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  1. Article ; Online: Tailoring treatment to the circumstance: reasoning behind metal versus plastic drainage of pancreatic collections - authors' reply.

    Karstensen, John Gásdal / Novovic, Srdan / Schmidt, Palle Nordblad

    Gut

    2023  

    Language English
    Publishing date 2023-09-12
    Publishing country England
    Document type Letter
    ZDB-ID 80128-8
    ISSN 1468-3288 ; 0017-5749
    ISSN (online) 1468-3288
    ISSN 0017-5749
    DOI 10.1136/gutjnl-2023-330948
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    Zs.A 160: Show issues Location:
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  2. Article: Dysfunction of Biliary Sphincter of Oddi-Clinical, Diagnostic and Treatment Challenges.

    Kegnæs, Marina / Novovic, Srdan / Shabanzadeh, Daniel Mønsted

    Journal of clinical medicine

    2023  Volume 12, Issue 14

    Abstract: Biliary Sphincter of Oddi dysfunction (SOD) is one of the main causes of post-cholecystectomy pain. In this review, we aimed to provide an update on the current knowledge on biliary SOD, with an emphasis on diagnostics and therapy. Overall, current but ... ...

    Abstract Biliary Sphincter of Oddi dysfunction (SOD) is one of the main causes of post-cholecystectomy pain. In this review, we aimed to provide an update on the current knowledge on biliary SOD, with an emphasis on diagnostics and therapy. Overall, current but scarce data support biliary sphincterotomy for patients with type 1 and 2 SOD, but not for type 3. However, sphincterotomy is associated with post-treatment pancreatitis rates of from 10% to 15%, thus calling for improved diagnostics, patient selection and treatment modalities for SOD. The role of pharmacologic therapy for patients with SOD is poorly explored and only two randomized controlled trials are available. Currently, studies comparing treatment outcomes are few. There is an unmet need for randomized sham/placebo-controlled clinical trials related to both pharmacological and non-pharmacological treatments of SOD.
    Language English
    Publishing date 2023-07-20
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12144802
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  3. Article ; Online: Circulating Biomarkers Involved in the Development of and Progression to Chronic Pancreatitis-A Literature Review.

    Poulsen, Valborg Vang / Hadi, Amer / Werge, Mikkel Parsberg / Karstensen, John Gásdal / Novovic, Srdan

    Biomolecules

    2024  Volume 14, Issue 2

    Abstract: Chronic pancreatitis (CP) is the end-stage of continuous inflammation and fibrosis in the pancreas evolving from acute- to recurrent acute-, early, and, finally, end-stage CP. Currently, prevention is the only way to reduce disease burden. In this ... ...

    Abstract Chronic pancreatitis (CP) is the end-stage of continuous inflammation and fibrosis in the pancreas evolving from acute- to recurrent acute-, early, and, finally, end-stage CP. Currently, prevention is the only way to reduce disease burden. In this setting, early detection is of great importance. Due to the anatomy and risks associated with direct sampling from pancreatic tissue, most of our information on the human pancreas arises from circulating biomarkers thought to be involved in pancreatic pathophysiology or injury. The present review provides the status of circulating biomarkers involved in the development of and progression to CP.
    MeSH term(s) Humans ; Pancreatitis, Chronic/diagnosis ; Pancreatitis, Chronic/complications ; Pancreatitis, Chronic/pathology ; Pancreas ; Inflammation/pathology ; Fibrosis ; Biomarkers
    Chemical Substances Biomarkers
    Language English
    Publishing date 2024-02-18
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom14020239
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  4. Article ; Online: Pancreatic-portal vein fistula in acute pancreatitis successfully treated with endoscopic approach.

    Poulsen, Valborg Vang / Jensen, Annette Bøjer / Hadi, Amer / Ærenlund, Mia Prindahl / Karstensen, John Gásdal / Novovic, Srdan

    Endoscopy

    2024  Volume 56, Issue S 01, Page(s) E354–E355

    MeSH term(s) Humans ; Portal Vein/diagnostic imaging ; Pancreatic Fistula/etiology ; Pancreatic Fistula/surgery ; Pancreatic Fistula/diagnostic imaging ; Pancreatic Fistula/therapy ; Pancreatitis/etiology ; Pancreatitis/complications ; Pancreatitis/surgery ; Male ; Acute Disease ; Arteriovenous Fistula/surgery ; Arteriovenous Fistula/complications ; Arteriovenous Fistula/diagnostic imaging ; Arteriovenous Fistula/etiology ; Middle Aged
    Language English
    Publishing date 2024-04-25
    Publishing country Germany
    Document type Journal Article ; Case Reports ; Video-Audio Media
    ZDB-ID 80120-3
    ISSN 1438-8812 ; 0013-726X
    ISSN (online) 1438-8812
    ISSN 0013-726X
    DOI 10.1055/a-2299-2052
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 669: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 162: Show issues

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  5. Article: EUS-guided transcolonic drainage and necrosectomy in walled-off necrosis: a retrospective, single-center case series.

    Ebrahim, Mohamed / Novovic, Srdan / Schmidt, Palle Nordblad / Feldager Hansen, Erik / Karstensen, John Gásdal

    Endoscopy international open

    2023  Volume 11, Issue 6, Page(s) E618–E622

    Abstract: Background and study ... ...

    Abstract Background and study aims
    Language English
    Publishing date 2023-06-29
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2761052-4
    ISSN 2196-9736 ; 2364-3722
    ISSN (online) 2196-9736
    ISSN 2364-3722
    DOI 10.1055/a-2095-0272
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  6. Article ; Online: [No title information]

    Al-Bazy, Safa Aiad / Werge, Mikkel Parsberg / Gluud, Lise Lotte / Therkildsen, Christina / Novovic, Srdan

    Ugeskrift for laeger

    2023  Volume 185, Issue 23

    Abstract: Pancreatic cancer poses a challenge in healthcare and is one of a leading cause of cancer-related mortality. In 2021, around 1,000 new cases were diagnosed in Denmark. The disease itself is associated with a poor prognosis. Partly due to its silent ... ...

    Title translation Pancreatic cancer.
    Abstract Pancreatic cancer poses a challenge in healthcare and is one of a leading cause of cancer-related mortality. In 2021, around 1,000 new cases were diagnosed in Denmark. The disease itself is associated with a poor prognosis. Partly due to its silent nature and partly due to the lack of sensitive and specific tumour markers for early detection. The five-year survival rate among patients with pancreatic cancer in Denmark is 5-6%. I this review, we describe the current diagnostic and treatment options as well as the status on cancer-predictive biomarkers and their screening potential.
    MeSH term(s) Humans ; Early Detection of Cancer ; Pancreatic Neoplasms/diagnosis ; Pancreatic Neoplasms/therapy ; Biomarkers, Tumor ; Prognosis
    Chemical Substances Biomarkers, Tumor
    Language Danish
    Publishing date 2023-06-15
    Publishing country Denmark
    Document type Review ; English Abstract ; Journal Article
    ZDB-ID 124102-3
    ISSN 1603-6824 ; 0041-5782
    ISSN (online) 1603-6824
    ISSN 0041-5782
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    Zs.B 302: Show issues Location:
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  7. Article ; Online: Endoscopic transvaginal drainage and necrosectomy of presacral walled-off pancreatic necrosis.

    Ærenlund, Mia Prindahl / Lindgaard, Lars / Novovic, Srdan / Lauritsen, Morten Laksáfoss / Karstensen, John Gásdal / Schmidt, Palle Nordblad

    Endoscopy

    2023  Volume 55, Issue S 01, Page(s) E940–E941

    MeSH term(s) Humans ; Pancreatitis, Acute Necrotizing/surgery ; Endoscopy ; Pancreas ; Drainage ; Necrosis ; Stents ; Treatment Outcome
    Language English
    Publishing date 2023-08-01
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 80120-3
    ISSN 1438-8812 ; 0013-726X
    ISSN (online) 1438-8812
    ISSN 0013-726X
    DOI 10.1055/a-2127-4516
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 669: Show issues Location:
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    Zs.MO 162: Show issues

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  8. Article ; Online: Prediction of Admission to Intensive Care Unit and 1-Year Mortality After Acute Pancreatitis With Walled-Off Pancreatic Necrosis: A Retrospective, Single-Center Cohort Study.

    Ebrahim, Mohamed / Werge, Mikkel Parsberg / Novovic, Srdan / Amin, Nadia Emad Lotfi / Karstensen, John Gásdal / Jørgensen, Henrik Løvendahl

    Pancreas

    2024  Volume 53, Issue 5, Page(s) e386–e394

    Abstract: Background and aims: Pancreatic walled-off necrosis (WON) carries significant mortality and morbidity risks, often necessitating intensive care unit (ICU) admission. This retrospective study aimed to evaluate whether routine biochemical parameters at ... ...

    Abstract Background and aims: Pancreatic walled-off necrosis (WON) carries significant mortality and morbidity risks, often necessitating intensive care unit (ICU) admission. This retrospective study aimed to evaluate whether routine biochemical parameters at the time of the index endoscopic procedure could predict ICU admission and 1-year mortality following endoscopic treatment of WON.
    Materials and methods: We retrospectively identified 201 consecutive patients who underwent endoscopic drainage for WON between January 1, 2010, and December 31, 2020. Associations between routine biochemical blood tests and outcomes were assessed using logistic regression models.
    Results: Within 1 year of the index endoscopy, 31 patients (15.4%) died, and 40 (19.9%) were admitted to the ICU due to sepsis. Preoperative electrolyte disturbances were more prevalent among ICU-admitted patients and nonsurvivors. Hyperkalemia, hypoalbuminemia, and elevated urea were significant predictors of 1-year mortality, while hypernatremia, elevated serum creatinine, and hypoalbuminemia predicted ICU admission. Predictive models exhibited good discriminative ability, with an AUC of 0.84 (95% CI,0,75-0.93) for 1-year mortality and 0.86 (95%CI, 0.79-0.92) for ICU admission.
    Conclusions: Preoperative imbalances in routine blood tests effectively predict adverse outcomes in endoscopically treated WON patients.
    MeSH term(s) Humans ; Retrospective Studies ; Male ; Female ; Middle Aged ; Intensive Care Units/statistics & numerical data ; Adult ; Pancreatitis, Acute Necrotizing/mortality ; Pancreatitis, Acute Necrotizing/complications ; Pancreatitis, Acute Necrotizing/blood ; Aged ; Drainage/methods ; Risk Factors ; Patient Admission
    Language English
    Publishing date 2024-02-26
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 632831-3
    ISSN 1536-4828 ; 0885-3177
    ISSN (online) 1536-4828
    ISSN 0885-3177
    DOI 10.1097/MPA.0000000000002314
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2160: Show issues Location:
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  9. Article ; Online: Novel powered 5.0-mm endoscopic debridement catheter for endoscopic transmural necrosectomy of pancreatic walled-off necrosis: a case series of consecutive patients from a tertiary referral center (with video).

    Olsen, Gitte Aabye / Schmidt, Palle Nordblad / Novovic, Srdan / Hansen, Erik Feldager / Karstensen, John Gásdal

    Gastrointestinal endoscopy

    2023  Volume 99, Issue 2, Page(s) 267–270

    Abstract: Background and aims: EUS-guided drainage and, if required, endoscopic necrosectomy (EN) has become the criterion standard for the treatment of pancreatic walled-off necrosis (WON). A dedicated powered endoscopic debridement system, the EndoRotor ( ... ...

    Abstract Background and aims: EUS-guided drainage and, if required, endoscopic necrosectomy (EN) has become the criterion standard for the treatment of pancreatic walled-off necrosis (WON). A dedicated powered endoscopic debridement system, the EndoRotor (Interscope Inc, Northbridge, Mass, USA), has been introduced as an alternative to snare necrosectomy. This study evaluates the novel EndoRotor catheter, NecroMax 6.0 (Interscope Inc, Whitinsville, Mass, USA), for EN in patients with WON.
    Methods: This single-center retrospective case series included consecutive patients with WON treated with the NecroMax 6.0 catheter. Safety, ability to perform EN, and clinical resolution were evaluated.
    Results: Twenty patients underwent 30 EN procedures with the NecroMax 6.0 catheter. One suspected device-related adverse event was observed (3.3%). In 1 procedure, EN could not be performed because of excessive bending of the endoscope. Eighteen patients (90.0%) achieved clinical resolution.
    Conclusions: EN with the NecroMax 6.0 catheter was technically feasible in 96.7% of patients with a low rate of adverse events.
    MeSH term(s) Humans ; Catheters ; Debridement/methods ; Drainage/methods ; Necrosis/surgery ; Necrosis/etiology ; Pancreatitis, Acute Necrotizing/surgery ; Retrospective Studies ; Stents/adverse effects ; Tertiary Care Centers ; Treatment Outcome
    Language English
    Publishing date 2023-10-20
    Publishing country United States
    Document type Case Reports ; Journal Article ; Video-Audio Media
    ZDB-ID 391583-9
    ISSN 1097-6779 ; 0016-5107
    ISSN (online) 1097-6779
    ISSN 0016-5107
    DOI 10.1016/j.gie.2023.10.044
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 519: Show issues

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  10. Article: Pancreatic-portal vein fistula in acute pancreatitis successfully treated with endoscopic approach

    Poulsen, Valborg Vang / Jensen, Annette Bøjer / Hadi, Amer / Ærenlund, Mia Prindahl / Karstensen, John Gásdal / Novovic, Srdan

    Endoscopy

    2024  Volume 56, Issue S 01, Page(s) E354–E355

    Language English
    Publishing date 2024-04-25
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 80120-3
    ISSN 1438-8812 ; 0013-726X
    ISSN (online) 1438-8812
    ISSN 0013-726X
    DOI 10.1055/a-2299-2052
    Database Thieme publisher's database

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