Article ; Online: High specificity THz metamaterial-based biosensor for label-free transcription factor detection in melanoma diagnostics.
2023 Volume 13, Issue 1, Page(s) 20708
Abstract: In this work, we present a promising diagnostic tool for melanoma diagnosis. With the proposed terahertz biosensor, it was possible to selectively and sensitively detect the early growth response protein 2, a transcription factor with an increased ... ...
| Abstract | In this work, we present a promising diagnostic tool for melanoma diagnosis. With the proposed terahertz biosensor, it was possible to selectively and sensitively detect the early growth response protein 2, a transcription factor with an increased activity in melanoma cells, from a complex sample of cellular proteins. Fundamentally, the sensor belongs to the frequency selective surface type metamaterials and consists of a two-dimensional array of asymmetrically, doubly split ring resonator unit cells. The single elements are slits in a metallic layer and are complemented by an undercut etch. This allows a selective functionalization of the active area of the sensor and increases the sensitivity towards the target analyte. Hereby, specific detection of a defined transcription factor is feasible. |
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| MeSH term(s) | Humans ; Transcription Factors ; Melanoma/diagnosis ; Gene Expression Regulation ; Psychomotor Agitation |
| Chemical Substances | Transcription Factors |
| Language | English |
| Publishing date | 2023-11-24 |
| Publishing country | England |
| Document type | Journal Article |
| ZDB-ID | 2615211-3 |
| ISSN | 2045-2322 ; 2045-2322 |
| ISSN (online) | 2045-2322 |
| ISSN | 2045-2322 |
| DOI | 10.1038/s41598-023-46876-5 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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