LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 4 of total 4

Search options

  1. Book ; Thesis: Die Rolle von C-Type Lectin Domain Family 4 Member E bei der Entstehung der Aortenklappenstenose

    Nordsiek, Julia / Zimmer, Sebastian

    2021  

    Institution Rheinische Friedrich-Wilhelms-Universität Bonn
    Author's details Julia Nordsiek ; 1. Gutachter: Prof. Dr. med. Sebastian Zimmer
    Language German
    Size 107 Seiten, Diagramme
    Publishing place Bonn
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Rheinische Friedrich-Wilhelms-Universität Bonn, 2021
    HBZ-ID HT021087856
    Database Catalogue ZB MED Medicine, Health

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2022 D 344 order for loan Magazin

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Antithrombotic treatment and outcome after endovascular treatment and acute carotid artery stenting in stroke patients with atrial fibrillation.

    Weller, Johannes M / Dorn, Franziska / Meissner, Julius N / Stösser, Sebastian / Beckonert, Niklas M / Nordsiek, Julia / Kindler, Christine / Riegler, Christoph / Keil, Fee / Petzold, Gabor C / Bode, Felix J

    Neurological research and practice

    2022  Volume 4, Issue 1, Page(s) 42

    Abstract: Background: Oral anticoagulation (OAC) is the mainstay of secondary prevention in ischemic stroke patients with atrial fibrillation (AF). However, in AF patients with large vessel occlusion stroke treated by endovascular therapy (ET) and acute carotid ... ...

    Abstract Background: Oral anticoagulation (OAC) is the mainstay of secondary prevention in ischemic stroke patients with atrial fibrillation (AF). However, in AF patients with large vessel occlusion stroke treated by endovascular therapy (ET) and acute carotid artery stenting (CAS), the optimal antithrombotic medication remains unclear.
    Methods: This is a subgroup analysis of the German Stroke Registry-Endovascular Treatment (GSR-ET), a prospective multicenter cohort of patients with large vessel occlusion stroke undergoing ET. Patients with AF and CAS during ET were included. We analyzed baseline and periprocedural characteristics, antithrombotic strategies and functional outcome at 90 days.
    Results: Among 6635 patients in the registry, a total of 82 patients (1.2%, age 77.9 ± 8.0 years, 39% female) with AF and extracranial CAS during ET were included. Antithrombotic medication at admission, during ET, postprocedural and at discharge was highly variable and overall mortality in hospital (21%) and at 90 days (39%) was high. Among discharged patients (n = 65), most frequent antithrombotic regimes were dual antiplatelet therapy (DAPT, 37%), single APT + OAC (25%) and DAPT + OAC (20%). Comparing DAPT to single or dual APT + OAC, clinical characteristics at discharge were similar (median NIHSS 7.5 [interquartile range, 3-10.5] vs 7 [4-11], p = 0.73, mRS 4 [IQR 3-4] vs. 4 [IQR 3-5], p = 0.79), but 90-day mortality was higher without OAC (32 vs 4%, p = 0.02).
    Conclusions: In AF patients who underwent ET and CAS, 90-day mortality was higher in patients not receiving OAC.
    Registration: https://www.
    Clinicaltrials: gov

    Unique identifier: NCT03356392.
    Language English
    Publishing date 2022-09-12
    Publishing country England
    Document type Journal Article
    ISSN 2524-3489
    ISSN (online) 2524-3489
    DOI 10.1186/s42466-022-00207-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Article ; Online: Endovascular thrombectomy in young patients with stroke.

    Weller, Johannes M / Dorn, Franziska / Meissner, Julius N / Stösser, Sebastian / Beckonert, Niklas M / Nordsiek, Julia / Kindler, Christine / Deb-Chatterji, Milani / Petzold, Gabor C / Bode, Felix J

    International journal of stroke : official journal of the International Stroke Society

    2022  Volume 18, Issue 4, Page(s) 453–461

    Abstract: Background: Endovascular treatment (ET) is standard of care in patients with acute ischemic stroke due to large vessel occlusion, but data on ET in young patients remain limited.: Aim: We aim to compare outcomes for young stroke patients undergoing ... ...

    Abstract Background: Endovascular treatment (ET) is standard of care in patients with acute ischemic stroke due to large vessel occlusion, but data on ET in young patients remain limited.
    Aim: We aim to compare outcomes for young stroke patients undergoing ET in a matched cohort.
    Methods: We analyzed patients from an observational multicenter cohort with acute ischemic stroke and ET, the German Stroke Registry-Endovascular Treatment trial. Baseline characteristics, procedural parameters, and functional outcome at 90 days were compared between young (<50 years) and older (⩾50 years) patients with and without nearest-neighbor 1:1 propensity score matching.
    Results: Out of 6628 acute ischemic stroke patients treated with ET, 363 (5.5%) were young. Young patients differed with regard to prognostic outcome characteristics. Specifically, National Institutes of Health Stroke Scale (NIHSS) at admission was lower (median 13, interquartile range (IQR) 8-17 vs. 15, IQR 9-19, p < 0.001), and prestroke dependence was less frequent (2.9% vs. 12.2%, p < 0.001) than in older patients. Compared to a matched cohort of older patients, ET was faster (time from groin puncture to flow restoration, 35 vs. 45 min, p < 0.001) and intracranial hemorrhage was less frequent in young patients (10.0% vs. 25.9%, p < 0.001). Good functional outcome (modified Rankin Scale (mRS) 0-2) at 3 months was achieved more frequently in young patients (71.6% vs. 44.1%, p < 0.001), and overall mortality was lower (6.7% vs. 25.4%, p < 0.001). Among previously employed young patients (n = 177), 37.9% returned to work at 3-month follow-up, while 74.1% of the remaining patients were still undergoing rehabilitation.
    Conclusion: Young stroke patients undergoing ET have better outcomes compared to older patients, even when matched for prestroke condition, comorbidities, and stroke severity. Hence, more liberal guidelines to perform ET for younger patients may have to be established by future studies.
    MeSH term(s) Humans ; Aged ; Stroke/surgery ; Brain Ischemia/surgery ; Brain Ischemia/etiology ; Ischemic Stroke/etiology ; Treatment Outcome ; Endovascular Procedures/adverse effects ; Thrombectomy/adverse effects
    Language English
    Publishing date 2022-09-07
    Publishing country United States
    Document type Multicenter Study ; Journal Article
    ZDB-ID 2303728-3
    ISSN 1747-4949 ; 1747-4930
    ISSN (online) 1747-4949
    ISSN 1747-4930
    DOI 10.1177/17474930221119602
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 6582: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Graded murine wire-induced aortic valve stenosis model mimics human functional and morphological disease phenotype.

    Niepmann, Sven Thomas / Steffen, Eva / Zietzer, Andreas / Adam, Matti / Nordsiek, Julia / Gyamfi-Poku, Isabella / Piayda, Kerstin / Sinning, Jan-Malte / Baldus, Stephan / Kelm, Malte / Nickenig, Georg / Zimmer, Sebastian / Quast, Christine

    Clinical research in cardiology : official journal of the German Cardiac Society

    2019  Volume 108, Issue 8, Page(s) 847–856

    Abstract: Aortic valve stenosis (AS) is the most common valve disease requiring therapeutic intervention. Even though the incidence of AS has been continuously rising and AS is associated with significant morbidity and mortality, to date, no medical treatments ... ...

    Abstract Aortic valve stenosis (AS) is the most common valve disease requiring therapeutic intervention. Even though the incidence of AS has been continuously rising and AS is associated with significant morbidity and mortality, to date, no medical treatments have been identified that can modify disease progression. This unmet medical need is likely attributed to an incomplete understanding of the molecular mechanism driving disease development. To investigate the pathophysiology leading to AS, reliable and reproducible animal models that mimic human pathophysiology are needed. We have tested and expanded the protocols of a wire-injury induced AS mouse model. For this model, coronary wires were used to apply shear stress to the aortic valve cusps with increasing intensity. These protocols allowed distinction of mild, moderate and severe wire-injury. Upon moderate or severe injury, AS developed with a significant increase in aortic valve peak blood flow velocity. While moderate injury promoted solitary AS, severe-injury induced mixed aortic valve disease with concomitant mild to moderate aortic regurgitation. The changes in aortic valve function were reflected by dilation and hypertrophy of the left ventricle, as well as a decreased left ventricular ejection fraction. Histological analysis revealed the classic hallmarks of human disease with aortic valve thickening, increased macrophage infiltration, fibrosis and calcification. This new mouse model of AS promotes functional and morphological changes similar to moderate and severe human AS. It can be used to investigate the pathomechanisms contributing to AS development and to test novel therapeutic strategies.
    MeSH term(s) Animals ; Aortic Valve ; Aortic Valve Stenosis/diagnosis ; Aortic Valve Stenosis/physiopathology ; Disease Models, Animal ; Echocardiography ; Heart Ventricles/diagnostic imaging ; Heart Ventricles/physiopathology ; Humans ; Male ; Mice, Inbred C57BL ; Severity of Illness Index ; Stroke Volume/physiology ; Ventricular Function, Left/physiology
    Language English
    Publishing date 2019-02-14
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2213295-8
    ISSN 1861-0692 ; 1861-0684
    ISSN (online) 1861-0692
    ISSN 1861-0684
    DOI 10.1007/s00392-019-01413-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ui IV Zs 10: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top