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Book: Appropriate use of antibiotics for intra abdominal infections

Esposito, Silvano / Novelli, Andrea

(Journal of chemotherapy ; 21, Suppl. 1)

2009

Title variant	Appropriate use of antibiotics for intra-abdominal infections
Author's details	[suppl. ed.: Silvano Esposito and Andrea Novelli]
Series title	Journal of chemotherapy ; 21, Suppl. 1
Collection
Language	English
Size	60 S. : graph. Darst.
Publisher	E.S.I.F.T. srl
Publishing place	Firenze
Publishing country	Italy
Document type	Book
HBZ-ID	HT017060005
Database	Catalogue ZB MED Medicine, Health

In stock of ZB MED Cologne/Königswinter

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Zs A 2701 -21,Suppl.1-	not available for loan	Zeitschriften-Lesesaal

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Article ; Online: Resistenze antibiotiche e nuove molecole: qual è lo scenario attuale? .

Novelli, Andrea

Urologia

2018 Volume 85, Issue 1_suppl, Page(s) S5–S13

Abstract: Antibiotic resistance and new drugs in urologic setting: what we need to know? Urinary tract infections (UTIs) are among the most frequent infectious diseases, and represent an important public health problem with a substantial economic burden. In recent ...

Abstract	Antibiotic resistance and new drugs in urologic setting: what we need to know? Urinary tract infections (UTIs) are among the most frequent infectious diseases, and represent an important public health problem with a substantial economic burden. In recent years the chemoresistance of the main uropathogens has significantly increased worldwide. Extended spectrum beta-lactamase (ESBL) production and multi-drug resistant (MDR) clones of Escherichia coli and Klebsiella pneumoniae are limiting available treatment options. Carbapenems and aminoglycosides are still effective in complicated UTI. New beta-lactam combinations such as ceftolozane-tazobactam and ceftazidime-avibactam may be highly useful in treating severe infections while contributing to the carbapenem sparing strategy. For uncomplicated UTI, within older antibiotics, fosfomycin trometamol may be considered a first-choice drug since it is still retaining a good activity against MDR uropathogens. On the other hand, there are extensive data showing that the administration of antimicrobials according to pharmacokinetic/pharmacodynamic (PK/PD) parameters improves the possibility of a positive clinical outcome, particularly in severely ill patients. Evidence is growing that when PK/PD parameters are used to target not only clinical cure. This article discusses the PK/PD characteristics of antimicrobial agents for the treatment of UTIs, and the pharmacological and therapeutic strategies for limiting or preventing bacterial resistance.
MeSH term(s)	Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Bacterial Infections/drug therapy ; Drug Resistance, Bacterial ; Humans ; Urinary Tract Infections/drug therapy
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2018-11-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	204043-8
ISSN	1724-6075 ; 0376-0057 ; 0391-5603
ISSN (online)	1724-6075
ISSN	0376-0057 ; 0391-5603
DOI	10.1177/0391560318773251
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Article ; Online: Rediscovering the value of fosfomycin trometamol in the era of antimicrobial resistance: A systematic review and expert opinion.

Cai, Tommaso / Novelli, Andrea / Tascini, Carlo / Stefani, Stefania

International journal of antimicrobial agents

2023 Volume 62, Issue 6, Page(s) 106983

Abstract: The worldwide prevalence of uncomplicated lower urinary tract infections (uUTIs) caused by multidrug-resistant Escherichia coli is increasing. To address this emergency, international guidelines recommend reducing administration of fluoroquinolones, in ... ...

Abstract	The worldwide prevalence of uncomplicated lower urinary tract infections (uUTIs) caused by multidrug-resistant Escherichia coli is increasing. To address this emergency, international guidelines recommend reducing administration of fluoroquinolones, in the context of growing resistance and the long-lasting and potentially disabling side effects of these drugs. The favoured drug to replace fluoroquinolones is fosfomycin trometamol (FT), a well-known derivate of phosphonic acid with broad-spectrum activity against Gram-negative and Gram-positive bacteria, including multidrug-resistant (MDR) strains. The European Committee on Antimicrobial Susceptibility Testing (EUCAST) recently reduced the susceptibility breakpoint for E. coli from 32 mg/L to 8 mg/L regarding FT used for uUTIs. This might lead to increased appropriate use of oral fosfomycin target therapy against E. coli and other microorganisms, and may be associated with a high likelihood of success. For species such as Klebsiella spp, particularly MDR strains, the absence of clinical breakpoints might lead to reduced use of oral fosfomycin, particularly if minimum inhibitory concentration is not available. To address this issue, this review presents an overview of the preclinical evidence on the activity of FT, and a systematic review of the clinical activity of FT in uUTIs in women, and in the prevention of infectious complications after prostate biopsy. The findings indicate that the safety and microbiological and clinical effectiveness of a single oral dose of FT are similar to that for comparator regimens with longer treatment schedules in women with uUTI, and FT can be considered a viable alternative to fluoroquinolones for antimicrobial prophylaxis in prostate biopsy. These observations and a broad clinical experience support the empirical use of FT for treating uUTI and indicate that FT is a promising candidate to effectively counteract antibiotic-resistant uUTIs throughout Europe.
MeSH term(s)	Male ; Female ; Humans ; Fosfomycin/pharmacology ; Fosfomycin/therapeutic use ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Tromethamine/pharmacology ; Tromethamine/therapeutic use ; Escherichia coli ; Expert Testimony ; Urinary Tract Infections/drug therapy ; Urinary Tract Infections/microbiology ; Anti-Infective Agents/pharmacology ; Fluoroquinolones/therapeutic use
Chemical Substances	Fosfomycin (2N81MY12TE) ; Anti-Bacterial Agents ; Tromethamine (023C2WHX2V) ; Anti-Infective Agents ; Fluoroquinolones
Language	English
Publishing date	2023-09-24
Publishing country	Netherlands
Document type	Systematic Review ; Journal Article ; Review
ZDB-ID	1093977-5
ISSN	1872-7913 ; 0924-8579
ISSN (online)	1872-7913
ISSN	0924-8579
DOI	10.1016/j.ijantimicag.2023.106983
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Zs.A 3368: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Environmental Risk Assessment of Drugs in Tropical Freshwaters Using Ceriodaphnia silvestrii as Test Organism.

Caldas, Lucas Lopes / Moreira, Raquel Aparecida / Espíndola, Evaldo Luiz Gaeta / Novelli, Andrea

Bulletin of environmental contamination and toxicology

2023 Volume 110, Issue 6, Page(s) 106

Abstract: In this study we evaluated the acute (immobility/mortality) and chronic (survival and reproduction) effects of the drugs caffeine, diclofenac sodium salt, ketoprofen, paracetamol and salicylic acid on the cladoceran Ceriodaphnia silvestrii. The ... ...

Abstract	In this study we evaluated the acute (immobility/mortality) and chronic (survival and reproduction) effects of the drugs caffeine, diclofenac sodium salt, ketoprofen, paracetamol and salicylic acid on the cladoceran Ceriodaphnia silvestrii. The environmental risks of these substances for tropical freshwaters were estimated from the risk quotient MEC/PNEC. Sensitivity in acute exposures varied up on the drug as follows: salicylic acid (EC
MeSH term(s)	Animals ; Acetaminophen ; Diclofenac ; Caffeine ; Ketoprofen/pharmacology ; Cladocera ; Fresh Water ; Risk Assessment ; Salicylic Acid/pharmacology ; Water Pollutants, Chemical/toxicity
Chemical Substances	Acetaminophen (362O9ITL9D) ; Diclofenac (144O8QL0L1) ; Caffeine (3G6A5W338E) ; Ketoprofen (90Y4QC304K) ; Salicylic Acid (O414PZ4LPZ) ; Water Pollutants, Chemical
Language	English
Publishing date	2023-06-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	6895-0
ISSN	1432-0800 ; 0007-4861
ISSN (online)	1432-0800
ISSN	0007-4861
DOI	10.1007/s00128-023-03739-z
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Article: Glutathione: Pharmacological aspects and implications for clinical use in non-alcoholic fatty liver disease.

Santacroce, Giovanni / Gentile, Antonella / Soriano, Simone / Novelli, Andrea / Lenti, Marco Vincenzo / Di Sabatino, Antonio

Frontiers in medicine

2023 Volume 10, Page(s) 1124275

Abstract: Glutathione is a tripeptide synthesized at cytosolic level, that exists in cells in a reduced form (thiol-reduced-GSH-) and in an oxidized form (disulfide-oxidized). The antioxidant function of GSH has led to speculation about its therapeutic role in ... ...

Abstract	Glutathione is a tripeptide synthesized at cytosolic level, that exists in cells in a reduced form (thiol-reduced-GSH-) and in an oxidized form (disulfide-oxidized). The antioxidant function of GSH has led to speculation about its therapeutic role in numerous chronic diseases characterized by altered redox balance and reduced GSH levels, including, for instance, neurodegenerative disorders, cancer, and chronic liver diseases. Among these latter, non-alcoholic fatty liver disease (NAFLD), characterized by lipid accumulation in hepatocytes, in the absence of alcohol abuse or other steatogenic factors, is one of the most prevalent. The umbrella term NAFLD includes the pure liver fat accumulation, the so-called hepatic steatosis or non-alcoholic fatty liver, and the progressive form with inflammation, also known as non-alcoholic steatohepatitis, which is related to the increase in oxidative stress and reactive oxygen species, eventually leading to liver fibrosis. Although the pathogenetic role of oxidative stress in these diseases is well established, there is still limited evidence on the therapeutic role of GSH in such conditions. Hence, the aim of this review is to depict the current molecular and pharmacological knowledge on glutathione, focusing on the available studies related to its therapeutic activity in NAFLD.
Language	English
Publishing date	2023-03-22
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2775999-4
ISSN	2296-858X
ISSN	2296-858X
DOI	10.3389/fmed.2023.1124275
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Article: Some Suggestions from PK/PD Principles to Contain Resistance in the Clinical Setting-Focus on ICU Patients and Gram-Negative Strains.

Adembri, Chiara / Novelli, Andrea / Nobili, Stefania

Antibiotics (Basel, Switzerland)

2020 Volume 9, Issue 10

Abstract: The containment of the phenomenon of resistance towards antimicrobials is a priority, especially in preserving molecules acting against Gram-negative pathogens, which represent the isolates more frequently found in the fragile population of patients ... ...

Abstract	The containment of the phenomenon of resistance towards antimicrobials is a priority, especially in preserving molecules acting against Gram-negative pathogens, which represent the isolates more frequently found in the fragile population of patients admitted to Intensive Care Units. Antimicrobial therapy aims to prevent resistance through several actions, which are collectively known as "antimicrobial stewardship", to be taken together, including the application of pharmacokinetic/pharmacodynamic (PK/PD) principles. PK/PD application has been shown to prevent the emergence of resistance in numerous experimental studies, although a straight translation to the clinical setting is not possible. Individualized antibiotic dosing and duration should be pursued in all patients, and even more especially when treating intensive care unit (ICU) septic patients in whom optimal exposure is both difficult to achieve and necessary. In this review, we report on the available data that support the application of PK/PD parameters to contain the development of resistance and we give some practical suggestions that can help to translate the benefit of PK/PD application to the bedside.
Language	English
Publishing date	2020-10-06
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2681345-2
ISSN	2079-6382
ISSN	2079-6382
DOI	10.3390/antibiotics9100676
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Article ; Online: The role of PK/PD-based strategies to preserve new molecules against multi-drug resistant gram-negative strains.

Adembri, Chiara / Cappellini, Iacopo / Novelli, Andrea

Journal of chemotherapy (Florence, Italy)

2020 Volume 32, Issue 5, Page(s) 219–225

Language	English
Publishing date	2020-07-06
Publishing country	England
Document type	Editorial
ZDB-ID	1036294-0
ISSN	1973-9478 ; 1120-009X
ISSN (online)	1973-9478
ISSN	1120-009X
DOI	10.1080/1120009X.2020.1786634
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Article: Ideal Features of Topical Antibiotic Therapy for the Treatment of Impetigo: An Italian Expert Consensus Report.

Neri, Iria / Miraglia Del Giudice, Michele / Novelli, Andrea / Ruggiero, Giuseppe / Pappagallo, Giovanni / Galli, Luisa

Current therapeutic research, clinical and experimental

2022 Volume 98, Page(s) 100690

Abstract: Background: A group of Italian experts in impetigo medical care sought to define 10 statements to describe the ideal characteristics of the best local antibiotic treatments, and to provide relevant information re- garding their appropriate use and ... ...

Abstract	Background: A group of Italian experts in impetigo medical care sought to define 10 statements to describe the ideal characteristics of the best local antibiotic treatments, and to provide relevant information re- garding their appropriate use and prescription that should be considered in clinical practice for impetigo management. Objective: A group of Italian experts in impetigo medical care sought to define 10 statements to describe the ideal characteristics of the best local antibiotic treatments, and to provide relevant information regarding their appropriate use and prescription that should be considered in clinical practice for impetigo management. Methods: A consensus on ideal features of antibiotic therapy for the treatment of impetigo was appraised by an online Delphi-based method, based on a panel of 61 infectious disease specialists, pediatricians, and dermatologists coordinated by a scientific committee of 5 experts specializing in impetigo management. Results: Full or very high consensus was reached on the 10 statements identified to describe the characteristics of the best hypothetic antibiotic therapy for impetigo together with indications for appropriate antibiotics use. Conclusions: Several criteria have to be considered when selecting topical antibacterial therapy for impetigo. Beyond efficacy and safety, antimicrobial susceptibility and pharmacological characteristics of the agent are essential points. Formulation of the antimicrobial product is fundamental, as well as patient and caregiver preference, to facilitate therapeutic adherence, to achieve the infection control, and to obtain the best benefit from treatment (
Language	English
Publishing date	2022-12-24
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	205697-5
ISSN	1879-0313 ; 0011-393X
ISSN (online)	1879-0313
ISSN	0011-393X
DOI	10.1016/j.curtheres.2022.100690
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Article ; Online: Anidulafungin biliary passage in liver transplant patients.

Adembri, Chiara / Nure, Erida / Tofani, Lorenzo / Agnes, Salvatore / Novelli, Andrea / Sganga, Gabriele

Transplant infectious disease : an official journal of the Transplantation Society

2022 Volume 24, Issue 4, Page(s) e13848

MeSH term(s)	Anidulafungin ; Antifungal Agents/therapeutic use ; Biliary Tract ; Echinocandins/therapeutic use ; Humans ; Liver Transplantation/adverse effects
Chemical Substances	Antifungal Agents ; Echinocandins ; Anidulafungin (9HLM53094I)
Language	English
Publishing date	2022-06-01
Publishing country	Denmark
Document type	Letter
ZDB-ID	1476094-0
ISSN	1399-3062 ; 1398-2273
ISSN (online)	1399-3062
ISSN	1398-2273
DOI	10.1111/tid.13848
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Article ; Online: Pharmacological properties of oral antibiotics for the treatment of uncomplicated urinary tract infections.

Novelli, Andrea / Rosi, Elia

Journal of chemotherapy (Florence, Italy)

2017 Volume 29, Issue sup1, Page(s) 10–18

Abstract: The therapeutic management of uncomplicated bacterial urinary tract infections (UTIs) is based on short-term courses of oral antibiotics. The preferred drugs are nitrofurantoin trimethoprim-sulfamethoxazole, fosfomycin trometamol, fluoroquinolones and β- ... ...

Abstract	The therapeutic management of uncomplicated bacterial urinary tract infections (UTIs) is based on short-term courses of oral antibiotics. The preferred drugs are nitrofurantoin trimethoprim-sulfamethoxazole, fosfomycin trometamol, fluoroquinolones and β-lactam agents. The choice of agent for treating uncomplicated UTIs should be based on the pharmacokinetic characteristics of the molecule so that clinical benefit is optimized and the risk of antibacterial resistance is minimized. This article discusses the general pharmacokinetic-pharmacodynamic (PK/PD) aspects of antimicrobial chemotherapy, the PK/PD characteristics of oral antimicrobial agents for the treatment of uncomplicated UTIs and the pharmacological and therapeutic strategies for limiting or preventing bacterial resistance.
MeSH term(s)	Administration, Oral ; Animals ; Anti-Bacterial Agents/administration & dosage ; Anti-Bacterial Agents/adverse effects ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Biological Availability ; Drug Resistance, Bacterial ; Drug Therapy, Combination/adverse effects ; Gram-Negative Bacteria/drug effects ; Gram-Negative Bacteria/growth & development ; Gram-Negative Bacteria/isolation & purification ; Gram-Negative Bacterial Infections/blood ; Gram-Negative Bacterial Infections/drug therapy ; Gram-Negative Bacterial Infections/microbiology ; Gram-Positive Bacteria/drug effects ; Gram-Positive Bacteria/growth & development ; Gram-Positive Bacteria/isolation & purification ; Gram-Positive Bacterial Infections/blood ; Gram-Positive Bacterial Infections/drug therapy ; Gram-Positive Bacterial Infections/microbiology ; Half-Life ; Humans ; Metabolic Clearance Rate ; Practice Guidelines as Topic ; Urinary Tract Infections/blood ; Urinary Tract Infections/drug therapy ; Urinary Tract Infections/microbiology
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2017-12
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1036294-0
ISSN	1973-9478 ; 1120-009X
ISSN (online)	1973-9478
ISSN	1120-009X
DOI	10.1080/1120009X.2017.1380357
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