten T2DM patients consumed five isocaloric meals containing 120 g white bread combined with: (i) 39 g butter, (ii) 39 g butter and 400 mg ibuprofen, (iii) 40 mL OO (phenolic content < 10 mg/Kg), (iv) 40 mL OO with 250 mg/Kg oleocanthal and (v) 40 mL OO with 500 mg/Kg oleocanthal. Metabolic markers along with ex vivo ADP- and thrombin receptor-activating peptide (TRAP)-induced platelet aggregation were measured before and for 4 h after the meals. The glycemic and lipidemic response was similar between meals. However, a sustained (90-240 min) dose-dependent reduction in platelets' sensitivity to both ADP (50-100%) and TRAP (20-50%) was observed after the oleocanthal meals in comparison to OO or butter meals. The antiplatelet effect of the OO containing 500 mg/Kg oleocanthal was comparable to that of the ibuprofen meal. In conclusion, the consumption of meals containing oleocanthal-rich OO can reduce platelet activity during the postprandial period, irrespective of postprandial hyperglycemia and lipidemia.
MeSH term(s)	Humans ; Diabetes Mellitus, Type 2/drug therapy ; Olive Oil/pharmacology ; Ibuprofen ; Cross-Over Studies ; Postprandial Period ; Butter ; Cyclopentane Monoterpenes ; Aldehydes ; Phenols
Chemical Substances	oleocanthal (AC7QO6038O) ; Olive Oil ; Ibuprofen (WK2XYI10QM) ; Butter (8029-34-3) ; Cyclopentane Monoterpenes ; Aldehydes ; Phenols
Language	English
Publishing date	2024-01-11
Publishing country	Switzerland
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25020908
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Article ; Online: Plant Sterols and Plant Stanols in Cholesterol Management and Cardiovascular Prevention.

Barkas, Fotios / Bathrellou, Eirini / Nomikos, Tzortzis / Panagiotakos, Demosthenes / Liberopoulos, Evangelos / Kontogianni, Meropi D

Nutrients

2023 Volume 15, Issue 13

Abstract: Atherosclerotic cardiovascular disease (ASCVD) remains the major mortality cause in developed countries with hypercholesterolaemia being one of the primary modifiable causes. Lifestyle intervention constitutes the first step in cholesterol management and ...

Abstract	Atherosclerotic cardiovascular disease (ASCVD) remains the major mortality cause in developed countries with hypercholesterolaemia being one of the primary modifiable causes. Lifestyle intervention constitutes the first step in cholesterol management and includes dietary modifications along with the use of functional foods and supplements. Functional foods enriched with plant sterols/stanols have become the most widely used nonprescription cholesterol-lowering approach, despite the lack of randomized trials investigating their long-term safety and cardiovascular efficacy. The cholesterol-lowering effect of plant-sterol supplementation is well-established and a potential beneficial impact on other lipoproteins and glucose homeostasis has been described. Nevertheless, experimental and human observational studies investigating the association of phytosterol supplementation or circulating plant sterols with various markers of atherosclerosis and ASCVD events have demonstrated controversial results. Compelling evidence from recent genetic studies have also linked elevated plasma concentrations of circulating plant sterols with ASCVD presence, thus raising concerns about the safety of phytosterol supplementation. Thus, the aim of this review is to provide up-to-date data on the effect of plant sterols/stanols on lipid-modification and cardiovascular outcomes, as well as to discuss any safety issues and practical concerns.
MeSH term(s)	Humans ; Phytosterols ; Hypercholesterolemia/drug therapy ; Anticholesteremic Agents/therapeutic use ; Cholesterol ; Atherosclerosis ; Cardiovascular Diseases/prevention & control
Chemical Substances	Phytosterols ; Anticholesteremic Agents ; Cholesterol (97C5T2UQ7J)
Language	English
Publishing date	2023-06-22
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu15132845
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