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  1. Article ; Online: Health effects of gas fuels: interpreting evidence from a comprehensive meta-analysis.

    Norrie, John

    The Lancet. Respiratory medicine

    2024  Volume 12, Issue 4, Page(s) 259–260

    MeSH term(s) Humans ; Natural Gas
    Chemical Substances Natural Gas
    Language English
    Publishing date 2024-02-01
    Publishing country England
    Document type Meta-Analysis ; Journal Article
    ZDB-ID 2686754-0
    ISSN 2213-2619 ; 2213-2600
    ISSN (online) 2213-2619
    ISSN 2213-2600
    DOI 10.1016/S2213-2600(24)00005-5
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  2. Article ; Online: The importance of long-term follow-up in clinical trials.

    Norrie, John

    The Lancet. Global health

    2023  Volume 11, Issue 7, Page(s) e995–e996

    MeSH term(s) Humans ; Follow-Up Studies ; Clinical Trials as Topic
    Language English
    Publishing date 2023-06-22
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2723488-5
    ISSN 2214-109X ; 2214-109X
    ISSN (online) 2214-109X
    ISSN 2214-109X
    DOI 10.1016/S2214-109X(23)00244-9
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  3. Article ; Online: Some challenges of sparse data necessitating strong assumptions in investigating early COVID-19 disease.

    Norrie, John

    EClinicalMedicine

    2020  Volume 26, Page(s) 100499

    Keywords covid19
    Language English
    Publishing date 2020-08-12
    Publishing country England
    Document type Journal Article
    ISSN 2589-5370
    ISSN (online) 2589-5370
    DOI 10.1016/j.eclinm.2020.100499
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  4. Article ; Online: Remdesivir for COVID-19: challenges of underpowered studies.

    Norrie, John David

    Lancet (London, England)

    2020  Volume 395, Issue 10236, Page(s) 1525–1527

    MeSH term(s) Adenosine Monophosphate/analogs & derivatives ; Alanine/analogs & derivatives ; Antiviral Agents/therapeutic use ; Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Double-Blind Method ; Pandemics ; Pneumonia, Viral ; Randomized Controlled Trials as Topic ; SARS-CoV-2
    Chemical Substances Antiviral Agents ; remdesivir (3QKI37EEHE) ; Adenosine Monophosphate (415SHH325A) ; Alanine (OF5P57N2ZX)
    Keywords covid19
    Language English
    Publishing date 2020-04-29
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(20)31023-0
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  5. Article ; Online: The challenge of implementing AI models in the ICU.

    Norrie, John

    The Lancet. Respiratory medicine

    2018  Volume 6, Issue 12, Page(s) 886–888

    MeSH term(s) Critical Care ; Humans ; Intensive Care Units ; Machine Learning ; Retrospective Studies
    Language English
    Publishing date 2018-11-08
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2686754-0
    ISSN 2213-2619 ; 2213-2600
    ISSN (online) 2213-2619
    ISSN 2213-2600
    DOI 10.1016/S2213-2600(18)30412-0
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  7. Article ; Online: Some challenges of sparse data necessitating strong assumptions in investigating early COVID-19 disease

    Norrie, John

    EClinicalMedicine

    2020  Volume 26, Page(s) 100499

    Keywords covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ISSN 2589-5370
    DOI 10.1016/j.eclinm.2020.100499
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Using telemedicine to improve early medical abortion at home (UTAH): a randomised controlled trial to compare telemedicine with in-person consultation for early medical abortion.

    Reynolds-Wright, John Joseph / Norrie, John / Cameron, Sharon Tracey

    BMJ open

    2023  Volume 13, Issue 9, Page(s) e073630

    Abstract: Objectives: To compare telephone consultations with in-person consultations for the provision of medical abortion (using mifepristone 200 mg and misoprostol 800 µg). We hypothesised that telemedicine consultations would be non-inferior to in-person ... ...

    Abstract Objectives: To compare telephone consultations with in-person consultations for the provision of medical abortion (using mifepristone 200 mg and misoprostol 800 µg). We hypothesised that telemedicine consultations would be non-inferior to in-person consultations with a non-inferiority limit of 3%.
    Design: Randomised controlled trial with 1:1 allocation.
    Setting: Community abortion service housed within an integrated sexual and reproductive health service in Edinburgh, UK.
    Participants: The trial began on 13 January 2020, but was stopped early due to COVID-19; recruitment was suspended on 31 March 2020, and was formally closed on 31 August 2021. A total of 125 participants were randomised, approximately 10% of the total planned, with 63 assigned to telemedicine and 62 to in-person consultation.
    Primary and secondary outcome measures: Primary outcome: efficacy of medical abortion, defined as complete abortion without surgical intervention.
    Secondary outcomes: satisfaction with consultation type, preparedness, unscheduled contact with care, complication rate, time spent in clinical contact and uptake of long-acting contraception.
    Results: Primary outcome was available for 115 participants (lost-to-follow-up telemedicine=2, in-person=8), secondary outcomes were available for 110 participants (n=5 and n=10 in telemedicine and in-person groups did not complete questionnaires). There were no significant differences between groups in treatment efficacy (telemedicine 57/63 (90.5%), in-person 48/62 (77.4%)). However, non-inferiority was not demonstrated (+3.3% in favour of telemedicine, CI -6.6% to +13.3%, lower than non-inferiority margin). There were no significant differences in most secondary outcomes, however, there was more unscheduled contact with care in the telemedicine group (12 (19%) vs 3 (5%), p=0.01). The overall time spent in clinical contact was statistically significantly lower in the telemedicine group (mean 94 (SD 24) vs 111 (24) min, p=0.0005).
    Conclusions: Telemedicine for medical abortion appeared to be effective, safe and acceptable to women, with less time spent in the clinic. However, due to the small sample size resulting from early cessation, the study was underpowered to confirm this conclusion. These findings warrant further investigation in larger scale studies.
    Trial registration number: NCT04139382.
    MeSH term(s) Pregnancy ; Humans ; Female ; Utah ; COVID-19 ; Abortion, Induced ; Abortion, Spontaneous ; Referral and Consultation
    Language English
    Publishing date 2023-09-13
    Publishing country England
    Document type Randomized Controlled Trial ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2023-073630
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  9. Article ; Online: PRINCIPLE: a community-based COVID-19 platform trial.

    Macleod, John / Norrie, John

    The Lancet. Respiratory medicine

    2021  Volume 9, Issue 9, Page(s) 943–945

    MeSH term(s) Antiviral Agents/therapeutic use ; COVID-19 ; Humans ; Research ; SARS-CoV-2
    Chemical Substances Antiviral Agents
    Language English
    Publishing date 2021-07-28
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2686754-0
    ISSN 2213-2619 ; 2213-2600
    ISSN (online) 2213-2619
    ISSN 2213-2600
    DOI 10.1016/S2213-2600(21)00360-X
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  10. Article ; Online: ICON-6: the danger of changing study design midstream.

    Norrie, John

    Lancet (London, England)

    2016  Volume 387, Issue 10023, Page(s) 1031–1032

    MeSH term(s) Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Female ; Humans ; Neoplasm Recurrence, Local/drug therapy ; Neoplasms, Glandular and Epithelial/drug therapy ; Ovarian Neoplasms/drug therapy
    Language English
    Publishing date 2016-03-12
    Publishing country England
    Document type Comment ; Journal Article
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(16)00658-9
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    Ua VI Zs.5: Show issues Location:
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