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  1. Book ; Online: Evaluating Evidence of Mechanisms in Medicine : Principles and Procedures

    Parkkinen, Veli-Pekka / Wallmann, Christian / Wilde, Michael / Clarke, Brendan / Illari, Phyllis / Kelly, Michael P / Norell, Charles / Russo, Federica / Shaw, Beth / Williamson, Jon

    2018  

    Keywords Philosophy ; Philosophy: epistemology & theory of knowledge ; Medicine-Philosophy ; Epistemology
    Size 1 electronic resource (125 pages)
    Publisher Springer Nature
    Publishing place Cham
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021028826
    ISBN 978-3-319-94610-8 ; 3-319-94610-2
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online: Evaluating Evidence of Mechanisms in Medicine

    Parkkinen, Veli-Pekka / Wallmann, Christian / Wilde, Michael / Clarke, Brendan / Illari, Phyllis / Kelly, Michael P. / Norell, Charles / Russo, Federica / Shaw, Beth / Williamson, Jon

    Principles and Procedures

    (SpringerBriefs in Philosophy)

    2018  

    Author's details by Veli-Pekka Parkkinen, Christian Wallmann, Michael Wilde, Brendan Clarke, Phyllis Illari, Michael P Kelly, Charles Norell, Federica Russo, Beth Shaw, Jon Williamson
    Series title SpringerBriefs in Philosophy
    Keywords Philosophy ; Epistemology ; Medicine/Philosophy
    Subject code 610.1
    Language English
    Size 1 Online-Ressource (XVIII, 125 p. 14 illus)
    Publisher Springer International Publishing ; Imprint: Springer
    Publishing place Cham
    Document type Book ; Online
    HBZ-ID HT019767239
    ISBN 978-3-319-94610-8 ; 9783319946092 ; 3-319-94610-2 ; 3319946099
    DOI 10.1007/978-3-319-94610-8
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: Response to Open Peer Commentaries on "A Radical Approach to Ebola: Saving Humans and Other Animals".

    Edwards, Sarah J L / Norell, Charles H / Illari, Phyllis / Clarke, Brendan / Neuhaus, Carolyn P

    The American journal of bioethics : AJOB

    2019  Volume 19, Issue 1, Page(s) W8–W9

    MeSH term(s) Animals ; Hemorrhagic Fever, Ebola ; Humans
    Language English
    Publishing date 2019-01-23
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2060433-6
    ISSN 1536-0075 ; 1526-5161
    ISSN (online) 1536-0075
    ISSN 1526-5161
    DOI 10.1080/15265161.2018.1536770
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: A Radical Approach to Ebola: Saving Humans and Other Animals.

    Edwards, Sarah J L / Norell, Charles H / Illari, Phyllis / Clarke, Brendan / Neuhaus, Carolyn P

    The American journal of bioethics : AJOB

    2018  Volume 18, Issue 10, Page(s) 35–42

    Abstract: As the usual regulatory framework did not fit well during the last Ebola outbreak, innovative thinking still needed. In the absence of an outbreak, randomised controlled trials of clinical efficacy in humans cannot be done, while during an outbreak such ... ...

    Abstract As the usual regulatory framework did not fit well during the last Ebola outbreak, innovative thinking still needed. In the absence of an outbreak, randomised controlled trials of clinical efficacy in humans cannot be done, while during an outbreak such trials will continue to face significant practical, philosophical, and ethical challenges. This article argues that researchers should also test the safety and effectiveness of novel vaccines in wild apes by employing a pluralistic approach to evidence. There are three reasons to test vaccines in wild populations of apes: i) protect apes; ii) reduce Ebola transmission from wild animals to humans; and iii) accelerate vaccine development and licensing for humans. Data obtained from studies of vaccines among wild apes and chimpanzees may even be considered sufficient for licensing new vaccines for humans. This strategy will serve to benefit both wild apes and humans.
    MeSH term(s) Animals ; Animals, Wild/virology ; Ape Diseases/virology ; Biomedical Research/ethics ; Communicable Disease Control/methods ; Disease Outbreaks/ethics ; Disease Outbreaks/prevention & control ; Disease Outbreaks/veterinary ; Ebola Vaccines/administration & dosage ; Epidemiological Monitoring/veterinary ; Ethical Review ; Ethics, Research ; Gorilla gorilla/virology ; Hemorrhagic Fever, Ebola/drug therapy ; Hemorrhagic Fever, Ebola/immunology ; Hemorrhagic Fever, Ebola/prevention & control ; Hemorrhagic Fever, Ebola/veterinary ; Humans ; Public Health ; Vaccination/ethics ; Zoonoses/prevention & control
    Chemical Substances Ebola Vaccines
    Language English
    Publishing date 2018-10-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2060433-6
    ISSN 1536-0075 ; 1526-5161
    ISSN (online) 1536-0075
    ISSN 1526-5161
    DOI 10.1080/15265161.2018.1513584
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6814: Show issues Location:
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  5. Article ; Online: Exploring international differences in ovarian cancer treatment: a comparison of clinical practice guidelines and patterns of care.

    Norell, Charles H / Butler, John / Farrell, Rhonda / Altman, Alon / Bentley, James / Cabasag, Citadel J / Cohen, Paul A / Fegan, Scott / Fung-Kee-Fung, Michael / Gourley, Charlie / Hacker, Neville F / Hanna, Louise / Høgdall, Claus Kim / Kristensen, Gunnar / Kwon, Janice / McNally, Orla / Nelson, Gregg / Nordin, Andy / O'Donnell, Dearbhaile /
    Schnack, Tine / Sykes, Peter H / Zotow, Ewa / Harrison, Samantha

    International journal of gynecological cancer : official journal of the International Gynecological Cancer Society

    2020  Volume 30, Issue 11, Page(s) 1748–1756

    Abstract: Introduction: The International Cancer Benchmarking Partnership demonstrated international differences in ovarian cancer survival, particularly for women aged 65-74 with advanced disease. These findings suggest differences in treatment could be ... ...

    Abstract Introduction: The International Cancer Benchmarking Partnership demonstrated international differences in ovarian cancer survival, particularly for women aged 65-74 with advanced disease. These findings suggest differences in treatment could be contributing to survival disparities.
    Objective: To compare clinical practice guidelines and patterns of care across seven high-income countries.
    Methods: A comparison of guidelines was performed and validated by a clinical working group. To explore clinical practice, a patterns of care survey was developed. A questionnaire regarding management and potential health system-related barriers to providing treatment was emailed to gynecological specialists. Guideline and survey results were crudely compared with 3-year survival by 'distant' stage using Spearman's rho.
    Results: Twenty-seven guidelines were compared, and 119 clinicians completed the survey. Guideline-related measures varied between countries but did not correlate with survival internationally. Guidelines were consistent for surgical recommendations of either primary debulking surgery or neoadjuvant chemotherapy followed by interval debulking surgery with the aim of complete cytoreduction. Reported patterns of surgical care varied internationally, including for rates of primary versus interval debulking, extensive/'ultra-radical' surgery, and perceived barriers to optimal cytoreduction. Comparison showed that willingness to undertake extensive surgery correlated with survival across countries (r
    Discussion: Findings suggest international variations in ovarian cancer treatment. Characteristics relating to countries with higher stage-specific survival included higher reported rates of primary surgery; willingness to undertake extensive/ultra-radical procedures; greater access to high-cost drugs; and auditing.
    MeSH term(s) Adult ; Aged ; Australia ; Canada ; Carcinoma, Ovarian Epithelial/therapy ; Europe ; Female ; Gynecology/methods ; Health Services Accessibility ; Humans ; Medical Oncology/methods ; Middle Aged ; New Zealand ; Ovarian Neoplasms/therapy ; Practice Guidelines as Topic ; Surveys and Questionnaires
    Language English
    Publishing date 2020-08-11
    Publishing country England
    Document type Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1070385-8
    ISSN 1525-1438 ; 1048-891X
    ISSN (online) 1525-1438
    ISSN 1048-891X
    DOI 10.1136/ijgc-2020-001403
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3198: Show issues Location:
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  6. Book ; Online: Evaluating Evidence of Mechanisms in Medicine

    Williamson, Jon / Shaw, Beth / Russo, Federica / Norell, Charles / Kelly, Michael P / Illari, Phyllis / Clarke, Brendan / Wilde, Michael / Wallmann, Christian / Parkkinen, Veli-Pekka

    2018  

    Abstract: Philosophy; Medicine—Philosophy; ... ...

    Abstract Philosophy; Medicine—Philosophy; Epistemology
    Keywords Philosophy ; Medicine—Philosophy ; Epistemology
    Language English
    Publisher Springer Nature
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: New approaches to cancer care in a COVID-19 world.

    Butler, John / Finley, Christian / Norell, Charles H / Harrison, Samantha / Bryant, Heather / Achiam, Michael P / Altman, Alon D / Baxter, Nancy / Bentley, James / Cohen, Paul A / Chaudry, M Asif / Dixon, Elijah / Farrell, Rhonda / Fegan, Scott / Hashmi, Salila / Hogdall, Claus / Jenkins, John T / Kwon, Janice / Mala, Tom /
    McNally, Orla / Merrett, Neil / Nelson, Gregg / Nordin, Andy / Park, Jason / Porter, Geoff / Reynolds, John / Schieman, Colin / Schnack, Tine / Spigelman, Allan / Svendsen, Lars Bo / Sykes, Peter / Thomas, Robert

    The Lancet. Oncology

    2020  Volume 21, Issue 7, Page(s) e339–e340

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Humans ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-07-01
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2049730-1
    ISSN 1474-5488 ; 1470-2045
    ISSN (online) 1474-5488
    ISSN 1470-2045
    DOI 10.1016/S1470-2045(20)30340-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5696: Show issues Location:
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    Zs.MO 460: Show issues

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  8. Article ; Online: Exploring variations in ovarian cancer survival by age and stage (ICBP SurvMark-2): A population-based study.

    Cabasag, Citadel J / Butler, John / Arnold, Melina / Rutherford, Mark / Bardot, Aude / Ferlay, Jacques / Morgan, Eileen / Møller, Bjørn / Gavin, Anna / Norell, Charles H / Harrison, Samantha / Saint-Jacques, Nathalie / Eden, Michael / Rous, Brian / Nordin, Andy / Hanna, Louise / Kwon, Janice / Cohen, Paul A / Altman, Alon D /
    Shack, Lorraine / Kozie, Serena / Engholm, Gerda / De, Prithwish / Sykes, Peter / Porter, Geoff / Ferguson, Sarah / Walsh, Paul / Trevithick, Richard / Tervonen, Hanna / O'Connell, Dianne / Bray, Freddie / Soerjomataram, Isabelle

    Gynecologic oncology

    2020  Volume 157, Issue 1, Page(s) 234–244

    Abstract: Objective: The study aims to evaluate the differences in ovarian cancer survival by age and stage at diagnosis within and across seven high-income countries.: Methods: We analyzed data from 58,161 women diagnosed with ovarian cancer during 2010-2014, ...

    Abstract Objective: The study aims to evaluate the differences in ovarian cancer survival by age and stage at diagnosis within and across seven high-income countries.
    Methods: We analyzed data from 58,161 women diagnosed with ovarian cancer during 2010-2014, followed until 31 December 2015, from 21 population-based cancer registries in Australia, Canada, Denmark, Ireland, New Zealand, Norway, and United Kingdom. Comparisons of 1-year and 3-year age- and stage-specific net survival (NS) between countries were performed using the period analysis approach.
    Results: Minor variation in the stage distribution was observed between countries, with most women being diagnosed with 'distant' stage (ranging between 64% in Canada and 71% in Norway). The 3-year all-ages NS ranged from 45 to 57% with Australia (56%) and Norway (57%) demonstrating the highest survival. The proportion of women with 'distant' stage was highest for those aged 65-74 and 75-99 years and varied markedly between countries (range:72-80% and 77-87%, respectively). The oldest age group had the lowest 3-year age-specific survival (20-34%), and women aged 65-74 exhibited the widest variation across countries (3-year NS range: 40-60%). Differences in survival between countries were particularly stark for the oldest age group with 'distant' stage (3-year NS range: 12% in Ireland to 24% in Norway).
    Conclusions: International variations in ovarian cancer survival by stage exist with the largest differences observed in the oldest age group with advanced disease. This finding endorses further research investigating international differences in access to and quality of treatment, and prevalence of comorbid conditions particularly in older women with advanced disease.
    MeSH term(s) Adolescent ; Adult ; Age Factors ; Aged ; Aged, 80 and over ; Australia/epidemiology ; Canada/epidemiology ; Carcinoma, Ovarian Epithelial/mortality ; Carcinoma, Ovarian Epithelial/pathology ; Female ; Humans ; Ireland/epidemiology ; Middle Aged ; Neoplasm Invasiveness ; Neoplasm Staging ; New Zealand/epidemiology ; Norway/epidemiology ; Ovarian Neoplasms/mortality ; Ovarian Neoplasms/pathology ; Registries ; United Kingdom/epidemiology ; Young Adult
    Language English
    Publishing date 2020-01-28
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 801461-9
    ISSN 1095-6859 ; 0090-8258
    ISSN (online) 1095-6859
    ISSN 0090-8258
    DOI 10.1016/j.ygyno.2019.12.047
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 885: Show issues Location:
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  9. Article: New approaches to cancer care in a COVID-19 world

    Butler, John / Finley, Christian / Norell, Charles H / Harrison, Samantha / Bryant, Heather / Achiam, Michael P / Altman, Alon D / Baxter, Nancy / Bentley, James / Cohen, Paul A / Chaudry, M Asif / Dixon, Elijah / Farrell, Rhonda / Fegan, Scott / Hashmi, Salila / Hogdall, Claus / Jenkins, John T / Kwon, Janice / Mala, Tom /
    McNally, Orla / Merrett, Neil / Nelson, Gregg / Nordin, Andy / Park, Jason / Porter, Geoff / Reynolds, John / Schieman, Colin / Schnack, Tine / Spigelman, Allan / Svendsen, Lars Bo / Sykes, Peter / Thomas, Robert

    Lancet Oncol

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #626421
    Database COVID19

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  10. Article ; Online: New approaches to cancer care in a COVID-19 world

    Butler, John / Finley, Christian / Norell, Charles H. / Harrison, Samantha / Bryant, Heather / Achiam, Michael P. / Altman, Alon D. / Baxter, Nancy / Bentley, James / Cohen, Paul A. / Chaudry, Mohammed A. / Dixon, Elijah / Farrell, Rhonda / Fegan, Scott / Hashmi, Salila / Hogdall, Claus / Jenkins, John / Kwon, Janice / Mala, Tom /
    McNally, Orla / Merrett, Neil D. (R14270) / Nelson, Gregg / Nordin, Andy / Park, Jason / Porter, Geoff / Reynolds, John V. / Schieman, Colin / Schnack, Tine / Spigelman, Allan D. / Svendsen, Lars B. / Sykes, Peter / Thomas, Robert

    2020  

    Abstract: The effects of COVID-19 on cancer are substantial, highlighting both novel and existing challenges for health-care systems. We were therefore encouraged to see The Lancet Oncology’s call for cancer care to be safeguarded in a postCOVID-19 world.1 We ... ...

    Abstract The effects of COVID-19 on cancer are substantial, highlighting both novel and existing challenges for health-care systems. We were therefore encouraged to see The Lancet Oncology’s call for cancer care to be safeguarded in a postCOVID-19 world.1 We endorse this position for cancer surgery specifically, and propose several recommendations aiming to reduce the so-called collateral damage of COVID-19. The International Cancer Benchmarking Partnership (ICBP) is a global collaboration seeking to compare and improve cancer survival across high income countries.2 Within the ICBP, we came together to provide a voice for the international cancer surgery community.
    Keywords 320226 - Surgery ; 200199 - Clinical health not elsewhere classified ; COVID-19 (disease) ; pandemics ; cancer ; covid19
    Language English
    Publisher U.K., Lancet Publishing Group
    Publishing country au
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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