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  1. Article: DNA Profiling in Human Identification: From Past to Present.

    Panneerchelvam, Sundararajulu / Norazmi, Mohd Nor

    The Malaysian journal of medical sciences : MJMS

    2023  Volume 30, Issue 6, Page(s) 5–21

    Abstract: Forensic DNA typing has been widely accepted in the courts all over the world. This is because DNA profiling is a very powerful tool to identify individuals on the basis of their unique genetic makeup. DNA evidence is capable of not only identifying the ... ...

    Abstract Forensic DNA typing has been widely accepted in the courts all over the world. This is because DNA profiling is a very powerful tool to identify individuals on the basis of their unique genetic makeup. DNA evidence is capable of not only identifying the presence of specific biospecimens in a crime scene, but it is also used to exonerate suspects who are innocent of a crime. Technological advancements in DNA profiling, including the development of validated kits and statistical methods have made this tool to be more precise in forensic investigations. Therefore, validated combined DNA index system (CODIS) short tandem repeats (STRs) kits which require very small amount of DNA, coupled with real-time polymerase chain reaction (PCR) and the statistical strengths are used routinely to identify human remains, establish paternity or to match suspected crime scene biospecimens. The road to modern DNA profiling has been long, and it has taken scientists decades of work and fine tuning to develop highly accurate testing and analyses that are used today. This review will discuss the various DNA polymorphisms and their utility in human identity testing.
    Language English
    Publishing date 2023-12-19
    Publishing country Malaysia
    Document type Journal Article ; Review
    ZDB-ID 2197205-9
    ISSN 2180-4303 ; 1394-195X
    ISSN (online) 2180-4303
    ISSN 1394-195X
    DOI 10.21315/mjms2023.30.6.2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Immunometabolism of Immune Cells in Mucosal Environment Drives Effector Responses against

    Tukiman, Mohd Hatimi / Norazmi, Mohd Nor

    International journal of molecular sciences

    2022  Volume 23, Issue 15

    Abstract: Tuberculosis remains a major threat to global public health, with more than 1.5 million deaths recorded in 2020. Improved interventions against tuberculosis are urgently needed, but there are still gaps in our knowledge of the host-pathogen interaction ... ...

    Abstract Tuberculosis remains a major threat to global public health, with more than 1.5 million deaths recorded in 2020. Improved interventions against tuberculosis are urgently needed, but there are still gaps in our knowledge of the host-pathogen interaction that need to be filled, especially at the site of infection. With a long history of infection in humans,
    MeSH term(s) Host-Pathogen Interactions ; Humans ; Immunity, Innate ; Mucosal-Associated Invariant T Cells ; Mycobacterium tuberculosis ; Tuberculosis/microbiology
    Language English
    Publishing date 2022-08-01
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23158531
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  3. Article ; Online: Interferon-β controls non-tuberculous mycobacterial infection in mice.

    Norazmi, Mohd-Nor

    Virulence

    2017  , Page(s) 1–3

    Language English
    Publishing date 2017-06-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2657572-3
    ISSN 2150-5608 ; 2150-5594
    ISSN (online) 2150-5608
    ISSN 2150-5594
    DOI 10.1080/21505594.2017.1341035
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Immunogenicity mechanism of mRNA vaccines and their limitations in promoting adaptive protection against SARS-CoV-2.

    Salleh, Mohd Zulkifli / Norazmi, Mohd Nor / Deris, Zakuan Zainy

    PeerJ

    2022  Volume 10, Page(s) e13083

    Abstract: Since the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19) in late 2019, hundreds of millions of people have been infected worldwide. There have been unprecedented ... ...

    Abstract Since the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19) in late 2019, hundreds of millions of people have been infected worldwide. There have been unprecedented efforts in acquiring effective vaccines to confer protection against the disease. mRNA vaccines have emerged as promising alternatives to conventional vaccines due to their high potency with the capacity for rapid development and low manufacturing costs. In this review, we summarize the currently available vaccines against SARS-CoV-2 in development, with the focus on the concepts of mRNA vaccines, their antigen selection, delivery and optimization to increase the immunostimulatory capability of mRNA as well as its stability and translatability. We also discuss the host immune responses to the SARS-CoV-2 infection and expound in detail, the adaptive immune response upon immunization with mRNA vaccines, in which high levels of spike-specific IgG and neutralizing antibodies were detected after two-dose vaccination. mRNA vaccines have been shown to induce a robust CD8
    Language English
    Publishing date 2022-03-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2703241-3
    ISSN 2167-8359
    ISSN 2167-8359
    DOI 10.7717/peerj.13083
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: A novel peptide vaccination augments cytotoxic CD8

    Lew, Min Han / Norazmi, Mohd Nor / Nordin, Fazlina / Tye, Gee Jun

    Immunobiology

    2022  Volume 227, Issue 3, Page(s) 152201

    Abstract: Cellular immunity is a critical factor determining the safety and efficacy of newly developed vaccines against Mycobacterium tuberculosis infection. Crosstalk between ... ...

    Abstract Cellular immunity is a critical factor determining the safety and efficacy of newly developed vaccines against Mycobacterium tuberculosis infection. Crosstalk between CD4
    MeSH term(s) Animals ; Antineoplastic Agents ; CD8-Positive T-Lymphocytes ; Cancer Vaccines ; Heat-Shock Proteins ; Mice ; Mice, Inbred C57BL ; Mycobacterium tuberculosis ; Peptides ; T-Lymphocytes, Cytotoxic ; Tuberculosis/prevention & control ; Vaccination ; Vaccines, Subunit
    Chemical Substances Antineoplastic Agents ; Cancer Vaccines ; Heat-Shock Proteins ; Peptides ; Vaccines, Subunit
    Language English
    Publishing date 2022-03-05
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 563292-4
    ISSN 1878-3279 ; 0171-2985
    ISSN (online) 1878-3279
    ISSN 0171-2985
    DOI 10.1016/j.imbio.2022.152201
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    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.32: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Allelic Polymorphisms of Killer Immunoglobulin-Like Receptor Genes in Malay and Orang Asli Populations of Peninsular Malaysia.

    NurWaliyuddin, Hanis Z A / Norazmi, Mohd Nor / Zafarina, Zainuddin

    Human immunology

    2022  Volume 83, Issue 7, Page(s) 564–573

    Abstract: Next-generation DNA sequencing (NGS) technology advancements provide new insight into the level of variation in killer immunoglobulin-like receptor (KIR) genes. High resolution allele genotyping of seven KIR genes was conducted among 94 unrelated Malay ... ...

    Abstract Next-generation DNA sequencing (NGS) technology advancements provide new insight into the level of variation in killer immunoglobulin-like receptor (KIR) genes. High resolution allele genotyping of seven KIR genes was conducted among 94 unrelated Malay and Orang Asli (OA) individuals of Peninsular Malaysia. A manual bioinformatics analysis is performed and optimised by Sanger sequencing method. The Malays expressed a total of 22 alleles, as compared to only 15 alleles in the OA population. In total, 12 centromeric and 9 telomeric allelic haplotypes were identified in the Malays, whereas 8 centromeric and 5 telomeric allelic haplotypes were identified in the OA. The KIR2DL1, KIR2DL3, and KIR2DS4 genes exhibited a high degree of variation and balanced distribution in the Malay and OA populations. On the other hand, KIR2DL4, KIR3DL1, KIR3DL2 and KIR3DL3 genes exhibited a high degree of conservation, with less number of alleles identified and the dominance of a single allele at high frequency. High-resolution KIR allele genotyping has revealed unique sequence variations and allelic haplotypes between individuals and populations. The distributions of KIR alleles and haplotypes are useful for genetic population studies and serve as a baseline for future transplantation matching and disease association research.
    MeSH term(s) Alleles ; Gene Frequency ; Genotype ; Haplotypes ; Humans ; Malaysia ; Polymorphism, Genetic ; Receptors, KIR/genetics
    Chemical Substances Receptors, KIR
    Language English
    Publishing date 2022-04-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 801524-7
    ISSN 1879-1166 ; 0198-8859
    ISSN (online) 1879-1166
    ISSN 0198-8859
    DOI 10.1016/j.humimm.2022.04.005
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1597: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article: Does our Mycobacteriome Influence COVID-19 Morbidity and Lethality?

    Acosta, Armando / Fonte, Luis / Sarmiento, Maria E / Norazmi, Mohd Nor

    Frontiers in microbiology

    2021  Volume 12, Page(s) 589165

    Language English
    Publishing date 2021-02-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2021.589165
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Live, Genetically Attenuated, Cold-Chain-Free Cholera Vaccine-A Research and Development Journey: Light at the End of a Long Tunnel.

    Ravichandran, Manickam / Tew, Hui Xian / Prabhakaran, Guruswamy / Parasuraman, Subramani / Norazmi, Mohd Nor

    The Malaysian journal of medical sciences : MJMS

    2022  Volume 29, Issue 2, Page(s) 1–7

    Abstract: Cholera, a diarrheal disease caused ... ...

    Abstract Cholera, a diarrheal disease caused by
    Language English
    Publishing date 2022-04-21
    Publishing country Malaysia
    Document type Editorial
    ZDB-ID 2197205-9
    ISSN 2180-4303 ; 1394-195X
    ISSN (online) 2180-4303
    ISSN 1394-195X
    DOI 10.21315/mjms2022.29.2.1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Effectiveness of Booster Vaccinations on the Control of COVID-19 during the Spread of Omicron Variant in Malaysia.

    Wong, Matthew Tze Jian / Dhaliwal, Satvinder Singh / Balakrishnan, Venugopal / Nordin, Fazlina / Norazmi, Mohd Nor / Tye, Gee Jun

    International journal of environmental research and public health

    2023  Volume 20, Issue 2

    Abstract: 1) Background: The assessment of vaccine effectiveness against the Omicron variant is vital in the fight against COVID-19, but research on booster vaccine efficacy using nationwide data was lacking at the time of writing. This study investigates the ... ...

    Abstract (1) Background: The assessment of vaccine effectiveness against the Omicron variant is vital in the fight against COVID-19, but research on booster vaccine efficacy using nationwide data was lacking at the time of writing. This study investigates the effectiveness of booster doses on the Omicron wave in Malaysia against COVID-19 infections and deaths; (2) Methods: This study uses nationally representative data on COVID-19 from 1 January to 31 March 2022, when the Omicron variant was predominant in Malaysia. Daily new infections, deaths, ICU utilization and Rt values were compared. A screening method was used to predict the vaccine effectiveness against COVID-19 infections, whereas logistic regression was used to estimate vaccine effectiveness against COVID-19-related deaths, with efficacy comparison between AZD1222, BNT162b2 and CoronaVac; (3) Results: Malaysia's Omicron wave started at the end of January 2022, peaking on 5 March 2022. At the time of writing, statistics for daily new deaths, ICU utilization, and effective reproductive values (Rt) were showing a downtrend. Boosted vaccination is 95.4% (95% CI: 95.4, 95.4) effective in curbing COVID-19 infection, compared to non-boosted vaccination, which is 87.2% (95% CI: 87.2, 87.2). For symptomatic infection, boosted vaccination is 97.4% (95% CI: 97.4, 97.4) effective, and a non-boosted vaccination is 90.9% (95% CI: 90.9, 90.9). Against COVID-19-related death, boosted vaccination yields a vaccine effectiveness (VE) of 91.7 (95% CI: 90.6, 92.7) and full vaccination yields a VE of 65.7% (95% CI: 61.9, 69.1). Looking into the different vaccines as boosters, AZD1222 is 95.2% (CI 95%: 92.7, 96.8) effective, BNT162b2 is 91.8% (CI 95%: 90.7, 92.8) effective and CoronaVac is 88.8% (CI 95%: 84.9, 91.7) effective against COVID-19 deaths. (4) Conclusions: Boosters are effective in increasing protection against COVID-19, including the Omicron variant. Given that the VE observed was lower, CoronaVac recipients are encouraged to take boosters due to its lower VE.
    MeSH term(s) Humans ; Malaysia/epidemiology ; BNT162 Vaccine ; COVID-19/epidemiology ; COVID-19/prevention & control ; ChAdOx1 nCoV-19 ; SARS-CoV-2 ; Vaccination
    Chemical Substances sinovac COVID-19 vaccine ; BNT162 Vaccine ; ChAdOx1 nCoV-19 (B5S3K2V0G8)
    Language English
    Publishing date 2023-01-16
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph20021647
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Enhancement of immune response against Mycobacterium tuberculosis HspX antigen by incorporation of combined molecular adjuvant (CASAC).

    Lew, Min Han / Norazmi, Mohd Nor / Tye, Gee Jun

    Molecular immunology

    2019  Volume 117, Page(s) 54–64

    Abstract: Tuberculosis (TB) is one of the deadliest human diseases worldwide caused by mycobacterial infection in the lung. Bacillus Calmette-Guerin (BCG) vaccine protects against disseminated TB in children, but its effectiveness is still questionable due to ... ...

    Abstract Tuberculosis (TB) is one of the deadliest human diseases worldwide caused by mycobacterial infection in the lung. Bacillus Calmette-Guerin (BCG) vaccine protects against disseminated TB in children, but its effectiveness is still questionable due to highly variable protections in adolescence and elderly individuals. Targeting the latency M.tb antigen is a recent therapeutic approach to eradicate dormant pathogen that could possibly lead to disease activation. In this study, we aimed to potentiate immune responses elicited against 16 kDa α-crystalline (HspX) tuberculosis latency antigen by incorporation of Combined Adjuvant for Synergistic Activation of Cellular immunity (CASAC). Histidine-tagged recombinant HspX protein was initially produced in Escherichia coli and purified using Ni-NTA chromatography. To evaluate its adjuvanticity, C57BL/6 mice (n = 5) were initially primed and intradermally immunised in 2-weeks interval for 4 rounds with recombinant HspX, formulated with and without CASAC. Humoral and cell-mediated immune responses elicited against HspX antigen were evaluated using ELISA and Flow Cytometry. Our findings showed that CASAC improved humoral immunity with increased antigen-specific IgG1 and IgG2a antibody response. Stronger CD8+ and Th1-driven immunity was induced by CASAC formulation as supported by elevated level of IFN-γ, TNF-α, IL-12 and IL-17A; and with low IL-10 secretion. Interestingly, adjuvanted HspX vaccine triggered a higher percentage of effector memory T-cell population than those immunised with unadjuvanted vaccine. In conclusion, CASAC adjuvant has great potential to enhance immunogenicity elicited against HspX antigen, which could be an alternative regimen to improve the efficacy of future therapeutic vaccine against Mycobacterium tuberculosis.
    MeSH term(s) Adjuvants, Immunologic/pharmacology ; Animals ; Antigens, Bacterial/immunology ; Bacterial Proteins/immunology ; Female ; Mice ; Mice, Inbred C57BL ; Mycobacterium tuberculosis/immunology ; Tuberculosis/immunology ; Tuberculosis Vaccines/immunology ; Tuberculosis Vaccines/pharmacology
    Chemical Substances Adjuvants, Immunologic ; Antigens, Bacterial ; Bacterial Proteins ; HspX protein, Mycobacterium tuberculosis ; Tuberculosis Vaccines
    Language English
    Publishing date 2019-11-15
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 424427-8
    ISSN 1872-9142 ; 0161-5890
    ISSN (online) 1872-9142
    ISSN 0161-5890
    DOI 10.1016/j.molimm.2019.10.023
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 166: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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