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  1. Article: Sensitivity Patterns of Bacterial Pathogens Isolated from Blood Cultures of Under-Five Children with Pneumonia and Clinical Sepsis.

    Islam, Sufia / Akand, Ashiqur Rahman / Nova, Tasnova Tasnim / Lehmann, Christian / Chisti, Mohammod Jobayer

    Life (Basel, Switzerland)

    2021  Volume 11, Issue 5

    Abstract: Treatment options for pneumonia and sepsis by antibiotics are limited due to the development of multidrug-resistant bacterial strains. This unmatched case-control study determined the antibiotic sensitivity against bacterial isolates obtained from septic ...

    Abstract Treatment options for pneumonia and sepsis by antibiotics are limited due to the development of multidrug-resistant bacterial strains. This unmatched case-control study determined the antibiotic sensitivity against bacterial isolates obtained from septic and nonseptic children with pneumonia. Children of either sex aged 0-59 months with a history of cough or shortness of breath and radiologically confirmed pneumonia were enrolled in this study. Cases with clinical signs of sepsis at admission (
    Language English
    Publishing date 2021-05-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life11050450
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Prevalence of CYP2C19 and ITGB3 polymorphisms among Bangladeshi patients who underwent percutaneous coronary intervention.

    Islam, Md Rabiul / Nova, Tasnova Tasnim / Momenuzzaman, Nam / Rabbi, Sikder Nahidul Islam / Jahan, Ishrat / Binder, Thomas / Islam, Mohammad Safiqul / Hasnat, Abul / Nahar, Zabun

    SAGE open medicine

    2021  Volume 9, Page(s) 20503121211042209

    Abstract: Introduction: Antithrombotic agents are the basic therapeutic option for patients with arterial thrombosis who underwent percutaneous coronary intervention (PCI). In Bangladesh, aspirin and clopidogrel are frequently prescribed as antithrombotics or ... ...

    Abstract Introduction: Antithrombotic agents are the basic therapeutic option for patients with arterial thrombosis who underwent percutaneous coronary intervention (PCI). In Bangladesh, aspirin and clopidogrel are frequently prescribed as antithrombotics or platelet inhibitors. Studies reported the genetic polymorphisms of CYP2C19*2, CYP2C19*17, and ITGB3 cause an alteration of the pharmacodynamic and pharmacokinetic profile of aspirin and clopidogrel. Therefore, we aimed to assess the prevalence of CYP2C19*2, CYP2C19*17, and ITGB3 polymorphisms among Bangladeshi patients with cardiovascular disease (CVD) who underwent PCI.
    Methods: Here we assessed a total of 1,000 CVD patients (male 782 and female 218) who underwent PCI and were treated with clopidogrel and/or aspirin. We performed genotyping of patients treated with clopidogrel and aspirin by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and tetra-primer amplification refractory mutation system PCR (T-ARMS-PCR) methods. The PCR products of clopidogrel-treated patients were screened with agarose gel electrophoresis and then digested with SmaI and NsiI-HF for CYP2C19*2 and CYP2C19*17, respectively. We genotyped aspirin-treated patients with T-ARMS-PCR for missense rs5918 (PlA1/A1) polymorphism of the ITGB3 gene. Then we ran the digested PCR products on 2% agarose gel electrophoresis to detect the mentioned polymorphisms.
    Results: Among the clopidogrel-treated patients, we observed 64.1% polymorphism (hetero + mutant) of CYP2C19*2 (loss-of-function allele) and 22.7% (hetero + mutant) of CYP2C19*17 (gain-of-function allele). On the other hand, among the aspirin-treated patients, polymorphisms of ITGB3 were 84.1% homozygous (PlA1/A1), 15.6% heterozygous (PlA1/A2), and 0.3% mutant homozygous.
    Conclusion: In the present study, we observed a high prevalence of genetic polymorphisms of CYP2C19 and ITGB3 genes. Therefore, we recommend genotyping of CVD patients before prescribing clopidogrel or aspirin to prevent coagulation. Based on the genotyping study, the adjustment of doses or alternative generics might require to avoid therapeutic failure or toxicity in some cases.
    Language English
    Publishing date 2021-08-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 2735399-0
    ISSN 2050-3121
    ISSN 2050-3121
    DOI 10.1177/20503121211042209
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Disposal Practices of Unused and Leftover Medicines in the Households of Dhaka Metropolis.

    Begum, Mst Marium / Rivu, Sanzana Fareen / Hasan, Md Mahmud Al / Nova, Tasnova Tasnim / Rahman, Md Motiar / Alim, Md Abdul / Uddin, Md Sahab / Islam, Azharul / Nurnahar / Tabassum, Nuzhat / Moni, Md Marufur Rahman / Roselin, Rehnuma / Das, Munny / Begum, Rayhana / Rahman, Md Sohanur

    Pharmacy (Basel, Switzerland)

    2021  Volume 9, Issue 2

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2021-05-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2737194-3
    ISSN 2226-4787 ; 2226-4787
    ISSN (online) 2226-4787
    ISSN 2226-4787
    DOI 10.3390/pharmacy9020103
    Database MEDical Literature Analysis and Retrieval System OnLINE

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