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  1. Book ; Online: Resolution Pharmacology - Innovative Therapeutic Approaches Based on the Biology of Resolution to Control Chronic Diseases of Western Societies

    Perretti, Mauro / Montero-Melendez, Trinidad / Norling, Lucy V.

    2019  

    Keywords Science: general issues ; Pharmacology ; Resolution Pharmacology ; vesicle-based therapies ; Inflammation Pharmacology
    Size 1 electronic resource (205 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021231485
    ISBN 9782889630844 ; 2889630846
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Being old and female is an inflammatory combination.

    Norling, Lucy V / Cooper, Dianne

    Journal of leukocyte biology

    2023  Volume 114, Issue 4, Page(s) 299–300

    MeSH term(s) Male ; Humans ; Female ; Peritoneal Cavity ; Cytokines ; Leukocytes
    Chemical Substances Cytokines
    Language English
    Publishing date 2023-07-25
    Publishing country England
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 605722-6
    ISSN 1938-3673 ; 0741-5400
    ISSN (online) 1938-3673
    ISSN 0741-5400
    DOI 10.1093/jleuko/qiad077
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 603: Show issues Location:
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  3. Article ; Online: Helpful inflammation turned harmful in non-communicable diseases.

    Norling, Lucy V / Halade, Ganesh V

    Current opinion in pharmacology

    2022  Volume 67, Page(s) 102317

    MeSH term(s) Humans ; Noncommunicable Diseases ; Inflammation
    Language English
    Publishing date 2022-11-08
    Publishing country England
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2037057-X
    ISSN 1471-4973 ; 1471-4892
    ISSN (online) 1471-4973
    ISSN 1471-4892
    DOI 10.1016/j.coph.2022.102317
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Proresolving lipid mediators enhance PMN-mediated bacterial clearance.

    Norling, Lucy V / Perretti, Mauro

    Proceedings of the National Academy of Sciences of the United States of America

    2020  Volume 117, Issue 17, Page(s) 9148–9150

    MeSH term(s) Humans ; Lipoxins ; Neutrophils ; Phagocytosis ; Pneumonia ; Toll-Like Receptor 9
    Chemical Substances Lipoxins ; TLR9 protein, human ; Toll-Like Receptor 9 ; lipoxin A4
    Language English
    Publishing date 2020-04-16
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2004241117
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1148: Show issues Location:
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  5. Article ; Online: Pro-resolving lipid mediators in sepsis and critical illness.

    Padovan, Michele G / Norling, Lucy V

    Current opinion in clinical nutrition and metabolic care

    2020  Volume 23, Issue 2, Page(s) 76–81

    Abstract: Purpose of review: Sepsis is a life-threatening condition caused by a dysregulated host response to infection that remains a huge clinical challenge. Recent evidence indicates that bioactive lipid mediators derived from polyunsaturated fatty acids ... ...

    Abstract Purpose of review: Sepsis is a life-threatening condition caused by a dysregulated host response to infection that remains a huge clinical challenge. Recent evidence indicates that bioactive lipid mediators derived from polyunsaturated fatty acids termed specialized pro-resolving mediators (SPMs) are promising new candidates for treating critical illness.
    Recent findings: We highlight herein the protective actions of SPMs in experimental sepsis, cardiac dysfunction, and also lung and cerebral injury, and discuss their mechanisms of action. We also emphasize that failed resolution responses and dysregulated SPM pathways may provide an explanation for the ongoing chronic inflammation in many diseases including chronic heart failure.
    Summary: Importantly, monitoring plasma SPM profiles can predict patient outcomes in sepsis indicating their utility as new early biomarkers that may help stratify patients upon ICU admission.
    MeSH term(s) Biomarkers/blood ; Critical Illness/therapy ; Docosahexaenoic Acids/analogs & derivatives ; Docosahexaenoic Acids/blood ; Eicosanoids/blood ; Eicosanoids/pharmacology ; Eicosapentaenoic Acid/analogs & derivatives ; Eicosapentaenoic Acid/blood ; Humans ; Sepsis/blood ; Sepsis/drug therapy ; Signal Transduction/drug effects
    Chemical Substances Biomarkers ; Eicosanoids ; Docosahexaenoic Acids (25167-62-8) ; Eicosapentaenoic Acid (AAN7QOV9EA)
    Language English
    Publishing date 2020-01-06
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1460178-3
    ISSN 1473-6519 ; 1363-1950
    ISSN (online) 1473-6519
    ISSN 1363-1950
    DOI 10.1097/MCO.0000000000000633
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5586: Show issues Location:
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  6. Article ; Online: Cardiac Dysfunction in Rheumatoid Arthritis: The Role of Inflammation.

    Chen, Jianmin / Norling, Lucy V / Cooper, Dianne

    Cells

    2021  Volume 10, Issue 4

    Abstract: Rheumatoid arthritis is a chronic, systemic inflammatory disease that carries an increased risk of mortality due to cardiovascular disease. The link between inflammation and atherosclerotic disease is clear; however, recent evidence suggests that ... ...

    Abstract Rheumatoid arthritis is a chronic, systemic inflammatory disease that carries an increased risk of mortality due to cardiovascular disease. The link between inflammation and atherosclerotic disease is clear; however, recent evidence suggests that inflammation may also play a role in the development of nonischemic heart disease in rheumatoid arthritis (RA) patients. We consider here the link between inflammation and cardiovascular disease in the RA community with a focus on heart failure with preserved ejection fraction. The effect of current anti-inflammatory therapeutics, used to treat RA patients, on cardiovascular disease are discussed as well as whether targeting resolution of inflammation might offer an alternative strategy for tempering inflammation and subsequent inflammation-driven comorbidities in RA.
    MeSH term(s) Anti-Inflammatory Agents/therapeutic use ; Antibodies, Monoclonal, Humanized/therapeutic use ; Antirheumatic Agents/therapeutic use ; Arthritis, Rheumatoid/complications ; Arthritis, Rheumatoid/drug therapy ; Arthritis, Rheumatoid/genetics ; Arthritis, Rheumatoid/immunology ; Atherosclerosis/drug therapy ; Atherosclerosis/etiology ; Atherosclerosis/genetics ; Atherosclerosis/immunology ; Etanercept/therapeutic use ; Heart Failure/drug therapy ; Heart Failure/etiology ; Heart Failure/genetics ; Heart Failure/immunology ; Humans ; Hydroxychloroquine/therapeutic use ; Inflammation ; Methotrexate/therapeutic use ; Myocardial Infarction/drug therapy ; Myocardial Infarction/etiology ; Myocardial Infarction/genetics ; Myocardial Infarction/immunology ; Myocardial Ischemia/drug therapy ; Myocardial Ischemia/etiology ; Myocardial Ischemia/genetics ; Myocardial Ischemia/immunology ; Risk Factors ; Stroke Volume/drug effects ; Stroke Volume/physiology ; Sulfasalazine/therapeutic use
    Chemical Substances Anti-Inflammatory Agents ; Antibodies, Monoclonal, Humanized ; Antirheumatic Agents ; Sulfasalazine (3XC8GUZ6CB) ; Hydroxychloroquine (4QWG6N8QKH) ; tocilizumab (I031V2H011) ; Etanercept (OP401G7OJC) ; Methotrexate (YL5FZ2Y5U1)
    Language English
    Publishing date 2021-04-13
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells10040881
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: β1-Integrin-Mediated Uptake of Chondrocyte Extracellular Vesicles Regulates Chondrocyte Homeostasis.

    Hussain, Mohammed Tayab / Austin-Williams, Shani / Wright, Thomas Dudley / Dhawan, Umesh Kumar / Pinto, Andreia L / Cooper, Dianne / Norling, Lucy V

    International journal of molecular sciences

    2024  Volume 25, Issue 9

    Abstract: Osteoarthritis (OA) is the most prevalent age-related degenerative disorder, which severely reduces the quality of life of those affected. Whilst management strategies exist, no cures are currently available. Virtually all joint resident cells generate ... ...

    Abstract Osteoarthritis (OA) is the most prevalent age-related degenerative disorder, which severely reduces the quality of life of those affected. Whilst management strategies exist, no cures are currently available. Virtually all joint resident cells generate extracellular vesicles (EVs), and alterations in chondrocyte EVs during OA have previously been reported. Herein, we investigated factors influencing chondrocyte EV release and the functional role that these EVs exhibit. Both 2D and 3D models of culturing C28I/2 chondrocytes were used for generating chondrocyte EVs. We assessed the effect of these EVs on chondrogenic gene expression as well as their uptake by chondrocytes. Collectively, the data demonstrated that chondrocyte EVs are sequestered within the cartilage ECM and that a bi-directional relationship exists between chondrocyte EV release and changes in chondrogenic differentiation. Finally, we demonstrated that the uptake of chondrocyte EVs is at least partially dependent on β1-integrin. These results indicate that chondrocyte EVs have an autocrine homeostatic role that maintains chondrocyte phenotype. How this role is perturbed under OA conditions remains the subject of future work.
    MeSH term(s) Chondrocytes/metabolism ; Extracellular Vesicles/metabolism ; Integrin beta1/metabolism ; Homeostasis ; Humans ; Cell Differentiation ; Osteoarthritis/metabolism ; Osteoarthritis/pathology ; Chondrogenesis ; Animals ; Extracellular Matrix/metabolism ; Cartilage, Articular/metabolism ; Cells, Cultured
    Chemical Substances Integrin beta1
    Language English
    Publishing date 2024-04-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25094756
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Enhancing extracellular vesicles for therapeutic treatment of arthritic joints.

    Austin-Williams, Shani / Hussain, Mohammed T / Oggero, Silvia / Norling, Lucy V

    Free radical biology & medicine

    2021  Volume 175, Page(s) 80–94

    Abstract: Extracellular vesicles are small membrane-derived packages of information that are released from virtually all cell types. These nano-packages contain regulatory material including proteins, lipids, mRNA and microRNA and are a key mechanism of ... ...

    Abstract Extracellular vesicles are small membrane-derived packages of information that are released from virtually all cell types. These nano-packages contain regulatory material including proteins, lipids, mRNA and microRNA and are a key mechanism of paracellular communication within a given microenvironment. Encompassed with a lipid bilayer, these organelles have been attributed numerous roles in regulating both physiological and pathological functions. Herein, we describe the role of EVs in the context of Rheumatoid and Osteoarthritis and explore how they could be harnessed to treat inflammatory and degenerative joint conditions. These structures offer a promising therapeutic strategy for treating musculoskeletal diseases due to their bioactive content, stability, small size and intrinsic ability to enter the avascular cartilage, a notoriously challenging tissue to target. We also discuss how EVs can be manipulated to load therapeutic cargo or present additional targeting moieties to enhance their beneficial actions and tissue regenerative properties.
    MeSH term(s) Cartilage ; Extracellular Vesicles ; MicroRNAs ; RNA, Messenger ; Wound Healing
    Chemical Substances MicroRNAs ; RNA, Messenger
    Language English
    Publishing date 2021-08-27
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 807032-5
    ISSN 1873-4596 ; 0891-5849
    ISSN (online) 1873-4596
    ISSN 0891-5849
    DOI 10.1016/j.freeradbiomed.2021.08.235
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2109: Show issues Location:
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  9. Article ; Online: Actions of SPM in regulating host responses in arthritis.

    Perretti, Mauro / Norling, Lucy V

    Molecular aspects of medicine

    2017  Volume 58, Page(s) 57–64

    Abstract: The discovery and identification of omega-3 fatty acid derived specialized pro-resolving mediators (SPM) provides a molecular mechanism for the beneficial effects of fish oil supplementation in patients suffering from arthritis. Here we review the ... ...

    Abstract The discovery and identification of omega-3 fatty acid derived specialized pro-resolving mediators (SPM) provides a molecular mechanism for the beneficial effects of fish oil supplementation in patients suffering from arthritis. Here we review the plethora of bioactions of SPM in the context of joint diseases, focusing on both cellular targets and molecular mechanisms. Whenever possible, a parallel to clinical and preclinical data produced with fish oil supplementation is made to strengthen the mechanistic link between omega-3 fatty acids and SPM biosynthesis. SPM can modulate the reactivity of many cells that are pivotal to the development and/or maintenance of joint disease. Whereas work has so far focused on the actions of SPM on immune cells and therefore, within this context, macrophages, neutrophils, mast cells and T cells, we reason that more work needs to focus on the effects that these bioactive lipid mediators may have on the structural cell component of the joint, this encompassing synovial fibroblasts, chondrocytes, osteoclasts and osteoblasts. Full definition of the properties that SPM may exert on these cells can help in unveiling their ability to promote tissue restoration and regeneration, a prerequisite to repair joint damage, and as such promote the development of innovative therapeutic strategies based on the science of SPM and resolution.
    MeSH term(s) Animals ; Anti-Inflammatory Agents/metabolism ; Anti-Inflammatory Agents/therapeutic use ; Arthritis/diagnosis ; Arthritis/drug therapy ; Arthritis/etiology ; Arthritis/metabolism ; Arthritis, Rheumatoid/drug therapy ; Arthritis, Rheumatoid/etiology ; Arthritis, Rheumatoid/metabolism ; Bone and Bones/drug effects ; Bone and Bones/metabolism ; Bone and Bones/pathology ; Cartilage/drug effects ; Cartilage/metabolism ; Cartilage/pathology ; Complementary Therapies ; Fatty Acids, Omega-3/metabolism ; Fatty Acids, Omega-3/therapeutic use ; Host-Pathogen Interactions ; Humans ; Inflammation Mediators/metabolism ; Inflammation Mediators/therapeutic use
    Chemical Substances Anti-Inflammatory Agents ; Fatty Acids, Omega-3 ; Inflammation Mediators
    Language English
    Publishing date 2017-05-05
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 197640-0
    ISSN 1872-9452 ; 0098-2997
    ISSN (online) 1872-9452
    ISSN 0098-2997
    DOI 10.1016/j.mam.2017.04.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1189: Show issues Location:
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  10. Article ; Online: The resolution of inflammation: Principles and challenges.

    Headland, Sarah E / Norling, Lucy V

    Seminars in immunology

    2015  Volume 27, Issue 3, Page(s) 149–160

    Abstract: The concept that chemokines, cytokines and pro-inflammatory mediators act in a co-ordinated fashion to drive the initiation of the inflammatory reaction is well understood. The significance of such networks acting during the resolution of inflammation ... ...

    Abstract The concept that chemokines, cytokines and pro-inflammatory mediators act in a co-ordinated fashion to drive the initiation of the inflammatory reaction is well understood. The significance of such networks acting during the resolution of inflammation however is poorly appreciated. In recent years, specific pro-resolving mediators were discovered which activate resolution pathways to return tissues to homeostasis. These mediators are diverse in nature, and include specialized lipid mediators (lipoxins, resolvins, protectins and maresins) proteins (annexin A1, galectins) and peptides, gaseous mediators including hydrogen sulphide, a purine (adenosine), as well as neuromodulator release under the control of the vagus nerve. Functionally, they can act to limit further leukocyte recruitment, induce neutrophil apoptosis and enhance efferocytosis by macrophages. They can also switch macrophages from classical to alternatively activated cells, promote the return of non-apoptotic cells to the lymphatics and help initiate tissue repair mechanisms and healing. Within this review we highlight the essential cellular aspects required for successful tissue resolution, briefly discuss the pro-resolution mediators that drive these processes and consider potential challenges faced by researchers in the quest to discover how inflammation resolves and why chronic inflammation persists.
    MeSH term(s) Anti-Inflammatory Agents/therapeutic use ; Apoptosis/immunology ; Cell Hypoxia/immunology ; Cytokines/immunology ; Humans ; Inflammation/drug therapy ; Inflammation/immunology ; Inflammation Mediators/immunology ; Macrophage Activation/immunology ; Macrophages/immunology ; Neutrophils/immunology
    Chemical Substances Anti-Inflammatory Agents ; Cytokines ; Inflammation Mediators
    Language English
    Publishing date 2015-05
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1018141-6
    ISSN 1096-3618 ; 1044-5323
    ISSN (online) 1096-3618
    ISSN 1044-5323
    DOI 10.1016/j.smim.2015.03.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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