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Article ; Online: Risk factors for clinical progression in patients with pulmonary Mycobacterium avium complex disease without culture-positive sputum: a single-center, retrospective study.

Nonaka, Mizu / Matsuyama, Masashi / Sakai, Chio / Matsumura, Sosuke / Arai, Naoki / Nakajima, Masayuki / Saito, Takefumi / Hizawa, Nobuyuki

European journal of medical research

2023 Volume 28, Issue 1, Page(s) 186

Abstract: Objectives: Limited data are available on the progression of pulmonary Mycobacterium avium complex (MAC) disease without culture-positive sputum. The aim of this study was to identify the risk factors associated with clinical progression of pulmonary ... ...

Abstract	Objectives: Limited data are available on the progression of pulmonary Mycobacterium avium complex (MAC) disease without culture-positive sputum. The aim of this study was to identify the risk factors associated with clinical progression of pulmonary MAC disease diagnosed by bronchoscopy. Methods: A single-center, retrospective, observational study was conducted. Pulmonary MAC patients diagnosed by bronchoscopy without culture-positive sputum from January 1, 2013, to December 31, 2017 were analyzed. Clinical progression after diagnosis was defined as having culture-positive sputum at least once or initiation of guideline-based therapy. Then, clinical characteristics were compared between clinically progressed patients and stable patients. Results: Ninety-three pulmonary MAC patients diagnosed by bronchoscopy were included in the analysis. During the 4-year period after diagnosis, 38 patients (40.9%) started treatment, and 35 patients (37.6%) had new culture-positive sputum. Consequently, 52 patients (55.9%) were classified into the progressed group, and 41 patients (44.1%) were classified into the stable group. There were no significant differences between the progressed and the stable groups in age, body mass index, smoking status, comorbidities, symptoms, or species isolated from bronchoscopy. On multivariate analysis, male sex, monocyte to lymphocyte ratio (MLR) ≥ 0.17, and the presence of combined lesions in the middle (lingula) and lower lobes were risk factors for clinical progression. Conclusions: Some patients with pulmonary MAC disease without culture-positive sputum progress within 4 years. Therefore, pulmonary MAC patients, especially male patients, having higher MLR or lesions in the middle (lingula) and lower lobes might need careful follow-up for a longer time.
MeSH term(s)	Humans ; Male ; Mycobacterium avium Complex ; Retrospective Studies ; Mycobacterium avium-intracellulare Infection/diagnosis ; Mycobacterium avium-intracellulare Infection/drug therapy ; Mycobacterium avium-intracellulare Infection/microbiology ; Sputum/microbiology ; Lung Diseases/drug therapy ; Risk Factors ; Disease Progression
Language	English
Publishing date	2023-06-08
Publishing country	England
Document type	Observational Study ; Letter
ZDB-ID	1329381-3
ISSN	2047-783X ; 0949-2321
ISSN (online)	2047-783X
ISSN	0949-2321
DOI	10.1186/s40001-023-01152-0
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Article ; Online: Pathophysiology of pulmonary nontuberculous mycobacterial (NTM) disease.

Matsuyama, Masashi / Matsumura, Sosuke / Nonaka, Mizu / Nakajima, Masayuki / Sakai, Chio / Arai, Naoki / Ueda, Kodai / Hizawa, Nobuyuki

Respiratory investigation

2023 Volume 61, Issue 2, Page(s) 135–148

Abstract: In recent years, the incidence and prevalence of pulmonary nontuberculous mycobacterial (NTM) disease have increased worldwide. Although the reasons for this increase are unclear, dealing with this disease is essential. Pulmonary NTM disease is a chronic ...

Abstract	In recent years, the incidence and prevalence of pulmonary nontuberculous mycobacterial (NTM) disease have increased worldwide. Although the reasons for this increase are unclear, dealing with this disease is essential. Pulmonary NTM disease is a chronic pulmonary infection caused by NTM bacteria, which are ubiquitous in various environments. In Japan, Mycobacterium avium-intracellulare complex (MAC) accounts for approximately 90% of the causative organisms of pulmonary NTM disease, which is also called pulmonary MAC disease or pulmonary MAI disease. It is important to elucidate the pathophysiology of this disease, which occurs frequently in postmenopausal women despite the absence of obvious immunodeficiency. The pathophysiology of this disease has not been fully elucidated; however, it can largely be divided into bacterial (environmental) and host-side problems. The host factors can be further divided into immune and airway problems. The authors suggest that the triangular relationship between bacteria, immunity, and the airway is important in the pathophysiology of this disease. The latest findings on the pathophysiology of pulmonary NTM disease are reviewed.
MeSH term(s)	Humans ; Female ; Mycobacterium Infections, Nontuberculous/epidemiology ; Mycobacterium avium Complex ; Nontuberculous Mycobacteria ; Lung Diseases/epidemiology ; Lung
Language	English
Publishing date	2023-01-12
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	2660821-2
ISSN	2212-5353 ; 2212-5345
ISSN (online)	2212-5353
ISSN	2212-5345
DOI	10.1016/j.resinv.2022.12.002
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Article: The Role of NRF2 in Mycobacterial Infection

Matsuyama, Masashi / Nonaka, Mizu / Nakajima, Masayuki / Morishima, Yuko / Ishii, Yukio / Hizawa, Nobuyuki

Antioxidants. 2021 Nov. 23, v. 10, no. 12

2021

Abstract: The incidence of pulmonary nontuberculous mycobacterial (NTM) infection is increasing worldwide, and its clinical outcomes with current chemotherapies are unsatisfactory. The incidence of tuberculosis (TB) is still high in Africa, and the existence of ... ...

Abstract	The incidence of pulmonary nontuberculous mycobacterial (NTM) infection is increasing worldwide, and its clinical outcomes with current chemotherapies are unsatisfactory. The incidence of tuberculosis (TB) is still high in Africa, and the existence of drug-resistant tuberculosis is also an important issue for treatment. To discover and develop new efficacious anti-mycobacterial treatments, it is important to understand the host-defense mechanisms against mycobacterial infection. Nuclear erythroid 2 p45-related factor-2 (NRF2) is known to be a major regulator of various antioxidant response element (ARE)-driven cytoprotective gene expressions, and its protective role has been demonstrated in infections. However, there are not many papers or reviews regarding the role of NRF2 in mycobacterial infectious disease. Therefore, this review focuses on the role of NRF2 in the pathogenesis of Mycobacterium tuberculosis and Mycobacterium avium infection.
Keywords	Mycobacterium avium ; Mycobacterium tuberculosis ; antioxidant activity ; drug resistance ; genes ; pathogenesis ; protective effect ; tuberculosis ; Africa
Language	English
Dates of publication	2021-1123
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox10121861
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Blood eosinophil phenotype during treatment with mepolizumab in patients with severe eosinophilic asthma.

Sakai, Chio / Matsuyama, Masashi / Nakajima, Masayuki / Matsumura, Sosuke / Nonaka, Mizu / Arai, Naoki / Kuramoto, Kenya / Yoshida, Kazufumi / Morishima, Yuko / Muratani, Masafumi / Hizawa, Nobuyuki

Allergology international : official journal of the Japanese Society of Allergology

2024

Language	English
Publishing date	2024-04-05
Publishing country	England
Document type	Letter
ZDB-ID	1336498-4
ISSN	1440-1592 ; 1323-8930
ISSN (online)	1440-1592
ISSN	1323-8930
DOI	10.1016/j.alit.2024.03.005
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Article ; Online: Amikacin liposome inhalation suspension for Mycobacterium avium complex pulmonary disease: A subgroup analysis of Japanese patients in the randomized, phase 3, CONVERT study.

Morimoto, Kozo / Nonaka, Mizu / Yamazaki, Yoshitaka / Nakagawa, Taku / Takasaki, Jin / Tsuyuguchi, Kazunari / Kitada, Seigo / Jumadilova, Zhanna / Yuen, Dayton W / Ciesielska, Monika / Hasegawa, Naoki

Respiratory investigation

2024 Volume 62, Issue 2, Page(s) 284–290

Abstract: Background: CONVERT, a randomized, active-controlled, global, Phase 3 trial demonstrated that patients with treatment-refractory Mycobacterium avium complex (MAC) pulmonary disease were more likely to achieve culture conversion with amikacin liposome ... ...

Abstract	Background: CONVERT, a randomized, active-controlled, global, Phase 3 trial demonstrated that patients with treatment-refractory Mycobacterium avium complex (MAC) pulmonary disease were more likely to achieve culture conversion with amikacin liposome inhalation suspension (ALIS) plus guideline-based therapy (GBT) versus those continuing on GBT alone. This subgroup analysis reports the efficacy and safety of ALIS in Japanese patients enrolled in CONVERT. Methods: Japanese patients aged ≥20 years with treatment-refractory MAC pulmonary disease from Japanese sites were included. Patients were randomized to receive once-daily 590 mg ALIS + GBT or GBT alone; patients converting by Month 6 remained in the study to complete 12-month treatment followed by a 12-month off-treatment period. Nonconverters exited the study at Month 8. The primary endpoint was the proportion of patients achieving culture conversion by Month 6. Results: Of the 59 Japanese patients screened, 48 were randomized to receive ALIS + GBT (n = 34) or GBT alone (n = 14), and 41/48 (85.4 %) were women. The mean (standard deviation) age of patients was 64.5 (8.6) years, and 83.3 % of patients had bronchiectasis at baseline. By Month 6, sputum culture conversion was cumulatively achieved in 9/34 (26.5 %) patients receiving ALIS + GBT versus none receiving GBT alone. Treatment-emergent adverse events were reported in 94.1 % and 100.0 % of patients receiving ALIS + GBT and GBT alone, respectively. No deaths were reported. Conclusions: The efficacy observed in the Japanese subpopulation was largely consistent with that in the overall CONVERT study population, with more patients achieving culture conversion with ALIS + GBT versus GBT alone. Safety profiles were similar between the overall population and the Japanese subpopulation. Clinical trial registration: NCT02344004.
MeSH term(s)	Female ; Humans ; Male ; Amikacin/adverse effects ; Anti-Bacterial Agents/adverse effects ; Japan ; Liposomes/therapeutic use ; Lung Diseases/chemically induced ; Mycobacterium avium Complex ; Mycobacterium avium-intracellulare Infection/drug therapy ; Middle Aged ; Aged
Chemical Substances	Amikacin (84319SGC3C) ; Anti-Bacterial Agents ; Liposomes
Language	English
Publishing date	2024-01-25
Publishing country	Netherlands
Document type	Randomized Controlled Trial ; Clinical Trial, Phase III ; Journal Article
ZDB-ID	2660821-2
ISSN	2212-5353 ; 2212-5345
ISSN (online)	2212-5353
ISSN	2212-5345
DOI	10.1016/j.resinv.2023.12.012
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Article: The Role of NRF2 in Mycobacterial Infection.

Matsuyama, Masashi / Nonaka, Mizu / Nakajima, Masayuki / Morishima, Yuko / Ishii, Yukio / Hizawa, Nobuyuki

Antioxidants (Basel, Switzerland)

2021 Volume 10, Issue 12

Abstract	The incidence of pulmonary nontuberculous mycobacterial (NTM) infection is increasing worldwide, and its clinical outcomes with current chemotherapies are unsatisfactory. The incidence of tuberculosis (TB) is still high in Africa, and the existence of drug-resistant tuberculosis is also an important issue for treatment. To discover and develop new efficacious anti-mycobacterial treatments, it is important to understand the host-defense mechanisms against mycobacterial infection. Nuclear erythroid 2 p45-related factor-2 (NRF2) is known to be a major regulator of various antioxidant response element (ARE)-driven cytoprotective gene expressions, and its protective role has been demonstrated in infections. However, there are not many papers or reviews regarding the role of NRF2 in mycobacterial infectious disease. Therefore, this review focuses on the role of NRF2 in the pathogenesis of
Language	English
Publishing date	2021-11-23
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox10121861
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Article: Usual interstitial pneumonia progressing to nonspecific interstitial pneumonia-like pattern on high-resolution CT with histologic confirmation.

Yazaki, Kai / Nonaka, Mizu / Shigemasa, Rie / Minami, Yuko / Saito, Takefumi / Hizawa, Nobuyuki

Radiology case reports

2021 Volume 16, Issue 5, Page(s) 1019–1022

Abstract: Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal disease. Although high-resolution computed tomography (HRCT) is important for the diagnosis of IPF, the changes in the HRCT findings in IPF are not fully understood. The patient was a 66-year- ...

Abstract	Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal disease. Although high-resolution computed tomography (HRCT) is important for the diagnosis of IPF, the changes in the HRCT findings in IPF are not fully understood. The patient was a 66-year-old man. His HRCT findings had atypically developed from a probable usual interstitial pneumonia pattern to a nonspecific interstitial pneumonia (NSIP) like pattern over 6 years. On the basis of the histologic examination and multidisciplinary discussion, IPF was diagnosed, and nintedanib, administered. This case can be useful for the differential diagnosis of IPF and NSIP.
Language	English
Publishing date	2021-02-24
Publishing country	Netherlands
Document type	Case Reports
ZDB-ID	2406300-9
ISSN	1930-0433
ISSN	1930-0433
DOI	10.1016/j.radcr.2021.02.019
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Article ; Online: A case of primary multidrug-resistant pulmonary tuberculosis with high minimum inhibitory concentration value for bedaquiline.

Kobayashi, Masahiro / Motoki, Yuya / Yamagishi, Tetuya / Hirano, Hitomi / Nonaka, Mizu / Aono, Akio / Mitarai, Satoshi / Saito, Takefumi

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy

2022 Volume 28, Issue 8, Page(s) 1193–1197

Abstract: Bedaquiline is a new ATP synthesis inhibitor developed as an anti-tuberculosis agent. It has resistance-associated variants (RAV), regardless of preceding bedaquiline exposure. Herein, we describe the case of a patient with multidrug-resistant ... ...

Abstract	Bedaquiline is a new ATP synthesis inhibitor developed as an anti-tuberculosis agent. It has resistance-associated variants (RAV), regardless of preceding bedaquiline exposure. Herein, we describe the case of a patient with multidrug-resistant tuberculosis (MDR-TB) who had no history of bedaquiline therapy but presented a relatively high minimum inhibitory concentration (MIC) of bedaquiline (1 μg/mL). Whole genome sequencing revealed a mutation in the resistance-associated gene Rv0678. The patient was first treated with a five-drug regimen (bedaquiline, delamanid, levofloxacin, cycloserine, and amikacin), which induced negative sputum culture conversion. Despite the successful treatment outcome, several questions remain regarding the efficacy of bedaquiline in this patient. Bedaquiline is an indispensable drug for MDR-TB treatment, but its clinical efficiency in the presence of Rv0678 mutations remains unclear. Therefore, evaluating the MIC of bedaquiline even in patients without a history of bedaquiline use is important for therapeutic regimen selection and may emphasize the importance of therapeutic drug monitoring in cases of bedaquiline RAV.
MeSH term(s)	Antitubercular Agents/pharmacology ; Antitubercular Agents/therapeutic use ; Diarylquinolines/pharmacology ; Diarylquinolines/therapeutic use ; Humans ; Microbial Sensitivity Tests ; Mycobacterium tuberculosis/genetics ; Tuberculosis, Multidrug-Resistant/drug therapy ; Tuberculosis, Pulmonary/drug therapy
Chemical Substances	Antitubercular Agents ; Diarylquinolines ; bedaquiline (78846I289Y)
Language	English
Publishing date	2022-05-10
Publishing country	Netherlands
Document type	Case Reports ; Journal Article
ZDB-ID	1355399-9
ISSN	1437-7780 ; 1341-321X
ISSN (online)	1437-7780
ISSN	1341-321X
DOI	10.1016/j.jiac.2022.04.028
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Zs.A 5236: Show issues

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Article ; Online: Variations in

Arai, Naoki / Nakajima, Masayuki / Matsuyama, Masashi / Matsumura, Sosuke / Yazaki, Kai / Sakai, Chio / Nonaka, Mizu / Yanai, Hidetoshi / Numata, Takeshi / Yamamoto, Yusuke / Akatsu, Yoshibumi / Iijima, Hiroaki / Morishima, Yuko / Matsuno, Yosuke / Endo, Takeo / Muratani, Masafumi / Ishii, Yukio / Saito, Takefumi / Hizawa, Nobuyuki

American journal of respiratory cell and molecular biology

2023 Volume 69, Issue 2, Page(s) 242–246

MeSH term(s)	Humans ; Idiopathic Pulmonary Fibrosis/drug therapy ; Idiopathic Pulmonary Fibrosis/genetics ; Idiopathic Pulmonary Fibrosis/metabolism ; Indoles/pharmacology ; Indoles/therapeutic use ; Gene Expression ; Treatment Outcome
Chemical Substances	nintedanib (G6HRD2P839) ; Indoles
Language	English
Publishing date	2023-08-01
Publishing country	United States
Document type	Letter ; Research Support, Non-U.S. Gov't
ZDB-ID	1025960-0
ISSN	1535-4989 ; 1044-1549
ISSN (online)	1535-4989
ISSN	1044-1549
DOI	10.1165/rcmb.2023-0054LE
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Zs.A 2851: Show issues

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Article ; Online: Impact of sleep-related hypoventilation in patients with pleuroparenchymal fibroelastosis.

Yabuuchi, Yuki / Saito, Takefumi / Hirano, Hitomi / Nonaka, Mizu / Arai, Naoki / Hyodo, Kentaro / Kanazawa, Jun / Miura, Yukiko / Usui, Shingo / Tamura, Katsumi / Kasamatsu, Tomotaka / Oh-Ishi, Shuji / Hayashihara, Kenji / Matsuyama, Masashi / Hizawa, Nobuyuki

Respiratory research

2022 Volume 23, Issue 1, Page(s) 295

Abstract: Background: Pleuroparenchymal fibroelastosis (PPFE) is a rare fibrosing lung disease with a predilection for the upper lobe and its progression causes hypoventilation, resulting in hypercapnia. Even though the association between sleep-related ... ...

Abstract	Background: Pleuroparenchymal fibroelastosis (PPFE) is a rare fibrosing lung disease with a predilection for the upper lobe and its progression causes hypoventilation, resulting in hypercapnia. Even though the association between sleep-related hypoventilation (SRH) and chronic obstructive pulmonary disease was well documented, its impact in patients with PPFE was not evaluated. The aim of this study is to clarify the impact of SRH on prognosis in PPFE. Methods: A retrospective review of the medical records of 52 patients with PPFE who underwent transcutaneous carbon dioxide monitoring during sleep was done. Patients were stratified into SRH (n = 28) and non-SRH (n = 24) groups based on American Academy of Sleep Medicine criteria. The impact of SRH on the prognosis of PPFE, as well as the clinical factors and comorbidities of PPFE associated with SRH, were evaluated. Results: Forced expiratory volume in the first second (FEV Conclusions: SRH may be a poor prognostic factor for PPFE. Additionally, SRH may modify susceptibility to Aspergillosis in patients with PPFE. HOT plus NPPV may improve the disease outcomes in patients with SRH.
MeSH term(s)	Humans ; Hypoventilation ; Tomography, X-Ray Computed ; Lung ; Vital Capacity ; Connective Tissue Diseases ; Sleep
Language	English
Publishing date	2022-10-31
Publishing country	England
Document type	Journal Article
ZDB-ID	2041675-1
ISSN	1465-993X ; 1465-993X
ISSN (online)	1465-993X
ISSN	1465-993X
DOI	10.1186/s12931-022-02224-1
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