LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 12

Search options

  1. Article ; Online: Retraction

    Fouque, Denis / Nouvier, Mathilde

    Bulletin de la Dialyse à Domicile; Vol 3 No; Bulletin de la Dialyse à Domicile; Vol. 3 No 1 (2020): Bulletin de la Dialyse à Domicile ; 2607-9917

    First viral replication of Covid-19 identified in the peritoneal dialysis fluid ; Rétractation : Première réplication virale du Covid-19 identifiée dans le liquide de dialyse péritonéale d’un patient symptomatique

    2020  Volume 1, Issue : Bulletin de la Dialyse à Domicile

    Abstract: Note editor : retraction of case report https://doi.org/10.25796/bdd.v3i1.54503 Dear Editor-in-chief,By this letter we would like to retract our case report entitled « First viral replication ofCovid-19 identified in the peritoneal dialysis fluid of a ... ...

    Abstract Note editor : retraction of case report https://doi.org/10.25796/bdd.v3i1.54503 Dear Editor-in-chief,By this letter we would like to retract our case report entitled « First viral replication ofCovid-19 identified in the peritoneal dialysis fluid of a symptomatic patient» that wesubmitted to your journal one week ago. We indeed wanted to inform the renalcommunity of a potential presence of Covid-19 virus in the peritoneal dialysis fluid inpatients undergoing peritoneal dialysis treatment. However, the patient general statusimpaired and he was transferred to an intensive care unit for acute myocardialinsufficiency. During this stay, he was re-checked for a number of other organsalterations. A total of 7 RT-PCR SARS-Cov2 tests , validated by the National ReferenceCenter, were done : 2 by nasopharyngeal swabs, 1 in bronchoalveolar lavage, 3 peritonealdialysate and one in stool. A serological test was also performed. All tests were foundnegative. The CT scan was analyzed again by a specialized radiologist and although aCOVID-19 pulmonary disease was likely, it was not possible to rule out a pulmonaryedema secondary to an acute myocarditis of different origin.Therefore, based on these later information, and after careful discussion with thevirologists, we think that the first positive PCR result was erroneous, without clearexplanation for this. Until new cases appear, the fact that two subsequent peritonealdialysate carefully processed were negative indicates that we cannot reliably prove aperitoneal dialysate contamination by COVID-19 virus in our patient. We deeply apologizefor this premature publication.M.Nouvier and D.Fouque for the authors

    Note editor : retraction of case report https://doi.org/10.25796/bdd.v3i1.54503 Dear Editor-in-chief,By this letter we would like to retract our case report entitled « First viral replication ofCovid-19 identified in the peritoneal dialysis fluid of a symptomatic patient» that wesubmitted to your journal one week ago. We indeed wanted to inform the renalcommunity of a potential presence of Covid-19 virus in the peritoneal dialysis fluid inpatients undergoing peritoneal dialysis treatment. However, the patient general statusimpaired and he was transferred to an intensive care unit for acute myocardialinsufficiency. During this stay, he was re-checked for a number of other organsalterations. A total of 7 RT-PCR SARS-Cov2 tests , validated by the National ReferenceCenter, were done : 2 by nasopharyngeal swabs, 1 in bronchoalveolar lavage, 3 peritonealdialysate and one in stool. A serological test was also performed. All tests were foundnegative. The CT scan was analyzed again by a specialized radiologist and although aCOVID-19 pulmonary disease was likely, it was not possible to rule out a pulmonaryedema secondary to an acute myocarditis of different origin.Therefore, based on these later information, and after careful discussion with thevirologists, we think that the first positive PCR result was erroneous, without clearexplanation for this. Until new cases appear, the fact that two subsequent peritonealdialysate carefully processed were negative indicates that we cannot reliably prove aperitoneal dialysate contamination by COVID-19 virus in our patient. We deeply apologizefor this premature publication.M.Nouvier and D.Fouque for the authors
    Keywords retracted ; covid-19 ; rétractation ; covid19
    Language English
    Publishing date 2020-04-20
    Publisher RDPLF
    Publishing country be
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    More links

    Kategorien

  2. Article ; Online: A case of Schönlein-Henoch purpura induced by immune checkpoint inhibitor in a patient with metastatic melanoma.

    Belkaid, Samy / Berger, Mathilde / Nouvier, Mathilde / Picard, Cécile / Dalle, Stéphane

    European journal of cancer (Oxford, England : 1990)

    2020  Volume 139, Page(s) 169–172

    MeSH term(s) Aged ; Antineoplastic Agents, Immunological/adverse effects ; Antineoplastic Agents, Immunological/therapeutic use ; Humans ; Immune Checkpoint Inhibitors/adverse effects ; Immune Checkpoint Inhibitors/therapeutic use ; Ipilimumab/adverse effects ; Ipilimumab/therapeutic use ; Male ; Melanoma/drug therapy ; Nivolumab/adverse effects ; Nivolumab/therapeutic use ; Purpura, Schoenlein-Henoch/chemically induced
    Chemical Substances Antineoplastic Agents, Immunological ; Immune Checkpoint Inhibitors ; Ipilimumab ; Nivolumab (31YO63LBSN)
    Language English
    Publishing date 2020-09-29
    Publishing country England
    Document type Case Reports ; Letter
    ZDB-ID 82061-1
    ISSN 1879-0852 ; 0277-5379 ; 0959-8049 ; 0964-1947
    ISSN (online) 1879-0852
    ISSN 0277-5379 ; 0959-8049 ; 0964-1947
    DOI 10.1016/j.ejca.2020.08.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  3. Article ; Online: Situation of the Covid-19 epidemic in patients on peritoneal dialysis on 2020/05/15 in France

    Nouvier, Mathilde / Verger, Christian / Fouque, Denis

    Bulletin de la Dialyse à Domicile; Vol 3 No; 73-81 ; Bulletin de la Dialyse à Domicile; Vol. 3 No 2 (2020): Bulletin de la Dialyse à Domicile; 73-81 ; 2607-9917

    RDPLF data-base ; Situation de l’épidémie de Covid-19 chez les patients en dialyse péritonéale au 15/05/2020 en France base de données du RDPLF

    2020  Volume 2, Issue : Bulletin de la Dialyse à Domicile

    Abstract: Numerous studies have shown that chronic renal failure, whatever the treatment, is an important risk factor during the SARS-Cov2 pandemic. We present the incidence of COVID-19 infection, and its lethality, in France according to data from the French ... ...

    Abstract Numerous studies have shown that chronic renal failure, whatever the treatment, is an important risk factor during the SARS-Cov2 pandemic. We present the incidence of COVID-19 infection, and its lethality, in France according to data from the French Language Peritoneal Dialysis Registry (RDPLF), during the period of the epidemic peak between March 1 and May 15, 2020. Of the 3,104 patients treated with PD during this period, from 156 centers, 59 contracted COVID-19, ie 1.8%, a percentage significantly lower than that observed in center hemodialysis. Diabetes was found in 64% of infected patients while it was only present in 36% of uncontaminated patients. The mode of contamination was attributed to a hospital stay in 19% of the cases, a family infection in 17% of the cases, treatment in nursing homes in 15% of the cases, unknown in 44% of the cases. Sixty-two percent of the infected patients were on assisted PD, without identifying the source of contamination. The mortality rate was high at 40%, comparable to other countries in PD. A comparison with hemodialysis could only be made after adjustment for comorbidities and patient profiles: data on hemodialysis are not available in the RDPLF. Home peritoneal dialysis decreases the risk of Covid-19 contamination, but associated comorbidities and age are the source of high mortality. Non-autonomous patients have a higher risk of contamination.

    De nombreux travaux ont montré que l’insuffisance rénale chronique, quel qu’en soit le traitement, est un facteur de risque important au cours de la pandémie à SARS-Cov2. Nous présentons l’incidence de l’infection au COVID-19, et sa létalité, en France, d’après les données du Registre de Dialyse Péritonéale de Langue Française, au cours de la période du pic épidémique entre le 1er mars et le 15 mai 2020. Sur les 3 104 patients traités par DP durant cette période, issus de 156 centres, 59 ont contracté le COVID-19 soit 1,8 %, pourcentage nettement inférieur à celui observé en hémodialyse en centre. Parmi les patients contaminés, 64% présentaient un diabète, alors qu’il n’était présent que chez 36% des patients non contaminés. Le mode de contamination a été attribué à un séjour hospitalier dans 19 % des cas, un contact familial dans 17 % des cas, un traitement en EHPAD dans 14 % des cas, inconnu dans 44 % des cas. Soixante-deux pour cent des patients contaminés était en DP assistée, sans identification de la source de contamination. Le taux de mortalité était élevé à 40 %, chiffres comparables à ceux d’autres pays. Une comparaison avec l’hémodialyse ne pourrait être faite qu’après ajustement sur les comorbidités et profils des patients : les données en hémodialyse ne sont pas disponibles dans le RDPLF. La dialyse péritonéale à domicile diminue le risque de contamination par le Covid-19, mais les comorbidités associées et l’âge sont la source d’une mortalité élevée. Les patients non autonomes ont un risque de contamination plus important.
    Keywords SARS-CoV-2 ; Peritoneal dialysis ; France ; pandemia ; COVID-19 ; Dialyse péritonéale ; pandémie ; covid19
    Language French
    Publishing date 2020-06-15
    Publisher RDPLF
    Publishing country be
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    More links

    Kategorien

  4. Article: Severe tubulointerstitial nephritis: tracking tuberculosis even in the absence of renal granuloma.

    Delafosse, Marion / Teuma, Cécile / Miailhes, Patrick / Nouvier, Mathilde / Rabeyrin, Maud / Fouque, Denis

    Clinical kidney journal

    2018  Volume 11, Issue 5, Page(s) 667–669

    Abstract: Extra-pulmonary tuberculosis is frequently located in the kidneys and, in such cases, could be associated with a granulomatous interstitial nephritis. Granulomas are not always detected, especially in human immunodeficiency virus (HIV)-positive patients. ...

    Abstract Extra-pulmonary tuberculosis is frequently located in the kidneys and, in such cases, could be associated with a granulomatous interstitial nephritis. Granulomas are not always detected, especially in human immunodeficiency virus (HIV)-positive patients. We report here a case of tubulointerstitial nephritis without granulomas in an HIV-negative patient. Since all laboratory tests failed to isolate
    Language English
    Publishing date 2018-01-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 2655800-2
    ISSN 2048-8513 ; 2048-8505
    ISSN (online) 2048-8513
    ISSN 2048-8505
    DOI 10.1093/ckj/sfx157
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  5. Article ; Online: Acute Renal Colic Due to Immunoglobulin Free Light Chain Kidney Stones: A Case Report of an Unusual Complication of Multiple Myeloma.

    Bouchet, Antonin / Teuma, Cécile / Nouvier, Mathilde / Rousset, Pascal / Javaugue, Vincent / Lazareth, Anne / Lombard, Christine / Isaac, Sylvie / Fouque, Denis

    American journal of kidney diseases : the official journal of the National Kidney Foundation

    2019  Volume 74, Issue 5, Page(s) 700–702

    Abstract: Kidney failure is common in patients with a monoclonal gammopathy, most frequently due to hypercalcemia or myeloma cast nephropathy. Immunoglobulin crystallization is an uncommon phenomenon that also results in kidney injury. We report the case of a 74- ... ...

    Abstract Kidney failure is common in patients with a monoclonal gammopathy, most frequently due to hypercalcemia or myeloma cast nephropathy. Immunoglobulin crystallization is an uncommon phenomenon that also results in kidney injury. We report the case of a 74-year-old man with recurrent renal colic and acute kidney injury. He presented with κ light chain Bence-Jones proteinuria, hypogammaglobulinemia, anemia, and high plasma κ light chain level, leading to the diagnosis of κ light chain multiple myeloma. One calculus was collected and its analysis revealed a unique protein structure consisting of κ immunoglobulin free light chain. Genetic sequencing of the κ light chain identified a subgroup of variable domain previously identified as prone to crystallization. Eight cycles of cyclophosphamide-bortezomib-dexamethasone chemotherapy resulted in a partial hematologic response and kidney recovery without recurrence of renal colic. This rare case of urinary light chain nephrolithiasis highlights the importance of genetic and molecular analysis of the immunoglobulin variable domain to better understand the wide spectrum of monoclonal gammopathies.
    MeSH term(s) Acute Disease ; Aged ; Diagnosis, Differential ; Humans ; Immunoglobulin Light Chains/metabolism ; Kidney Calculi/complications ; Kidney Calculi/diagnosis ; Kidney Calculi/metabolism ; Kidney Tubules/metabolism ; Kidney Tubules/pathology ; Male ; Multiple Myeloma/complications ; Multiple Myeloma/diagnosis ; Renal Colic/diagnosis ; Renal Colic/etiology ; Tomography, X-Ray Computed
    Chemical Substances Immunoglobulin Light Chains
    Language English
    Publishing date 2019-05-30
    Publishing country United States
    Document type Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 604539-x
    ISSN 1523-6838 ; 0272-6386
    ISSN (online) 1523-6838
    ISSN 0272-6386
    DOI 10.1053/j.ajkd.2019.03.426
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  6. Article ; Online: First viral replication of Covid-19 identified in the peritoneal dialysis fluid of a symptomatic patient ; Première réplication virale du Covid-19 identifiée dans le liquide de dialyse péritonéale d’un patient symptomatique

    Nouvier, Mathilde / Chalençon, Elodie / Novel-Catin, Etienne / Pelletier, Solenne / Hallonet, Patrick / Charre, Caroline / Koppe, Laetitia / Fouque, Denis

    Bulletin de la Dialyse à Domicile; Vol 3 No; 49-50 ; Bulletin de la Dialyse à Domicile; Vol. 3 No 1 (2020): Bulletin de la Dialyse à Domicile; 49-50 ; 2607-9917

    2020  Volume 1, Issue : Bulletin de la Dialyse à Domicile

    Abstract: RETRACTED : the authors retracted see : https://bdd.rdplf.org/index.php/bdd/article/view/54713 The COVID-19 pandemic is characterized by a disease with mainly respiratory tropism and varying severity. Viral excretion of COVID-19 has been described in ... ...

    Abstract RETRACTED : the authors retracted see : https://bdd.rdplf.org/index.php/bdd/article/view/54713 The COVID-19 pandemic is characterized by a disease with mainly respiratory tropism and varying severity. Viral excretion of COVID-19 has been described in both urine and stool with the risk of contamination by stool. No viral replication in the peritoneal dialysis fluid has been reported to date. We report an observation demonstrating the presence of the virus in the peritoneal dialysis drainage fluid of a COVID-19 patient. This underlines the importance in COVID-19 patients of considering dialysis fluid as a possible source of contamination.

    EN RAISON D'UNE ERREUR DE MESURE DECOUVERTE PAR LES AUTEURS APRES PUBLICATION ILS ONT SOUHAITE SE RETRACTER DE CET ARTICLE, VOIR : https://bdd.rdplf.org/index.php/bdd/article/view/54713 La pandémie liée au Covid-19 se caractérise par une maladie avec un tropisme principalement respiratoire et de sévérité variable . L’excrétion virale du Covid-19 a été décrite dans les urines et les selles avec un risque de contamination par les selles. Aucune réplication virale dans le liquide de dialyse péritonéale n’avait été rapportée à ce jour . Nous rapportons une observation démontrant la présence du virus dans le liquide de drainage de dialyse péritonéale d’un patient COVID-19. Cela souligne l’importance chez les patients COVID-19 de considérer le liquide de dalyse comme une source de contamination possible.
    Keywords SARS-CoV2 ; COVID-19 ; peritoneal dialysis ; dialysate ; dialyse péritonéale ; Dialysat ; covid19
    Language French
    Publishing date 2020-04-13
    Publisher RDPLF
    Publishing country be
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    More links

    Kategorien

  7. Article ; Online: Induction failure in granulomatosis with polyangiitis: a nationwide case-control study of risk factors and outcomes.

    Sorin, Boris / Iudici, Michele / Guerry, Mary-Jane / Samson, Maxime / Bielefeld, Philip / Maillet, Thibault / Nouvier, Mathilde / Karras, Alexandre / Meyer, Lara / Lavigne, Christian / Régent, Alexis / Durel, Cécile-Audrey / Fabre, Marc / Charles, Pierre / Raimbourg, Quentin / Lanteri, Aurélia / Pugnet, Grégory / Rivière, Frédéric / Pineton de Chambrun, Marc /
    Cacoub, Patrice / Le Guenno, Guillaume / Jourdain, Pierre / Mekinian, Arsène / Paule, Romain / Dion, Jérémie / Legendre, Paul / Cohen, Pascal / Guillevin, Loïc / Puéchal, Xavier / Terrier, Benjamin

    Rheumatology (Oxford, England)

    2023  Volume 62, Issue 11, Page(s) 3662–3671

    Abstract: Objective: To identify characteristics of granulomatosis with polyangiitis (GPA) associated with induction failure, describe salvage therapies and their efficacy.: Methods: We conducted a nationwide retrospective case-control study of GPA with ... ...

    Abstract Objective: To identify characteristics of granulomatosis with polyangiitis (GPA) associated with induction failure, describe salvage therapies and their efficacy.
    Methods: We conducted a nationwide retrospective case-control study of GPA with induction failure between 2006 and 2021. Each patient with induction failure was randomly paired to three controls matched for age, sex and induction treatment.
    Results: We included 51 patients with GPA and induction failure (29 men and 22 women). At induction therapy, median age was 49 years. Twenty-seven patients received intravenous cyclophosphamide (ivCYC) and 24 rituximab (RTX) as induction therapy. Patients with ivCYC induction failure more frequently had PR3-ANCA (93% vs 70%, P = 0.02), relapsing disease (41% vs 7%, P < 0.001) and orbital mass (15% vs 0%, P < 0.01) compared with controls. Patients with disease progression despite RTX induction therapy more frequently had renal involvement (67% vs 25%, P = 0.02) with renal failure (serum creatinine >100 µmol/l in 42% vs 8%, P = 0.02) compared with controls. After salvage therapy, remission was achieved at 6 months in 35 (69%) patients. The most frequent salvage therapy was switching from ivCYC to RTX (or vice versa), showing an efficacy in 21/29 (72%). Remission was achieved in nine (50%) patients with inappropriate response to ivCYC, while in patients with progression after RTX induction, remission was achieved in four (100%) who received ivCYC (with or without immunomodulatory therapy), but only in three (50%) after adding immunomodulatory therapy alone.
    Conclusion: In patients with induction failure, characteristics of GPA, salvage therapies and their efficacy vary according to induction therapy and failure modality.
    MeSH term(s) Male ; Humans ; Female ; Middle Aged ; Granulomatosis with Polyangiitis/complications ; Granulomatosis with Polyangiitis/drug therapy ; Retrospective Studies ; Case-Control Studies ; Treatment Outcome ; Rituximab/therapeutic use ; Cyclophosphamide/therapeutic use ; Risk Factors ; Remission Induction ; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
    Chemical Substances Rituximab (4F4X42SYQ6) ; Cyclophosphamide (8N3DW7272P)
    Language English
    Publishing date 2023-02-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 1464822-2
    ISSN 1462-0332 ; 1462-0324
    ISSN (online) 1462-0332
    ISSN 1462-0324
    DOI 10.1093/rheumatology/kead098
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  8. Article ; Online: Results of a nation-wide cohort study suggest favorable long-term outcomes of clone-targeted chemotherapy in immunotactoid glomerulopathy.

    Javaugue, Vincent / Dufour-Nourigat, Léa / Desport, Estelle / Sibille, Audrey / Moulin, Bruno / Bataille, Pierre / Bindi, Pascal / Garrouste, Cyril / Mariat, Christophe / Karlin, Lionel / Nouvier, Mathilde / Goujon, Jean-Michel / Gnemmi, Viviane / Fermand, Jean-Paul / Touchard, Guy / Bridoux, Frank

    Kidney international

    2020  Volume 99, Issue 2, Page(s) 421–430

    Abstract: Immunotactoid glomerulopathy is a rare disease defined by glomerular microtubular immunoglobulin deposits. Since management and long-term outcomes remain poorly described, we retrospectively analyzed results of 27 adults from 21 departments of nephrology ...

    Abstract Immunotactoid glomerulopathy is a rare disease defined by glomerular microtubular immunoglobulin deposits. Since management and long-term outcomes remain poorly described, we retrospectively analyzed results of 27 adults from 21 departments of nephrology in France accrued over 19 years. Inclusion criteria were presence of glomerular Congo red-negative monotypic immunoglobulin deposits with ultrastructural microtubular organization, without evidence for cryoglobulinemic glomerulonephritis. Baseline manifestations of this cohort included: proteinuria (median 6.0 g/day), nephrotic syndrome (70%), microscopic hematuria (74%) and hypertension (56%) with a median serum creatinine of 1.5 mg/dL. Nineteen patients had detectable serum and/or urine monoclonal gammopathy. A bone marrow and/or peripheral blood clonal disorder was identified in 18 cases (16 lymphocytic and 2 plasmacytic disorders). Hematologic diagnosis was chronic/small lymphocytic lymphoma in 13, and monoclonal gammopathy of renal significance in 14 cases. Kidney biopsy showed atypical membranous in 16 or membranoproliferative glomerulonephritis in 11 cases, with microtubular monotypic IgG deposits (kappa in 17 of 27 cases), most commonly IgG1. Identical intracytoplasmic microtubules were observed in clonal lymphocytes from 5 of 10 tested patients. Among 21 patients who received alkylating agents, rituximab-based or bortezomib-based chemotherapy, 18 achieved a kidney response. After a median follow-up of 40 months, 16 patients had sustained kidney response, 7 had reached end-stage kidney disease, and 6 died. Chronic/small lymphocytic lymphoma appears as a common underlying condition in immunotactoid glomerulopathy, but clonal detection remains inconstant with routine techniques in patients with monoclonal gammopathy of renal significance. Thus, early diagnosis and hematological response after clone-targeted chemotherapy was associated with favorable outcomes. Hence, thorough pathologic and hematologic workup is key to the management of immunotactoid glomerulopathy.
    MeSH term(s) Adult ; Clone Cells ; Cohort Studies ; France/epidemiology ; Glomerulonephritis/drug therapy ; Glomerulonephritis/epidemiology ; Humans ; Retrospective Studies
    Language English
    Publishing date 2020-07-30
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2020.06.039
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  9. Article ; Online: Clinicopathological spectrum of renal parenchymal involvement in B-cell lymphoproliferative disorders.

    Javaugue, Vincent / Debiais-Delpech, Céline / Nouvier, Mathilde / Gand, Elise / Chauvet, Sophie / Ecotiere, Laure / Desport, Estelle / Goujon, Jean-Michel / Delwail, Vincent / Guidez, Stéphanie / Tomowiak, Cécile / Leleu, Xavier / Jaccard, Arnaud / Rioux-Leclerc, Nathalie / Vigneau, Cécile / Fermand, Jean-Paul / Touchard, Guy / Thierry, Antoine / Bridoux, Frank

    Kidney international

    2019  Volume 96, Issue 1, Page(s) 94–103

    Abstract: The clinicopathological characteristics of kidney infiltration in B-cell lymphoproliferative disorders remain poorly described. We retrospectively studied 52 adults with biopsy-proven malignant B-cell kidney infiltration, including Waldenström's ... ...

    Abstract The clinicopathological characteristics of kidney infiltration in B-cell lymphoproliferative disorders remain poorly described. We retrospectively studied 52 adults with biopsy-proven malignant B-cell kidney infiltration, including Waldenström's macroglobulinemia (n=21), chronic lymphocytic leukemia (n=11), diffuse large B-cell lymphoma (DLBCL) (n=8), other lymphoma (n=11), and multiple myeloma (n=1). Kidney disease varied according to the underlying lymphoproliferative disorder. In DLBCL, malignant kidney infiltration was prominent, resulting in acute kidney injury (AKI, 75%) and kidney enlargement (88%). In the other types, associated immunoglobulin-related nephropathy (most commonly AL amyloidosis) was more common (45%), and chronic kidney disease with proteinuria was the primary presentation. All patients received chemotherapy. Over a median follow-up of 31 months, 20 patients died and 21 reached end-stage kidney disease. Renal response, achieved in 25 patients (48%), was associated with higher overall survival (97 vs. 37 months in non-renal responders). In univariate analysis, percentage of sclerotic glomeruli, kidney enlargement, and complete hematological response at 6 months were predictive of renal response. In multivariate analysis, concomitant immunoglobulin-related nephropathy was the sole independent predictor of poor renal outcome. In conclusion, clinical presentation of renal lymphomatous infiltration depends on the nature of the underlying lymphoproliferative disorder. In DLBCL, massive renal infiltration manifests with enlarged kidneys and AKI, and the diagnosis primarily relies on lymph node biopsy. In other B-cell lymphoproliferative disorders, the clinicopathological spectrum is more heterogeneous, with a high frequency of immunoglobulin-related nephropathy that may affect renal outcome; thus kidney biopsy is required for early diagnosis and prognostic assessment.
    MeSH term(s) Acute Kidney Injury/epidemiology ; Acute Kidney Injury/etiology ; Acute Kidney Injury/pathology ; Acute Kidney Injury/therapy ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Biopsy ; Female ; Humans ; Incidence ; Kidney Cortex/pathology ; Lymphoproliferative Disorders/complications ; Lymphoproliferative Disorders/urine ; Male ; Middle Aged ; Proteinuria/epidemiology ; Proteinuria/etiology ; Proteinuria/pathology ; Proteinuria/therapy ; Renal Dialysis/statistics & numerical data ; Renal Insufficiency, Chronic/epidemiology ; Renal Insufficiency, Chronic/etiology ; Renal Insufficiency, Chronic/pathology ; Renal Insufficiency, Chronic/therapy ; Retrospective Studies ; Young Adult
    Language English
    Publishing date 2019-03-15
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2019.01.027
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  10. Article ; Online: Clinical and Prognostic Factors in Patients with IgG4-Related Kidney Disease.

    Chaba, Anis / Devresse, Arnaud / Audard, Vincent / Boffa, Jean Jacques / Karras, Alexandre / Cartery, Claire / Deltombe, Clément / Chemouny, Jonathan / Contamin, Claudine / Courivaud, Cecile / Duquennoy, Simon / Garcia, Hugo / Joly, Dominique / Goumri, Nabila / Hanouna, Guillaume / Halimi, Jean Michel / Plaisier, Emmanuelle / Hamidou, Mohamed / Landron, Cédric /
    Launay, David / Lebas, Celine / Legendre, Mathieu / Masseau, Agathe / Mathian, Alexis / Mercadal, Lucile / Morel, Nathalie / Mutinelli-Szymanski, Prisca / Palat, Sylvain / Pennaforte, Jean-Loup / Peraldi, Marie Noelle / Pozdzik, Agnieszka / Schleinitz, Nicolas / Thaunat, Olivier / Titeca-Beauport, Dimitri / Mussini, Charlotte / Touati, Sonia / Prinz, Eric / Faller, Anne Laure / Richter, Sarah / Vilaine, Eve / Ferlicot, Sophie / Von-Kotze, Clarissa / Belliere, Julie / Olagne, Jerome / Mesbah, Rafik / Snanoudj, Renaud / Nouvier, Mathilde / Ebbo, Mikael / Zaidan, Mohamad

    Clinical journal of the American Society of Nephrology : CJASN

    2023  Volume 18, Issue 8, Page(s) 1031–1040

    Abstract: Background: IgG4-related kidney disease is a major manifestation of IgG4-related disease, a systemic fibroinflammatory disorder. However, the clinical and prognostic kidney-related factors in patients with IgG4-related kidney disease are insufficiently ... ...

    Abstract Background: IgG4-related kidney disease is a major manifestation of IgG4-related disease, a systemic fibroinflammatory disorder. However, the clinical and prognostic kidney-related factors in patients with IgG4-related kidney disease are insufficiently defined.
    Methods: We conducted an observational cohort study using data from 35 sites in two European countries. Clinical, biologic, imaging, and histopathologic data; treatment modalities; and outcomes were collected from medical records. Logistic regression was performed to identify the possible factors related to an eGFR ≤30 ml/min per 1.73 m 2 at the last follow-up. Cox proportional hazards model was performed to assess the factors associated with the risk of relapse.
    Results: We studied 101 adult patients with IgG4-related disease with a median follow-up of 24 (11-58) months. Of these, 87 (86%) patients were male, and the median age was 68 (57-76) years. Eighty-three (82%) patients had IgG4-related kidney disease confirmed by kidney biopsy, with all biopsies showing tubulointerstitial involvement and 16 showing glomerular lesions. Ninety (89%) patients were treated with corticosteroids, and 18 (18%) patients received rituximab as first-line therapy. At the last follow-up, the eGFR was below 30 ml/min per 1.73 m 2 in 32% of patients; 34 (34%) patients experienced a relapse, while 12 (13%) patients had died. By Cox survival analysis, the number of organs involved (hazard ratio [HR], 1.26; 95% confidence interval [CI], 1.01 to 1.55) and low C3 and C4 concentrations (HR, 2.31; 95% CI, 1.10 to 4.85) were independently associated with a higher risk of relapse, whereas first-line therapy with rituximab was protective (HR, 0.22; 95% CI, 0.06 to 0.78). At their last follow-up, 19 (19%) patients had an eGFR ≤30 ml/min per 1.73 m 2 . Age (odd ratio [OR], 1.11; 95% CI, 1.03 to 1.20), peak serum creatinine (OR, 2.74; 95% CI, 1.71 to 5.47), and serum IgG4 level ≥5 g/L (OR, 4.46; 95% CI, 1.23 to 19.40) were independently predictive for severe CKD.
    Conclusions: IgG4-related kidney disease predominantly affected middle-aged men and manifested as tubulointerstitial nephritis with potential glomerular involvement. Complement consumption and the number of organs involved were associated with a higher relapse rate, whereas first-line therapy with rituximab was associated with lower relapse rate. Patients with high serum IgG4 concentrations (≥5 g/L) had more severe kidney disease.
    MeSH term(s) Adult ; Middle Aged ; Humans ; Male ; Aged ; Female ; Immunoglobulin G4-Related Disease/complications ; Immunoglobulin G4-Related Disease/diagnosis ; Immunoglobulin G4-Related Disease/drug therapy ; Rituximab/adverse effects ; Cohort Studies ; Prognosis ; Kidney/pathology ; Nephritis, Interstitial/pathology ; Immunoglobulin G ; Recurrence ; Retrospective Studies
    Chemical Substances Rituximab (4F4X42SYQ6) ; Immunoglobulin G
    Language English
    Publishing date 2023-06-07
    Publishing country United States
    Document type Observational Study ; Journal Article
    ZDB-ID 2226665-3
    ISSN 1555-905X ; 1555-9041
    ISSN (online) 1555-905X
    ISSN 1555-9041
    DOI 10.2215/CJN.0000000000000193
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

To top