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  1. Article ; Online: Eat, sleep, repeat: the role of the circadian system in balancing sleep-wake control with metabolic need.

    Northeast, Rebecca C / Vyazovskiy, Vladyslav V / Bechtold, David A

    Current opinion in physiology

    2020  Volume 15, Page(s) 183–191

    Abstract: Feeding and sleep are behaviours fundamental to survival, and as such are subject to powerful homeostatic control. Of course, these are mutually exclusive behaviours, and therefore require coordinated temporal organisation to ensure that both energy ... ...

    Abstract Feeding and sleep are behaviours fundamental to survival, and as such are subject to powerful homeostatic control. Of course, these are mutually exclusive behaviours, and therefore require coordinated temporal organisation to ensure that both energy demands and sleep need are met. Under optimal conditions, foraging/feeding and sleep can be simply partitioned to appropriate phases of the circadian cycle so that they are in suitable alignment with the external environment. However, under conditions of negative energy balance, increased foraging activity must be balanced against sleep requirements and energy conservation. In mammals and many other species, neural circuits that regulate sleep and energy balance are intimately and reciprocally linked. Here, we examine this circuitry, discuss how homeostatic regulation and temporal patterning of sleep are modulated by altered food availability, and describe the role of circadian system in adaptation to metabolic stress.
    Language English
    Publishing date 2020-06-16
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2918626-2
    ISSN 2468-8673 ; 2468-8681
    ISSN (online) 2468-8673
    ISSN 2468-8681
    DOI 10.1016/j.cophys.2020.02.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Timekeeping in the hindbrain: a multi-oscillatory circadian centre in the mouse dorsal vagal complex.

    Chrobok, Lukasz / Northeast, Rebecca C / Myung, Jihwan / Cunningham, Peter S / Petit, Cheryl / Piggins, Hugh D

    Communications biology

    2020  Volume 3, Issue 1, Page(s) 225

    Abstract: Metabolic and cardiovascular processes controlled by the hindbrain exhibit 24 h rhythms, but the extent to which the hindbrain possesses endogenous circadian timekeeping is unresolved. Here we provide compelling evidence that genetic, neuronal, and ... ...

    Abstract Metabolic and cardiovascular processes controlled by the hindbrain exhibit 24 h rhythms, but the extent to which the hindbrain possesses endogenous circadian timekeeping is unresolved. Here we provide compelling evidence that genetic, neuronal, and vascular activities of the brainstem's dorsal vagal complex are subject to intrinsic circadian control with a crucial role for the connection between its components in regulating their rhythmic properties. Robust 24 h variation in clock gene expression in vivo and neuronal firing ex vivo were observed in the area postrema (AP) and nucleus of the solitary tract (NTS), together with enhanced nocturnal responsiveness to metabolic cues. Unexpectedly, we also find functional and molecular evidence for increased penetration of blood borne molecules into the NTS at night. Our findings reveal that the hindbrain houses a local network complex of neuronal and non-neuronal autonomous circadian oscillators, with clear implications for understanding local temporal control of physiology in the brainstem.
    MeSH term(s) Animals ; Area Postrema/metabolism ; Circadian Clocks/genetics ; Circadian Clocks/physiology ; Gene Knock-In Techniques ; Male ; Mice ; Neurons/metabolism ; Rhombencephalon/physiology ; Solitary Nucleus/metabolism ; Vagus Nerve/physiology
    Language English
    Publishing date 2020-05-08
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2399-3642
    ISSN (online) 2399-3642
    DOI 10.1038/s42003-020-0960-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Keeping time in the lamina terminalis: Novel oscillator properties of forebrain sensory circumventricular organs.

    Northeast, Rebecca C / Chrobok, Lukasz / Hughes, Alun T L / Petit, Cheryl / Piggins, Hugh D

    FASEB journal : official publication of the Federation of American Societies for Experimental Biology

    2019  Volume 34, Issue 1, Page(s) 974–987

    Abstract: Drinking behavior and osmotic regulatory mechanisms exhibit clear daily variation which is necessary for achieving the homeostatic osmolality. In mammals, the master clock in the brain's suprachiasmatic nuclei has long been held as the main driver of ... ...

    Abstract Drinking behavior and osmotic regulatory mechanisms exhibit clear daily variation which is necessary for achieving the homeostatic osmolality. In mammals, the master clock in the brain's suprachiasmatic nuclei has long been held as the main driver of circadian (24 h) rhythms in physiology and behavior. However, rhythmic clock gene expression in other brain sites raises the possibility of local circadian control of neural activity and function. The subfornical organ (SFO) and the organum vasculosum laminae terminalis (OVLT) are two sensory circumventricular organs (sCVOs) that play key roles in the central control of thirst and water homeostasis, but the extent to which they are subject to intrinsic circadian control remains undefined. Using a combination of ex vivo bioluminescence and in vivo gene expression, we report for the first time that the SFO contains an unexpectedly robust autonomous clock with unusual spatiotemporal characteristics in core and noncore clock gene expression. Furthermore, putative single-cell oscillators in the SFO and OVLT are strongly rhythmic and require action potential-dependent communication to maintain synchrony. Our results reveal that these thirst-controlling sCVOs possess intrinsic circadian timekeeping properties and raise the possibility that these contribute to daily regulation of drinking behavior.
    MeSH term(s) Animals ; Circadian Rhythm ; Circumventricular Organs/physiology ; Colforsin/pharmacology ; Gene Expression Regulation ; Homeostasis ; Hypothalamus/physiology ; Luminescence ; Male ; Mice ; Neurons/physiology ; Oscillometry ; Prosencephalon/physiology ; Subfornical Organ/physiology ; Tetrodotoxin/pharmacology
    Chemical Substances Colforsin (1F7A44V6OU) ; Tetrodotoxin (4368-28-9)
    Language English
    Publishing date 2019-11-28
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639186-2
    ISSN 1530-6860 ; 0892-6638
    ISSN (online) 1530-6860
    ISSN 0892-6638
    DOI 10.1096/fj.201901111R
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2266: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 296: Show issues

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  4. Article ; Online: Sleep homeostasis during daytime food entrainment in mice.

    Northeast, Rebecca C / Huang, Yige / McKillop, Laura E / Bechtold, David A / Peirson, Stuart N / Piggins, Hugh D / Vyazovskiy, Vladyslav V

    Sleep

    2019  Volume 42, Issue 11

    Abstract: Twenty-four hour rhythms of physiology and behavior are driven by the environment and an internal endogenous timing system. Daily restricted feeding (RF) in nocturnal rodents during their inactive phase initiates food anticipatory activity (FAA) and a ... ...

    Abstract Twenty-four hour rhythms of physiology and behavior are driven by the environment and an internal endogenous timing system. Daily restricted feeding (RF) in nocturnal rodents during their inactive phase initiates food anticipatory activity (FAA) and a reorganization of the typical 24-hour sleep-wake structure. Here, we investigate the effects of daytime feeding, where food access was restricted to 4 hours during the light period ZT4-8 (Zeitgeber time; ZT0 is lights on), on sleep-wake architecture and sleep homeostasis in mice. Following 10 days of RF, mice were returned to ad libitum feeding. To mimic the spontaneous wakefulness associated with FAA and daytime feeding, mice were then sleep deprived between ZT3-6. Although the amount of wake increased during FAA and subsequent feeding, total wake time over 24 hours remained stable as the loss of sleep in the light phase was compensated for by an increase in sleep in the dark phase. Interestingly, sleep that followed spontaneous wake episodes during the dark period and the extended period of wake associated with FAA, exhibited lower levels of slow-wave activity (SWA) when compared to baseline or after sleep deprivation, despite a similar duration of waking. This suggests an evolutionary mechanism of reducing sleep drive during negative energy balance to enable greater arousal for food-seeking behaviors. However, the total amount of sleep and SWA accumulated during the 24 hours was similar between baseline and RF. In summary, our study suggests that despite substantial changes in the daily distribution and quality of wake induced by RF, sleep homeostasis is maintained.
    MeSH term(s) Animals ; Arousal ; Circadian Rhythm/physiology ; Electroencephalography ; Food ; Homeostasis/physiology ; Male ; Mice ; Sleep/physiology ; Wakefulness/physiology
    Language English
    Publishing date 2019-07-17
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 424441-2
    ISSN 1550-9109 ; 0161-8105
    ISSN (online) 1550-9109
    ISSN 0161-8105
    DOI 10.1093/sleep/zsz157
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1475: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Adipocyte NR1D1 dictates adipose tissue expansion during obesity.

    Hunter, Ann Louise / Pelekanou, Charlotte E / Barron, Nichola J / Northeast, Rebecca C / Grudzien, Magdalena / Adamson, Antony D / Downton, Polly / Cornfield, Thomas / Cunningham, Peter S / Billaud, Jean-Noel / Hodson, Leanne / Loudon, Andrew Si / Unwin, Richard D / Iqbal, Mudassar / Ray, David W / Bechtold, David A

    eLife

    2021  Volume 10

    Abstract: The circadian clock component NR1D1 (REVERBα) is considered a dominant regulator of lipid metabolism, with ... ...

    Abstract The circadian clock component NR1D1 (REVERBα) is considered a dominant regulator of lipid metabolism, with global
    MeSH term(s) Adipocytes/metabolism ; Adipose Tissue/metabolism ; Animals ; Energy Metabolism ; Gene Deletion ; Lipid Metabolism ; Male ; Mice ; Nuclear Receptor Subfamily 1, Group D, Member 1/genetics ; Nuclear Receptor Subfamily 1, Group D, Member 1/metabolism ; Obesity/genetics ; Obesity/metabolism
    Chemical Substances Nr1d1 protein, mouse ; Nuclear Receptor Subfamily 1, Group D, Member 1
    Language English
    Publishing date 2021-08-05
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.63324
    Database MEDical Literature Analysis and Retrieval System OnLINE

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