Article ; Online: Successful intravenous thrombolysis of a wake-up stroke with underlying valvular atrial fibrillation.
The journal of the Royal College of Physicians of Edinburgh
2018 Volume 48, Issue 3, Page(s) 239–241
Abstract: A 42-year-old female admitted with new-onset atrial fibrillation had a wake-up stroke on the high-dependency unit and the time last seen well (TLSW) was 6.5 h. She suffered left-sided body weakness and her National Institutes of Health Stroke Scale ( ... ...
| Abstract | A 42-year-old female admitted with new-onset atrial fibrillation had a wake-up stroke on the high-dependency unit and the time last seen well (TLSW) was 6.5 h. She suffered left-sided body weakness and her National Institutes of Health Stroke Scale (NIHSS) score was 17. An emergency CT perfusion showed right M1 segment occlusion with more than 50% penumbra. She was given recombinant tissue plasminogen activator (r-tPA) at 9 h from TLSW. An immediate diagnostic angiogram with intention to treat, owing to the presence of large vessel occlusion, showed complete reperfusion after intravenous r-tPA. She was discharged with NIHSS of 2, and at 3-month follow up her Modified Rankin Scale was 0. We demonstrated a successful reperfusion and excellent clinical recovery with intravenous thrombolysis in a patient who presented with a wake-up stroke with underlying valvular atrial fibrillation despite evidence of large vessel occlusion. |
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| MeSH term(s) | Administration, Intravenous ; Adult ; Atrial Fibrillation/complications ; Female ; Fibrinolytic Agents/administration & dosage ; Fibrinolytic Agents/therapeutic use ; Humans ; Recombinant Proteins/therapeutic use ; Reperfusion ; Stroke/diagnostic imaging ; Stroke/drug therapy ; Tissue Plasminogen Activator/administration & dosage ; Tissue Plasminogen Activator/therapeutic use | |||||
| Chemical Substances | Fibrinolytic Agents ; Recombinant Proteins ; Tissue Plasminogen Activator (EC 3.4.21.68) | |||||
| Language | English | |||||
| Publishing date | 2018-10-09 | |||||
| Publishing country | Scotland | |||||
| Document type | Case Reports ; Journal Article | |||||
| ZDB-ID | 2866363-9 | |||||
| ISSN | 2042-8189 ; 0953-0932 | |||||
| ISSN (online) | 2042-8189 | |||||
| ISSN | 0953-0932 | |||||
| DOI | 10.4997/JRCPE.2018.308 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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