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Article ; Online: Author Response: Association of Ventricular Arrhythmias With Dementia: The Atherosclerosis Risk in Communities (ARIC) Study.

Norby, Faye L

2021 Volume 97, Issue 2, Page(s) 100

MeSH term(s)	Arrhythmias, Cardiac ; Atherosclerosis/complications ; Atherosclerosis/epidemiology ; Dementia/complications ; Dementia/epidemiology ; Humans
Language	English
Publishing date	2021-07-12
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	207147-2
ISSN	1526-632X ; 0028-3878
ISSN (online)	1526-632X
ISSN	0028-3878
DOI	10.1212/WNL.0000000000012252
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Article ; Online: Percutaneous left atrial appendage occlusion and risk of stroke, hospitalized bleeding and death in Medicare beneficiaries.

Wang, Wendy / Chen, Lin Yee / Walker, Rob F / Alonso, Alvaro / Norby, Faye L / Lakshminarayan, Kamakshi / Lutsey, Pamela L

Pharmacoepidemiology and drug safety

2024 Volume 33, Issue 4, Page(s) e5786

Abstract: Purpose: Among patients with atrial fibrillation (AF), a nonpharmacologic option (e.g., percutaneous left atrial appendage occlusion [LAAO]) is needed for patients with oral anticoagulant (OAC) contraindications. Among beneficiaries in the Medicare fee- ... ...

Abstract	Purpose: Among patients with atrial fibrillation (AF), a nonpharmacologic option (e.g., percutaneous left atrial appendage occlusion [LAAO]) is needed for patients with oral anticoagulant (OAC) contraindications. Among beneficiaries in the Medicare fee-for-service coverage 20% sample databases (2015-18) who had AF and an elevated CHA Methods: Patients undergoing percutaneous LAAO were matched to up to five OAC users by sex, age, date of enrollment, index date, CHA Results: Median follow-up was 10.3 months. After multivariable adjustments, no significant difference for risk of stroke or death was noted when patients with percutaneous LAAO were compared with OAC users (HRs [95% CIs]: 1.14 [0.86-1.52], 0.98 [0.86-1.10]). There was a 2.94-fold (95% CI: 2.50-3.45) increased risk for hospitalized bleeding for percutaneous LAAO compared with OAC use. Among patients 65 to <78 years old, those undergoing percutaneous LAAO had higher risk of stroke compared with OAC users. No association was present in those ≥78 years. Conclusion: In this analysis of real-world AF patients, percutaneous LAAO versus OAC use was associated with similar risk of death, nonsignificantly elevated risk of stroke, and an elevated risk of bleeding in the post-procedural period. Overall, these results support results of randomized trials that percutaneous LAAO may be an alternative to OAC use for patients with contraindications.
MeSH term(s)	Humans ; Female ; Aged ; United States/epidemiology ; Male ; Atrial Appendage/surgery ; Treatment Outcome ; Medicare ; Stroke/epidemiology ; Stroke/etiology ; Stroke/prevention & control ; Hemorrhage/chemically induced ; Hemorrhage/epidemiology ; Atrial Fibrillation/complications ; Atrial Fibrillation/epidemiology ; Atrial Fibrillation/chemically induced ; Anticoagulants/adverse effects
Chemical Substances	Anticoagulants
Language	English
Publishing date	2024-03-31
Publishing country	England
Document type	Journal Article
ZDB-ID	1099748-9
ISSN	1099-1557 ; 1053-8569
ISSN (online)	1099-1557
ISSN	1053-8569
DOI	10.1002/pds.5786
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Article ; Online: Oral Anticoagulants, Proton Pump Inhibitors, and Fracture-Reply.

Lutsey, Pamela L / Norby, Faye L / Alonso, Alvaro

JAMA internal medicine

2020 Volume 180, Issue 4, Page(s) 617–618

MeSH term(s)	Anticoagulants/adverse effects ; Atrial Fibrillation/drug therapy ; Fractures, Bone ; Humans ; Proton Pump Inhibitors/adverse effects
Chemical Substances	Anticoagulants ; Proton Pump Inhibitors
Language	English
Publishing date	2020-04-06
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	2699338-7
ISSN	2168-6114 ; 2168-6106
ISSN (online)	2168-6114
ISSN	2168-6106
DOI	10.1001/jamainternmed.2020.0271
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Article ; Online: Racial and Ethnic Considerations in Patients With Atrial Fibrillation: JACC Focus Seminar 5/9.

Norby, Faye L / Benjamin, Emelia J / Alonso, Alvaro / Chugh, Sumeet S

Journal of the American College of Cardiology

2021 Volume 78, Issue 25, Page(s) 2563–2572

Abstract: Atrial fibrillation (AF) affects at least 60 million individuals globally and is associated with substantial impacts on morbidity, mortality, and health care expenditures. This review focuses on how race and ethnicity influence AF epidemiology, risk ... ...

Abstract	Atrial fibrillation (AF) affects at least 60 million individuals globally and is associated with substantial impacts on morbidity, mortality, and health care expenditures. This review focuses on how race and ethnicity influence AF epidemiology, risk prediction, treatment, and outcomes; knowledge gaps in these areas are identified. Most AF studies have predominantly included White populations, with an underrepresentation of racial and ethnic groups, including but not limited to Black, Hispanic, and Indigenous individuals. Enhancement and implementation of AF risk prediction, prevention, and management call for studies that will gather accurate race-based epidemiologic data and evaluate social determinants and genetic factors in the context of multiple races and ethnicities. Available studies highlight inequities in access to treatment as well as outcomes between White individuals and persons of other races/ethnicities. These inequities will need to be addressed by a renewed emphasis on structural and social determinants of health that contribute to AF.
MeSH term(s)	Atrial Fibrillation/ethnology ; Atrial Fibrillation/therapy ; Healthcare Disparities ; Heart Disease Risk Factors ; Humans ; Mass Screening
Language	English
Publishing date	2021-11-09
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	605507-2
ISSN	1558-3597 ; 0735-1097
ISSN (online)	1558-3597
ISSN	0735-1097
DOI	10.1016/j.jacc.2021.04.110
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Article ; Online: Thirty-Year Trends in the Incidence of Atrial Fibrillation: The ARIC Study.

Ghelani, Kunali P / Chen, Lin Yee / Norby, Faye L / Soliman, Elsayed Z / Koton, Silvia / Alonso, Alvaro

Journal of the American Heart Association

2022 Volume 11, Issue 8, Page(s) e023583

Abstract: Background Long-term data to study recent trends in the incidence of atrial fibrillation (AF), overall and among sex and race groups, are scarce. We evaluated the 30-year trends in the incidence of AF in the ARIC (Atherosclerosis Risk in Communities) ... ...

Abstract	Background Long-term data to study recent trends in the incidence of atrial fibrillation (AF), overall and among sex and race groups, are scarce. We evaluated the 30-year trends in the incidence of AF in the ARIC (Atherosclerosis Risk in Communities) study cohort and explored race and sex differences in these trends. Methods and Results We included 15 343 men and women aged 45 to 64 years in 1987 to 1989 without AF from 4 US communities in the ARIC cohort. Incident AF was identified based on study ECGs, hospital discharge codes, and death certificates through 2017. We calculated age and period-specific incidence rates (IRs) of AF. We used Poisson regression to calculate IR ratios of AF over time adjusting for age, sex, and race. A total of 3241 AF cases were identified during a mean (SD) follow-up of 22 years (8.4 years) (599 in Black participants, 2642 in White participants, 1582 in women, and 1659 in men). Overall, the IR of AF in the ARIC cohort was 9.6 per 1000 person-years (6.9 in Black participants, 10.5 in White participants, 8.1 in women, and 11.6 in men). Age-specific IR by time period did not show significant changes over time. In a model adjusted for sex, race, and age group, the rate of AF did not change significantly from 1987 to 1991 compared with 2012 to 2017 (IR ratio, 1.10 [95% CI, 0.88-1.36] comparing 2012-2017 with 1987-1991). Similarly, no evidence of changes over time in AF rates were identified in men and women or White and Black participants separately. Conclusions Even though IRs of AF increase as age increases, our analysis provided evidence suggesting that the overall IRs of AF have not changed over time in a multicenter cohort of Black and White individuals in the United States from 1987 to 2017.
MeSH term(s)	Atrial Fibrillation/diagnosis ; Atrial Fibrillation/epidemiology ; Cohort Studies ; Female ; Humans ; Incidence ; Male ; Prospective Studies ; Racial Groups ; Risk Factors ; United States/epidemiology
Language	English
Publishing date	2022-04-12
Publishing country	England
Document type	Journal Article ; Multicenter Study ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, P.H.S. ; Research Support, Non-U.S. Gov't
ZDB-ID	2653953-6
ISSN	2047-9980 ; 2047-9980
ISSN (online)	2047-9980
ISSN	2047-9980
DOI	10.1161/JAHA.121.023583
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Article ; Online: Comparative effectiveness of rivaroxaban in the treatment of nonvalvular atrial fibrillation.

Norby, Faye L / Alonso, Alvaro

Journal of comparative effectiveness research

2017 Volume 6, Issue 6, Page(s) 549–560

Abstract: Rivaroxaban is a direct oral anticoagulant (DOAC) approved for the prevention of stroke and systemic embolism in patients with nonvalvular atrial fibrillation, a common arrhythmia. In this review, we summarize the effectiveness of rivaroxaban versus ... ...

Abstract	Rivaroxaban is a direct oral anticoagulant (DOAC) approved for the prevention of stroke and systemic embolism in patients with nonvalvular atrial fibrillation, a common arrhythmia. In this review, we summarize the effectiveness of rivaroxaban versus warfarin and the DOACs dabigatran, apixaban and edoxaban. The primary focus is on primary evidence from clinical trials, indirect comparison studies and real-world studies. While there are gaps in the literature, the evidence thus far indicates that rivaroxaban is superior to warfarin and similar to dabigatran, apixaban and edoxaban for the prevention of stroke or systemic embolism in patients with nonvalvular atrial fibrillation, although rivaroxaban may be associated with an elevated bleeding risk compared with other DOACs.
MeSH term(s)	Administration, Oral ; Anticoagulants/administration & dosage ; Anticoagulants/adverse effects ; Atrial Fibrillation/drug therapy ; Dabigatran/adverse effects ; Drug Administration Schedule ; Epidemiologic Methods ; Factor Xa Inhibitors/administration & dosage ; Female ; Humans ; Male ; Pyrazoles/administration & dosage ; Pyrazoles/adverse effects ; Pyridines/administration & dosage ; Pyridines/adverse effects ; Pyridones/administration & dosage ; Pyridones/adverse effects ; Rivaroxaban/administration & dosage ; Rivaroxaban/adverse effects ; Stroke/prevention & control ; Thiazoles/administration & dosage ; Thiazoles/adverse effects ; Treatment Outcome ; Warfarin/administration & dosage ; Warfarin/adverse effects
Chemical Substances	Anticoagulants ; Factor Xa Inhibitors ; Pyrazoles ; Pyridines ; Pyridones ; Thiazoles ; apixaban (3Z9Y7UWC1J) ; Warfarin (5Q7ZVV76EI) ; Rivaroxaban (9NDF7JZ4M3) ; Dabigatran (I0VM4M70GC) ; edoxaban (NDU3J18APO)
Language	English
Publishing date	2017-07-24
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2669725-7
ISSN	2042-6313 ; 2042-6305
ISSN (online)	2042-6313
ISSN	2042-6305
DOI	10.2217/cer-2017-0025
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Article ; Online: Diagnosed Gonorrhea Among Privately Insured Women: Analysis of United States Claims Data.

Groene, Emily A / Norby, Faye L / Eaton, Anne A / Mason, Susan M / Enns, Eva A / Kulasingam, Shalini / Vock, David M

Journal of women's health (2002)

2023 Volume 32, Issue 9, Page(s) 942–949

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Pregnancy ; Female ; United States ; Humans ; Gonorrhea/epidemiology ; Chlamydia Infections/epidemiology ; Retrospective Studies ; Chlamydia trachomatis ; Pregnancy, Ectopic/epidemiology ; Pregnancy, Ectopic/etiology ; Pelvic Inflammatory Disease/complications ; Pelvic Inflammatory Disease/diagnosis ; Insurance, Health
Language	English
Publishing date	2023-06-29
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1139774-3
ISSN	1931-843X ; 1059-7115 ; 1540-9996
ISSN (online)	1931-843X
ISSN	1059-7115 ; 1540-9996
DOI	10.1089/jwh.2023.0006
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Article ; Online: SGLT2 Inhibitors Are Associated With Reduced Cardiovascular Disease in Patients With Type 2 Diabetes: An Analysis of Real-World Data.

Wang, Wendy / Chen, Lin Yee / Walker, Rob F / Chow, Lisa S / Norby, Faye L / Alonso, Alvaro / Pankow, James S / Lutsey, Pamela L

Mayo Clinic proceedings

2023 Volume 98, Issue 7, Page(s) 985–996

Abstract: Objective: To assess the association between sodium-glucose cotransporter-2 (SGLT2) inhibitors and other second-line diabetes therapies with risk of cardiovascular disease (CVD), as well as conduct head-to-head comparisons between SGLT2 inhibitors.: ... ...

Abstract	Objective: To assess the association between sodium-glucose cotransporter-2 (SGLT2) inhibitors and other second-line diabetes therapies with risk of cardiovascular disease (CVD), as well as conduct head-to-head comparisons between SGLT2 inhibitors. Patients and methods: Using data from the MarketScan databases (January 1, 2013, through December 31, 2019), SGLT2 inhibitor users were matched with up to five other second-line therapy users by age, sex, date of enrollment, and date of second-line therapy initiation. The primary composite outcome included stroke, atrial fibrillation, myocardial infarction, and heart failure. Hazard ratios were estimated, adjusting for demographics and a propensity score reflecting comorbidities and medications. Results: In this study population of 313,396 patients (mean age 53±10 years; 47% female), 9787 incident CVD events occurred over a median follow-up of 1.36 years. After multivariable adjustments, SGLT2 inhibitor users had a lower risk of CVD than other second-line therapy users (HR, 0.66; 95% CI, 0.62 to 0.71). Significant associations were also observed when each CVD outcome was assessed separately. No differences were noted when comparing individual SGLT2 inhibitors. Conclusion: SGLT2 inhibitors were associated with a clinically meaningfully lower CVD risk in the real-world setting. In head-to-head comparisons, the different SGLT2 inhibitors were consistent in their protective associations with CVD. This suggests that as a class, SGLT2 inhibitors may have widespread benefit in preventing CVD among patients with type 2 diabetes.
MeSH term(s)	Sodium-Glucose Transporter 2 Inhibitors/therapeutic use ; Humans ; Cardiovascular Diseases/prevention & control ; Diabetes Mellitus, Type 2/drug therapy ; Male ; Female ; Adult ; Middle Aged
Chemical Substances	Sodium-Glucose Transporter 2 Inhibitors
Language	English
Publishing date	2023-07-05
Publishing country	England
Document type	Journal Article
ZDB-ID	124027-4
ISSN	1942-5546 ; 0025-6196
ISSN (online)	1942-5546
ISSN	0025-6196
DOI	10.1016/j.mayocp.2023.01.023
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Article ; Online: Predicting Atrial Fibrillation and Its Complications.

Alonso, Alvaro / Norby, Faye L

Circulation journal : official journal of the Japanese Circulation Society

2016 Volume 80, Issue 5, Page(s) 1061–1066

Abstract: Atrial fibrillation (AF) is a common cardiac arrhythmia associated with an increased risk of stroke and other complications. Identifying individuals at higher risk of developing AF in the community is now possible using validated predictive models that ... ...

Abstract	Atrial fibrillation (AF) is a common cardiac arrhythmia associated with an increased risk of stroke and other complications. Identifying individuals at higher risk of developing AF in the community is now possible using validated predictive models that take into account clinical variables and circulating biomarkers. These models have shown adequate performance in racially and ethnically diverse populations. Similarly, risk stratification schemes predict incidence of ischemic stroke in persons with AF, assisting clinicians and patients in decisions regarding oral anticoagulation use. Complementary schemes have been developed to predict the risk of bleeding in AF patients taking vitamin K antagonists. However, major gaps exist in our ability to predict AF and its complications. Additional research should refine models for AF prediction and determine their value to improve population health and clinical outcomes, advance our ability to predict stroke and other complications in AF patients, and develop predictive models for bleeding events and other adverse effects in patients using non-vitamin K oral anticoagulants. (Circ J 2016; 80: 1061-1066).
MeSH term(s)	Aged ; Atrial Fibrillation/complications ; Atrial Fibrillation/diagnosis ; Diagnostic Techniques, Cardiovascular ; Humans ; Predictive Value of Tests ; Risk Assessment ; Risk Factors
Language	English
Publishing date	2016-03-24
Publishing country	Japan
Document type	Journal Article ; Review
ZDB-ID	2068090-9
ISSN	1347-4820 ; 1346-9843
ISSN (online)	1347-4820
ISSN	1346-9843
DOI	10.1253/circj.CJ-16-0239
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Article ; Online: Association of P-Wave Abnormalities With Sudden Cardiac and Cardiovascular Death: The ARIC Study.

Maheshwari, Ankit / Norby, Faye L / Soliman, Elsayed Z / Alonso, Alvaro / Sotoodehnia, Nona / Chen, Lin Y

Circulation. Arrhythmia and electrophysiology

2021 Volume 14, Issue 2, Page(s) e009314

MeSH term(s)	Cardiovascular Diseases/complications ; Cardiovascular Diseases/diagnosis ; Cardiovascular Diseases/physiopathology ; Death, Sudden, Cardiac/etiology ; Electrocardiography ; Heart Conduction System/physiopathology ; Heart Rate/physiology ; Humans ; Risk Assessment/methods ; Risk Factors
Language	English
Publishing date	2021-02-16
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	2426129-4
ISSN	1941-3084 ; 1941-3149
ISSN (online)	1941-3084
ISSN	1941-3149
DOI	10.1161/CIRCEP.120.009314
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