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Article: Structural, Electrical and Corrosion Properties of Bulk Ti-Cu Alloys Produced by Mechanical Alloying and Powder Metallurgy.

Arkusz, Katarzyna / Pasik, Kamila / Nowak, Marek / Jurczyk, Mieczyslaw

2024 Volume 17, Issue 7

Abstract: ... Binary ... ...

Abstract	Binary Ti
Language	English
Publishing date	2024-03-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma17071473
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Article: Cancer Immunoediting: Elimination, Equilibrium, and Immune Escape in Solid Tumors.

Wilczyński, Jacek R / Nowak, Marek

Experientia supplementum (2012)

2022 Volume 113, Page(s) 1–57

Abstract: Emphasizing the dynamic processes between cancer and host immune system, the initially discovered concept of cancer immunosurveillance has been replaced by the current concept of cancer immunoediting consisting of three phases: elimination, equilibrium, ... ...

Abstract	Emphasizing the dynamic processes between cancer and host immune system, the initially discovered concept of cancer immunosurveillance has been replaced by the current concept of cancer immunoediting consisting of three phases: elimination, equilibrium, and escape. Solid tumors composed of both cancer and host stromal cells are an example how the three phases of cancer immunoediting functionally evolve and how tumor shaped by the host immune system gets finally resistant phenotype. The elimination, equilibrium, and escape have been described in this chapter in details, including the role of immune surveillance, cancer dormancy, disruption of the antigen-presenting machinery, tumor-infiltrating immune cells, resistance to apoptosis, as well as the function of tumor stroma, microvesicles, exosomes, and inflammation.
MeSH term(s)	Humans ; Immunologic Surveillance ; Inflammation ; Neoplasms/genetics ; Tumor Escape/genetics
Language	English
Publishing date	2022-02-15
Publishing country	Switzerland
Document type	Journal Article
ISSN	1664-431X
ISSN	1664-431X
DOI	10.1007/978-3-030-91311-3_1
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Article: Rapidly growing uterine myoma - should we be afraid of it?

Nowak, Marek / Bartosik, Wojciech / Witana, Weronika / Nowak, Krzysztof / Wilkusz, Julia

Przeglad menopauzalny = Menopause review

2023 Volume 22, Issue 3, Page(s) 161–164

Abstract: During a year, myomas may undergo radical changes in their dimensions - from decreasing by 90% to growing by 200%. On average, myomas of the uterus increase in volume by 20-30% annually in the premenopausal period. On the other hand, myomas regress ... ...

Abstract	During a year, myomas may undergo radical changes in their dimensions - from decreasing by 90% to growing by 200%. On average, myomas of the uterus increase in volume by 20-30% annually in the premenopausal period. On the other hand, myomas regress spontaneously in about 20% of women. After menopause uterine fibroids stabilize or regress. Every new or growing lesion of the uterus after menopause has to be diagnosed. There is no general definition of fast growing uterine myoma. The presence of fast growing uterine myoma, regardless of its definition, is associated with some clinical issues: it may become symptomatic (pain, bleeding, bulk symptoms), may be responsible for infertility, and a malignant process (leiomyosarcoma) may be present. Regardless of common belief, the risk of sarcoma is not related to the size of the uterus or its fast enlargement. The prevalence of sarcoma in myomas is 0.26%, and in rapidly growing myomas is 0.27%. Treatment should be individualized, selected for the age of the woman and her expectations (preservation of fertility, uterus), symptoms, size and localization of the myomas. The methods of surgical treatment of unsuspected "rapidly growing myomas" are the same as those of common uterine fibroids. Minimally invasive surgery is optimal, but a decision has to be made after evaluation of the risk factors of sarcoma.
Language	English
Publishing date	2023-09-25
Publishing country	Poland
Document type	Journal Article ; Review
ZDB-ID	2596140-8
ISSN	2299-0038 ; 1643-8876
ISSN (online)	2299-0038
ISSN	1643-8876
DOI	10.5114/pm.2023.131497
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Article ; Online: The Role of Tumor-Associated Macrophages in the Progression and Chemoresistance of Ovarian Cancer.

Nowak, Marek / Klink, Magdalena

Cells

2020 Volume 9, Issue 5

Abstract: Tumor-associated macrophages (TAMs) constitute the main population of immune cells present in the ovarian tumor microenvironment. These cells are characterized by high plasticity and can be easily polarized by colony-stimulating factor-1, which is ... ...

Abstract	Tumor-associated macrophages (TAMs) constitute the main population of immune cells present in the ovarian tumor microenvironment. These cells are characterized by high plasticity and can be easily polarized by colony-stimulating factor-1, which is released by tumor cells, into an immunosuppressive M2-like phenotype. These cells are strongly implicated in both the progression and chemoresistance of ovarian cancer. The main pro-tumoral function of M2-like TAMs is the secretion of a variety of cytokines, chemokines, enzymes and exosomes that reach microRNAs, directly inducing the invasion potential and chemoresistance of ovarian cancer cells by triggering their pro-survival signaling pathways. The M2-like TAMs are also important players in the metastasis of ovarian cancer cells in the peritoneum through their assistance in spheroid formation and attachment of cancer cells to the metastatic area-the omentum. Moreover, TAMs interplay with other immune cells, such as lymphocytes, natural killer cells, and dendritic cells, to inhibit their responsiveness, resulting in the development of immunosuppression. The detrimental character of the M2-like type of TAMs in ovarian tumors has been confirmed by a number of studies, demonstrating the positive correlation between their high level in tumors and low overall survival of patients.
MeSH term(s)	Animals ; Disease Progression ; Drug Resistance, Neoplasm ; Female ; Humans ; Molecular Targeted Therapy ; Ovarian Neoplasms/drug therapy ; Ovarian Neoplasms/pathology ; Tumor Microenvironment ; Tumor-Associated Macrophages/pathology
Language	English
Publishing date	2020-05-22
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells9051299
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Article: Microstructure, Mechanical and Corrosion Properties of Copper-Nickel 90/10 Alloy Produced by CMT-WAAM Method.

Maleta, Marcin / Kulasa, Joanna / Kowalski, Aleksander / Kwaśniewski, Paweł / Boczkal, Sonia / Nowak, Marek

Materials (Basel, Switzerland)

2023 Volume 17, Issue 1

Abstract: In the case of copper and its alloys, Wire Arc Additive Manufacturing (WAAM) 3D printing technology is mainly used to produce elements for the maritime industry and research has focused on the use of Cu-Al alloys. There is little information devoted to ... ...

Abstract	In the case of copper and its alloys, Wire Arc Additive Manufacturing (WAAM) 3D printing technology is mainly used to produce elements for the maritime industry and research has focused on the use of Cu-Al alloys. There is little information devoted to the use of Cu-Ni alloys in this technology, which are also widely used in the maritime industry. In this work, tests were carried out on the microstructure, mechanical properties, and corrosion properties in a 1M NaCl solution of Cu-Ni 90/10 alloy 3D walls printed using the WAAM method. The obtained objects are characterized by a microstructure with elongated column grains and particles of the Ni-Ti phase, hardness in the range of 138-160 HV10, ultimate tensile strength of 495-520 MPa, yield strength of 342-358 MPa, elongation of 16.6-17.9%, and a low average corrosion rate of 7.4 × 10
Language	English
Publishing date	2023-12-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma17010050
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Article ; Online: The use of PLANS and NetworkX in modeling power grid system failures.

Hadaj, Piotr / Strzałka, Dominik / Nowak, Marek / Łatka, Małgorzata / Dymora, Paweł

Scientific reports

2022 Volume 12, Issue 1, Page(s) 17445

Abstract: The theoretical and practical aspects and results of simulations based on a specialized tool that is used in the energy industry were adressed. The previously discussed cases in the literature by taking into account the worst case and critical states of ... ...

Abstract	The theoretical and practical aspects and results of simulations based on a specialized tool that is used in the energy industry were adressed. The previously discussed cases in the literature by taking into account the worst case and critical states of networks in terms of complex networks were extended. Using the Monte-Carlo method, the vulnerability of the power grid to node failures was investigated, both in terms of the use of specialized software, which is used in the power industry, and a tool for the analysis of complex networks graphs. We present the results obtained and the observed analogy between the results of the analysis performed in specialized software and the complex network graph analysis tool. It has been shown that the results obtained coincide for both software packages, even though their application focuses on slightly different aspects of system operation. Moreover, further possibilities of extending the research in this direction are proposed, taking into account not only the improvement of the method used, but also a significant increase in the size of the tested structure model.
Language	English
Publishing date	2022-10-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-22268-z
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Article ; Online: Plant macro-remains from a large Middle Neolithic settlement in SE Poland - internal diversification and possible status of the settlers

Mueller-Bieniek, Aldona / Moskal-del Hoyo, Magdalena / Korczyńska-Cappenberg, Marta / Kapcia, Magda / Nowak, Marek

Journal of Archaeological Science: Reports. , p.104016-

2023 , Page(s) 104016–

Abstract: The Mozgawa site, covering area of ca. 40 hectares, is located in the loess area in SE Poland. It belongs to large settlements of the Middle Neolithic Funnel Beaker culture (TRB) and was occupied ca. 3600 - 3200 BCE. The aim of the research was to assess ...

Abstract	The Mozgawa site, covering area of ca. 40 hectares, is located in the loess area in SE Poland. It belongs to large settlements of the Middle Neolithic Funnel Beaker culture (TRB) and was occupied ca. 3600 - 3200 BCE. The aim of the research was to assess the role of plants in the life of the settlers, including domesticated and wild food resources as well as possibilities of non-alimentary use of herbal plants. The connection of two types of plant macroremains, namely seeds/fruits and wood charcoal, found in three different parts of the site was done to evaluate possibility of spatial palaeoeconomic differentiation between the sectors of the settlement. The site is exceptional among the other TRB dry sites studied due to high quantities of flax seeds and pulses, namely lentil, although the most numerous were wheat remains, mostly emmer grains. The high number of charred seeds of gromwell, the crop weed but also a source of purple dye, which was linked to flax seeds in statistical analysis, could suggest production of purple or red textiles at the site. High significance of textile production can be supported by discovery of a broad spectrum of utensils, representing all chaîne opératoire stages. Nonetheless, there are no convincing archaeological premises according specialisation of textile production at the settlement. Taking into account the proportions of main groups of plants among the three studied parts of the site, some differences were noticed, which could indicate the diversification of past activities at the settlement. The detailed study of other categories of findings and exact spatial-temporal scheme of settlement development are necessary to confirm this diversification and assess whether it mirrors higher material and social status of people living in the central part of the settlement than those living in the NW and SE parts.
Keywords	Triticum turgidum subsp. dicoccon ; archaeology ; charcoal ; dyes ; fabrics ; flax ; lentils ; loess ; socioeconomic status ; statistical analysis ; weeds ; wheat ; wood ; Poland ; Funnel Beaker culture ; Mozgawa site ; field gromwell
Language	English
Publishing place	Elsevier Ltd
Document type	Article ; Online
Note	Pre-press version
ISSN	2352-409X
DOI	10.1016/j.jasrep.2023.104016
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: The implication of IL-6 in the invasiveness and chemoresistance of ovarian cancer cells. Systematic review of its potential role as a biomarker in ovarian cancer patients.

Szulc-Kielbik, Izabela / Kielbik, Michal / Nowak, Marek / Klink, Magdalena

Biochimica et biophysica acta. Reviews on cancer

2021 Volume 1876, Issue 2, Page(s) 188639

Abstract: Interleukin 6 (IL-6) is a pleiotropic cytokine that is strongly implicated in the development and progression of ovarian cancer. The most recognized actions of IL-6 in ovarian cancer (OC) cells are the induction of cell proliferation and inhibition of ... ...

Abstract	Interleukin 6 (IL-6) is a pleiotropic cytokine that is strongly implicated in the development and progression of ovarian cancer. The most recognized actions of IL-6 in ovarian cancer (OC) cells are the induction of cell proliferation and inhibition of cell apoptosis. Equally important is its ability to enhance the migratory and invasive potential of OC cells. Moreover, the increased expression and secretion of this cytokine positively correlates with OC cell chemoresistance. Elevated concentrations of IL-6 are observed in the serum and ascites of ovarian cancer patients. Thus, its level is discussed in the literature as a potential biomarker that can help to discriminate malignant and nonmalignant ovarian tumors and allow for the prediction of the chemotherapy response. The importance of IL-6 in ovarian cancer is proved by the fact that this cytokine is a potential target to anti-cancer therapy. This review is divided into two parts. The first summarizes the general biological activity of IL-6, and overviews its impact on OC cells, as well as discusses the current proposition of IL-6 inclusion in combination of anti-OC therapy. The second part is a systematic review of IL-6 as a possible biomarker in ovarian cancer patients.
MeSH term(s)	Biomarkers, Tumor/metabolism ; Disease Progression ; Female ; Humans ; Interleukin-6/metabolism ; Neoplasm Invasiveness ; Ovarian Neoplasms/genetics ; Ovarian Neoplasms/pathology
Chemical Substances	Biomarkers, Tumor ; Interleukin-6
Language	English
Publishing date	2021-10-22
Publishing country	Netherlands
Document type	Journal Article ; Systematic Review
ZDB-ID	2918802-7
ISSN	1879-2561 ; 0304-419X
ISSN (online)	1879-2561
ISSN	0304-419X
DOI	10.1016/j.bbcan.2021.188639
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Article ; Online: The use of CA125, human epididymis protein 4 (HE4), risk of ovarian malignancy algorithm (ROMA), risk of malignancy index (RMI) and subjective assessment (SA) in preoperative diagnosing of ovarian tumors.

Janas, Lukasz / Stachowiak, Grzegorz / Glowacka, Ewa / Piwowarczyk, Iwona / Kajdos, Magdalena / Soja, Malwina / Masternak, Martyna / Nowak, Marek

Ginekologia polska

2023

Abstract: Objectives: To compare utility of CA125, human epididymis protein 4 (HE4), risk of ovarian malignancy algorithm (ROMA), risk of malignancy index (RMI) and subjective assessment (SA) in preoperative diagnosis of ovarian tumors.: Material and methods: ... ...

Abstract	Objectives: To compare utility of CA125, human epididymis protein 4 (HE4), risk of ovarian malignancy algorithm (ROMA), risk of malignancy index (RMI) and subjective assessment (SA) in preoperative diagnosis of ovarian tumors. Material and methods: Research was conducted among 456 patients qualified for surgery due to ovarian tumor. Preoperatively, CA125 and HE4 serum levels were estimated, and transvaginal ultrasound was performed. ROMA and RMI values and SA qualifications were obtained. Results were compared with pathomorphological findings. Results: Receiver Operating Characteristic (ROC)-Area Under Curve (AUC) values for CA125, HE4, ROMA, RMI and SA in preoperative diagnosis of malignant lesions were 0.819, 0.909, 0.911, 0.895 and 0.895, respectively. Combinations of biochemical and sonographic methods increased sensitivity in diagnosis of ovarian tumors. Combinations utilizing serum HE4 concentrations were most useful. Conclusions: CA125, HE4, ROMA, RMI and SA proved to be useful in preoperative diagnosis of ovarian tumors. HE4 and ROMA occurred to be the most useful. Ultrasonographic methods are considerably useful in diagnosis of ovarian tumors. RMI and SA present similar overall diagnostic value.
Language	English
Publishing date	2023-01-04
Publishing country	Poland
Document type	Journal Article
ZDB-ID	130894-4
ISSN	2543-6767 ; 0017-0011
ISSN (online)	2543-6767
ISSN	0017-0011
DOI	10.5603/GP.a2022.0144
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Article: Chemokine expression in patients with ovarian cancer or benign ovarian tumors.

Nowak, Marek / Janas, Łukasz / Soja, Malwina / Głowacka, Ewa / Szyłło, Krzysztof / Misiek, Marcin / Klink, Magdalena

Archives of medical science : AMS

2021 Volume 18, Issue 3, Page(s) 682–689

Abstract: Introduction: Chemokines play a crucial role in tumor growth and progression according to proangiogenic and immunosuppressive action. The aim of this study was to investigate the serum levels of selected chemokines in patients with ovarian cancer or ... ...

Abstract	Introduction: Chemokines play a crucial role in tumor growth and progression according to proangiogenic and immunosuppressive action. The aim of this study was to investigate the serum levels of selected chemokines in patients with ovarian cancer or benign ovarian tumors to assess their role in tumorigenesis and their potential use in preoperative diagnosis of an adnexal mass. Material and methods: The study group consisted of 59 women with ovarian cancer: 17 epithelial ovarian cancer (EOC) patients and 42 women with benign ovarian tumors. We measured in sera obtained preoperatively the level of CA125 and a panel of 5 chemokines - CX3CL1/fractalkine, CXCL1/GRO-α, CXCL12/SDF-1, CCL20/MIP-3α and IL-17F - using the chemiluminescence method with multiplexed bead based immunoassay. Results: CX3CL1 was significantly elevated in sera of advanced ovarian cancer patients compared to women with benign ovarian tumors. The significant elevation of CXCL1 was also observed (both early and advanced stages). A similar pattern was present with the standard ovarian cancer marker CA125. In our patients with endometriotic cysts CA125 levels were significantly higher than in women with other benign tumors, whereas all analyzed chemokines had similar serum titers in patients with endometriotic vs. other benign ovarian cysts. Conclusions: CX3CL1 and CXCL1 are elevated in sera of EOC patients, which indicates their role in cancer development. Moreover, they might be useful in preoperative differential diagnosis of ovarian tumors, especially as they were not elevated in cases of endometriosis.
Language	English
Publishing date	2021-03-21
Publishing country	Poland
Document type	Journal Article
ZDB-ID	2203781-0
ISSN	1734-1922
ISSN	1734-1922
DOI	10.5114/aoms/110672
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